| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fernández-Gallardo S et al. | The role of platelet-activating factor and peptidoleukotrienes in the vascular changes of rat passive anaphylaxis. | 1992 | Br. J. Pharmacol. | pmid:1596674 |
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| Webber SE et al. | PAF-induced muscarinic cholinoceptor hyperresponsiveness of ferret tracheal smooth muscle and gland secretion in vitro. | 1992 | Br. J. Pharmacol. | pmid:1596686 |
| Hogaboam CM et al. | Platelet-activating factor synthesis by peritoneal mast cells and its inhibition by two quinoline-based compounds. | 1992 | Br. J. Pharmacol. | pmid:1596692 |
| Tiemann U et al. | Influence of ovarian steroid hormones or platelet-activating factor on mRNA of platelet-activating factor receptor in endometrial explant perfusion cultures from ovariectomized bovine. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15967160 |
| Bone RC | Phospholipids and their inhibitors: a critical evaluation of their role in the treatment of sepsis. | 1992 | Crit. Care Med. | pmid:1597045 |
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| Louis NA et al. | Lipid mediator networks and leukocyte transmigration. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15979294 |
| Ozger S et al. | Effects of platelet-activating factor on nitrergic transmission in rabbit corpus cavernosum. | 2005 | Int. J. Urol. | pmid:15985080 |
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| Jin Y et al. | Human resting CD16-, CD16+ and IL-2-, IL-12-, IL-15- or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine, lysophosphatidylcholine and platelet-activating factor. | 2005 | Eur. J. Immunol. | pmid:16078278 |
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| Chang GT et al. | Purification and characterization of a new anticoagulant protein, PP27, from placenta. | 2005 | Thromb. Res. | pmid:16122555 |
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| Kleber G et al. | Hemodynamic effects of endotoxin and platelet activating factor in cirrhotic rats. | 1992 | Gastroenterology | pmid:1612334 |
| Chang GT et al. | Inhibitory effect of the Korean herbal medicine, Dae-Jo-Whan, on platelet-activating factor-induced platelet aggregation. | 2005 | J Ethnopharmacol | pmid:16125889 |
| Iversen VV et al. | Platelet activating factor (PAF) increases plasma protein extravasation and induces lowering of interstitial fluid pressure (P) in rat skin. | 2005 | Acta Physiol. Scand. | pmid:16128692 |
| Rola-Pleszczynski M and Stankova J | Differentiation-dependent modulation of TNF production by PAF in human HL-60 myeloid leukemia cells. | 1992 | J. Leukoc. Biol. | pmid:1613396 |
| Andersson PB et al. | Intracerebral injection of proinflammatory cytokines or leukocyte chemotaxins induces minimal myelomonocytic cell recruitment to the parenchyma of the central nervous system. | 1992 | J. Exp. Med. | pmid:1613459 |
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| Ueda Y et al. | Antianaphylactic and antipruritic effects of the flowers of Impatiens textori MIQ. | 2005 | Biol. Pharm. Bull. | pmid:16141562 |
| Corcoran PC et al. | Platelet activating factor antagonist enhances lung preservation in a canine model of single lung allotransplantation. | 1992 | J. Thorac. Cardiovasc. Surg. | pmid:1614217 |
| Tran KC et al. | Induction of angiogenesis by platelet-activating factor in the rat striatum. | 2005 | Neuroreport | pmid:16148749 |
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| Ahmed A and Smith SK | Platelet-activating factor stimulates phospholipase C activity in human endometrium. | 1992 | J. Cell. Physiol. | pmid:1618919 |
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| Raj JU et al. | Effects of endothelin, platelet activating factor and thromboxane A2 in ferret lungs. | 1992 Apr-May | Respir Physiol | pmid:1626132 |
| Kushikata T et al. | Platelet activating factor and its metabolite promote sleep in rabbits. | 2006 | Neurosci. Lett. | pmid:16263215 |
| Ward JR et al. | Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor. | 2005 | Thromb. Haemost. | pmid:16270639 |
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| Chepenik KP and Wykle RL | Synthesis of platelet activating factor and metabolism of related lipids in embryonic cells. | 1992 | Biochim. Biophys. Acta | pmid:1627622 |
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| Morooka S et al. | Platelet-activating factor (PAF) plays an important role in the immediate asthmatic response in guinea-pig by augmenting the response to histamine. | 1992 | Br. J. Pharmacol. | pmid:1628161 |
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| Cheng L et al. | Hydrogen peroxide reduces lower esophageal sphincter tone in human esophagitis. | 2005 | Gastroenterology | pmid:16285965 |
| Nathan N et al. | Role of paf-acether in protamine-induced thrombocytopenia in rabbits. | 1992 | Eur J Anaesthesiol | pmid:1628640 |
| Ko HM et al. | Platelet-activating factor induces matrix metalloproteinase-9 expression through Ca(2+)- or PI3K-dependent signaling pathway in a human vascular endothelial cell line. | 2005 | FEBS Lett. | pmid:16288746 |
| Valone FH and Ruis NM | Stimulation of tumour necrosis factor release by cytotoxic analogues of platelet-activating factor. | 1992 | Immunology | pmid:1628897 |
| Turk J et al. | Quantification of distinct molecular species of the 2-lyso metabolite of platelet-activating factor by gas chromatography-negative-ion chemical ionization mass spectrometry. | 1992 | J. Chromatogr. | pmid:1629294 |
| Cooney SJ et al. | Measurement of PAF in blood by radioimmunoassay. Examination of interfering factors and problems involved in accurate quantification. | 1992 | J. Immunol. Methods | pmid:1629604 |
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