Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Shmueli O et al. | Platelet-activating factor (PAF) acetylhydrolase activity, LIS1 expression, and seizures. | 1999 | J. Neurosci. Res. | pmid:10398295 |
Liu Q et al. | The effect of lexipafant on bacterial translocation in acute necrotizing pancreatitis in rats. | 1999 | Am Surg | pmid:10399968 |
Li L et al. | Estrogen effects on platelet-activating factor and platelet-activating factor acetylhydrolase activity in rat uterus during the late stages of pregnancy. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10402216 |
Kudolo GB and DeFronzo RA | Urinary platelet-activating factor excretion is elevated in non-insulin dependent diabetes mellitus. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10410380 |
Salas A et al. | Reperfusion-induced oxidative stress in diabetes: cellular and enzymatic sources. | 1999 | J. Leukoc. Biol. | pmid:10410990 |
Calcerrada MC et al. | Platelet-activating factor stimulation of p125(FAK) and p130(Cas) tyrosine phosphorylation in brain. | 1999 | Brain Res. | pmid:10415383 |
M'Rabet L et al. | Differential fMet-Leu-Phe- and platelet-activating factor-induced signaling toward Ral activation in primary human neutrophils. | 1999 | J. Biol. Chem. | pmid:10419502 |
Geijsen N et al. | Regulation of p21rac activation in human neutrophils. | 1999 | Blood | pmid:10419906 |
Panés J et al. | Impaired mesenteric leukocyte recruitment in experimental portal hypertension in the rat. | 1999 | Hepatology | pmid:10421653 |
Shan L et al. | Platelet-activating factor increases the expression of metalloproteinase-9 in human bronchial epithelial cells. | 1999 | Eur. J. Pharmacol. | pmid:10422651 |