| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Saad MM et al. | Persistency and pathway of isoflurane-induced inhibition of superoxide production by neutrophils. | 2010 | Can J Anaesth | pmid:19882198 |
| Mrówczyńska L and Hägerstrand H | Platelet-activating factor interaction with the human erythrocyte membrane. | 2009 Sep-Oct | J. Biochem. Mol. Toxicol. | pmid:19827129 |
| Babayigit A et al. | Effects of Ginkgo biloba on airway histology in a mouse model of chronic asthma. | 2009 Mar-Apr | Allergy Asthma Proc | pmid:19118503 |
| Mann O et al. | Effect of platelet-activating factor antagonist WEB 2086 on microcirculatory disorders in acute experimental pancreatitis of graded severity. | 2009 | Pancreas | pmid:18695628 |
| Yang HQ et al. | PMS777, a new cholinesterase inhibitor with anti-platelet activated factor activity, regulates amyloid precursor protein processing in vitro. | 2009 | Neurochem. Res. | pmid:18758955 |
| Steel HC et al. | Posaconazole attenuates leukotriene B4 release and uptake of calcium by chemoattractant-activated human neutrophils: a potential strategy to control neutrophil-mediated inflammation. | 2009 | J. Antimicrob. Chemother. | pmid:19744985 |
| Liu SH et al. | [Effects of p38 mitogen-activated protein kinase in protection of carbon monoxide against lipopolysaccharide induced rat small intestine injury]. | 2009 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21189571 |
| Castro DP et al. | Physalin B inhibits Rhodnius prolixus hemocyte phagocytosis and microaggregation by the activation of endogenous PAF-acetyl hydrolase activities. | 2009 | J. Insect Physiol. | pmid:19232405 |
| Yao Y et al. | Ultraviolet B radiation generated platelet-activating factor receptor agonist formation involves EGF-R-mediated reactive oxygen species. | 2009 | J. Immunol. | pmid:19234179 |
| Shindou H and Shimizu T | [New development of lysophospholipid acyltransferases]. | 2009 | Tanpakushitsu Kakusan Koso | pmid:19205351 |
| Seki M et al. | Expression and DNA microarray analysis of a platelet activating factor-related molecule in severe pneumonia in mice due to influenza virus and bacterial co-infection. | 2009 | Jpn. J. Infect. Dis. | pmid:19168951 |
| Schneider DJ and Sobel BE | Streamlining the design of promising clinical trials: in-vitro testing of antithrombotic regimens and multiple agonists of platelet activation. | 2009 | Coron. Artery Dis. | pmid:19194284 |
| Li J et al. | Protection of PMS777, a new AChE inhibitor with PAF antagonism, against amyloid-beta-induced neuronal apoptosis and neuroinflammation. | 2009 | Cell. Mol. Neurobiol. | pmid:19194797 |
| Fité-Mora R | Torsade de pointes associated with rupatadine. | 2009 | Rev Esp Cardiol | pmid:19268083 |
| Kim DD et al. | Independent regulation of periarteriolar and perivenular nitric oxide mechanisms in the in vivo hamster cheek pouch microvasculature. | 2009 | Microcirculation | pmid:19235626 |
| Musio S et al. | Anaphylaxis to a self-peptide in the absence of mast cells or histamine. | 2009 | Lab. Invest. | pmid:19188909 |
| Welch EJ et al. | Opposing effects of platelet-activating factor and lyso-platelet-activating factor on neutrophil and platelet activation. | 2009 | Mol. Pharmacol. | pmid:18931035 |
| Yost CC et al. | Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. | 2009 | Blood | pmid:19221037 |
| Tsoupras AB et al. | The implication of platelet activating factor in cancer growth and metastasis: potent beneficial role of PAF-inhibitors and antioxidants. | 2009 | Infect Disord Drug Targets | pmid:19689381 |
| Cheng L et al. | A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19773578 |
| Wijman CA | Is platelet activity important in acute intracerebral hemorrhage? | 2009 | Neurocrit Care | pmid:19714496 |
| Baka S et al. | Treatment of sperm with platelet-activating factor does not improve intrauterine insemination outcome in unselected cases of mild male factor infertility: a prospective double-blind randomized crossover study. | 2009 | Urology | pmid:19716589 |
| Bao GQ and Ju AZ | [Signal pathways of eryptosis-review]. | 2009 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:19698269 |
| Shi B et al. | [Influence of intensive insulin therapy on the intestinal microcirculatory dysfunction in rats with sepsis]. | 2009 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:19695175 |
