| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Johnson M et al. | Levocetirizine and rupatadine in chronic idiopathic urticaria. | 2015 | Int. J. Dermatol. | pmid:25521304 |
| Kim H et al. | Higher plasma platelet-activating factor levels are associated with increased risk of vertebral fracture and lower bone mineral density in postmenopausal women. | 2015 | J. Bone Miner. Metab. | pmid:25501698 |
| Mullol J et al. | Update on rupatadine in the management of allergic disorders. | 2015 | Allergy | pmid:25491409 |
| Zhao YM and Maimone TJ | Short, enantioselective total synthesis of chatancin. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:25470723 |
| Kattan JD and Sicherer SH | Optimizing the diagnosis of food allergy. | 2015 | Immunol Allergy Clin North Am | pmid:25459577 |
| Ohshima N et al. | New members of the mammalian glycerophosphodiester phosphodiesterase family: GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity. | 2015 | J. Biol. Chem. | pmid:25528375 |
| Pei HX et al. | Ginkgolide B Reduces the Degradation of Membrane Phospholipids to Prevent Ischemia/Reperfusion Myocardial Injury in Rats. | 2015 | Pharmacology | pmid:26382046 |
| Tiniakou I et al. | Natural human apoA-I mutations L141RPisa and L159RFIN alter HDL structure and functionality and promote atherosclerosis development in mice. | 2015 | Atherosclerosis | pmid:26363436 |
| Vlachogianni IC et al. | Platelet Activating Factor (PAF) biosynthesis is inhibited by phenolic compounds in U-937 cells under inflammatory conditions. | 2015 | Prostaglandins Other Lipid Mediat. | pmid:26358846 |
| Sato A et al. | Angiotensin peptides attenuate platelet-activating factor-induced inflammatory activity in rats. | 2015 | Peptides | pmid:26348270 |
| Damiani E et al. | Platelet-Activating Factor Induces Epigenetic Modifications in Human Mast Cells. | 2015 | J. Invest. Dermatol. | pmid:26316070 |
| Starossom SC et al. | Platelets Play Differential Role During the Initiation and Progression of Autoimmune Neuroinflammation. | 2015 | Circ. Res. | pmid:26294656 |
| Jiao D et al. | Macrophages are the dominant effector cells responsible for IgG-mediated passive systemic anaphylaxis challenged by natural protein antigen in BALB/c and C57BL/6 mice. | 2014 May-Jun | Cell. Immunol. | pmid:24751884 |
| Yamauchi A et al. | Systematic single cell analysis of migration and morphological changes of human neutrophils over stimulus concentration gradients. | 2014 | J. Immunol. Methods | pmid:24370750 |
| Flasiński M et al. | Influence of platelet-activating factor, lyso-platelet-activating factor and edelfosine on Langmuir monolayers imitating plasma membranes of cell lines differing in susceptibility to anti-cancer treatment: the effect of plasmalogen level. | 2014 | J R Soc Interface | pmid:24694892 |
| Sato A et al. | C-reactive protein specifically enhances platelet-activating factor-induced inflammatory activity in vivo. | 2014 | Eur. J. Pharmacol. | pmid:25455842 |
| Zebrowska A et al. | Mediators of mast cells in bullous pemphigoid and dermatitis herpetiformis. | 2014 | Mediators Inflamm. | pmid:25400334 |
| Sahu RP et al. | Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor. | 2014 | Cancer Res. | pmid:25304264 |
| Yu Y et al. | Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells. | 2014 | J. Exp. Clin. Cancer Res. | pmid:25261977 |
| Agrawal V et al. | Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice. | 2014 | Biol. Reprod. | pmid:25253732 |
| Wang M et al. | Mouse anaphylactic shock is caused by reduced cardiac output, but not by systemic vasodilatation or pulmonary vasoconstriction, via PAF and histamine. | 2014 | Life Sci. | pmid:25252221 |
| Liu X et al. | Ginkgolide B inhibits platelet release by blocking Syk and p38 MAPK phosphorylation in thrombin-stimulated platelets. | 2014 | Thromb. Res. | pmid:25223809 |
| Kang LP et al. | Steroidal saponins from Tribulus terrestris. | 2014 | Phytochemistry | pmid:25172515 |
| Wu KZ et al. | Establishment of the method for screening the potential targets and effective components of huatuo reconstruction pill. | 2014 | Interdiscip Sci | pmid:25172450 |
| Nitoda E et al. | Correlation of platelet activating factor and age-related macular degeneration. | 2014 | Expert Opin. Ther. Targets | pmid:25077601 |
