| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zang BX et al. | [Inhibitory effect of kaempferol against binding of platelet activating factor to its receptor]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15506296 |
| Bankers-Fulbright JL et al. | Platelet-activating factor stimulates cytoplasmic alkalinization and granule acidification in human eosinophils. | 2004 | J. Cell. Sci. | pmid:15507482 |
| Hertelendy F and Zakár T | Prostaglandins and the myometrium and cervix. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14683694 |
| Diez-Fraile A et al. | Effect of proinflammatory mediators and glucocorticoids on L-selectin expression in peripheral blood neutrophils from dairy cows in various stages of lactation. | 2004 | Am. J. Vet. Res. | pmid:15524330 |
| Mangan NE et al. | Helminth infection protects mice from anaphylaxis via IL-10-producing B cells. | 2004 | J. Immunol. | pmid:15528374 |
| Jung TT et al. | Effect of inhibitors of leukotriene and/or platelet activating factor on killed H. influenzae induced experimental otitis media with effusion. | 2004 | Int. J. Pediatr. Otorhinolaryngol. | pmid:14687688 |
| Barbanoj MJ et al. | Central and peripheral evaluation of rupatadine, a new antihistamine/platelet-activating factor antagonist, at different doses in healthy volunteers. | 2004 | Neuropsychobiology | pmid:15539863 |
| Fujii S et al. | Chromogenic assay for the activity of sphingomyelinase from Bacillus cereus and its application to the enzymatic hydrolysis of lysophospholipids. | 2004 | Biol. Pharm. Bull. | pmid:15516713 |
| Göggel R et al. | PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. | 2004 | Nat. Med. | pmid:14704790 |
| Suenaga A and Ueki H | Effect of orthovanadate on platelet aggregation induced by platelet-activating factor. | 2004 | Biol. Pharm. Bull. | pmid:15516737 |
| Tsutsumi T et al. | Phorbol myristate acetate stimulates degradation of a structural analogue of platelet-activating factor to a neutral lipid in human leukemic K562 cells: relevance to the release of lipids. | 2004 | Biol. Pharm. Bull. | pmid:14709893 |
| Nakagawa K et al. | Sperm-immobilizing antibodies suppress an increase in the plasma membrane fluidity of human spermatozoa. | 2004 | Fertil. Steril. | pmid:15474073 |
| Nie ZG et al. | [Effects of ginkgolide B on lipopolysaccharide-induced TNFalpha production in mouse peritoneal macrophages and NF-kappaB activation in rat pleural polymorphonuclear leukocytes]. | 2004 | Yao Xue Xue Bao | pmid:15491096 |
| Barnes PJ | Ceramide lances the lungs. | 2004 | Nat. Med. | pmid:14760419 |
| Goldring WP and Pattenden G | Total synthesis of (+/-)-phomactin G, a platelet activating factor antagonist from the marine fungus Phoma sp. | 2004 | Org. Biomol. Chem. | pmid:14770224 |
| Rollin S et al. | VEGF-mediated endothelial P-selectin translocation: role of VEGF receptors and endogenous PAF synthesis. | 2004 | Blood | pmid:14764537 |
| Chami O et al. | Components of a platelet-activating factor-signaling loop are assembled in the ovine endometrium late in the estrous cycle. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:15271646 |
| Axelrad TW et al. | Platelet-activating factor (PAF) induces activation of matrix metalloproteinase 2 activity and vascular endothelial cell invasion and migration. | 2004 | FASEB J. | pmid:14715700 |
| Chinybaeva LA | [Comparative characterization of hemostatic parameters in patients with cerebral stroke]. | 2004 | Klin Med (Mosk) | pmid:15449775 |
| Gambero A et al. | Signalling pathways regulating human neutrophil migration induced by secretory phospholipases A2. | 2004 | Toxicon | pmid:15450921 |
| Tokiwano T et al. | Biosynthesis of phomactins: common intermediate phomactatriene and taxadiene. | 2004 | Chem. Commun. (Camb.) | pmid:15154058 |
| Zhelev DV et al. | Controlled pseudopod extension of human neutrophils stimulated with different chemoattractants. | 2004 | Biophys. J. | pmid:15240502 |
| Hla T | Prostaglandins & other lipid mediators: a new phase, a new team. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165026 |
| Ruan Z et al. | Effects of platelet-activating factor and thromboxane A2 on isolated perfused guinea pig liver. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165033 |
| Nomikos TN et al. | Application of a TCA-precipitation method for the determination of 1-alkyl-sn-glycero-3-phosphate: Acetyl-CoA acetyltransferase in human renal tissue. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165037 |
