| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rhee CK | Candidate's thesis: Platelet-activating factor-induced hearing loss: mediated by nitric oxide? | 2003 | Laryngoscope | pmid:14660903 |
| Diaper CM et al. | A total synthesis of (+/-)-phomactin A. | 2003 | Org. Biomol. Chem. | pmid:14664384 |
| Narahara H et al. | Platelet-activating factor inhibits the secretion of platelet-activating factor acetylhydrolase by human decidual macrophages. | 2003 | J. Clin. Endocrinol. Metab. | pmid:14671207 |
| Gálvez J et al. | The intestinal anti-inflammatory activity of UR-12746S on reactivated experimental colitis is mediated through downregulation of cytokine production. | 2003 | Inflamm. Bowel Dis. | pmid:14671485 |
| Ishizuka S et al. | Effects of rhinovirus infection on the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells. | 2003 | J. Infect. Dis. | pmid:14673774 |
| Eldar M et al. | Effects of coronary angioplasty on plasma platelet-activating factor in man. | 1992 | J Lipid Mediat | pmid:1467464 |
| Herd CM et al. | Effect of a 5-lipoxygenase inhibitor and leukotriene antagonist (PF 5901) on PAF-induced airway responses in neonatally immunized rabbits. | 1992 | Br. J. Pharmacol. | pmid:1467833 |
| Heuer HO | Current status of PAF antagonists. | 1992 | Clin. Exp. Allergy | pmid:1468031 |
| Schmitt JD et al. | A facile synthesis of 1-O-alkyl-2-(R)-hydroxypropane-3-phosphonocholine (lyso-phosphono-platelet activating factor). | 1992 | Chem. Phys. Lipids | pmid:1468125 |
| Trovati M et al. | Moderate exercise increases platelet function in type I diabetic patients without severe angiopathy and in good control. | 1992 | Diabetes Care | pmid:1468311 |
| Hertelendy F and Zakár T | Prostaglandins and the myometrium and cervix. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14683694 |
| Zingarelli B et al. | Platelet activating factor interaction with tumor necrosis factor and myocardial depressant factor in splanchnic artery occlusion shock. | 1992 | Eur. J. Pharmacol. | pmid:1468489 |
| Gómez-Garre D et al. | Aggregation of human polymorphonuclear leukocytes by endothelin: role of platelet-activating factor. | 1992 | Eur. J. Pharmacol. | pmid:1468506 |
| Mayerle J et al. | [Conservative treatment of acute pancreatitis]. | 2003 | Med. Klin. (Munich) | pmid:14685675 |
| Jung TT et al. | Effect of inhibitors of leukotriene and/or platelet activating factor on killed H. influenzae induced experimental otitis media with effusion. | 2004 | Int. J. Pediatr. Otorhinolaryngol. | pmid:14687688 |
| Hidalgo MA et al. | Platelet-activating factor increases pH(i) in bovine neutrophils through the PI3K-ERK1/2 pathway. | 2004 | Br. J. Pharmacol. | pmid:14691048 |
| Koyama N | Platelet activating factor in surfactant-TA is inhibited by coexisting inhibitors. | 2003 | Lung | pmid:14692561 |
| Tellis C et al. | Localization of an alkyl-acetyl-glycerol-CDP-choline: cholinephosphotransferase activity in submitochondrial fractions of Tetrahymena pyriformis. | 2003 | Eur. J. Cell Biol. | pmid:14703014 |
| Göggel R et al. | PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. | 2004 | Nat. Med. | pmid:14704790 |
| Stafforini DM et al. | Platelet-activating factor, a pleiotrophic mediator of physiological and pathological processes. | 2003 | Crit Rev Clin Lab Sci | pmid:14708958 |
| Tsutsumi T et al. | Phorbol myristate acetate stimulates degradation of a structural analogue of platelet-activating factor to a neutral lipid in human leukemic K562 cells: relevance to the release of lipids. | 2004 | Biol. Pharm. Bull. | pmid:14709893 |
| Bouayad A et al. | Developmental regulation of prostaglandin E2 synthase in porcine ductus arteriosus. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:14715488 |
| Axelrad TW et al. | Platelet-activating factor (PAF) induces activation of matrix metalloproteinase 2 activity and vascular endothelial cell invasion and migration. | 2004 | FASEB J. | pmid:14715700 |
| Ewer AK et al. | The role of platelet activating factor in a neonatal piglet model of necrotising enterocolitis. | 2004 | Gut | pmid:14724152 |
| Nathan N et al. | Variations of blood PAF-acether levels during coronary artery surgery. | 1992 | J. Cardiothorac. Vasc. Anesth. | pmid:1472665 |
