Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yaffe MB et al. | Priming of the neutrophil respiratory burst is species-dependent and involves MAP kinase activation. | 1999 | Surgery | pmid:10455891 |
| Werner J et al. | Multidrug strategies are effective in the treatment of severe experimental pancreatitis. | 2012 | Surgery | pmid:21982067 |
| Unno N et al. | Single nucleotide polymorphism (G994-->T) in the plasma platelet-activating factor-acetylhydrolase gene is associated with graft patency of femoropopliteal bypass. | 2002 | Surgery | pmid:12110797 |
| Kim FJ et al. | Disparate signal transduction in neutrophil CD18 adhesion receptor expression versus superoxide generation. | 1994 | Surgery | pmid:8047994 |
| Takada Y et al. | Prolonged hepatic warm ischemia in non-heart-beating donors: protective effects of FK506 and a platelet activating factor antagonist in porcine liver transplantation. | 1998 | Surgery | pmid:9626320 |
| Cuschieri J et al. | Platelet-activating factor priming of inflammatory cell activity requires cellular adherence. | 2002 | Surgery | pmid:12219006 |
| Wang KS et al. | Protective effect of platelet-activating factor antagonist on ischemia-induced liver injury in rats. | 1993 | Surgery | pmid:8417492 |
| Fukuoka T et al. | The platelet activating factor as a pivotal mediator of shock after liver ischemia. | 1995 | Surg. Today | pmid:7633127 |
| Ono S et al. | Clinical and experimental studies on the role of platelet-activating factor (PAF) in the pathogenesis of septic DIC. | 1993 | Surg. Today | pmid:8467174 |
| Denham W and Norman J | The potential role of therapeutic cytokine manipulation in acute pancreatitis. | 1999 | Surg. Clin. North Am. | pmid:10470326 |
| Biffl WL et al. | Neutrophil apoptosis is delayed by trauma patients' plasma via a mechanism involving proinflammatory phospholipids and protein kinase C. | 2001 | Surg Infect (Larchmt) | pmid:12593704 |
| Anderson BO et al. | The role of platelet activating factor and its antagonists in shock, sepsis and multiple organ failure. | 1991 | Surg Gynecol Obstet | pmid:1851337 |
| Wei Y et al. | Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 A resolution. | 1998 | Structure | pmid:9562561 |
| Sirén AL et al. | Increased release of tumor necrosis factor-alpha into the cerebrospinal fluid and peripheral circulation of aged rats. | 1993 | Stroke | pmid:8506560 |
| Lindsberg PJ et al. | Evidence for platelet-activating factor as a novel mediator in experimental stroke in rabbits. | 1990 | Stroke | pmid:2219210 |
| Sirén AL et al. | Release of proinflammatory and prothrombotic mediators in the brain and peripheral circulation in spontaneously hypertensive and normotensive Wistar-Kyoto rats. | 1992 | Stroke | pmid:1440713 |
| Joseph R et al. | Effect of therapy on platelet activating factor-induced aggregation in acute stroke. | 1989 | Stroke | pmid:2718200 |
| Joseph R and Welch KM | Granulocytes, platelet activating factor, and stroke. | 1989 | Stroke | pmid:2756548 |
| Uhl E et al. | Influence of platelet-activating factor on cerebral microcirculation in rats: part 1. Systemic application. | 1999 | Stroke | pmid:10187894 |
| Uhl E et al. | Influence of platelet-activating factor on cerebral microcirculation in rats: part 2. Local application. | 1999 | Stroke | pmid:10187895 |
| Bielenberg GW et al. | Infarct reduction by the platelet activating factor antagonist apafant in rats. | 1992 | Stroke | pmid:1731428 |
| Joseph R et al. | Effect of ticlopidine and aspirin on platelet ionized calcium in ischemic stroke. | 1991 | Stroke | pmid:2024285 |
| Kochanek PM et al. | Endogenous platelet activating factor does not modulate blood flow and metabolism in normal rat brain. | 1990 | Stroke | pmid:2309270 |
| Feuerstein G et al. | Platelet-activating factor. A putative mediator in central nervous system injury? | 1990 | Stroke | pmid:2237991 |
| Yoshida H et al. | Platelet-activating factor acetylhydrolase in red cell membranes. Does decreased activity impair erythrocyte deformability in ischemic stroke patients? | 1993 | Stroke | pmid:8418541 |
| Nishida K and Markey SP | Platelet-activating factor in brain regions after transient ischemia in gerbils. | 1996 | Stroke | pmid:8610322 |
