| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kochanek PM et al. | Platelet activating factor antagonists do not alter normal cerebral blood flow or cerebral oxygen consumption. | 1990 | Adv. Exp. Med. Biol. | pmid:2096640 |
| Camussi G et al. | Antiflammins inhibit synthesis of platelet-activating factor and intradermal inflammatory reactions. | 1990 | Adv. Exp. Med. Biol. | pmid:2096695 |
| Paubert-Braquet M et al. | Platelet-activating factor amplifies tumour necrosis factor-induced superoxide generation by human neutrophils. | 1990 | Adv. Exp. Med. Biol. | pmid:2173875 |
| Vernadakis A et al. | C-6 glioma cells of early passage have progenitor properties in culture. | 1991 | Adv. Exp. Med. Biol. | pmid:1685850 |
| Yue TL et al. | Platelet-activating factor (PAF)--a putative mediator in inflammatory tissue injury. | 1991 | Adv. Exp. Med. Biol. | pmid:1667965 |
| Droy-Lefaix MT et al. | Effect of the platelet-activating factor (PAF) antagonist, BN 52021, on free radical-induced intestinal ischemia-reperfusion damage in the rat. | 1990 | Adv. Exp. Med. Biol. | pmid:2244522 |
| Damas J et al. | Endotoxin shock, kinin system and PAF-acether in the rat. | 1989 | Adv. Exp. Med. Biol. | pmid:2610092 |
| Schlondorff D | Interactions of platelet activating factor and prostaglandins in the glomerulus and in mesangial cells. | 1989 | Adv. Exp. Med. Biol. | pmid:2696352 |
| Remuzzi G | Eicosanoids and platelet activating factor as possible mediators of injury in experimental nephropathies. | 1989 | Adv. Exp. Med. Biol. | pmid:2696353 |
| Rabinovici R et al. | PAF and TNF alpha interactions in the pathophysiology of septic shock. | 1991 | Adv. Exp. Med. Biol. | pmid:1818486 |
| Jin N et al. | Platelet activating factor causes relaxation of isolated pulmonary artery and aorta. | 1991 | Adv. Exp. Med. Biol. | pmid:1803920 |
| Bourgain RH et al. | Vivo effects of PAF-acether and arterial thrombosis. | 1986 | Adv. Exp. Med. Biol. | pmid:3799334 |
| Kurachi M et al. | Suppression of bronchial response to platelet activating factor following taurine administration. | 1987 | Adv. Exp. Med. Biol. | pmid:3434419 |
| Bourgain RH et al. | Arterial obstruction induced by PAF-acether (1-O-alkyl-sn-glycero-3-phosphocholine). | 1987 | Adv. Exp. Med. Biol. | pmid:3673721 |
| Fisher RA et al. | AGEPC: a potent calcium-dependent chemical mediator in the liver. | 1988 | Adv. Exp. Med. Biol. | pmid:3213685 |
| Bourgain RH et al. | PAF-acether induced arterial thrombosis and the effect of specific antagonists. | 1992 | Adv. Exp. Med. Biol. | pmid:1288104 |
| van Rossem K et al. | The role of PAF and the effect of a specific PAF antagonist on local tissue PO2 and neuronal integrity during and after photothrombotic brain infarction in unanesthetised rabbits. | 1996 | Adv. Exp. Med. Biol. | pmid:8798843 |
| Shimizu T and Mutoh H | Structure and regulation of platelet activating factor receptor gene. | 1997 | Adv. Exp. Med. Biol. | pmid:9321953 |
| Mori M et al. | Localization of platelet-activating factor receptor in the rat brain. | 1997 | Adv. Exp. Med. Biol. | pmid:9321976 |
| Erickson KL et al. | Alteration of platelet activating factor-induced macrophage tumoricidal response, IA expression, and signal transduction by N-3 fatty acids. | 1997 | Adv. Exp. Med. Biol. | pmid:9321978 |
| Muguruma K et al. | The central role of PAF in necrotizing enterocolitis development. | 1997 | Adv. Exp. Med. Biol. | pmid:9321979 |
| Aoki Y et al. | A simple, rapid and specific radioreceptor assay for platelet-activating factor. | 1997 | Adv. Exp. Med. Biol. | pmid:9321990 |
| Si Y et al. | The change in plasma PAF activity before and after delivery. | 1997 | Adv. Exp. Med. Biol. | pmid:9322006 |
| Rementzis J et al. | Biologically active lipids from S. scombrus. | 1996 | Adv. Exp. Med. Biol. | pmid:9131128 |
| Orevi M et al. | Purification and partial characterization of the PAF antagonist from the saliva of the leech Hirudo medicinalis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131129 |
| Shimizu T et al. | Platelet-activating factor receptor. Gene structure and tissue-specific regulation. | 1996 | Adv. Exp. Med. Biol. | pmid:9131130 |
| Sato S et al. | Up-regulation of the intracellular Ca2+ signaling and mRNA expression of platelet-activating factor receptor by estradiol in human uterine endometrial cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131133 |
