Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Brain Injuries D001930 4 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Osteonecrosis D010020 5 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Gastritis D005756 27 associated lipids
Pulmonary Edema D011654 23 associated lipids
Coronary Disease D003327 70 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Pancreatitis D010195 10 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Mann O et al. Effect of platelet-activating factor antagonist WEB 2086 on microcirculatory disorders in acute experimental pancreatitis of graded severity. 2009 Pancreas pmid:18695628
Yang HQ et al. PMS777, a new cholinesterase inhibitor with anti-platelet activated factor activity, regulates amyloid precursor protein processing in vitro. 2009 Neurochem. Res. pmid:18758955
Castro DP et al. Physalin B inhibits Rhodnius prolixus hemocyte phagocytosis and microaggregation by the activation of endogenous PAF-acetyl hydrolase activities. 2009 J. Insect Physiol. pmid:19232405
Yao Y et al. Ultraviolet B radiation generated platelet-activating factor receptor agonist formation involves EGF-R-mediated reactive oxygen species. 2009 J. Immunol. pmid:19234179
Shindou H and Shimizu T [New development of lysophospholipid acyltransferases]. 2009 Tanpakushitsu Kakusan Koso pmid:19205351
Seki M et al. Expression and DNA microarray analysis of a platelet activating factor-related molecule in severe pneumonia in mice due to influenza virus and bacterial co-infection. 2009 Jpn. J. Infect. Dis. pmid:19168951
Schneider DJ and Sobel BE Streamlining the design of promising clinical trials: in-vitro testing of antithrombotic regimens and multiple agonists of platelet activation. 2009 Coron. Artery Dis. pmid:19194284
Li J et al. Protection of PMS777, a new AChE inhibitor with PAF antagonism, against amyloid-beta-induced neuronal apoptosis and neuroinflammation. 2009 Cell. Mol. Neurobiol. pmid:19194797
Fité-Mora R Torsade de pointes associated with rupatadine. 2009 Rev Esp Cardiol pmid:19268083
Wijman CA Is platelet activity important in acute intracerebral hemorrhage? 2009 Neurocrit Care pmid:19714496
Baka S et al. Treatment of sperm with platelet-activating factor does not improve intrauterine insemination outcome in unselected cases of mild male factor infertility: a prospective double-blind randomized crossover study. 2009 Urology pmid:19716589
Bao GQ and Ju AZ [Signal pathways of eryptosis-review]. 2009 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:19698269
Shi B et al. [Influence of intensive insulin therapy on the intestinal microcirculatory dysfunction in rats with sepsis]. 2009 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:19695175
Rastogi P and McHowat J Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium. 2009 Respir Physiol Neurobiol pmid:19059366
Wen J et al. Simultaneous determination of rupatadine and its metabolite desloratadine in human plasma by a sensitive LC-MS/MS method: application to the pharmacokinetic study in healthy Chinese volunteers. 2009 J Pharm Biomed Anal pmid:19059745
Deng Y et al. Blood-brain barrier breakdown by PAF and protection by XQ-1H due to antagonism of PAF effects. 2009 Eur. J. Pharmacol. pmid:19555682
Edwards LJ and Constantinescu CS Platelet activating factor/platelet activating factor receptor pathway as a potential therapeutic target in autoimmune diseases. 2009 Inflamm Allergy Drug Targets pmid:19601878
Camerer E et al. Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. 2009 J. Clin. Invest. pmid:19603543
Xu J et al. Platelet-activating factor-stimulated production of reactive oxygen species in ovarian granulosa cells from periovulatory follicles. 2009 Cytometry A pmid:19565634
Eggert D et al. Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders. 2009 J. Neuroimmunol. pmid:19541372
Coy ED et al. Macrophyllin-type bicyclo[3.2.1]octanoid neolignans from the leaves of Pleurothyrium cinereum. 2009 J. Nat. Prod. pmid:19548690
Coy-Barrera ED et al. PAF-antagonistic bicyclo[3.2.1]octanoid neolignans from leaves of Ocotea macrophylla Kunth. (Lauraceae). 2009 Phytochemistry pmid:19674762
Kordan W et al. Effect of platelet-activating factor on motility, plasmalemma integrity, the process of capacitation and acrosome reaction of fresh and cryopreserved boar spermatozoa. 2009 Pol J Vet Sci pmid:19645346
