| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mann O et al. | Effect of platelet-activating factor antagonist WEB 2086 on microcirculatory disorders in acute experimental pancreatitis of graded severity. | 2009 | Pancreas | pmid:18695628 |
| Yang HQ et al. | PMS777, a new cholinesterase inhibitor with anti-platelet activated factor activity, regulates amyloid precursor protein processing in vitro. | 2009 | Neurochem. Res. | pmid:18758955 |
| Castro DP et al. | Physalin B inhibits Rhodnius prolixus hemocyte phagocytosis and microaggregation by the activation of endogenous PAF-acetyl hydrolase activities. | 2009 | J. Insect Physiol. | pmid:19232405 |
| Yao Y et al. | Ultraviolet B radiation generated platelet-activating factor receptor agonist formation involves EGF-R-mediated reactive oxygen species. | 2009 | J. Immunol. | pmid:19234179 |
| Shindou H and Shimizu T | [New development of lysophospholipid acyltransferases]. | 2009 | Tanpakushitsu Kakusan Koso | pmid:19205351 |
| Seki M et al. | Expression and DNA microarray analysis of a platelet activating factor-related molecule in severe pneumonia in mice due to influenza virus and bacterial co-infection. | 2009 | Jpn. J. Infect. Dis. | pmid:19168951 |
| Schneider DJ and Sobel BE | Streamlining the design of promising clinical trials: in-vitro testing of antithrombotic regimens and multiple agonists of platelet activation. | 2009 | Coron. Artery Dis. | pmid:19194284 |
| Li J et al. | Protection of PMS777, a new AChE inhibitor with PAF antagonism, against amyloid-beta-induced neuronal apoptosis and neuroinflammation. | 2009 | Cell. Mol. Neurobiol. | pmid:19194797 |
| Fité-Mora R | Torsade de pointes associated with rupatadine. | 2009 | Rev Esp Cardiol | pmid:19268083 |
| Baka S et al. | Treatment of sperm with platelet-activating factor does not improve intrauterine insemination outcome in unselected cases of mild male factor infertility: a prospective double-blind randomized crossover study. | 2009 | Urology | pmid:19716589 |
| Bao GQ and Ju AZ | [Signal pathways of eryptosis-review]. | 2009 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:19698269 |
| Shi B et al. | [Influence of intensive insulin therapy on the intestinal microcirculatory dysfunction in rats with sepsis]. | 2009 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:19695175 |
| Rastogi P and McHowat J | Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium. | 2009 | Respir Physiol Neurobiol | pmid:19059366 |
| Wen J et al. | Simultaneous determination of rupatadine and its metabolite desloratadine in human plasma by a sensitive LC-MS/MS method: application to the pharmacokinetic study in healthy Chinese volunteers. | 2009 | J Pharm Biomed Anal | pmid:19059745 |
| Camerer E et al. | Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. | 2009 | J. Clin. Invest. | pmid:19603543 |
| Xu J et al. | Platelet-activating factor-stimulated production of reactive oxygen species in ovarian granulosa cells from periovulatory follicles. | 2009 | Cytometry A | pmid:19565634 |
| Eggert D et al. | Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders. | 2009 | J. Neuroimmunol. | pmid:19541372 |
| Coy ED et al. | Macrophyllin-type bicyclo[3.2.1]octanoid neolignans from the leaves of Pleurothyrium cinereum. | 2009 | J. Nat. Prod. | pmid:19548690 |
| Coy-Barrera ED et al. | PAF-antagonistic bicyclo[3.2.1]octanoid neolignans from leaves of Ocotea macrophylla Kunth. (Lauraceae). | 2009 | Phytochemistry | pmid:19674762 |
| Kordan W et al. | Effect of platelet-activating factor on motility, plasmalemma integrity, the process of capacitation and acrosome reaction of fresh and cryopreserved boar spermatozoa. | 2009 | Pol J Vet Sci | pmid:19645346 |
| Poisson C et al. | Caveolae facilitate but are not essential for platelet-activating factor-mediated calcium mobilization and extracellular signal-regulated kinase activation. | 2009 | J. Immunol. | pmid:19620302 |
| Pantaler E and Lückhoff A | Inhibitors of TRP channels reveal stimulus-dependent differential activation of Ca2+ influx pathways in human neutrophil granulocytes. | 2009 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:19894037 |
| He YG et al. | Functional analysis of platelet-activating factor in the retinal pigment epithelial cells and choroidal endothelial cells. | 2009 | Curr. Eye Res. | pmid:19958112 |
| Babayigit A et al. | Effects of Ginkgo biloba on airway histology in a mouse model of chronic asthma. | 2009 Mar-Apr | Allergy Asthma Proc | pmid:19118503 |