| Sirangelo I et al. | Platelet-activating factor mediates the cytotoxicity induced by W7FW14F apomyoglobin amyloid aggregates in neuroblastoma cells. | 2014 | J. Cell. Biochem. | pmid:25053109 |
| Xanthopoulou MN et al. | Effect of Robola and Cabernet Sauvignon extracts on platelet activating factor enzymes activity on U937 cells. | 2014 | Food Chem | pmid:25038648 |
| Concha C et al. | Oxidative response of neutrophils to platelet-activating factor is altered during acute ruminal acidosis induced by oligofructose in heifers. | 2014 | J. Vet. Sci. | pmid:25013355 |
| Mazereeuw G et al. | Platelet-activating factors are associated with cognitive deficits in depressed coronary artery disease patients: a hypothesis-generating study. | 2014 | J Neuroinflammation | pmid:24996486 |
| Uhlig S et al. | Differential regulation of lung endothelial permeability in vitro and in situ. | 2014 | Cell. Physiol. Biochem. | pmid:24977477 |
| Triggiani M et al. | Anaphylaxis and cardiovascular diseases: a dangerous liaison. | 2014 | Curr Opin Allergy Clin Immunol | pmid:24915548 |
| Jin XL and O'Neill C | Systematic analysis of the factors that adversely affect the rate of cell accumulation in mouse embryos during their culture in vitro. | 2014 | Reprod. Biol. Endocrinol. | pmid:24885989 |
| Wu H et al. | Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. | 2014 | PLoS ONE | pmid:24671173 |
| Papakonstantinou VD et al. | In vivo effect of two first-line ART regimens on inflammatory mediators in male HIV patients. | 2014 | Lipids Health Dis | pmid:24884881 |
| Marathe GK et al. | To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase. | 2014 | J. Lipid Res. | pmid:24859738 |
| Zanatta AL et al. | Fish oil supplementation decreases oxidative stress but does not affect platelet-activating factor bioactivity in lungs of asthmatic rats. | 2014 | Lipids | pmid:24858941 |
| Mitchell MJ et al. | Fluid shear stress increases neutrophil activation via platelet-activating factor. | 2014 | Biophys. J. | pmid:24853753 |
| Carlioglu A et al. | The platelet activating factor acetyl hydrolase, oxidized low-density lipoprotein, paraoxonase 1 and arylesterase levels in treated and untreated patients with polycystic ovary syndrome. | 2014 | Arch. Gynecol. Obstet. | pmid:24840107 |
| Yu Y et al. | Epidermal growth factor induces platelet-activating factor production through receptors transactivation and cytosolic phospholipase A2 in ovarian cancer cells. | 2014 | J Ovarian Res | pmid:24721622 |
| Forkel S et al. | Inositoylated platelet-activating factor (Ino-C2-PAF) modulates dynamic lymphocyte-endothelial cell interactions and alleviates psoriasis-like skin inflammation in two complementary mouse models. | 2014 | J. Invest. Dermatol. | pmid:24714204 |
| Kim SJ et al. | Quantitative determination of major platelet activating factors from human plasma. | 2014 | Anal Bioanal Chem | pmid:24682147 |
| Kaplanis M et al. | Re(I) tricarbonyl complex of 1,10-phenanthroline-5,6-dione: DNA binding, cytotoxicity, anti-inflammatory and anti-coagulant effects towards platelet activating factor. | 2014 | J. Inorg. Biochem. | pmid:24632342 |
| Mallet de Lima CD et al. | Central role of PAFR signalling in ExoU-induced NF-κB activation. | 2014 | Cell. Microbiol. | pmid:24612488 |
| Moschos MM et al. | In vitro effects of vitamin supplements on platelet-activating factor and its metabolism in age-related macular degeneration. | 2014 | Cutan Ocul Toxicol | pmid:24147947 |
| Abdulnour RE et al. | Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25369934 |
| Chou YI et al. | Correlations of platelet-derived microparticles with thromboxane B2, platelet-activating factor, endothelin-1, and neutrophil to lymphocyte ratio in patients with coronary intermediate lesions. | 2014 | Biomarkers | pmid:25391885 |
| Chacón-Salinas R et al. | An essential role for platelet-activating factor in activating mast cell migration following ultraviolet irradiation. | 2014 | J. Leukoc. Biol. | pmid:24009177 |
| Mehta A and Sigman M | Identification and preparation of sperm for ART. | 2014 | Urol. Clin. North Am. | pmid:24286775 |
| Reyes-Quiroz ME et al. | Platelet-activating factor downregulates the expression of liver X receptor-α and its target genes in human neutrophils. | 2014 | FEBS J. | pmid:24289152 |
