| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Borin ML et al. | [Relation between the changes in Na+/H+-exchange and cytoplasmic Ca levels in platelet activation]. | 1988 | Biull Eksp Biol Med | pmid:2844320 |
| Joseph R et al. | Cytosolic ionized calcium homeostasis in platelets: an abnormal sensitivity to PAF-activation in migraine. | 1988 | Headache | pmid:2844693 |
| Arnoux B et al. | Effect of PAF-acether in non-human primates. | 1988 | Prog. Clin. Biol. Res. | pmid:2837781 |
| Livio M et al. | Role of platelet-activating factor in primary hemostasis. | 1988 | Am. J. Physiol. | pmid:2837916 |
| Bekker AY et al. | Dose-response relationships between platelet activating factor and permeability--surface area product of FITC-dextran 150 in the hamster cheek pouch. | 1988 | Microcirc Endothelium Lymphatics | pmid:2475751 |
| Vivier E et al. | Immunoregulatory functions of paf-acether. II. Decrease of CD2 and CD3 antigen expression. | 1988 | Eur. J. Immunol. | pmid:2895712 |
| Hoffman DR et al. | Synthesis of platelet activating factor by cholinephosphotransferase in developing fetal rabbit lung. | 1988 | Lipids | pmid:2897059 |
| Leff AR | Neurohumoral regulation of airway contractile responses. | 1988 | Chest | pmid:2897271 |
| Junier MP et al. | Inhibitory effect of platelet-activating factor (PAF) on luteinizing hormone-releasing hormone and somatostatin release from rat median eminence in vitro correlated with the characterization of specific PAF receptor sites in rat hypothalamus. | 1988 | Endocrinology | pmid:2898362 |
| Bachelet M et al. | Interaction between PAF-acether and drugs that stimulate cyclic AMP in guinea-pig alveolar macrophages. | 1988 | Eur. J. Pharmacol. | pmid:2840303 |
| Crouch MF and Lapetina EG | No direct correlation between Ca2+ mobilization and dissociation of Gi during platelet phospholipase A2 activation. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3132162 |
| Russell JA et al. | Changes in the levels of bioactive components of cotton bracts accompanying senescence. | 1988 | Lung | pmid:3132575 |
| Martins MA et al. | Intravenous injections of PAF-acether induce platelet aggregation in rats. | 1988 | Eur. J. Pharmacol. | pmid:3135199 |
| Peers SH | Dexamethasone inhibits platelet activating factor-induced inflammation in the paw but not the pleural cavity of rats. | 1988 | Eur. J. Pharmacol. | pmid:3136026 |
| Mangold HK | Synthesis of biologically active ether lipids. | 1988 | Prog Biochem Pharmacol | pmid:3136454 |
| Anderson GP et al. | Increased airways responsiveness to histamine induced by platelet activating factor in the guinea-pig: possible role of lipoxygenase metabolites. | 1988 | Agents Actions | pmid:3136622 |
| Levine L | Platelet-activating factor stimulates arachidonic acid metabolism in rat liver cells (C-9 cell line) by a receptor-mediated mechanism. | 1988 | Mol. Pharmacol. | pmid:2849046 |
| Ferrell JE et al. | Membrane bilayer balance and platelet shape: morphological and biochemical responses to amphipathic compounds. | 1988 | Biochim. Biophys. Acta | pmid:3355815 |
| López-Farré A et al. | Glomeruli from ischemic rat kidneys produce increased amounts of platelet activating factor. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3358756 |
| Kuiper J et al. | The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3144970 |
| Valone FH and Epstein LB | Biphasic platelet-activating factor synthesis by human monocytes stimulated with IL-1-beta, tumor necrosis factor, or IFN-gamma. | 1988 | J. Immunol. | pmid:3141509 |
| Berti F et al. | New pharmacological data on the bronchospasmolytic activity of bamifylline. | 1988 | Arzneimittelforschung | pmid:3365275 |
| Sun XM and Hsueh W | Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor. | 1988 | J. Clin. Invest. | pmid:3366898 |
| Calignano A et al. | Isolation and identification of platelet-activating factor in UV-irradiated guinea pig skin. | 1988 | J Pharmacol Methods | pmid:3367652 |
| Nolte D | [Bronchial hyperreactivity: pingpong between cells, nerves and mediators]. | 1988 | Med. Klin. (Munich) | pmid:3367876 |
| Smith RJ et al. | Diacylglycerols modulate human polymorphonuclear neutrophil responsiveness: effects on intracellular calcium mobilization, granule exocytosis, and superoxide anion production. | 1988 | J. Leukoc. Biol. | pmid:2836539 |