| Leont'ev VK and Kankanian AP | [The local activation of leukocytes and thrombocytes in periodontal diseases: the role of thrombocyte-activating factor]. | 1996 | Stomatologiia (Mosk) | pmid:8658569 |
| Liu J et al. | New vernocuminosides from the stem barks of Vernonia cumingiana Benth. | 2009 | Steroids | pmid:18840454 |
| Donnard M et al. | Membrane and intracellular platelet-activating factor receptor expression in leukemic blasts of patients with acute myeloid and lymphoid leukemia. | 2002 | Stem Cells | pmid:12351810 |
| Costa M et al. | Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization. | 2013 | Stem Cell Res | pmid:23164599 |
| Wintroub BU and Soter NA | Biology of the mast cell and its role in cutaneous inflammation. | 1981 | Springer Semin. Immunopathol. | pmid:7022722 |
| Baltás E et al. | Platelet-activating factor antagonist WEB 2086 inhibits ultraviolet-B radiation-induced dermatitis in the human skin. | 2003 Jul-Aug | Skin Pharmacol. Appl. Skin Physiol. | pmid:12784066 |
| Glaser KB et al. | Cellular and topical in vivo inflammatory murine models in the evaluation of inhibitors of phospholipase A2. | 1995 | Skin Pharmacol. | pmid:8688196 |
| Kruse-Elliott KT et al. | Role of lipid-derived mediators in tumor necrosis factor-induced endothelin-1 release in vivo. | 1998 | Shock | pmid:9466472 |
| Kruse-Elliott KT et al. | Low molecular weight heparin alters porcine neutrophil responses to platelet-activating factor. | 1998 | Shock | pmid:9744648 |
| Cuschieri J et al. | Calcium/calmodulin-dependent kinase II is required for platelet-activating factor priming. | 2005 | Shock | pmid:15665723 |
| Rios-Santos F et al. | A critical role of leukotriene B4 in neutrophil migration to infectious focus in cecal ligaton and puncture sepsis. | 2003 | Shock | pmid:12558146 |
| Buripakdi D and Karlstad MD | The role of platelet-activating factor in alterations of system A amino acid transport in rat soleus and extensor digitorum longus muscles during endotoxic shock. | 1994 | Shock | pmid:7735984 |
| Enzan K et al. | Thromboxane rather than platelet activating factor mediates pulmonary vasoconstriction after antigen challenge in rabbits. | 1996 | Shock | pmid:8885083 |
| Koch T et al. | Effects of stroma-free hemoglobin solutions on pulmonary vascular resistance and mediator release in the isolated perfused rabbit lung. | 1994 | Shock | pmid:7538430 |
| Shouji K et al. | Platelet-activating factor is a key mediator of pulmonary vasoconstriction and bronchoconstriction after antigen challenge in the perfused sensitized rabbit lung. | 1998 | Shock | pmid:9645492 |
| Laniyonu AA et al. | Endotoxin-induced microvascular leakage is prevented by a PAF antagonist and NO synthase inhibitor. | 1997 | Shock | pmid:8989836 |
| Albert DH et al. | ABT-299, a novel PAF antagonist, attenuates multiple effects of endotoxemia in conscious rats. | 1996 | Shock | pmid:8856845 |
| Poeze M et al. | Decreased organ failure in patients with severe SIRS and septic shock treated with the platelet-activating factor antagonist TCV-309: a prospective, multicenter, double-blind, randomized phase II trial. TCV-309 Septic Shock Study Group. | 2000 | Shock | pmid:11049104 |
| Karlstad MD et al. | Platelet-activating factor (PAF)-induced decreases in whole-body and skeletal muscle protein synthesis. | 2000 | Shock | pmid:11049115 |
| James JH and Fischer JE | Are the effects of platelet-activating factor on muscle metabolism of carbohydrates, amino acids and proteins attributable mainly to epinephrine? | 2000 | Shock | pmid:11049116 |
| Ciesla DJ et al. | Hypertonic saline inhibits neutrophil (PMN) priming via attenuation of p38 MAPK signaling. | 2000 | Shock | pmid:11028541 |
| Klabunde RE and Calvello C | Inhibition of endotoxin-induced microvascular leakage by a platelet-activating factor antagonist and 5-lipoxygenase inhibitor. | 1995 | Shock | pmid:8595525 |
| Cureton EL et al. | Endothelin 1 and prostacyclin attenuate increases in hydraulic permeability caused by platelet-activating factor in rats. | 2010 | Shock | pmid:19940814 |
| Mariano F et al. | Platelet-activating factor synthesis by neutrophils, monocytes, and endothelial cells is modulated by nitric oxide production. | 2003 | Shock | pmid:12688545 |