| Chen L et al. | [Determination of platelet activating factor in middle ear effusion of patients with secretory oitits media]. | 2003 | Lin Chuang Er Bi Yan Hou Ke Za Zhi | pmid:14727433 |
| Shi H et al. | The effect of platelet activating factor on different phases of murine in vitro fertilization. | 1992 | J. Assist. Reprod. Genet. | pmid:1472817 |
| Chakrabarty S et al. | Effects of the PAF antagonists BN50726 and BN50739 on arrhythmogenesis and extent of necrosis during myocardial ischaemia/reperfusion in rabbits. | 1992 | Br. J. Pharmacol. | pmid:1472967 |
| Gabrijelcic J et al. | Formoterol protects against platelet-activating factor-induced effects in asthma. | 2004 | Eur. Respir. J. | pmid:14738234 |
| Chen CR et al. | Pulmonary vascular reactivity: effect of PAF and PAF antagonists. | 1992 | J. Appl. Physiol. | pmid:1474049 |
| Geiser T | The role of neutrophils and neutrophil products in pulmonary hemodynamics of endotoxin in oleic acid-induced lung injury. | 2004 | Anesth. Analg. | pmid:14742354 |
| Hill LL et al. | Neutrophils and neutrophil products do not mediate pulmonary hemodynamic effects of endotoxin on oleic acid-induced lung injury. | 2004 | Anesth. Analg. | pmid:14742386 |
| Li X and Luo H | [Advances in pharmacological study of Piper kadsura (Choisy) Ohwi]. | 2002 | Zhong Yao Cai | pmid:14748373 |
| Zhang GQ et al. | [The effects of milkvetch and memantain on the synthesis of cerebral PAF in neonatal rats with hypoxic-ischemic reperfusion]. | 2003 | Zhonghua Er Ke Za Zhi | pmid:14751060 |
| Trochtenberg DS et al. | Effects of thromboxane synthase and cyclooxygenase inhibition on PAF-induced changes in lung function and arachidonic acid metabolism. | 1992 | Prostaglandins | pmid:1475377 |
| Lyman BA et al. | In vitro and in vivo activities of the novel antiplatelet agent alpha,alpha'-bis[3-(N,N-diethylcarbamoyl)piperidino]-p-xylene dihydrobromide. | 1992 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1475529 |
| Barnes PJ | Ceramide lances the lungs. | 2004 | Nat. Med. | pmid:14760419 |
| Rollin S et al. | VEGF-mediated endothelial P-selectin translocation: role of VEGF receptors and endogenous PAF synthesis. | 2004 | Blood | pmid:14764537 |
| Resetkova E et al. | Effect of human thyroglobulin on the production of platelet activating factor from peripheral blood mononuclear cells from patients with autoimmune thyroid diseases. | 1992 Jul-Aug | Reg Immunol | pmid:1476872 |
| Goldring WP and Pattenden G | Total synthesis of (+/-)-phomactin G, a platelet activating factor antagonist from the marine fungus Phoma sp. | 2004 | Org. Biomol. Chem. | pmid:14770224 |
| Gentry PA et al. | Bovine platelets retain functional activity in the presence of penicillin G. | 1992 | Can. J. Vet. Res. | pmid:1477805 |
| Triggiani M and Chilton FH | Metabolism of platelet-activating factor in the guinea-pig heart. | 1992 | J. Mol. Cell. Cardiol. | pmid:1479612 |
| Chatham WW et al. | Ligand dependent release of activated neutrophil collagenase--a role for surface bound IgG in the degradation of articular collagens. | 1992 | Matrix Suppl | pmid:1480027 |
| Schoonderwoerd K and Stam H | Lipid metabolism of myocardial endothelial cells. | 1992 | Mol. Cell. Biochem. | pmid:1480146 |
| Ganbo T et al. | [The inhibitory effects of platelet activating factor (PAF) on ciliary activity of human paranasal sinus mucosa]. | 1992 | Arerugi | pmid:1482297 |
| Murphy CT et al. | Evidence for the presence and location of annexins in human platelets. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1482379 |
| Sengoku K et al. | Effects of platelet activating factor on mouse sperm function. | 1992 | J. Assist. Reprod. Genet. | pmid:1482839 |
| Lai CK et al. | Effect of inhaled platelet-activating factor on bronchial inflammation in atopic non-asthmatic subjects. | 1992 | Int. Arch. Allergy Immunol. | pmid:1483069 |
| Koenigsmann M et al. | Lack of therapeutic effects of platelet activating factor antagonists in WEHI-3B leukemia, human xenotransplanted colorectal and lung cancer and Lewis-lung tumor in vivo. | 1992 | Cancer Lett. | pmid:1483263 |
