| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Tselepis AD et al. | Association of the inflammatory state in active juvenile rheumatoid arthritis with hypo-high-density lipoproteinemia and reduced lipoprotein-associated platelet-activating factor acetylhydrolase activity. | 1999 | Arthritis Rheum. | pmid:10025933 |
| Bussolati B et al. | Interleukin-12 is synthesized by mesangial cells and stimulates platelet-activating factor synthesis, cytoskeletal reorganization, and cell shape change. | 1999 | Am. J. Pathol. | pmid:10027419 |
| Van de Weerdt ML et al. | Ketoprofen and phenylbutazone attenuation of PAF-induced lung inflammation in calves. | 1999 | Vet. J. | pmid:10030127 |
| Zallen G et al. | Postinjury suppression of human neutrophil cytokine production results from the stabilization of inhibitory kappaB. | 1999 | Shock | pmid:10030791 |
| Delong P et al. | Bacterial lipopolysaccharide induction of the prostaglandin G/H synthase 2 gene causes thromboxane-dependent pulmonary hypertension in rabbits. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10030848 |
| Mukherjee PK et al. | Glutamate receptor signaling interplay modulates stress-sensitive mitogen-activated protein kinases and neuronal cell death. | 1999 | J. Biol. Chem. | pmid:10037742 |
| Tsuchiya R et al. | Role of platelet activating factor in development of thrombocytopenia and neutropenia in dogs with endotoxemia. | 1999 | Am. J. Vet. Res. | pmid:10048555 |
| Okayama N et al. | Intracellular mechanisms of hydrogen peroxide-mediated neutrophil adherence to cultured human endothelial cells. | 1999 | Microvasc. Res. | pmid:10049654 |
| Satoh N et al. | Plasma platelet-activating factor acetylhydrolase deficiency in Japanese patients with asthma. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10051281 |
| Tokumura A et al. | Substrate specificity of lysophospholipase D which produces bioactive lysophosphatidic acids in rat plasma. | 1999 | Biochim. Biophys. Acta | pmid:10064906 |
| Stojanov T et al. | In-vitro fertilization and culture of mouse embryos in vitro significantly retards the onset of insulin-like growth factor-II expression from the zygotic genome. | 1999 | Mol. Hum. Reprod. | pmid:10065866 |
| Kaminskaia GO et al. | [Platelet activating factor in biological fluids of animals with different species-specific resistance at the stage of infective process after inoculation with mycobacterium tuberculosis]. | 1998 | Probl Tuberk | pmid:10067355 |
| Hurst J et al. | PAF binding to a single receptor in corneal epithelium plasma membrane. | 1999 | Invest. Ophthalmol. Vis. Sci. | pmid:10067986 |
| Oguchi A et al. | Platelet activating factor causes a rapid increase in activity of prior expressed tissue factor on monocyte surface membrane. | 1999 | Int. J. Hematol. | pmid:10071462 |
| Suzuki T et al. | 2-(3-Pyridyl)thiazolidine-4-carboxamide derivatives. III.) Synthesis of metabolites and metabolism of 2-(3-pyridyl)thiazolidine-4-carboxamides YM461 and YM264 as platelet-activating factor (PAF) receptor antagonists. | 1999 | Chem. Pharm. Bull. | pmid:10071851 |
| Bartemes KR et al. | Endogenous platelet-activating factor is critically involved in effector functions of eosinophils stimulated with IL-5 or IgG. | 1999 | J. Immunol. | pmid:10072549 |
| Zeng S and Guo ZG | Mepyramine inhibits platelet activating factor-induced rabbit platelet aggregation: role of intracellular histamine. | 1997 | Zhongguo Yao Li Xue Bao | pmid:10072970 |
| Shohet RV et al. | Plasma platelet-activating factor acetylhydrolase activity is not associated with premature coronary atherosclerosis. | 1999 | Am. J. Cardiol. | pmid:10073795 |