| Dohi T et al. | Functional role of platelet-activating factor receptor in secretory response in adrenal chromaffin cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131134 |
| Lee T | Acetylation of sphingosine by PAF-dependent transacetylase. | 1996 | Adv. Exp. Med. Biol. | pmid:9131136 |
| Muguruma K et al. | The prevention of necrotizing enterocolitis. The role of platelet-activating factor acetylhydrolase. | 1996 | Adv. Exp. Med. Biol. | pmid:9131138 |
| Baltas G et al. | Implication of PAF and acetylhydrolase (PAF-AH) activity in periodontal disease. | 1996 | Adv. Exp. Med. Biol. | pmid:9131139 |
| Ye RD et al. | Stimulation of NF-kappa B activation and gene expression by platelet-activating factor. | 1996 | Adv. Exp. Med. Biol. | pmid:9131140 |
| Shukla SD | Tyrosine kinase activation by PAF leads to downstream gene expression. | 1996 | Adv. Exp. Med. Biol. | pmid:9131141 |
| Morooka S and Natsume Y | Effect of SM-12502 on disseminated intravascular coagulation (DIC) in tumor-bearing rats. | 1996 | Adv. Exp. Med. Biol. | pmid:9131147 |
| Sanchez Crespo M et al. | Platelet-activating factor is an effector of rapid reactions and an inductor of late responses in immune-mediated injury. | 1996 | Adv. Exp. Med. Biol. | pmid:9131148 |
| Saito K | PAF response to inflammatory and non-inflammatory stimuli. | 1996 | Adv. Exp. Med. Biol. | pmid:9131150 |
| Silver D et al. | Role of platelet-activating factor in skeletal muscle ischemia-reperfusion injury. | 1996 | Adv. Exp. Med. Biol. | pmid:9131151 |
| Lopes-Martins RA et al. | Platelet-activating factor. A possible role in the modulation of the vasomotor tone and blood pressure. | 1996 | Adv. Exp. Med. Biol. | pmid:9131152 |
| Camussi G et al. | Platelet-activating factor and angiogenesis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131153 |
| Oh-Ishi S et al. | Role of synergistic action of PAF and kinin in bacterial endotoxin-induced hypotension in rats. | 1996 | Adv. Exp. Med. Biol. | pmid:9131154 |
| Tetta C et al. | The role of platelet-activating factor in the biocompatibility of hemodialysis membranes. | 1996 | Adv. Exp. Med. Biol. | pmid:9131156 |
| O'Neill C | PAF promotes the development of the preimplantation embryo. | 1996 | Adv. Exp. Med. Biol. | pmid:9131158 |
| Ammit AJ and O'Neill C | PAF released by preimplantation embryos binds to albumin. | 1996 | Adv. Exp. Med. Biol. | pmid:9131159 |
| Michibayashi T | Neurogenic inhibitory action through platelets of platelet activating factor (PAF) on vasoconstrictive responsiveness to pressor agents. | 1997 | Adv. Exp. Med. Biol. | pmid:9561145 |
| Ishii I et al. | High and low affinity mutants of platelet-activating factor receptor. | 1997 | Adv. Exp. Med. Biol. | pmid:9561146 |
| Ohkuni H et al. | Purification and partial characterization of a novel human platelet aggregation factor in the extracellular products of Streptococcus mitis, strain Nm-65. | 1997 | Adv. Exp. Med. Biol. | pmid:9331745 |
| Bazan NG | Bioactive lipids and gene expression in neuronal plasticity. | 1998 | Adv. Exp. Med. Biol. | pmid:10079836 |
| Marshall LA et al. | Respective roles of the 14 kDa and 85 kDa phospholipase A2 enzymes in human monocyte eicosanoid formation. | 1999 | Adv. Exp. Med. Biol. | pmid:10667333 |
| Kato K | Modulation of long-term potentiation in the CA1 area of rat hippocampus by platelet-activating factor. | 1999 | Adv. Exp. Med. Biol. | pmid:10667334 |
| Goldman R et al. | Lipid mediators stimulate reactive oxygen species formation in immortalized human keratinocytes. | 1999 | Adv. Exp. Med. Biol. | pmid:10667361 |
| Kosar-Hashemi B et al. | Glyceryl ether monooxygenase [EC 1.14.16.5]: stoichiometry and inhibition. | 1993 | Adv. Exp. Med. Biol. | pmid:8304231 |
| Armant DR | Intracellular Ca2+ signaling and preimplantation development. | 2015 | Adv. Exp. Med. Biol. | pmid:25956298 |
| Pirotzky E et al. | Involvement of platelet-activating factor in renal processes. | 1989 | Adv. Lipid Res. | pmid:2698054 |
| Holleran WM | Lipid modulators of epidermal proliferation and differentiation. | 1991 | Adv. Lipid Res. | pmid:1763711 |
| Koltai M et al. | Platelet-activating factor antagonists: scientific background and possible clinical applications. | 1994 | Adv. Pharmacol. | pmid:8080821 |
| Summers JB and Albert DH | Platelet activating factor antagonists. | 1995 | Adv. Pharmacol. | pmid:7748804 |
| Sullivan MH et al. | Altered platelet responses to P.A.F. in pregnancy-induced hypertension. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825415 |