| Sheng Y and Birkle DL | Intracamerally injected platelet activating factor (PAF) induces marked intraocular inflammatory reactions. | 1992 | Curr. Eye Res. | pmid:1483337 |
| Gebremichael I and Leuenberger P | Platelet-activating factor does not induce bronchial hyperreactivity in nonasthmatic subjects. | 1992 | Respiration | pmid:1485002 |
| Wysocki H | The role of polymorphonuclear neutrophils in myocardial damage during ischemia and reperfusion. | 1992 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:1485826 |
| Ortiz JL et al. | Rolipram inhibits PAF-induced airway microvascular leakage in guinea-pig: a comparison with milrinone and theophylline. | 1992 | Fundam Clin Pharmacol | pmid:1487228 |
| Yoshikawa T et al. | Effects of a platelet-activating factor antagonist, CV-6209, on gastric mucosal lesions induced by ischemia-reperfusion. | 1992 | Lipids | pmid:1487954 |
| Bethel RA et al. | Effects of neutrophil depletion and repletion on PAF-induced hyperresponsiveness of canine trachea. | 1992 | J. Appl. Physiol. | pmid:1490952 |
| Toga H et al. | Vascular effects of platelet-activating factor in lambs: role of cyclo- and lipoxygenase. | 1992 | J. Appl. Physiol. | pmid:1490969 |
| Montalescot G et al. | Role of platelet-activating factor in the ovine heparin-protamine reaction. | 1992 | J. Appl. Physiol. | pmid:1490976 |
| Norman SJ and Poyser NL | The effects of platelet-activating factor on the output of prostaglandins from the guinea-pig uterus. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1492106 |
| Vieweg H et al. | [Synthesis of N-(2-carboxy-thieno(2,3-b)pyridin-3-yl)-amidines by the reaction with 4-oxo-4H-pyrido(3',2':4,5)-thieno(3,2-d)-1,3-oxazines with secondary cycloaliphatic amines]. | 1992 | Pharmazie | pmid:1492113 |
| Triggiani M et al. | Characterization of platelet-activating factor synthesized by normal and granulocyte-macrophage colony-stimulating factor-primed human eosinophils. | 1992 | Immunology | pmid:1493922 |
| Lee TC et al. | 1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase. | 1992 | Meth. Enzymol. | pmid:1495421 |
| Sugiura T and Waku K | Coenzyme A-independent acyltransferase. | 1992 | Meth. Enzymol. | pmid:1495438 |
| Victorino GP et al. | Modulation of microvascular hydraulic permeability by platelet-activating factor. | 2004 | J Trauma | pmid:14960983 |
| Wang KS et al. | Protective effects of a PAF antagonist against liver injury induced by warm ischemia or cold preservation. | 1992 | Transplant. Proc. | pmid:1496669 |
| Taylor KE | Familial cancer and developmental dyslexia: an observational pilot study. | 2004 | Dev Med Child Neurol | pmid:14974637 |
| Podsiadly BT et al. | Prefertilization treatment of mice with platelet activating factor affects pregnancy. | 1992 | Mol. Reprod. Dev. | pmid:1497884 |
| Smalling WE et al. | Protective effect of pentoxifylline on volume-induced lung injury in newborn piglets. | 2004 | Biol. Neonate | pmid:14981352 |
| Haslberger A et al. | Membrane potential modulates release of tumor necrosis factor in lipopolysaccharide-stimulated mouse macrophages. | 1992 | Mol. Biol. Cell | pmid:1498365 |
| Daniel EE et al. | Effects of inflammatory mediators on canine airway neuromuscular function. | 1992 | Can. J. Physiol. Pharmacol. | pmid:1498728 |
| Samson Y et al. | Effect of alpha-glyceril-phosphorylcholine on cerebral glucose metabolism in normal volunteers. | 1992 | Clin Neuropharmacol | pmid:1498942 |
| Dinarello CA | The IL-1 family and inflammatory diseases. | 2002 Sep-Oct | Clin. Exp. Rheumatol. | pmid:14989423 |
| Matsumoto K et al. | Platelet-activating factor in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome. | 1992 | Clin. Exp. Pharmacol. Physiol. | pmid:1499148 |
| Zang BX et al. | [Antagonistic effect of myricetin on platelet activing factor]. | 2003 | Yao Xue Xue Bao | pmid:14991995 |
| Slomiany BL and Slomiany A | Platelet-activating factor mediates Helicobacter pylori lipopolysaccharide interference with gastric mucin synthesis. | 2004 | IUBMB Life | pmid:14992379 |
| Jung TT et al. | Effect of platelet activating factor with and without receptor antagonist (WEB2170) on morphology of isolated cochlear outer hair cells. | 2004 | Ann. Otol. Rhinol. Laryngol. | pmid:14994775 |
