Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Acute Kidney Injury D058186 34 associated lipids
Acute Lung Injury D055371 33 associated lipids
Mucositis D052016 7 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Atherosclerosis D050197 85 associated lipids
Jaundice, Obstructive D041781 2 associated lipids
Hyperuricemia D033461 4 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Coronary Stenosis D023921 6 associated lipids
Peanut Hypersensitivity D021183 2 associated lipids
Egg Hypersensitivity D021181 1 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Fetal Weight D020567 12 associated lipids
Stroke D020521 32 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Enterocolitis, Necrotizing D020345 3 associated lipids
Migraine without Aura D020326 1 associated lipids
Amnesia, Anterograde D020324 2 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Venous Thrombosis D020246 11 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Optic Nerve Injuries D020221 4 associated lipids
Brain Hemorrhage, Traumatic D020201 1 associated lipids
Thrombophilia D019851 6 associated lipids
Hepatitis C, Chronic D019698 12 associated lipids
Hepatitis B, Chronic D019694 4 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Capillary Leak Syndrome D019559 2 associated lipids
Endotoxemia D019446 27 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Leukostasis D018921 1 associated lipids
Encephalitis, Viral D018792 3 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Leukocyte-Adhesion Deficiency Syndrome D018370 1 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Pelvic Pain D017699 7 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Hypertrophy, Right Ventricular D017380 4 associated lipids
Strongylida Infections D017206 5 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Liver Failure D017093 5 associated lipids
Colitis, Ischemic D017091 3 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Leishmaniasis, Cutaneous D016773 6 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Kochanek PM et al. Platelet activating factor antagonists do not alter normal cerebral blood flow or cerebral oxygen consumption. 1990 Adv. Exp. Med. Biol. pmid:2096640
Camussi G et al. Antiflammins inhibit synthesis of platelet-activating factor and intradermal inflammatory reactions. 1990 Adv. Exp. Med. Biol. pmid:2096695
Paubert-Braquet M et al. Platelet-activating factor amplifies tumour necrosis factor-induced superoxide generation by human neutrophils. 1990 Adv. Exp. Med. Biol. pmid:2173875
Vernadakis A et al. C-6 glioma cells of early passage have progenitor properties in culture. 1991 Adv. Exp. Med. Biol. pmid:1685850
Yue TL et al. Platelet-activating factor (PAF)--a putative mediator in inflammatory tissue injury. 1991 Adv. Exp. Med. Biol. pmid:1667965
Schlondorff D Interactions of platelet activating factor and prostaglandins in the glomerulus and in mesangial cells. 1989 Adv. Exp. Med. Biol. pmid:2696352
Remuzzi G Eicosanoids and platelet activating factor as possible mediators of injury in experimental nephropathies. 1989 Adv. Exp. Med. Biol. pmid:2696353
Rabinovici R et al. PAF and TNF alpha interactions in the pathophysiology of septic shock. 1991 Adv. Exp. Med. Biol. pmid:1818486
Jin N et al. Platelet activating factor causes relaxation of isolated pulmonary artery and aorta. 1991 Adv. Exp. Med. Biol. pmid:1803920
Maes L et al. In vivo arterial platelet-vessel wall interaction and thrombosis: induction, on-line registration and ultrastructural control. 1985 Adv. Exp. Med. Biol. pmid:3832867
Tuffin DP et al. Specific binding of [3H]-1-O-octadecyl Paf-acether to washed human platelets. 1985 Adv. Exp. Med. Biol. pmid:3834789
Kurachi M et al. Suppression of bronchial response to platelet activating factor following taurine administration. 1987 Adv. Exp. Med. Biol. pmid:3434419
Bourgain RH et al. Arterial obstruction induced by PAF-acether (1-O-alkyl-sn-glycero-3-phosphocholine). 1987 Adv. Exp. Med. Biol. pmid:3673721
Fisher RA et al. AGEPC: a potent calcium-dependent chemical mediator in the liver. 1988 Adv. Exp. Med. Biol. pmid:3213685
Bourgain RH et al. PAF-acether induced arterial thrombosis and the effect of specific antagonists. 1992 Adv. Exp. Med. Biol. pmid:1288104
van Rossem K et al. The role of PAF and the effect of a specific PAF antagonist on local tissue PO2 and neuronal integrity during and after photothrombotic brain infarction in unanesthetised rabbits. 1996 Adv. Exp. Med. Biol. pmid:8798843
Hanahan DJ The continuing biochemical challenge of PAF and closely related lipid mediators. 1996 Adv. Exp. Med. Biol. pmid:9131117
Snyder F et al. Biosynthesis of platelet-activating factor and enzyme inhibitors. 1996 Adv. Exp. Med. Biol. pmid:9131118