| Mrówczyńska L and Hägerstrand H | Platelet-activating factor interaction with the human erythrocyte membrane. | 2009 Sep-Oct | J. Biochem. Mol. Toxicol. | pmid:19827129 |
| Thiele T et al. | [Heparin-induced thrombocytopenia]. | 2010 | Internist (Berl) | pmid:20694716 |
| Jiang P et al. | PMS-1077, a PAF antagonist, induced differentiation of HL-60 cells with its novel activity. | 2010 | Cell Biol. Int. | pmid:20812915 |
| Renteria LS et al. | Prolonged hypoxia modulates platelet activating factor receptor-mediated responses by fetal ovine pulmonary vascular smooth muscle cells. | 2010 | Mol. Genet. Metab. | pmid:20813571 |
| Church MK | Efficacy and tolerability of rupatadine at four times the recommended dose against histamine- and platelet-activating factor-induced flare responses and ex vivo platelet aggregation in healthy males. | 2010 | Br. J. Dermatol. | pmid:20819087 |
| Hasan AM et al. | Phosphoinositide 3-kinase gamma mediates chemotactic responses of human eosinophils to platelet-activating factor. | 2010 | Int. Immunopharmacol. | pmid:20685403 |
| Zhao W et al. | [Expression and regulation of pituitary adenylate cyclase-activating polypeptide mRNA in pregnant rat corpus luteum]. | 2010 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21038678 |
| Rechka A et al. | Identification of VEGF receptor-2 tyrosine phosphorylation sites involved in VEGF-mediated endothelial platelet-activating factor synthesis. | 2010 | Can. J. Physiol. Pharmacol. | pmid:20962896 |
| Soliman A et al. | Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis. | 2010 | PLoS ONE | pmid:20976181 |
| Gao F et al. | [The levels of platelet-activating factor and nitric oxide synthase in bronchial asthma at high altitude]. | 2010 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:20979844 |
| Zhu X et al. | Effects of ropivacaine on adhesion molecule CD11b expression and function in human neutrophils. | 2010 | Int. Immunopharmacol. | pmid:20348036 |
| Zhao D et al. | PAF exerts a direct apoptotic effect on the rat H9c2 cardiomyocytes in Ca2+-dependent manner. | 2010 | Int. J. Cardiol. | pmid:19237210 |
| Karantonis HC et al. | Platelet-activating factor involvement in thioacetamide-induced experimental liver fibrosis and cirrhosis. | 2010 | Dig. Dis. Sci. | pmid:19242794 |
| Lefebvre JS et al. | Toll-like receptor ligands induce polymorphonuclear leukocyte migration: key roles for leukotriene B4 and platelet-activating factor. | 2010 | FASEB J. | pmid:19843712 |
| Kida T et al. | Bepotastine besilate, a highly selective histamine H(1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models. | 2010 | Exp. Eye Res. | pmid:20412793 |
| Lorrain DS et al. | Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation. | 2010 | Eur. J. Pharmacol. | pmid:20519143 |
| Esquenazi S and Bazan HE | Role of platelet-activating factor in cell death signaling in the cornea: A review. | 2010 | Mol. Neurobiol. | pmid:20431963 |
| Iyú D et al. | The role of prostanoid receptors in mediating the effects of PGE(2) on human platelet function. | 2010 | Platelets | pmid:20433310 |
| Denizot Y | Platelet-activating factor and acute myelogenous leukemia. | 2010 | Exp. Hematol. | pmid:20303379 |
| Rieder F et al. | Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20299604 |
| Prokosch V et al. | Alpha2-adrenergic receptors and their core involvement in the process of axonal growth in retinal explants. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20592227 |
| Morimoto R et al. | Phosphorylation of lysophosphatidylcholine acyltransferase 2 at Ser34 enhances platelet-activating factor production in endotoxin-stimulated macrophages. | 2010 | J. Biol. Chem. | pmid:20663880 |
| Balestrieri ML et al. | Endothelial progenitor cells express PAF receptor and respond to PAF via Ca(2+)-dependent signaling. | 2010 | Biochim. Biophys. Acta | pmid:20637897 |
| Dyer KD et al. | Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor. | 2010 | J. Immunol. | pmid:20421642 |
| Bate C et al. | Glycosylphosphatidylinositol anchor analogues sequester cholesterol and reduce prion formation. | 2010 | J. Biol. Chem. | pmid:20427265 |
| Shin SH et al. | Platelet-activating factor receptor mediates oxidized low density lipoprotein-induced migration of bone marrow-derived mesenchymal stem cells. | 2010 | Cell. Physiol. Biochem. | pmid:21063106 |