| Rydzewska G and Gabryelewicz A | [Platelet activating factor (PAF) and its inhibitors]. | 1988 | Pol. Arch. Med. Wewn. | pmid:2482481 |
| Jouquey S et al. | Comparison of the effects of the ace inhibitors trandolapril and enalapril on phlogogen induced foot pad oedema in the rat. | 1988 | Agents Actions | pmid:2459935 |
| Spinks NR and O'Neill C | Antagonists of embryo-derived platelet-activating factor prevent implantation of mouse embryos. | 1988 | J. Reprod. Fertil. | pmid:2460623 |
| Dorsch W et al. | Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract PAF and allergen-induced bronchial obstruction in vivo. | 1988 | Biochem. Pharmacol. | pmid:2462422 |
| Barnes PJ | Inflammatory mechanisms and nocturnal asthma. | 1988 | Am. J. Med. | pmid:3041827 |
| Camussi G and Salvidio G | Platelet-activating factor in graft rejection. | 1988 | Prog Biochem Pharmacol | pmid:3043426 |
| Hénocq E | PAF-acether and eosinophils. | 1988 | Prog Biochem Pharmacol | pmid:3043428 |
| Lagente V and Fortes ZB | Role of PAF-acether in the vascular events of inflammation. | 1988 | Prog Biochem Pharmacol | pmid:3043429 |
| Cordeiro RS et al. | Proinflammatory activity of platelet-activating factor: pharmacological modulation and cellular involvement. | 1988 | Prog Biochem Pharmacol | pmid:3043430 |
| Pirotzky E and Braquet P | PAF-acether and kidney pathology. | 1988 | Prog Biochem Pharmacol | pmid:3043431 |
| Feuerstein G and Siren AL | Platelet-activating factor and shock. | 1988 | Prog Biochem Pharmacol | pmid:3043432 |
| There is a case for PAF-acether antagonists. Abstracts of the conference. Paris, France, May 25-27, 1988. | 1988 | Prostaglandins | pmid:3399682 | |
| Valone FH | Platelet-activating factor binding and metabolism during human platelet aggregation. | 1988 | Thromb. Res. | pmid:3400077 |
| Bratton DL et al. | Effects of platelet activating factor on calcium-lipid interactions and lateral phase separations in phospholipid vesicles. | 1988 | Biochim. Biophys. Acta | pmid:3401478 |
| Evans TW et al. | Effect of a Paf antagonist, WEB 2086, on airway microvascular leakage in the guinea-pig and platelet aggregation in man. | 1988 | Br. J. Pharmacol. | pmid:3401633 |
| Lagente V et al. | Interference of the Paf antagonist Ro 19-3704 with Paf and antigen-induced bronchoconstriction in the guinea-pig. | 1988 | Br. J. Pharmacol. | pmid:3401641 |
| Groscurth P et al. | Effects of platelet activating factor (PAF) on human citrated whole blood. | 1988 | Eur. J. Haematol. | pmid:3402585 |
| Rylander R et al. | Modulation of pulmonary inflammation after endotoxin inhalation with a platelet-activating factor antagonist (48740 RP). | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:3403044 |
| Tamura N et al. | Leukotriene C4 production from human eosinophils in vitro. Role of eosinophil chemotactic factors on eosinophil activation. | 1988 | J. Immunol. | pmid:2848892 |
| Pretolani M et al. | Active immunization induces lung hyperresponsiveness in the guinea pig. Pharmacologic modulation and triggering role of the booster injection. | 1988 | Am. Rev. Respir. Dis. | pmid:3202509 |
| Pirotzky E and Braquet P | [The role of the platelet-activating factor (PAF-acether) in renal pathology]. | 1988 | Presse Med | pmid:2966954 |
| Willuweit B and Aktories K | Heparin and heparinoids impair adrenaline and platelet-activating factor but not thrombin-induced inhibition of adenylate cyclase and stimulation of GTP hydrolysis in human platelet membranes. | 1988 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:2969081 |
| Jancar S et al. | Immune complex induced pancreatitis: effect of BN 52021, a selective antagonist of platelet-activating factor. | 1988 | Prostaglandins | pmid:2969600 |
| Tkhostov EB et al. | [Calcium metabolism in arterial hypertension. I. Myocardial hypertrophy and hormone-dependent increase in Ca2+ levels in the thrombocytes of patients with arterial hypertension]. | 1988 | Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR | pmid:2969736 |
| Wallace JL | Release of platelet-activating factor (PAF) and accelerated healing induced by a PAF antagonist in an animal model of chronic colitis. | 1988 | Can. J. Physiol. Pharmacol. | pmid:3167675 |
