Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Per page 10 20 50 100 | Total 288

PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Stoddart NR et al. Exogenous platelet-activating factor stimulates cell proliferation in mouse pre-implantation embryos prior to the fourth cell cycle and shows isoform-specific stimulatory effects. 2001 Zygote pmid:11510473
Yu P et al. [A study on changes and its mechanisms of intestinal mucosal permeability after severe burn]. 1996 Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi pmid:9387456
Liu Y et al. [The role and significance of PAF in the early pulmonary injury following burns combined with endotoxemia in rats]. 1999 Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi pmid:11501075
Zhang F [Protective effect of a platelet activating factor antagonist in experimental liver injury]. 1990 Zhonghua Yi Xue Za Zhi pmid:2171727
Ji Z et al. [The role of platelet activating factor in mesenterioangial microcirculatory disturbance complicated with acute pancreatitis in rats]. 1995 Zhonghua Yi Xue Za Zhi pmid:7780816
Xiao J et al. [Effect of platelet activating factor receptor at spinal cord neurocyte membrane on secondary damage after spinal cord injury]. 1996 Zhonghua Yi Xue Za Zhi pmid:8758444
Liu BJ et al. [Effect of BN52021 on platelet activating factor induced aggregation of psoriatic polymorphonuclear neutrophils]. 1994 Zhonghua Yi Xue Za Zhi pmid:7994650
Zeng N [Determination of plasma level of platelet activating factor in cirrhotic patients and its relation to endotoxemia]. 1992 Zhonghua Yi Xue Za Zhi pmid:1319804
Chen SH [Purification and some properties of platelet aggregating protein (PAP) from the plasma of a patient with thrombotic thrombocytopenic purpura]. 1989 Zhonghua Yi Xue Za Zhi pmid:2598093
Wang CP et al. [Influence of platelet activating factor and its antagonist on portal hypertension associated with liver cirrhosis: an experiment with rats]. 2005 Zhonghua Yi Xue Za Zhi pmid:16409839
Yu P et al. [Pathogenetic effect of platelet activating factor on enterogenic endotoxemia after burn]. 1999 Zhonghua Yi Xue Za Zhi pmid:11601022
Ma X et al. [Corneal epithelial wound healing is delayed by platelet activating factor treatment]. 2004 Zhonghua Yan Ke Za Zhi pmid:15307983
Qin X et al. [The effect of platelet-activating factor antagonists on early bacteria translocation of rat after burn injury]. 1995 Zhonghua Wai Ke Za Zhi pmid:7587673
Ji Z et al. [The role of platelet activating factor in pathogenesis of acute pancreatitis in dogs]. 1997 Zhonghua Wai Ke Za Zhi pmid:10374489
Xiao J et al. [Effects of platelet activating factor and platelet activating factor receptor antagonist on spinal cord blood flow after spinal cord injury]. 1995 Zhonghua Wai Ke Za Zhi pmid:8762548
Yu P et al. [The roles of platelet activating factor in intestinal mucosal barrier injury after burn]. 1995 Zhonghua Wai Ke Za Zhi pmid:8565724
Han E et al. [Effect of chronic antiplatelet treatment on platelet activating factor-induced platelet activity in stroke]. 1991 Zhonghua Shen Jing Jing Shen Ke Za Zhi pmid:1868762
Yu HP et al. [Experimental and clinical study of activated platelet in allergic asthma]. 1991 Zhonghua Nei Ke Za Zhi pmid:1806336
Wang ZY [Advances in the physiopathology of platelets]. 1984 Zhonghua Nei Ke Za Zhi pmid:6099795
Shi H et al. [Effects of a platelet-activating factor antagonist ONO-6240 on antigen induced eosinophil infiltration into the airways]. 1995 Zhonghua Nei Ke Za Zhi pmid:8731847
Ren G and Ye R [Changes in urinary excretion of platelet activating factor and its significance in patients with primary nephrotic syndrome]. 1996 Zhonghua Nei Ke Za Zhi pmid:9275622
Huang QY and Li MJ [Effect of platelet-activating factor on sperm function]. 2007 Zhonghua Nan Ke Xue pmid:17615981
Chou CT et al. Neutrophil chemiluminescence and superoxide production in patients with rheumatoid arthritis: the effect of zymosan, phorbol myristate acetate and platelet-activating factor. 1991 Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi pmid:1667989
Cheng DY and Chen WB [The current status of the research on platelet activating factor and pulmonary hypertension]. 1993 Zhonghua Jie He He Hu Xi Za Zhi pmid:8403064
Tu W et al. [Influences of BN50739 on neutrophil elastase and phospholipase A2 in lung and tracheal mucosa of pigs with acute severe pancreatitis]. 2000 Zhonghua Jie He He Hu Xi Za Zhi pmid:11372382
Zhou X et al. [Monocellular quantitative study on the adhesive ability of eosinophils in the course of eosinophils activation]. 1996 Zhonghua Jie He He Hu Xi Za Zhi pmid:9387483
