Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Owen JS et al. | An improved assay for platelet-activating factor using HPLC-tandem mass spectrometry. | 2005 | J. Lipid Res. | pmid:15520455 |
| Lemieux C et al. | Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses. | 2005 | Blood | pmid:15498854 |
| Mishra RK et al. | Differential dependence of eosinophil chemotactic responses on phosphoinositide 3-kinase (PI3K). | 2005 | Allergy | pmid:16076309 |
| Jin Y et al. | Human resting CD16-, CD16+ and IL-2-, IL-12-, IL-15- or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine, lysophosphatidylcholine and platelet-activating factor. | 2005 | Eur. J. Immunol. | pmid:16078278 |
| Meyer MC et al. | Potential role for mast cell tryptase in recruitment of inflammatory cells to endothelium. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:16079184 |
| Fernandes ES et al. | Cytokines and neutrophils as important mediators of platelet-activating factor-induced kinin B1 receptor expression. | 2005 | Br. J. Pharmacol. | pmid:16025141 |
| Bazan HE | Cellular and molecular events in corneal wound healing: significance of lipid signalling. | 2005 | Exp. Eye Res. | pmid:15781273 |
| Yasu T et al. | Activated leukocytes and endothelial cells enhance retention of ultrasound contrast microspheres containing perfluoropropane in inflamed venules. | 2005 | Int. J. Cardiol. | pmid:15686774 |
| Fell JM | Neonatal inflammatory intestinal diseases: necrotising enterocolitis and allergic colitis. | 2005 | Early Hum. Dev. | pmid:15707723 |
| Schaloske RH et al. | Molecular characterization of the lipopolysaccharide/platelet activating factor- and zymosan-induced pathways leading to prostaglandin production in P388D1 macrophages. | 2005 | Biochim. Biophys. Acta | pmid:15708354 |
| Mann NS and Leung JW | Pathogenesis of esophageal rings in eosinophilic esophagitis. | 2005 | Med. Hypotheses | pmid:15617859 |
| Cheng L et al. | Platelet-activating factor and prostaglandin E2 impair esophageal ACh release in experimental esophagitis. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15890711 |
| Qu XW et al. | Tetrahydrobiopterin prevents platelet-activating factor-induced intestinal hypoperfusion and necrosis: Role of neuronal nitric oxide synthase. | 2005 | Crit. Care Med. | pmid:15891335 |
| Gilli UO et al. | Human polymorphonuclear neutrophils are recruited by porcine chemokines acting on CXC chemokine receptor 2, and platelet-activating factor. | 2005 | Transplantation | pmid:15912099 |
| Park EJ et al. | Dietary ganglioside decreases cholesterol content, caveolin expression and inflammatory mediators in rat intestinal microdomains. | 2005 | Glycobiology | pmid:15917432 |
| Owen JS et al. | Stress-induced platelet-activating factor synthesis in human neutrophils. | 2005 | Biochim. Biophys. Acta | pmid:15863359 |
| Lang KS et al. | Mechanisms of suicidal erythrocyte death. | 2005 | Cell. Physiol. Biochem. | pmid:15956782 |
| Kita Y et al. | A multiplex quantitation method for eicosanoids and platelet-activating factor using column-switching reversed-phase liquid chromatography-tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15958190 |
| Fang YH et al. | [Relationship between serum vWF and PAF in type 2 diabetic patients and diabetic nephropathy]. | 2005 | Di Yi Jun Yi Da Xue Xue Bao | pmid:15958323 |
| Vinson SM et al. | Neutrophil adherence to bladder microvascular endothelial cells following platelet-activating factor acetylhydrolase inhibition. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15937147 |
| Sumita C et al. | Platelet activating factor induces cytoskeletal reorganization through Rho family pathway in THP-1 macrophages. | 2005 | FEBS Lett. | pmid:16004986 |
| Ou-Yang XY et al. | [Inhibitory effect of ginkgolide B on angiogenesis in chronic inflammation]. | 2005 | Yao Xue Xue Bao | pmid:16011257 |
| Estellés R et al. | Effect of boldine, secoboldine, and boldine methine on angiotensin II-induced neutrophil recruitment in vivo. | 2005 | J. Leukoc. Biol. | pmid:15944212 |
| Zhao T and Bokoch GM | Critical role of proline-rich tyrosine kinase 2 in reversion of the adhesion-mediated suppression of reactive oxygen species generation by human neutrophils. | 2005 | J. Immunol. | pmid:15944312 |