| Getting SJ et al. | Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis. | 2004 | J. Pharmacol. Exp. Ther. | pmid:14996949 |
| Aguiari G et al. | Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells. | 2004 | FASEB J. | pmid:15001556 |
| Gilroy DW et al. | A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation. | 2004 | FASEB J. | pmid:15003994 |
| Geromin D et al. | Glycoprotein 170 induces platelet-activating factor receptor membrane expression and confers tumor cell hypersensitivity to NK-dependent cell lysis. | 2004 | J. Immunol. | pmid:15004162 |
| Tunc SE et al. | Platelet-activating factor and P-selectin activities in thrombotic and nonthrombotic Behçet's patients. | 2005 | Rheumatol. Int. | pmid:15004723 |
| Ammit AJ et al. | Structural heterogeneity of platelet-activating factor produced by murine preimplantation embryos. | 1992 | Hum. Reprod. | pmid:1500487 |
| Peri A et al. | The effects of an autocrine loop mediated by platelet-activating factor (PAF) in HEC-1A cells are reverted by uteroglobin. | 2003 | Hum. Cell | pmid:15005239 |
| Wilks J | The impact of the pill on implantation factors--new research findings. | 2000 | Ethics Med | pmid:15015518 |
| Ramos G et al. | Platelet activating factor receptor binding plays a critical role in jet fuel-induced immune suppression. | 2004 | Toxicol. Appl. Pharmacol. | pmid:15020195 |
| Lu DP et al. | Trophic signals acting via phosphatidylinositol-3 kinase are required for normal pre-implantation mouse embryo development. | 2004 | J. Cell. Sci. | pmid:15020683 |
| Ziche M | Absence of PAF actions increases angiogenesis. | 2004 | Br. J. Pharmacol. | pmid:15023858 |
| Ferreira MA et al. | Sponge-induced angiogenesis and inflammation in PAF receptor-deficient mice (PAFR-KO). | 2004 | Br. J. Pharmacol. | pmid:15023865 |
| Yamano S et al. | Human spermatozoa capacitated with progesterone or a long incubation show accelerated internalization by an alkyl ether lysophospholipid. | 2004 | Fertil. Steril. | pmid:15037409 |
| DiPersio JF and Abboud CN | Activation of neutrophils by granulocyte-macrophage colony-stimulating factor. | 1992 | Immunol. Ser. | pmid:1504144 |
| Kroegel C et al. | The pathophysiological role and therapeutic implications of platelet activating factor in diseases of aging. | 1992 Jul-Aug | Drugs Aging | pmid:1504447 |
| Alloatti G et al. | Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease. | 2004 | Biochem. Soc. Trans. | pmid:15046613 |
| Naoki K et al. | PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15047169 |
| May GR et al. | The pharmacological modulation of thrombin-induced cerebral thromboembolism in the rabbit. | 1992 | Br. J. Pharmacol. | pmid:1504722 |
| Henriques MG et al. | Endothelin-1 inhibits PAF-induced paw oedema and pleurisy in the mouse. | 1992 | Br. J. Pharmacol. | pmid:1504742 |
| Dryden P et al. | Inhibition of human neutrophil responses by alpha-cyano-3,4-dihydroxythiocinnamamide; a protein-tyrosine kinase inhibitor. | 1992 | Br. J. Pharmacol. | pmid:1504749 |
| Billah MM et al. | Differential plasma duration of antiplatelet-activating factor and antihistamine activities of oral Sch 37370 in humans. | 1992 | Clin. Pharmacol. Ther. | pmid:1505150 |
| Sugatani J et al. | Tea polyphenols inhibit acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and platelet-activating factor-induced platelet aggregation. | 2004 | Int. Arch. Allergy Immunol. | pmid:15051936 |
| Balestrieri ML et al. | Lycopene in association with alpha-tocopherol or tomato lipophilic extracts enhances acyl-platelet-activating factor biosynthesis in endothelial cells during oxidative stress. | 2004 | Free Radic. Biol. Med. | pmid:15059646 |
| Martin C et al. | Pressor responses to platelet-activating factor and thromboxane are mediated by Rho-kinase. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15064228 |
| Baker KE and Curtis MJ | Left regional cardiac perfusion in vitro with platelet-activating factor, norepinephrine and K+ reveals that ischaemic arrhythmias are caused by independent effects of endogenous "mediators" facilitated by interactions, and moderated by paradoxical antagonism. | 2004 | Br. J. Pharmacol. | pmid:15066909 |