| Kato M et al. | Dual signaling and effector pathways mediate human eosinophil activation by platelet-activating factor. | 2004 | Int. Arch. Allergy Immunol. | pmid:15166482 |
| Besana A et al. | Activation of protein kinase C epsilon inhibits the two-pore domain K+ channel, TASK-1, inducing repolarization abnormalities in cardiac ventricular myocytes. | 2004 | J. Biol. Chem. | pmid:15184378 |
| Michail S and Abernathy F | A new model for studying eosinophil migration across cultured intestinal epithelial monolayers. | 2004 | J. Pediatr. Gastroenterol. Nutr. | pmid:15187782 |
| Lu H and Xue XD | [Platelet-activating factor and neonatal necrotizing enterocolitis]. | 2004 | Zhonghua Er Ke Za Zhi | pmid:15189692 |
| Seyffarth G et al. | Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture. | 2004 | Reprod. Biol. Endocrinol. | pmid:15191613 |
| Lekka ME et al. | The impact of intravenous fat emulsion administration in acute lung injury. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:14656749 |
| Lu J et al. | Platelet-activating factor-induced apoptosis is blocked by Bcl-2 in rat intestinal epithelial cells. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14512286 |
| Buduneli E et al. | Effects of combined systemic administration of low-dose doxycycline and alendronate on endotoxin-induced periodontitis in rats. | 2004 | J. Periodontol. | pmid:15633329 |
| Amer MD et al. | Platelet-activating factor concentration in the stool of human newborns: effects of enteral feeding and neonatal necrotizing enterocolitis. | 2004 | Biol. Neonate | pmid:14646336 |
| Cinamon G et al. | Chemoattractant signals and beta 2 integrin occupancy at apical endothelial contacts combine with shear stress signals to promote transendothelial neutrophil migration. | 2004 | J. Immunol. | pmid:15585851 |
| Bender A et al. | Molecular surface point environments for virtual screening and the elucidation of binding patterns (MOLPRINT 3D). | 2004 | J. Med. Chem. | pmid:15588092 |
| Vardar S et al. | Therapeutic versus prophylactic plus therapeutic administration of omega-3 fatty acid on endotoxin-induced periodontitis in rats. | 2004 | J. Periodontol. | pmid:15732866 |
| Wang Y et al. | Opposing effect of angiopoietin-1 on VEGF-mediated disruption of endothelial cell-cell interactions requires activation of PKC beta. | 2004 | J. Cell. Physiol. | pmid:14584044 |
| Takeda K | [Role of increase in permeability and circulatory failure in the development of organ dysfunction in severe acute pancreatitis]. | 2004 | Nippon Rinsho | pmid:15552880 |
| Takase K et al. | [New aspects of pharmaco-therapy for acute pancreatitis]. | 2004 | Nippon Rinsho | pmid:15552891 |
| Ranasinghe S and Bolsover S | Microglial calcium responses to platelet-activating factor are inhibited by analogue CAS 99103-16-9 and dihydropyridine PCA 4248 but not by ginkgolide A. | 2004 | Basic Clin. Pharmacol. Toxicol. | pmid:15379786 |
| Rothhut B | Benveniste's reputation was not written in water. | 2004 | Nature | pmid:15565124 |
| Morita K et al. | Development of tactile allodynia and thermal hyperalgesia by intrathecally administered platelet-activating factor in mice. | 2004 | Pain | pmid:15363879 |
| Serradji N et al. | Structure-activity relationships in platelet-activating factor. 12. Synthesis and biological evaluation of platelet-activating factor antagonists with anti-HIV-1 activity. | 2004 | J. Med. Chem. | pmid:15566310 |
| Nemcsik J et al. | Synergistic interaction of endogenous platelet-activating factor and vasopressin in generating angina in rats. | 2004 | Eur. J. Pharmacol. | pmid:15363995 |
| Roudebush WE et al. | Exposure of preimplantation embryos to platelet-activating factor increases birth rate. | 2004 | J. Assist. Reprod. Genet. | pmid:15568330 |
| Zinchuk O et al. | Dynamics of PAF-induced conjunctivitis reveals differential expression of PAF receptor by macrophages and eosinophils in the rat. | 2004 | Cell Tissue Res. | pmid:15290234 |
| Tarricone C et al. | Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase. | 2004 | Neuron | pmid:15572112 |
| Xu Y et al. | Targeted disruption of PSD-93 gene reduces platelet-activating factor-induced neurotoxicity in cultured cortical neurons. | 2004 | Exp. Neurol. | pmid:15296832 |
| Wanten G et al. | Lipid effects on neutrophil calcium signaling induced by opsonized particles: platelet activating factor is only part of the story. | 2004 | Clin Nutr | pmid:15297099 |