| Stenson WF | Platelet-activating factor and inflammatory bowel disease. | 1988 | Gastroenterology | pmid:3169505 |
| Valone FH et al. | Enhanced human monocyte cytotoxicity by platelet-activating factor. | 1988 | Immunology | pmid:3169845 |
| Popovich KJ et al. | Role of platelets in contraction of canine tracheal muscle elicited by PAF in vitro. | 1988 | J. Appl. Physiol. | pmid:3170437 |
| Moriyama T et al. | Elevation of cytosolic free Ca2+ is directly evoked by thromboxane A2 in human platelets during activation with collagen. | 1988 | J. Biochem. | pmid:3170519 |
| Lagente V et al. | PAF-acether and endotoxin display similar effects on rat mesenteric microvessels: inhibition by specific antagonists. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3171975 |
| Benveniste J et al. | Preformed PAF-acether and lyso PAF-acether are bound to blood lipoproteins. | 1988 | FEBS Lett. | pmid:3338565 |
| Lagente V et al. | Involvement of PAF-acether in anaphylactic bronchoconstriction induced in guinea pigs by aerosolized antigen. | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:3338855 |
| Imai T et al. | Pulmonary hypertension and edema induced by platelet-activating factor in isolated, perfused rat lungs are blocked by BN52021. | 1988 | J. Lab. Clin. Med. | pmid:3339274 |
| Wichrowski B et al. | Structure-activity relationship in PAF-acether. 4. Synthesis and biological activities of carboxylate isosteres. | 1988 | J. Med. Chem. | pmid:3339611 |
| Tilley JW et al. | Pyrido[2,1-b]quinazolinecarboxamide derivatives as platelet activating factor antagonists. | 1988 | J. Med. Chem. | pmid:3339617 |
| Ferguson MK et al. | Lymphatic smooth muscle responses to leukotrienes, histamine and platelet activating factor. | 1988 | J. Surg. Res. | pmid:3339877 |
| Kelefiotis D et al. | Study of digoxin as inhibitor of the in vivo effects of acetyl glyceryl ether phosphorylcholine (AGEPC) in mice. | 1988 | Life Sci. | pmid:3339951 |
| Valone FH | Identification of platelet-activating factor receptors in P388D1 murine macrophages. | 1988 | J. Immunol. | pmid:2832476 |
| Homma H and Hanahan DJ | Attenuation of platelet activating factor (PAF)-induced stimulation of rabbit platelet GTPase by phorbol ester, dibutyryl cAMP, and desensitization: concomitant effects on PAF receptor binding characteristics. | 1988 | Arch. Biochem. Biophys. | pmid:2833174 |
| Huang SJ et al. | Platelet-activating factor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate stimulates the production of reactive oxygen intermediates in macrophages. | 1988 | Biochem. J. | pmid:2833227 |
| Rees RS et al. | Plasma components are required for platelet activation by the toxin of Loxosceles reclusa. | 1988 | Toxicon | pmid:3245050 |
| Brass LF et al. | Interactions in platelets between G proteins and the agonists that stimulate phospholipase C and inhibit adenylyl cyclase. | 1988 | J. Biol. Chem. | pmid:2833506 |
| Blank ML et al. | Stimulation of the de novo pathway for the biosynthesis of platelet-activating factor (PAF) via cytidylyltransferase activation in cells with minimal endogenous PAF production. | 1988 | J. Biol. Chem. | pmid:2833508 |
| Mencia-Huerta JM et al. | [Effect of long-term administration of platelet activating factor on pulmonary response and morphology in the guinea pig]. | 1988 | Allerg Immunol (Paris) | pmid:3245884 |
| Rola-Pleszczynski M et al. | Immune regulation by platelet-activating factor. I. Induction of suppressor cell activity in human monocytes and CD8+ T cells and of helper cell activity in CD4+ T cells. | 1988 | J. Immunol. | pmid:2834440 |
| Takeuchi N et al. | The antagonist effects of compounds derived from khellactone on platelet-activating factor. | 1988 | Chem. Pharm. Bull. | pmid:3245999 |
| Worthen GS et al. | The priming of neutrophils by lipopolysaccharide for production of intracellular platelet-activating factor. Potential role in mediation of enhanced superoxide secretion. | 1988 | J. Immunol. | pmid:2834441 |
| Hofmann B et al. | Effect of specific antagonists on PAF-induced platelet aggregation and release of plasminogen activator. | 1988 | Biomed. Biochim. Acta | pmid:3248103 |
| Mest HJ et al. | The arrhythmogenic effect of platelet activating factor (PAF) is inhibited by PAF antagonist and by substances influencing eicosanoids. | 1988 | Biomed. Biochim. Acta | pmid:3248107 |