| Fink MP | Nitric oxide and the gut: one more piece in the puzzle. | 1999 | Crit. Care Med. | pmid:10075038 |
| Qu XW et al. | Roles of nitric oxide synthases in platelet-activating factor-induced intestinal necrosis in rats. | 1999 | Crit. Care Med. | pmid:10075061 |
| Bazan NG | Bioactive lipids and gene expression in neuronal plasticity. | 1998 | Adv. Exp. Med. Biol. | pmid:10079836 |
| Takami M and Tsukada W | Effect of DP-1904, a thromboxane synthetase inhibitor, on antigen- and spasmogen-induced bronchoconstriction in rodents. | 1999 | Eur. J. Pharmacol. | pmid:10082207 |
| Kim KA et al. | Pinusolide from the leaves of Biota orientalis as potent platelet activating factor antagonist. | 1999 | Planta Med. | pmid:10083843 |
| Karasawa K et al. | Purification and characterization from rat kidney membranes of a novel platelet-activating factor (PAF)-dependent transacetylase that catalyzes the hydrolysis of PAF, formation of PAF analogs, and C2-ceramide. | 1999 | J. Biol. Chem. | pmid:10085103 |
| Samples BL et al. | Subcellular localization of enzyme activities involved in the metabolism of platelet-activating factor in rainbow trout leukocytes. | 1999 | Biochim. Biophys. Acta | pmid:10101269 |
| Kobayashi K et al. | Platelet-activating factor receptor is not required for long-term potentiation in the hippocampal CA1 region. | 1999 | Eur. J. Neurosci. | pmid:10103126 |
| Uhl E et al. | Influence of platelet-activating factor on cerebral microcirculation in rats: part 1. Systemic application. | 1999 | Stroke | pmid:10187894 |
| Uhl E et al. | Influence of platelet-activating factor on cerebral microcirculation in rats: part 2. Local application. | 1999 | Stroke | pmid:10187895 |
| Oh-hashi K et al. | Dietary alpha-linolenate suppresses endotoxin-induced platelet-activating factor production in rat kidney. | 1999 | Lipids | pmid:10188594 |
| Lim H et al. | Inhibitory effect of sulfur-containing compounds in Scorodocarpus borneensis Becc. on the aggregation of rabbit platelets. | 1999 | Biosci. Biotechnol. Biochem. | pmid:10192909 |
| Park TS et al. | Platelet-activating factor mediates ischemia-induced leukocyte-endothelial adherence in newborn pig brain. | 1999 | J. Cereb. Blood Flow Metab. | pmid:10197511 |
| Yamaguchi S et al. | Effects of Y-24180, a receptor antagonist to platelet-activating factor, on allergic cutaneous eosinophilia in mice. | 1999 | Life Sci. | pmid:10201647 |
| Wang X et al. | Inhibition of platelet-activating factor, intercellular adhesion molecule 1 and platelet endothelial cell adhesion molecule 1 reduces experimental pancreatitis-associated gut endothelial barrier dysfunction. | 1999 | Br J Surg | pmid:10201790 |
| Calcerrada MC et al. | Glutamate release is involved in PAF-increased cyclic GMP levels in hippocampus. | 1999 | Biochem. Mol. Biol. Int. | pmid:10204090 |
| Held HD et al. | Characterization of airway and vascular responses in murine lungs. | 1999 | Br. J. Pharmacol. | pmid:10205008 |
| Brizzi MF et al. | Thrombopoietin stimulates endothelial cell motility and neoangiogenesis by a platelet-activating factor-dependent mechanism. | 1999 | Circ. Res. | pmid:10205146 |
| Johnson CD | Platelet-activating factor and platelet-activating factor antagonists in acute pancreatitis. | 1999 | Dig Surg | pmid:10207233 |
| Hasselwander O et al. | HDL composition and HDL antioxidant capacity in patients on regular haemodialysis. | 1999 | Atherosclerosis | pmid:10208487 |
| Klettke U et al. | Platelet-activating factor inhibits ciliary beat frequency of human bronchial epithelial cells. | 1999 Mar-Apr | Allergy Asthma Proc | pmid:10209689 |