Gao F et al. [The levels of platelet-activating factor and nitric oxide synthase in bronchial asthma at high altitude]. 2010 Zhonghua Jie He He Hu Xi Za Zhi pmid:20979844
Li Q [Effects of inhaled aerosol of platelet activating factor on pulmonary function and airway responsiveness in normal subjects]. 1992 Zhonghua Jie He He Hu Xi Za Zhi pmid:1307517
Wang C et al. [Inhalation of platelet-activating factor induced guinea pig airway hyperresponsiveness: role of eosinophils activation]. 1995 Zhonghua Jie He He Hu Xi Za Zhi pmid:8565083
Zhang S et al. [Determination of platelet activating factor and platelet associated IgG in pregnancy-induced hypertension]. 1996 Zhonghua Fu Chan Ke Za Zhi pmid:9206185
Jiang W et al. [Effects and mechanisms of platelet-activating factor on the invasiveness of ovarian cancer cells in vitro]. 2011 Zhonghua Fu Chan Ke Za Zhi pmid:22333285
Wang F et al. [The effect of platelet activating factor on the biosynthesis of thromboxane A2 and prostaglandin I2 in human placental villi and umbilical artery]. 1997 Zhonghua Fu Chan Ke Za Zhi pmid:9596897
Zhang GQ et al. [The effects of milkvetch and memantain on the synthesis of cerebral PAF in neonatal rats with hypoxic-ischemic reperfusion]. 2003 Zhonghua Er Ke Za Zhi pmid:14751060
Wu B et al. [Effects of bificobacterium longum on neonatal rat model of necrotizing enterocolitis and roles of platelet-activating factor and tumor necrosis factor-alpha]. 2007 Zhonghua Er Ke Za Zhi pmid:17953818
Huang LG et al. [Effects of glycomacropeptide on damage to intestinal tissue and apoptosis of intestinal epithelial cells in neonatal rats with necrotizing enterocolitis]. 2012 Zhonghua Er Ke Za Zhi pmid:22932017
Lu H and Xue XD [Platelet-activating factor and neonatal necrotizing enterocolitis]. 2004 Zhonghua Er Ke Za Zhi pmid:15189692
Li XJ et al. [Expression of platelet-activating factor in necrotizing enterocolitis and its clinical significance]. 2011 Zhonghua Bing Li Xue Za Zhi pmid:21426810
Zang BX et al. [Inhibitory effect of kaempferol against binding of platelet activating factor to its receptor]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15506296
Wang WJ et al. [Effects of musk glucoprotein on PAF production and cytosolic Ca2+ level in rat polymorphonuclear leukocytes in vitro]. 2000 Zhongguo Zhong Yao Za Zhi pmid:12525061
Cheng NN and Ma YM [A hypotensive analog of platelet-activating factor (PAF) in pheretima]. 1993 Zhongguo Zhong Yao Za Zhi pmid:8011088
Shi W et al. [Study on composing mechanism by effect of disassembled compositions of Yiqi Huoxue decoction on platelet aggregation of health adults]. 2007 Zhongguo Zhong Yao Za Zhi pmid:18309677
Li SH et al. [Effect of an extract from the cauline of Piper kadsura ohwi on endotoxin-induced hypotension and lung injury in rats]. 1989 Zhongguo Zhong Yao Za Zhi pmid:2619897
Li XG and Luo HM [Progress in studies of chemical constituents and pharmacological activities of Kadsura]. 2003 Zhongguo Zhong Yao Za Zhi pmid:15617488
Chen ZN et al. [Anti-platelet activating factor constituents, 2,5-diaryltetrahydrofuran type lignans, from Piper futokadsura Sied. et Zucc]. 1993 Zhongguo Zhong Yao Za Zhi pmid:8216803
Chen ZN [Recent progress in the study of anti-PAF (platelet activating factor) constituents of medicinal herbs]. 1993 Zhongguo Zhong Yao Za Zhi pmid:8274205
Dong JC et al. [Ginkgolides antagonizing some effects of platelet-activating factor in vitro]. 1995 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:8704427
Zhang J et al. [Experimental study on effect of Buyang Huanwu decoction on arterial blood platelet activating factor content pre- and post-arterial thrombosis of rats]. 1998 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:11475720
Shao P et al. [Research on relationship of syndrome type and parameters of hemorheology and platelet activation in patients with acute gout arthritis of dampness-heat blockage type and stasis-heat accumulate type]. 2006 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:17186728
Wang J et al. [Effect of Radix notoginseng saponins on platelet activating molecule expression and aggregation in patients with blood hyperviscosity syndrome]. 2004 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:15143716
Chen WM et al. [Experimental study on inhibitory effect of rutin against platelet activation induced by platelet activating factor in rabbits]. 2002 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:12584792