Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zang BX et al. | [Inhibitory effect of kaempferol against binding of platelet activating factor to its receptor]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15506296 |
| Bankers-Fulbright JL et al. | Platelet-activating factor stimulates cytoplasmic alkalinization and granule acidification in human eosinophils. | 2004 | J. Cell. Sci. | pmid:15507482 |
| Gambero A et al. | Signalling pathways regulating human neutrophil migration induced by secretory phospholipases A2. | 2004 | Toxicon | pmid:15450921 |
| Hla T | Prostaglandins & other lipid mediators: a new phase, a new team. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165026 |
| Ruan Z et al. | Effects of platelet-activating factor and thromboxane A2 on isolated perfused guinea pig liver. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165033 |
| Amer MD et al. | Platelet-activating factor concentration in the stool of human newborns: effects of enteral feeding and neonatal necrotizing enterocolitis. | 2004 | Biol. Neonate | pmid:14646336 |
| Cinamon G et al. | Chemoattractant signals and beta 2 integrin occupancy at apical endothelial contacts combine with shear stress signals to promote transendothelial neutrophil migration. | 2004 | J. Immunol. | pmid:15585851 |
| Bender A et al. | Molecular surface point environments for virtual screening and the elucidation of binding patterns (MOLPRINT 3D). | 2004 | J. Med. Chem. | pmid:15588092 |
| Bate C et al. | Phospholipase A2 inhibitors or platelet-activating factor antagonists prevent prion replication. | 2004 | J. Biol. Chem. | pmid:15210691 |
| Jakubowski A et al. | Involvement of platelet activating factor in immediate heart response to lipopolysaccharide. | 2004 | J. Physiol. Pharmacol. | pmid:15213362 |
| Taylor KE | Familial cancer and developmental dyslexia: an observational pilot study. | 2004 | Dev Med Child Neurol | pmid:14974637 |
| Seo KH et al. | Essential role for platelet-activating factor-induced NF-kappaB activation in macrophage-derived angiogenesis. | 2004 | Eur. J. Immunol. | pmid:15259010 |
| Zhu P et al. | Interplay among platelet-activating factor, oxidative stress, and group I metabotropic glutamate receptors modulates neuronal survival. | 2004 | J. Neurosci. Res. | pmid:15264222 |
| Lu DP et al. | Trophic signals acting via phosphatidylinositol-3 kinase are required for normal pre-implantation mouse embryo development. | 2004 | J. Cell. Sci. | pmid:15020683 |
| Sarchielli P et al. | Platelet-activating factor (PAF) in internal jugular venous blood of migraine without aura patients assessed during migraine attacks. | 2004 | Cephalalgia | pmid:15265050 |
| Ziche M | Absence of PAF actions increases angiogenesis. | 2004 | Br. J. Pharmacol. | pmid:15023858 |
| Roudebush WE et al. | Platelet-activating factor significantly enhances intrauterine insemination pregnancy rates in non-male factor infertility. | 2004 | Fertil. Steril. | pmid:15236989 |
| Ferreira MA et al. | Sponge-induced angiogenesis and inflammation in PAF receptor-deficient mice (PAFR-KO). | 2004 | Br. J. Pharmacol. | pmid:15023865 |
| Alloatti G et al. | Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease. | 2004 | Biochem. Soc. Trans. | pmid:15046613 |
| Shio MT et al. | PAF is involved in the Mycoplasma arthritidis superantigen-triggering pathway for iNOS and COX-2 expression in murine peritoneal cells. | 2004 | Exp. Cell Res. | pmid:15242784 |
| Naoki K et al. | PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15047169 |
| Sugatani J et al. | Tea polyphenols inhibit acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and platelet-activating factor-induced platelet aggregation. | 2004 | Int. Arch. Allergy Immunol. | pmid:15051936 |
| Martin C et al. | Pressor responses to platelet-activating factor and thromboxane are mediated by Rho-kinase. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15064228 |
| Alfaro V | Role of histamine and platelet-activating factor in allergic rhinitis. | 2004 | J. Physiol. Biochem. | pmid:15457928 |
| Baker KE and Curtis MJ | Left regional cardiac perfusion in vitro with platelet-activating factor, norepinephrine and K+ reveals that ischaemic arrhythmias are caused by independent effects of endogenous "mediators" facilitated by interactions, and moderated by paradoxical antagonism. | 2004 | Br. J. Pharmacol. | pmid:15066909 |