| Semini G et al. | Inositol-C2-PAF down-regulates components of the antigen presentation machinery in a 2D-model of epidermal inflammation. | 2014 | Biochem. Pharmacol. | pmid:24291779 |
| Sugatani J et al. | Antiobese function of platelet-activating factor: increased adiposity in platelet-activating factor receptor-deficient mice with age. | 2014 | FASEB J. | pmid:24100020 |
| Fang W et al. | Platelet activating factor induces transient blood-brain barrier opening to facilitate edaravone penetration into the brain. | 2014 | J. Neurochem. | pmid:24164378 |
| Chérifi F et al. | Isolation, functional characterization and proteomic identification of CC2-PLA₂ from Cerastes cerastes venom: a basic platelet-aggregation-inhibiting factor. | 2014 | Protein J. | pmid:24384926 |
| Rivera J et al. | Platelet-activating factor contributes to Bacillus anthracis lethal toxin-associated damage. | 2014 | J. Biol. Chem. | pmid:24478317 |
| Kim KJ et al. | Platelet-activating factor enhances tumour metastasis via the reactive oxygen species-dependent protein kinase casein kinase 2-mediated nuclear factor-κB activation. | 2014 | Immunology | pmid:24628121 |
| Gazos-Lopes F et al. | Structural and functional analysis of a platelet-activating lysophosphatidylcholine of Trypanosoma cruzi. | 2014 | PLoS Negl Trop Dis | pmid:25101628 |
| Semini G et al. | Glycosidated phospholipids - a promising group of anti-tumour lipids. | 2014 | Anticancer Agents Med Chem | pmid:24628240 |
| Morimoto R et al. | Rapid production of platelet-activating factor is induced by protein kinase Cα-mediated phosphorylation of lysophosphatidylcholine acyltransferase 2 protein. | 2014 | J. Biol. Chem. | pmid:24742674 |
| Summers C et al. | Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome. | 2014 | Thorax | pmid:24706039 |
| Yang Y et al. | Basophil activation through ASGM1 stimulation triggers PAF release and anaphylaxis-like shock in mice. | 2014 | Eur. J. Immunol. | pmid:24777913 |
| Tarui M et al. | Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2. | 2014 | J. Lipid Res. | pmid:24850807 |
| Frazer CA | Heparin-induced thrombocytopenia. | 2013 Nov-Dec | Medsurg Nurs | pmid:24600938 |
| Muñoz-Cano R et al. | Platelet-activating factor nasal challenge induces nasal congestion and reduces nasal volume in both healthy volunteers and allergic rhinitis patients. | 2013 Mar-Apr | Am J Rhinol Allergy | pmid:23562190 |
| Archer SL and Roudebush WE | Enhancement of sperm motility using pentoxifylline and platelet-activating factor. | 2013 | Methods Mol. Biol. | pmid:22992918 |
| Watschinger K and Werner ER | Orphan enzymes in ether lipid metabolism. | 2013 | Biochimie | pmid:22771767 |
| Flasiński M et al. | Interactions between single-chained ether phospholipids and sphingomyelin in mixed monolayers at the air/water interface-Grazing incidence X-ray diffraction and Brewster angle microscopy studies. | 2013 | Colloids Surf B Biointerfaces | pmid:23777791 |
| Grotta MB et al. | Obesity increases eosinophil activity in asthmatic children and adolescents. | 2013 | BMC Pulm Med | pmid:23773659 |
| Eriksson AC and Whiss PA | Nanomolar concentrations of adrenaline induce platelet adhesion in vitro. | 2013 | Platelets | pmid:22471400 |
| Zhou Z et al. | Chemical constituents of Callicarpa nudiflora and their anti-platelet aggregation activity. | 2013 | Fitoterapia | pmid:23669034 |
| Wang TM et al. | Alkyl and phenolic glycosides from Saussurea stella. | 2013 | Fitoterapia | pmid:23567860 |
| Schäfer-Somi S et al. | Vascular endothelial (VEGF) and epithelial growth factor (EGF) as well as platelet-activating factor (PAF) and receptors are expressed in the early pregnant canine uterus. | 2013 | Reprod. Domest. Anim. | pmid:22458960 |
| Liu G et al. | Characterization of streptococcal platelet-activating factor acetylhydrolase variants that are involved in innate immune evasion. | 2013 | Infect. Immun. | pmid:23774595 |
| Tokuoka SM et al. | Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23743196 |
| Stanca E et al. | Down-regulation of LPCAT expression increases platelet-activating factor level in cirrhotic rat liver: potential antiinflammatory effect of silybin. | 2013 | Biochim. Biophys. Acta | pmid:23851051 |
| Nagase T | [Respiratory failure]. | 2013 | Nippon Rinsho | pmid:23855209 |