| Wang X et al. | Treatment with lexipafant ameliorates the severity of pancreatic microvascular endothelial barrier dysfunction in rats with acute hemorrhagic pancreatitis. | 1999 | Int. J. Pancreatol. | pmid:10211421 |
| Nagahata Y et al. | Role of platelet activating factor on severity of ischemic colitis. | 1999 | Dis. Colon Rectum | pmid:10211499 |
| Zardini DM and Tschirhart EJ | [Selective differentiation and proliferation of human eosinophils from umbilical cord blood: calcium fluxes and superoxide ion secretion]. | 1999 Jan-Feb | Therapie | pmid:10216433 |
| Van de Weerdt ML et al. | Role of the cholinergic pathway in mediating platelet-activating factor-induced pulmonary dysfunctions in unsedated calves. | 1999 | Zentralbl Veterinarmed A | pmid:10216447 |
| Hüseyinov A et al. | Increased gastric production of platelet-activating factor, leukotriene-B4, and tumor necrosis factor-alpha in children with Helicobacter pylori infection. | 1999 | Dig. Dis. Sci. | pmid:10219821 |
| Lee IS et al. | Structure-activity relationships of lignans from Schisandra chinensis as platelet activating factor antagonists. | 1999 | Biol. Pharm. Bull. | pmid:10220282 |
| Harrison KA et al. | Negative ion electrospray and tandem mass spectrometric analysis of platelet activating factor (PAF) (1-hexadecyl-2-acetyl-glycerophosphocholine). | 1999 | J Mass Spectrom | pmid:10226361 |
| Bastien Y et al. | Detection of functional platelet-activating factor receptors on human tonsillar B lymphocytes. | 1999 | J. Immunol. | pmid:10228030 |
| Amroyan E et al. | Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation. | 1999 | Phytomedicine | pmid:10228608 |
| Han SJ et al. | Glucocorticoids prevent NF-kappaB activation by inhibiting the early release of platelet-activating factor in response to lipopolysaccharide. | 1999 | Eur. J. Immunol. | pmid:10229101 |
| Tool AT et al. | Phospholipase D-derived phosphatidic acid is involved in the activation of the CD11b/CD18 integrin in human eosinophils. | 1999 | Biochem. J. | pmid:10229663 |
| Hirashima Y et al. | Deficient platelet-activating factor and related enzymes in hemimegalencephaly. | 1999 | Childs Nerv Syst | pmid:10230665 |
| Reinhardt JC et al. | Immunofluorescent evidence of the platelet-activating factor receptor on human spermatozoa. | 1999 | Fertil. Steril. | pmid:10231061 |
| López-Novoa JM | Potential role of platelet activating factor in acute renal failure. | 1999 | Kidney Int. | pmid:10231429 |
| Yamaguchi Y et al. | Platelet-activating factor antagonist (TCV-309) attenuates the priming effects of bronchoalveolar macrophages in cerulein-induced pancreatitis rats. | 1999 | Pancreas | pmid:10231840 |
| Jenks PJ et al. | Comparison of weal and flare responses to platelet activating factor (PAF) and histamine, and the ultrastructural effects of PAF in the skin of atopic and normal subjects. | 1999 | Clin. Exp. Dermatol. | pmid:10233666 |
| Kavakli K et al. | Plasma platelet-activating factor (PAF) levels and desmopressin response in children with hemophilia A and von Willebrand's disease. | 1999 | Thromb. Haemost. | pmid:10235463 |
| Dong JC et al. | [Experimental study on antagonism of ginkgolides against effect of platelet-activating factor on lung strip of guinea pigs]. | 1997 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:10322836 |
| Denizot Y et al. | Are lipid mediators implicated in the production of pro- and anti-inflammatory cytokines during cardiopulmonary bypass graft with extracorporeal circulation? | 1999 | Cytokine | pmid:10328869 |
| Rigat B et al. | The GM2 activator protein, a novel inhibitor of platelet-activating factor. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10329374 |