| Rastogi P and McHowat J | Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium. | 2009 | Respir Physiol Neurobiol | pmid:19059366 |
| Wen J et al. | Simultaneous determination of rupatadine and its metabolite desloratadine in human plasma by a sensitive LC-MS/MS method: application to the pharmacokinetic study in healthy Chinese volunteers. | 2009 | J Pharm Biomed Anal | pmid:19059745 |
| Rehse K et al. | New 1H-pyrazole-4-carboxamides with antiplatelet activity. | 2009 | Arch. Pharm. (Weinheim) | pmid:19051198 |
| Detopoulou P et al. | Platelet activating factor (PAF) and activity of its biosynthetic and catabolic enzymes in blood and leukocytes of male patients with newly diagnosed heart failure. | 2009 | Clin. Biochem. | pmid:18955040 |
| Giannattasio G et al. | Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis. | 2009 | Biochim. Biophys. Acta | pmid:19130898 |
| Sharif NA et al. | Human conjunctival epithelial cell responses to platelet-activating factor (PAF): signal transduction and release of proinflammatory cytokines. | 2009 | Mol. Vis. | pmid:19513187 |
| Tang WZ et al. | Rearranged prenylated C6-C3 compounds and a highly oxygenated seco-prezizaane-type sesquiterpene from the stem bark of Illicium oligandrum. | 2009 | J. Nat. Prod. | pmid:19496609 |
| Hakim-Rad K et al. | Mast cells: makers and breakers of allergic inflammation. | 2009 | Curr Opin Allergy Clin Immunol | pmid:19550301 |
| Li Y et al. | Activation of a chloride channel by a trophic ligand is required for development of the mouse preimplantation embryo in vitro. | 2009 | Biol. Reprod. | pmid:19553604 |
| Deng Y et al. | Blood-brain barrier breakdown by PAF and protection by XQ-1H due to antagonism of PAF effects. | 2009 | Eur. J. Pharmacol. | pmid:19555682 |
| Edwards LJ and Constantinescu CS | Platelet activating factor/platelet activating factor receptor pathway as a potential therapeutic target in autoimmune diseases. | 2009 | Inflamm Allergy Drug Targets | pmid:19601878 |
| Camerer E et al. | Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. | 2009 | J. Clin. Invest. | pmid:19603543 |
| Xu J et al. | Platelet-activating factor-stimulated production of reactive oxygen species in ovarian granulosa cells from periovulatory follicles. | 2009 | Cytometry A | pmid:19565634 |
| Eggert D et al. | Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders. | 2009 | J. Neuroimmunol. | pmid:19541372 |
| Coy ED et al. | Macrophyllin-type bicyclo[3.2.1]octanoid neolignans from the leaves of Pleurothyrium cinereum. | 2009 | J. Nat. Prod. | pmid:19548690 |
| Coy-Barrera ED et al. | PAF-antagonistic bicyclo[3.2.1]octanoid neolignans from leaves of Ocotea macrophylla Kunth. (Lauraceae). | 2009 | Phytochemistry | pmid:19674762 |
| Kordan W et al. | Effect of platelet-activating factor on motility, plasmalemma integrity, the process of capacitation and acrosome reaction of fresh and cryopreserved boar spermatozoa. | 2009 | Pol J Vet Sci | pmid:19645346 |
| Poisson C et al. | Caveolae facilitate but are not essential for platelet-activating factor-mediated calcium mobilization and extracellular signal-regulated kinase activation. | 2009 | J. Immunol. | pmid:19620302 |
| Jeong YI et al. | The novel role of platelet-activating factor in protecting mice against lipopolysaccharide-induced endotoxic shock. | 2009 | PLoS ONE | pmid:19652714 |
| Keck M et al. | Pathophysiology of burns. | 2009 | Wien Med Wochenschr | pmid:19652939 |
| Tung JP et al. | Respiratory burst function of ovine neutrophils. | 2009 | BMC Immunol. | pmid:19422720 |
| Penna C et al. | Post-ischaemic activation of kinases in the pre-conditioning-like cardioprotective effect of the platelet-activating factor. | 2009 | Acta Physiol (Oxf) | pmid:19432589 |
| Dutra PM et al. | Stimulation of Leishmania tropica protein kinase CK2 activities by platelet-activating factor (PAF). | 2009 | Acta Trop. | pmid:19433049 |
| Mayerle J | A novel role for leucocytes in determining the severity of acute pancreatitis. | 2009 | Gut | pmid:19834113 |
| Pantaler E and Lückhoff A | Inhibitors of TRP channels reveal stimulus-dependent differential activation of Ca2+ influx pathways in human neutrophil granulocytes. | 2009 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:19894037 |
| He YG et al. | Functional analysis of platelet-activating factor in the retinal pigment epithelial cells and choroidal endothelial cells. | 2009 | Curr. Eye Res. | pmid:19958112 |