| Tao YK et al. | Elevated platelet activating factor level in ischemia-related arrhythmia and its electrophysiological effect on myocardium. | 2013 | Biomed. Environ. Sci. | pmid:23611129 |
| Vitte J and Bongrand P | Serum tryptase determination in patients with acute allergic reactions. | 2013 | J. Allergy Clin. Immunol. | pmid:23643096 |
| Vadas P | Reply: To PMID 23040367. | 2013 | J. Allergy Clin. Immunol. | pmid:23643097 |
| Vlachogianni IC et al. | Interleukin-1beta stimulates platelet-activating factor production in U-937 cells modulating both its biosynthetic and catabolic enzymes. | 2013 | Cytokine | pmid:23673285 |
| Hirayama F | Current understanding of allergic transfusion reactions: incidence, pathogenesis, laboratory tests, prevention and treatment. | 2013 | Br. J. Haematol. | pmid:23215650 |
| Harleton E et al. | Ability to induce atrial fibrillation in the peri-operative period is associated with phosphorylation-dependent inhibition of TWIK protein-related acid-sensitive potassium channel 1 (TASK-1). | 2013 | J. Biol. Chem. | pmid:23229553 |
| Detopoulou P et al. | Platelet activating factor in heart failure: potential role in disease progression and novel target for therapy. | 2013 | Curr Heart Fail Rep | pmid:23389700 |
| Kawano DF and Carvalho I | Targeting Trypanosoma cruzi platelet-activating factor receptors: scope for the development of novel drugs to treat Chagas Disease. | 2013 | Mini Rev Med Chem | pmid:23544467 |
| Wei JF et al. | Induction of mast-cell accumulation by promutoxin, an Arg-49 phospholipase A2. | 2013 | Biomed Res Int | pmid:23509689 |
| Forsman H et al. | Reactivation of desensitized formyl peptide receptors by platelet activating factor: a novel receptor cross talk mechanism regulating neutrophil superoxide anion production. | 2013 | PLoS ONE | pmid:23555913 |
| Ruchaud-Sparagano MH et al. | Effect of granulocyte-macrophage colony-stimulating factor on neutrophil function in idiopathic bronchiectasis. | 2013 | Respirology | pmid:23730995 |
| Miyamoto-Sasaki M et al. | Pitavastatin increases HDL particles functionally preserved with cholesterol efflux capacity and antioxidative actions in dyslipidemic patients. | 2013 | J. Atheroscler. Thromb. | pmid:23739642 |
| Nankar SA et al. | Differential interaction of peptides derived from C-terminal domain of human apolipoprotein E with platelet activating factor analogs. | 2013 | Biochimie | pmid:23376877 |
| Detopoulou P et al. | Baseline and 6-Week follow-up levels of PAF and activity of its metabolic enzymes in patients with heart failure and healthy volunteers--a pilot study. | 2013 | Angiology | pmid:23000600 |
| Xu B et al. | Effects of platelet-activating factor and its differential regulation by androgens and steroid hormones in prostate cancers. | 2013 | Br. J. Cancer | pmid:23949154 |
| Alevizos M et al. | Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor. | 2013 | Ann. Allergy Asthma Immunol. | pmid:24267366 |
| Cui H et al. | Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice. | 2013 | J. Allergy Clin. Immunol. | pmid:24021572 |
| Kim YH et al. | PAF enhances MMP-2 production in rat aortic VSMCs via a β-arrestin2-dependent ERK signaling pathway. | 2013 | J. Lipid Res. | pmid:23911909 |
| Fodran P and Minnaard AJ | Catalytic synthesis of enantiopure mixed diacylglycerols – synthesis of a major M. tuberculosis phospholipid and platelet activating factor. | 2013 | Org. Biomol. Chem. | pmid:24191360 |
| Fontbonne H et al. | Activation of bile salt dependent lipase by (lyso)phosphatidic acid and platelet activating factor. | 2013 | FEBS Lett. | pmid:23891620 |
| Feuerherm AJ et al. | Platelet-activating factor induces proliferation in differentiated keratinocytes. | 2013 | Mol. Cell. Biochem. | pmid:23975504 |
| Guerrero AT et al. | The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23187752 |
| Shi YM et al. | Lancolides, antiplatelet aggregation nortriterpenoids with tricyclo[6.3.0.0(2,11)]undecane-bridged system from Schisandra lancifolia. | 2013 | Org. Lett. | pmid:24059675 |
| Kang JW et al. | Anti-platelet activity of erythro-(7S,8R)-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan from Myristica fragrans. | 2013 | Phytother Res | pmid:23296979 |
| Bitencourt CS et al. | Cooperative role of endogenous leucotrienes and platelet-activating factor in ischaemia-reperfusion-mediated tissue injury. | 2013 | J. Cell. Mol. Med. | pmid:24373549 |