| Uemura K et al. | Superoxide production from human polymorphonuclear leukocytes by human mannan-binding protein (MBP). | 2004 | Glycoconj. J. | pmid:15467404 |
| Victorino GP et al. | Modulation of microvascular hydraulic permeability by platelet-activating factor. | 2004 | J Trauma | pmid:14960983 |
| Ko HH et al. | Structure-activity relationship studies on chalcone derivatives: potent inhibition of platelet aggregation. | 2004 | J. Pharm. Pharmacol. | pmid:15482650 |
| Ewer AK et al. | The role of platelet activating factor in a neonatal piglet model of necrotising enterocolitis. | 2004 | Gut | pmid:14724152 |
| Angeli V et al. | Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. | 2004 | Immunity | pmid:15485633 |
| Tai H et al. | TMVA, a snake C-type lectin-like protein from Trimeresurus mucrosquamatus venom, activates platelet via GPIb. | 2004 | Toxicon | pmid:15501291 |
| McDonagh PF et al. | Chronic expression of platelet adhesion proteins is associated with severe ischemic heart disease in type 2 diabetic patients: Chronic platelet activation in diabetic heart patients. | 2003 Sep-Oct | J. Diabetes Complicat. | pmid:12954156 |
| Kerek M et al. | Effects of recombinant platelet activating factor acetylhydrolase in obstructive jaundice. | 2003 Jul-Aug | Hepatogastroenterology | pmid:12845989 |
| Baltás E et al. | Platelet-activating factor antagonist WEB 2086 inhibits ultraviolet-B radiation-induced dermatitis in the human skin. | 2003 Jul-Aug | Skin Pharmacol. Appl. Skin Physiol. | pmid:12784066 |
| Hsueh W et al. | Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. | 2003 Jan-Feb | Pediatr. Dev. Pathol. | pmid:12424605 |
| Diez-Fraile A et al. | Analysis of selective mobilization of L-selectin and Mac-1 reservoirs in bovine neutrophils and eosinophils. | 2003 Jan-Feb | Vet. Res. | pmid:12588684 |
| Zhang GQ et al. | [The effects of milkvetch and memantain on the synthesis of cerebral PAF in neonatal rats with hypoxic-ischemic reperfusion]. | 2003 | Zhonghua Er Ke Za Zhi | pmid:14751060 |
| Mayerle J et al. | [Conservative treatment of acute pancreatitis]. | 2003 | Med. Klin. (Munich) | pmid:14685675 |
| Tokuoka SM et al. | Involvement of platelet-activating factor and LIS1 in neuronal migration. | 2003 | Eur. J. Neurosci. | pmid:12911752 |
| Lupia E et al. | Intra-plaque production of platelet-activating factor correlates with neoangiogenesis in human carotid atherosclerotic lesions. | 2003 | Int. J. Mol. Med. | pmid:12883648 |
| Handa RK et al. | Role of Nitric oxide in the renal and systemic vasodilatory responses to platelet-activating factor in the rat, in vivo. | 2003 | Kidney Blood Press. Res. | pmid:12886044 |
| Witko-Sarsat V et al. | AOPP-induced activation of human neutrophil and monocyte oxidative metabolism: a potential target for N-acetylcysteine treatment in dialysis patients. | 2003 | Kidney Int. | pmid:12787398 |
| Elovitz MA et al. | A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. | 2003 | Am. J. Pathol. | pmid:14578208 |
| Slomiany BL and Slomiany A | Platelet-activating factor modulates gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12788098 |
| Kogure K et al. | Temporary membrane distortion of vascular smooth muscle cells is responsible for their apoptosis induced by platelet-activating factor-like oxidized phospholipids and their degradation product, lysophosphatidylcholine. | 2003 | Chem. Phys. Lipids | pmid:14580708 |
| Schuster DP et al. | Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial. | 2003 | Crit. Care Med. | pmid:12794395 |
| Rabinovici R | Platelet activating factor inhibition in sepsis: the end? | 2003 | Crit. Care Med. | pmid:12794432 |
| Bernatchez PN et al. | Sphingosine 1-phosphate effect on endothelial cell PAF synthesis: role in cellular migration. | 2003 | J. Cell. Biochem. | pmid:14587028 |
| Kordan W et al. | Functions of platelet activating factor (PAF) in mammalian reproductive processes: a review. | 2003 | Pol J Vet Sci | pmid:12675470 |
| Loucks EB et al. | Role of platelet activating factor in cardiac dysfunction, apoptosis and nitric oxide synthase mRNA expression in the ischemic-reperfused rabbit heart. | 2003 | Can J Cardiol | pmid:12677282 |