| McLarnon JG et al. | Perturbations in calcium-mediated signal transduction in microglia from Alzheimer's disease patients. | 2005 | J. Neurosci. Res. | pmid:15948178 |
| Cao HC et al. | Determination of platelet-activating factor by reverse phase high-performance liquid chromatography and its application in viral hepatitis. | 2005 | World J. Gastroenterol. | pmid:16437644 |
| Asada Y | [Inflammatory and immune responses in arterial thrombus formation]. | 2005 | Rinsho Ketsueki | pmid:16447700 |
| Kira J | [Multiple sclerosis]. | 2005 | Rinsho Shinkeigaku | pmid:16447761 |
| Rubin BB et al. | Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity. | 2005 | J. Biol. Chem. | pmid:15475363 |
| Zinchuk O et al. | Direct action of platelet activating factor (PAF) induces eosinophil accumulation and enhances expression of PAF receptors in conjunctivitis. | 2005 | Mol. Vis. | pmid:15735601 |
| Lang PA et al. | Stimulation of erythrocyte ceramide formation by platelet-activating factor. | 2005 | J. Cell. Sci. | pmid:15741229 |
| Connelly PW et al. | Paraoxonase-1 does not reduce or modify oxidation of phospholipids by peroxynitrite. | 2005 | Free Radic. Biol. Med. | pmid:15607900 |
| Ivanov AI et al. | Albumin is not an irreplaceable carrier for amphipathic mediators of thermoregulatory responses to LPS: compensatory role of alpha1-acid glycoprotein. | 2005 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:15576666 |
| Denizot Y et al. | Platelet-activating factor does not stimulate cAMP formation from immature forms of freshly isolated leukaemic blasts. | 2005 | Leuk. Lymphoma | pmid:15621790 |
| Meyer MC et al. | Calcium-independent phospholipase A2 is regulated by a novel protein kinase C in human coronary artery endothelial cells. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15643055 |
| Granger J and Remick D | Acute pancreatitis: models, markers, and mediators. | 2005 | Shock | pmid:16374372 |
| Kihara Y et al. | Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor. | 2005 | J. Exp. Med. | pmid:16172262 |
| Tian X and Bazan NG | Neuroprotection by platelet-activating factor antagonism. | 2005 | Ann. N. Y. Acad. Sci. | pmid:16179552 |
| Zhang Q et al. | Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor. | 2005 | J. Clin. Invest. | pmid:16184199 |
| Pexa A and Deussen A | Modulation of ecto-5'-nucleotidase by phospholipids in human umbilical vein endothelial cells (HUVEC). | 2005 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16200394 |
| Karantonis HC et al. | Synthesis and biological evaluation of novel steroid-modified ether phospholipids. | 2005 | Chem. Phys. Lipids | pmid:16202400 |
| Antonopoulou S et al. | Bioactive polar lipids from Chroococcidiopsis sp. (Cyanobacteria). | 2005 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:16198133 |
| Hu G et al. | Isoflurane prevents platelets from enhancing neutrophil-induced coronary endothelial dysfunction. | 2005 | Anesth. Analg. | pmid:16243978 |
| Okumura N et al. | Platelet-activating factor in human normal tears. | 2005 | Curr. Eye Res. | pmid:16251126 |
| Ko HM et al. | Platelet-activating factor induces matrix metalloproteinase-9 expression through Ca(2+)- or PI3K-dependent signaling pathway in a human vascular endothelial cell line. | 2005 | FEBS Lett. | pmid:16288746 |
| Ward JR et al. | Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor. | 2005 | Thromb. Haemost. | pmid:16270639 |
| Buke AC et al. | Tumor necrosis factor alpha and interleukin 6 productions in response to platelet-activating factor in chronic hepatitis B virus infection. | 2004 Sep-Oct | Med Princ Pract | pmid:15316260 |
| Gilroy DW et al. | A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation. | 2004 | FASEB J. | pmid:15003994 |
| Venkatesha RT et al. | Platelet-activating factor-induced chemokine gene expression requires NF-kappaB activation and Ca2+/calcineurin signaling pathways. Inhibition by receptor phosphorylation and beta-arrestin recruitment. | 2004 | J. Biol. Chem. | pmid:15308653 |
| Balestrieri ML et al. | Lycopene in association with alpha-tocopherol or tomato lipophilic extracts enhances acyl-platelet-activating factor biosynthesis in endothelial cells during oxidative stress. | 2004 | Free Radic. Biol. Med. | pmid:15059646 |