| Han XB et al. | Macrophage inflammatory protein-2 mediates the bowel injury induced by platelet-activating factor. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15319184 |
| Bossi F et al. | Platelet-activating factor and kinin-dependent vascular leakage as a novel functional activity of the soluble terminal complement complex. | 2004 | J. Immunol. | pmid:15557188 |
| Kato M et al. | Apafant, a potent platelet-activating factor antagonist, blocks eosinophil activation and is effective in the chronic phase of experimental allergic conjunctivitis in guinea pigs. | 2004 | J. Pharmacol. Sci. | pmid:15286429 |
| Fourcade O et al. | Propofol inhibits human platelet aggregation induced by proinflammatory lipid mediators. | 2004 | Anesth. Analg. | pmid:15271713 |
| Rasheed H and Saeed SA | Involvement of thromboxane A2 and tyrosine kinase in the synergistic interaction of platelet activating factor and calcium ionophore A23187 in human platelet aggregation. | 2004 | Exp. Mol. Med. | pmid:15272233 |
| Bate C et al. | Phospholipase A2 inhibitors or platelet-activating factor antagonists prevent prion replication. | 2004 | J. Biol. Chem. | pmid:15210691 |
| Yamano S et al. | Human spermatozoa capacitated with progesterone or a long incubation show accelerated internalization by an alkyl ether lysophospholipid. | 2004 | Fertil. Steril. | pmid:15037409 |
| Jakubowski A et al. | Involvement of platelet activating factor in immediate heart response to lipopolysaccharide. | 2004 | J. Physiol. Pharmacol. | pmid:15213362 |
| Taylor KE | Familial cancer and developmental dyslexia: an observational pilot study. | 2004 | Dev Med Child Neurol | pmid:14974637 |
| Seo KH et al. | Essential role for platelet-activating factor-induced NF-kappaB activation in macrophage-derived angiogenesis. | 2004 | Eur. J. Immunol. | pmid:15259010 |
| Zhu P et al. | Interplay among platelet-activating factor, oxidative stress, and group I metabotropic glutamate receptors modulates neuronal survival. | 2004 | J. Neurosci. Res. | pmid:15264222 |
| Lu DP et al. | Trophic signals acting via phosphatidylinositol-3 kinase are required for normal pre-implantation mouse embryo development. | 2004 | J. Cell. Sci. | pmid:15020683 |
| Sarchielli P et al. | Platelet-activating factor (PAF) in internal jugular venous blood of migraine without aura patients assessed during migraine attacks. | 2004 | Cephalalgia | pmid:15265050 |
| Ziche M | Absence of PAF actions increases angiogenesis. | 2004 | Br. J. Pharmacol. | pmid:15023858 |
| Roudebush WE et al. | Platelet-activating factor significantly enhances intrauterine insemination pregnancy rates in non-male factor infertility. | 2004 | Fertil. Steril. | pmid:15236989 |
| Ferreira MA et al. | Sponge-induced angiogenesis and inflammation in PAF receptor-deficient mice (PAFR-KO). | 2004 | Br. J. Pharmacol. | pmid:15023865 |
| Alloatti G et al. | Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease. | 2004 | Biochem. Soc. Trans. | pmid:15046613 |
| Shio MT et al. | PAF is involved in the Mycoplasma arthritidis superantigen-triggering pathway for iNOS and COX-2 expression in murine peritoneal cells. | 2004 | Exp. Cell Res. | pmid:15242784 |
| Naoki K et al. | PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15047169 |
| Al-Darmaki S et al. | Delineation of the role of platelet-activating factor in the immunoglobulin G2 antibody response. | 2004 | Clin. Diagn. Lab. Immunol. | pmid:15242947 |
| Sugatani J et al. | Tea polyphenols inhibit acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and platelet-activating factor-induced platelet aggregation. | 2004 | Int. Arch. Allergy Immunol. | pmid:15051936 |
| Tsironis LD et al. | Effect of lipoprotein (a) on platelet activation induced by platelet-activating factor: role of apolipoprotein (a) and endogenous PAF-acetylhydrolase. | 2004 | Cardiovasc. Res. | pmid:15194469 |
| Aguiari G et al. | Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells. | 2004 | FASEB J. | pmid:15001556 |
| Sumita C et al. | Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage. | 2004 | Biochim. Biophys. Acta | pmid:15279882 |
| Ma YQ et al. | P-selectin binding to P-selectin glycoprotein ligand-1 induces an intermediate state of alphaMbeta2 activation and acts cooperatively with extracellular stimuli to support maximal adhesion of human neutrophils. | 2004 | Blood | pmid:15217824 |