| Flickinger BD and Olson MS | Localization of the platelet-activating factor receptor to rat pancreatic microvascular endothelial cells. | 1999 | Am. J. Pathol. | pmid:10329588 |
| Mori N et al. | Ischemia-reperfusion induced microvascular responses in LDL-receptor -/- mice. | 1999 | Am. J. Physiol. | pmid:10330250 |
| Rhee CK et al. | Effect of platelet activating factor and its antagonist on the mucociliary clearance of the eustachian tube in guinea pigs. | 1999 | Ann. Otol. Rhinol. Laryngol. | pmid:10335705 |
| Latorre E et al. | Platelet-activating factor modulates brain sphingomyelin metabolism. | 1999 | Eur. J. Biochem. | pmid:10336612 |
| Huang YH et al. | Lysophosphatidylcholine (LPC) induces proinflammatory cytokines by a platelet-activating factor (PAF) receptor-dependent mechanism. | 1999 | Clin. Exp. Immunol. | pmid:10337026 |
| Markert R and Modzelewski B | [Inflammatory mediators in the acute pancreatitis]. | 1999 | Pol. Merkur. Lekarski | pmid:10337184 |
| Alvi SA et al. | Corticotrophin-releasing hormone and platelet-activating factor induce transcription of the type-2 cyclo-oxygenase gene in human fetal membranes. | 1999 | Mol. Hum. Reprod. | pmid:10338371 |
| Aliberti JC et al. | Platelet-activating factor induces nitric oxide synthesis in Trypanosoma cruzi-infected macrophages and mediates resistance to parasite infection in mice. | 1999 | Infect. Immun. | pmid:10338485 |
| Yoshimura T et al. | Estrogen replacement therapy decreases platelet-activating factor-acetylhydrolase activity in post-menopausal women. | 1999 | Maturitas | pmid:10340285 |
| McNulty CA et al. | Characterization of the integrin and activation steps mediating human eosinophil and neutrophil adhesion to chronically inflamed airway endothelium. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10340944 |
| Nasu K et al. | Platelet-activating factor stimulates cytokine production by human endometrial stromal cells. | 1999 | Mol. Hum. Reprod. | pmid:10341002 |
| Cepinskas G et al. | PAF-induced elastase-dependent neutrophil transendothelial migration is associated with the mobilization of elastase to the neutrophil surface and localization to the migrating front. | 1999 | J. Cell. Sci. | pmid:10341212 |
| Mariano F et al. | Production of platelet-activating factor in patients with sepsis-associated acute renal failure. | 1999 | Nephrol. Dial. Transplant. | pmid:10344354 |
| Rainsford KD | Inhibition by leukotriene inhibitors, and calcium and platelet-activating factor antagonists, of acute gastric and intestinal damage in arthritic rats and in cholinomimetic-treated mice. | 1999 | J. Pharm. Pharmacol. | pmid:10344635 |
| Cruzado JM et al. | Effect of human natural xenoantibody depletion and complement inactivation on early pig kidney function. | 1999 May-Jun | Exp. Nephrol. | pmid:10352362 |
| Svetlov SI et al. | Decreased intraplatelet Ca2+ release and ATP secretion in pediatric nephrotic syndrome. | 1999 | Pediatr. Nephrol. | pmid:10353406 |
| Weber C et al. | Effects of oxidized low density lipoprotein, lipid mediators and statins on vascular cell interactions. | 1999 | Clin. Chem. Lab. Med. | pmid:10353467 |
| Del Sorbo L et al. | The synthesis of platelet-activating factor modulates chemotaxis of monocytes induced by HIV-1 Tat. | 1999 | Eur. J. Immunol. | pmid:10359105 |
| Crawford SE et al. | Captopril and platelet-activating factor (PAF) antagonist prevent cardiac allograft vasculopathy in rats: role of endogenous PAF and PAF-like compounds. | 1999 | J. Heart Lung Transplant. | pmid:10363692 |
| Goldman R et al. | Calcium-dependent PAF-stimulated generation of reactive oxygen species in a human keratinocyte cell line. | 1999 | Biochim. Biophys. Acta | pmid:10366777 |