| Wainwright CL et al. | The effects of PAF antagonists on ischaemia and reperfusion arrhythmias and ischaemia-induced platelet aggregation. | 1988 | Biomed. Biochim. Acta | pmid:3248108 |
| Prpic V et al. | Biochemical and functional responses stimulated by platelet-activating factor in murine peritoneal macrophages. | 1988 | J. Cell Biol. | pmid:2839520 |
| Kroegel C | The potential pathophysiological role of platelet-activating factor in human diseases. | 1988 | Klin. Wochenschr. | pmid:2839728 |
| Leslie CC et al. | Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7. | 1988 | Biochim. Biophys. Acta | pmid:3143418 |
| Egger M et al. | Human platelet electrorotation change induced by activation: inducer specificity and correlation to serotonin release. | 1988 | Biochim. Biophys. Acta | pmid:3143424 |
| Hammerschmidt DE et al. | Pentoxifylline inhibits granulocyte and platelet function, including granulocyte priming by platelet activating factor. | 1988 | J. Lab. Clin. Med. | pmid:2840477 |
| Pitcock JA | Morphometric studies of the renomedullary interstitial cells. | 1988 | Am. J. Med. Sci. | pmid:3284348 |
| Hwang SB et al. | Biochemical and pharmacological characterization of L-659,989: an extremely potent, selective and competitive receptor antagonist of platelet-activating factor. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2841449 |
| Parnham MJ | PAF receptors. | 1988 | Prog Biochem Pharmacol | pmid:2841664 |
| Shkhvatsabaia IK et al. | [Receptor-dependent regulation of the concentration of Ca2+ in the cytoplasm of thrombocytes in hypertensive patients]. | 1988 | Kardiologiia | pmid:2842537 |
| Tahraoui L et al. | High affinity specific binding sites for tritiated platelet-activating factor in canine platelet membranes: counterparts of platelet-activating factor receptors mediating platelet aggregation. | 1988 | Mol. Pharmacol. | pmid:2842653 |
| Croft KD et al. | The effect of dietary fish oil and long-term salt loading on blood pressure and eicosanoid metabolism in spontaneously hypertensive rats. | 1988 | Clin. Exp. Pharmacol. Physiol. | pmid:3271614 |
| Ng DS and Wong K | Effect of sulfhydryl reagents on PAF binding to human neutrophils and platelets. | 1988 | Eur. J. Pharmacol. | pmid:2846326 |
| Avdonin PV et al. | Blocking of the receptor-stimulated calcium entry into human platelets by verapamil and nicardipine. | 1988 | Thromb. Res. | pmid:3232128 |
| Storch J et al. | Influence of platelet activating factor and a nonmetabolizable analogue on superoxide production by bone marrow derived macrophages. | 1988 | J. Leukoc. Biol. | pmid:2846728 |
| Kiktev VG et al. | [Calcium metabolism of the thrombocytes in ischemic heart disease]. | 1988 | Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR | pmid:3233156 |
| Bussolino F et al. | Acetylcholine and dopamine promote the production of platelet activating factor in immature cells of chick embryonic retina. | 1988 | J. Neurochem. | pmid:2846783 |
| Yamada K et al. | Highly sensitive gas chromatographic--mass spectrometric method for the determination of platelet-activating factor in human blood. | 1988 | J. Chromatogr. | pmid:3235552 |
| Birkle DL et al. | Platelet-activating factor antagonist BN52021 decreases accumulation of free polyunsaturated fatty acid in mouse brain during ischemia and electroconvulsive shock. | 1988 | J. Neurochem. | pmid:2846788 |
| Yoshikawa D and Goto F | [Interactions between platelet activating factor and leukotrienes during endotoxin shock in the rat]. | 1988 | Masui | pmid:3236398 |
| Wykle RL et al. | Platelet-activating factor. | 1988 | Meth. Enzymol. | pmid:3237085 |
| Rouis M et al. | Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2847729 |
| Kioumis I et al. | Effect of inhaled platelet-activating factor on circulating neutrophils and platelets in vivo and ex vivo in man. | 1988 | Prostaglandins | pmid:3237997 |
| Doni MG et al. | Forskolin and prostacyclin inhibit fluoride induced platelet activation and protein kinase C dependent responses. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2847730 |
| Fradin A et al. | Inhibition of eicosanoid and PAF formation by dexamethasone in rat inflammatory polymorphonuclear neutrophils may implicate lipocortin 's'. | 1988 | Biochim. Biophys. Acta | pmid:2848583 |