| Du YM et al. | Effects of platelet activating factor on action potentials and potassium channels in guinea-pig ventricular myocytes. | 2004 | Sheng Li Xue Bao | pmid:15224138 |
| Geromin D et al. | Glycoprotein 170 induces platelet-activating factor receptor membrane expression and confers tumor cell hypersensitivity to NK-dependent cell lysis. | 2004 | J. Immunol. | pmid:15004162 |
| Pédrono F et al. | Natural 1-O-alkylglycerols reduce platelet-activating factor-induced release of [3H]-serotonin in rabbit platelets. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15172680 |
| Zimmerman GA and McIntyre TM | PAF, ceramide and pulmonary edema: alveolar flooding and a flood of questions. | 2004 | Trends Mol Med | pmid:15177186 |
| Lee SH et al. | Role of messenger RNA expression of platelet activating factor and its receptor in porcine in vitro-fertilized and cloned embryo development. | 2004 | Biol. Reprod. | pmid:15151927 |
| Ishii S et al. | Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model. | 2004 | J. Immunol. | pmid:15153532 |
| Zhang C et al. | The effect of Ginkgo biloba extract (EGb 761) on hepatic sinusoidal endothelial cells and hepatic microcirculation in CCl4 rats. | 2004 | Am. J. Chin. Med. | pmid:15154282 |
| Saint-Martin F et al. | A randomized, double-blind, parallel-group study, comparing the efficacy and safety of rupatadine (20 and 10 mg), a new PAF and H1 receptor-specific histamine antagonist, to loratadine 10 mg in the treatment of seasonal allergic rhinitis. | 2004 | J Investig Allergol Clin Immunol | pmid:15160440 |
| Xu Y and Tao YX | Involvement of the NMDA receptor/nitric oxide signal pathway in platelet-activating factor-induced neurotoxicity. | 2004 | Neuroreport | pmid:15076749 |
| Slomiany BL and Slomiany A | Platelet-activating factor mediates Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis via phosphatidylinositol 3-kinase-dependent constitutive nitric-oxide synthase activation. | 2004 | J. Physiol. Pharmacol. | pmid:15082869 |
| Yang YM et al. | Creation of reversed phase high-performance liquid chromatographic technique to assay platelet-activating factor. | 2004 | J. Zhejiang Univ. Sci. | pmid:15101112 |
| Ramos G et al. | Platelet activating factor receptor binding plays a critical role in jet fuel-induced immune suppression. | 2004 | Toxicol. Appl. Pharmacol. | pmid:15020195 |
| Bate C et al. | The role of platelet activating factor in prion and amyloid-beta neurotoxicity. | 2004 | Neuroreport | pmid:15094513 |
| Khreiss T et al. | Activation of extracellular signal-regulated kinase couples platelet-activating factor-induced adhesion and delayed apoptosis of human neutrophils. | 2004 | Cell. Signal. | pmid:15115659 |
| Ninio E et al. | Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease. | 2004 | Hum. Mol. Genet. | pmid:15115767 |
| Bonin F et al. | Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit. | 2004 | J. Biol. Chem. | pmid:15456758 |
| Martin C et al. | Pressor responses to platelet-activating factor and thromboxane are mediated by Rho-kinase. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15064228 |
| Alfaro V | Role of histamine and platelet-activating factor in allergic rhinitis. | 2004 | J. Physiol. Biochem. | pmid:15457928 |
| Baker KE and Curtis MJ | Left regional cardiac perfusion in vitro with platelet-activating factor, norepinephrine and K+ reveals that ischaemic arrhythmias are caused by independent effects of endogenous "mediators" facilitated by interactions, and moderated by paradoxical antagonism. | 2004 | Br. J. Pharmacol. | pmid:15066909 |
| Uemura K et al. | Superoxide production from human polymorphonuclear leukocytes by human mannan-binding protein (MBP). | 2004 | Glycoconj. J. | pmid:15467404 |
| Victorino GP et al. | Modulation of microvascular hydraulic permeability by platelet-activating factor. | 2004 | J Trauma | pmid:14960983 |
| Ko HH et al. | Structure-activity relationship studies on chalcone derivatives: potent inhibition of platelet aggregation. | 2004 | J. Pharm. Pharmacol. | pmid:15482650 |
| Ewer AK et al. | The role of platelet activating factor in a neonatal piglet model of necrotising enterocolitis. | 2004 | Gut | pmid:14724152 |
| Angeli V et al. | Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. | 2004 | Immunity | pmid:15485633 |
| Tai H et al. | TMVA, a snake C-type lectin-like protein from Trimeresurus mucrosquamatus venom, activates platelet via GPIb. | 2004 | Toxicon | pmid:15501291 |