Satoh K et al. Production of platelet-activating factor by brain microvascular endothelial cells. 1996 Adv. Exp. Med. Biol. pmid:9131120
Francescangeli E et al. PAF-synthesizing enzymes in neural cells during differentiation and in gerbil brain during ischemia. 1996 Adv. Exp. Med. Biol. pmid:9131121
Yamada M et al. Platelet-activating factor production in the stimulated macrophages is enhanced by the cyclooxygenase inhibitors. 1996 Adv. Exp. Med. Biol. pmid:9131122
van den Bosch H et al. The role of peroxisomes in ether lipid synthesis. Back to the roots of PAF. 1996 Adv. Exp. Med. Biol. pmid:9131123
Dohi T et al. Platelet-activating factor synthesis and its role in salivary glands. 1996 Adv. Exp. Med. Biol. pmid:9131124
Nakayama R et al. Physiological action of PAF in yeast Saccharomyces cerevisiae. 1996 Adv. Exp. Med. Biol. pmid:9131125
Demopoulos CA and Antonopoulou S A discovery trip to compounds with PAF-like activity. 1996 Adv. Exp. Med. Biol. pmid:9131127
Rementzis J et al. Biologically active lipids from S. scombrus. 1996 Adv. Exp. Med. Biol. pmid:9131128
Orevi M et al. Purification and partial characterization of the PAF antagonist from the saliva of the leech Hirudo medicinalis. 1996 Adv. Exp. Med. Biol. pmid:9131129
Shimizu T et al. Platelet-activating factor receptor. Gene structure and tissue-specific regulation. 1996 Adv. Exp. Med. Biol. pmid:9131130
Sato S et al. Up-regulation of the intracellular Ca2+ signaling and mRNA expression of platelet-activating factor receptor by estradiol in human uterine endometrial cells. 1996 Adv. Exp. Med. Biol. pmid:9131133
Dohi T et al. Functional role of platelet-activating factor receptor in secretory response in adrenal chromaffin cells. 1996 Adv. Exp. Med. Biol. pmid:9131134
Lee T Acetylation of sphingosine by PAF-dependent transacetylase. 1996 Adv. Exp. Med. Biol. pmid:9131136
Muguruma K et al. The prevention of necrotizing enterocolitis. The role of platelet-activating factor acetylhydrolase. 1996 Adv. Exp. Med. Biol. pmid:9131138
Baltas G et al. Implication of PAF and acetylhydrolase (PAF-AH) activity in periodontal disease. 1996 Adv. Exp. Med. Biol. pmid:9131139
Ye RD et al. Stimulation of NF-kappa B activation and gene expression by platelet-activating factor. 1996 Adv. Exp. Med. Biol. pmid:9131140
Korth RM Non-specific PAF binding to embryonal F9 cells and prostacyclin synthesis in human umbilical vein endothelial cells. 1996 Adv. Exp. Med. Biol. pmid:9131162
Zimmerman GA et al. Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions. 1996 Adv. Exp. Med. Biol. pmid:9131163
Yang HC et al. Characterization of plasmalogen-selective phospholipase A2 from bovine brain. 1996 Adv. Exp. Med. Biol. pmid:9131165
Ferby I et al. PAF-induced MAPK activation is inhibited by wortmannin in neutrophils and macrophages. 1996 Adv. Exp. Med. Biol. pmid:9131167
Thierse HJ et al. Evidence for activation of cyclooxygenase-1/-2 by endogenous nitric oxide in adjuvant arthritic Lewis rats. 1996 Adv. Exp. Med. Biol. pmid:9131171
Curtis LD Lexipafant (BB-882), a potent PAF antagonist in acute pancreatitis. 1996 Adv. Exp. Med. Biol. pmid:9131174
McKay C et al. The use of lexipafant in the treatment of acute pancreatitis. 1996 Adv. Exp. Med. Biol. pmid:9131175
Tamura G et al. Effect of a potent platelet-activating factor antagonist, WEB-2086, on asthma. A multicenter, double-blind placebo-controlled study in Japan. 1996 Adv. Exp. Med. Biol. pmid:9131176
Albert DH et al. Ex vivo inhibition of PAF-induced beta-thromboglobulin release in man by ABT-299, a potent PAF antagonist. 1996 Adv. Exp. Med. Biol. pmid:9131177
Elizarova EP Effects of taurine on calcium in platelets and their aggregation. 1996 Adv. Exp. Med. Biol. pmid:8915398
Michibayashi T Neurogenic inhibitory action through platelets of platelet activating factor (PAF) on vasoconstrictive responsiveness to pressor agents. 1997 Adv. Exp. Med. Biol. pmid:9561145
Ishii I et al. High and low affinity mutants of platelet-activating factor receptor. 1997 Adv. Exp. Med. Biol. pmid:9561146
Bazan NG Bioactive lipids and gene expression in neuronal plasticity. 1998 Adv. Exp. Med. Biol. pmid:10079836
Marshall LA et al. Respective roles of the 14 kDa and 85 kDa phospholipase A2 enzymes in human monocyte eicosanoid formation. 1999 Adv. Exp. Med. Biol. pmid:10667333
Kato K Modulation of long-term potentiation in the CA1 area of rat hippocampus by platelet-activating factor. 1999 Adv. Exp. Med. Biol. pmid:10667334
Goldman R et al. Lipid mediators stimulate reactive oxygen species formation in immortalized human keratinocytes. 1999 Adv. Exp. Med. Biol. pmid:10667361