| Steil AA et al. | Platelet-activating factor and eicosanoids are mediators of local and systemic changes induced by immune-complexes in mice. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10367295 |
| MartÃnez L et al. | Nitroprusside stimulates contractility and the synthesis of 14C-acetylated PAF-like substances in estrogen primed-mouse uterine horns. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10367296 |
| Cahana A and Reiner O | LIS1 and platelet-activating factor acetylhydrolase (Ib) catalytic subunits, expression in the mouse oocyte and zygote. | 1999 | FEBS Lett. | pmid:10371146 |
| Diaz E et al. | Presence of platelet-activating factor in rhesus (Macaca mulatta) spermatozoa. | 1999 | J. Med. Primatol. | pmid:10372538 |
| Rosenbaum JT et al. | Intravitreally injected platelet activating factor induces retinitis in experimental animals. | 1999 | Curr. Eye Res. | pmid:10372995 |
| Xiao J et al. | Synergetic protective effects of combined blockade by two kinds of autolesion mediator receptor on neurological function after cervical cord injury. | 1998 | Chin. Med. J. | pmid:10374355 |
| Ji Z et al. | [The role of platelet activating factor in pathogenesis of acute pancreatitis in dogs]. | 1997 | Zhonghua Wai Ke Za Zhi | pmid:10374489 |
| Yi FX and Guo ZG | Platelet-released ADP stabilizes PAF-induced rabbit platelet aggregation by stabilizing intracellular calcium. | 1998 | Zhongguo Yao Li Xue Bao | pmid:10375790 |
| Wang Y et al. | Increased neutrophil-endothelial adhesion induced by placental factors is mediated by platelet-activating factor in preeclampsia. | 1999 May-Jun | J. Soc. Gynecol. Investig. | pmid:10376269 |
| Callea L et al. | Platelet activating factor is elevated in cerebral spinal fluid and plasma of patients with relapsing-remitting multiple sclerosis. | 1999 | J. Neuroimmunol. | pmid:10376955 |
| McNeil RS et al. | Neuronal cytoskeletal alterations evoked by a platelet-activating factor (PAF) analogue. | 1999 | Cell Motil. Cytoskeleton | pmid:10379835 |
| Deigner HP et al. | Novel reversible, irreversible and fluorescent inhibitors of platelet-activating factor acetylhydrolase as mechanistic probes. | 1999 | Atherosclerosis | pmid:10381281 |
| Bandeira-Melo C et al. | Suppressive effect of distinct bradykinin B2 receptor antagonist on allergen-evoked exudation and leukocyte infiltration in sensitized rats. | 1999 | Br. J. Pharmacol. | pmid:10385228 |
| Guilbert M et al. | 5-Oxo-6,8,11,14-eicosatetraenoic acid induces important eosinophil transmigration through basement membrane components: comparison of normal and asthmatic eosinophils. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10385597 |
| Fujii E et al. | Microvascular permeability change induced by platelet-activating factor is impaired in diabetic mice. | 1999 | Microvasc. Res. | pmid:10388605 |
| Forte TM et al. | Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration. | 1999 | J. Lipid Res. | pmid:10393212 |
| Subramanian VS et al. | Role of lecithin-cholesterol acyltransferase in the metabolism of oxidized phospholipids in plasma: studies with platelet-activating factor-acetyl hydrolase-deficient plasma. | 1999 | Biochim. Biophys. Acta | pmid:10395969 |
| Kulikov VI and Muzya GI | Mechanisms of interaction of a plasmalogenic analog of platelet-activating factor with human platelets. | 1999 | Biochemistry Mosc. | pmid:10395976 |
| Strukova SM et al. | Modulation of mast cell activity by a peptide agonist of the thrombin receptor: role of nitric oxide. | 1999 | Biochemistry Mosc. | pmid:10395981 |
| Ishii S and Shimizu T | [Platelet-activating factor (PAF) receptor-related pathophysiology]. | 1999 | Tanpakushitsu Kakusan Koso | pmid:10396985 |