Poisson C et al. Caveolae facilitate but are not essential for platelet-activating factor-mediated calcium mobilization and extracellular signal-regulated kinase activation. 2009 J. Immunol. pmid:19620302
Pantaler E and Lückhoff A Inhibitors of TRP channels reveal stimulus-dependent differential activation of Ca2+ influx pathways in human neutrophil granulocytes. 2009 Naunyn Schmiedebergs Arch. Pharmacol. pmid:19894037
He YG et al. Functional analysis of platelet-activating factor in the retinal pigment epithelial cells and choroidal endothelial cells. 2009 Curr. Eye Res. pmid:19958112
Guo CJ et al. The synthesis and biological evaluation of 10-O-dialkylaminoethyl ginkgolide B as platelet-activating factor antagonist. 2008 Sep-Oct J Asian Nat Prod Res pmid:19003620
Kurdiumov IN et al. [Cerebrovascular and antiaggregative effects of GABA-docosahexaenoyldopamine conjugate]. 2008 Jul-Aug Eksp Klin Farmakol pmid:18819437
Chamogeorgakis TP et al. Effect of N-acetyl-L-cysteine on lung ischaemia reperfusion injury in a porcine experimental model. 2008 Jan-Feb ANZ J Surg pmid:18199211
Kikuchi M et al. Platelet-activating factor (PAF) increases NO production in human endothelial cells-real-time monitoring by DAR-4M AM. 2008 Apr-May Prostaglandins Leukot. Essent. Fatty Acids pmid:18502110
Zhang XP et al. The pathogenic mechanism of severe acute pancreatitis complicated with renal injury: a review of current knowledge. 2008 Dig. Dis. Sci. pmid:17597411
Smith JC et al. Identification of lysophosphatidylcholine (LPC) and platelet activating factor (PAF) from PC12 cells and mouse cortex using liquid chromatography/multi-stage mass spectrometry (LC/MS3). 2008 Rapid Commun. Mass Spectrom. pmid:18937225
Kihara Y et al. Platelet-activating factor production in the spinal cord of experimental allergic encephalomyelitis mice via the group IVA cytosolic phospholipase A2-lyso-PAFAT axis. 2008 J. Immunol. pmid:18802104
Wislet-Gendebien S et al. Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors. 2008 BMC Neurosci pmid:18808659
Zheng M et al. (3S)-N-(L-Aminoacyl)-1,2,3,4-tetrahydroisoquinolines, a class of novel antithrombotic agents: synthesis, bioassay, 3D QSAR, and ADME analysis. 2008 Bioorg. Med. Chem. pmid:18835178
Kasperska-Zajac A et al. Platelet activating factor as a mediator and therapeutic approach in bronchial asthma. 2008 Inflammation pmid:18193345
Vadas P et al. Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis. 2008 N. Engl. J. Med. pmid:18172172
Burks AW Factoring PAF in anaphylaxis. 2008 N. Engl. J. Med. pmid:18172180
Menzies-Gow NJ et al. Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses. 2008 Am. J. Vet. Res. pmid:18241016
Hemetsberger R et al. Association between the efficacy of dual antiplatelet therapy and the development of in-stent neointimal hyperplasia in porcine coronary arteries. 2008 Coron. Artery Dis. pmid:19005299
Kasperska-Zajac A et al. Platelet-activating factor (PAF): a review of its role in asthma and clinical efficacy of PAF antagonists in the disease therapy. 2008 Recent Pat Inflamm Allergy Drug Discov pmid:19075994
Shiva D et al. High dose of lipopolysaccharide pre-treatment prevents OVA-induced anaphylactic decreases in rectal temperature in the immunized mice. 2008 Immunol. Lett. pmid:18433880
Leary PJ et al. A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18441203
Cooper D et al. Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. 2008 J. Leukoc. Biol. pmid:18372340
Bansal AS et al. Platelet-activating factor, PAF acetylhydrolase, and anaphylaxis. 2008 N. Engl. J. Med. pmid:18389523
Okamoto H and Kamatani N Platelet-activating factor, PAF acetylhydrolase, and anaphylaxis. 2008 N. Engl. J. Med. pmid:18389524
Torres MI and Rios A Current view of the immunopathogenesis in inflammatory bowel disease and its implications for therapy. 2008 World J. Gastroenterol. pmid:18395894
Kim HA et al. Nitric oxide plays a key role in the platelet-activating factor-induced enhancement of resistance against systemic candidiasis. 2008 Immunology pmid:18397269
Galli SJ and Franco CB Basophils are back! 2008 Immunity pmid:18400194
Sreevidya CS et al. Inhibition of photocarcinogenesis by platelet-activating factor or serotonin receptor antagonists. 2008 Cancer Res. pmid:18483284