| Braquet P et al. | From ginkgolides to N-substituted piperidino-thieno diazepines, a new series of highly potent dual antagonists. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825436 |
| Berti F et al. | Opposite effects of PGI2 and PAF generated during acute myocardial ischemia in the perfused rabbit heart. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825437 |
| Takatani M et al. | Platelet activating factor (PAF) antagonists: development of a highly potent PAF antagonist, TCV-309. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825438 |
| Kawabe T et al. | Role of PAF and cytokines in the modulation of Fc epsilon RII/CD23 expression on human eosinophils. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825444 |
| Weber PC and Sellmayer A | Modification of the eicosanoid system and cell signalling by precursor fatty acids. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825543 |
| Balazy M et al. | A novel method for the analysis of PAF and alkyl-ether phospholipids by mass spectrometry. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825562 |
| Magni F et al. | Determination of platelet-activating factor in biological samples by high resolution mass spectrometry. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825563 |
| Coceani F et al. | Leukotrienes in cerebrospinal fluid of the conscious cat: effect of platelet-activating factor and pyrogens. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825586 |
| Shen TY et al. | Recent development of platelet-activating factor antagonists. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546389 |
| Handley DA et al. | Chemistry and pharmacology of PAF antagonists. Evaluation of changes at potential metabolism sites on activity and duration of activity. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546390 |
| Dray F et al. | Recent studies on icosanoids and PAF-acether modulation of some central neurosecretions in the rat. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546391 |
| Desquand S et al. | Interference of the PAF-acether antagonist BN 52021 with anaphylaxis in the guinea pig. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2445183 |
| Benveniste J | PAF-acether (platelet-activating factor). | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526498 |
| Hsueh W and Sun XM | Tumor necrosis factor-induced bowel necrosis: the role of platelet-activating factor. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526499 |
| Pignol B et al. | Effect of chronic administration of platelet-activating factor (PAF) in the guinea-pig and the rat. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526500 |
| Foegh ML et al. | Platelet-activating factor in organ transplant rejection. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526501 |
| Pickett WC and Ramesha C | Modulation of mediator precursors by changes in essential fatty acid composition. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526546 |
| Bussolino F et al. | Chick retina generates platelet-activating factor. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2890284 |
| Braquet P | Proofs of involvement of PAF-acether in various immune disorders using BN 52021 (ginkgolide B): a powerful PAF-acether antagonist isolated from Ginkgo biloba L. | 1986 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2949548 |
| Foegh ML et al. | Leukotrienes, thromboxane, and platelet activating factor in organ transplantation. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959038 |
| Robertson DN and Smith GM | Role of thromboxane A2, 5-hydroxytryptamine, and platelet activating factor in collagen-induced sudden death in rabbits. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959049 |
| d'Humieres S et al. | Platelet activating factor acether is involved in thrombin-induced synthesis of prostacyclin by human endothelial cells. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959051 |
| Whittle BJ et al. | Gastric vascular and mucosal damaging actions of platelet activating factor in the canine stomach. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959063 |
| Montrucchio G et al. | In vitro oxytocic activity of platelet-activating factor on human myometrium. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960158 |
| Mallet AI et al. | Platelet activating factor in chronic plaque psoriasis. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960170 |
| Bourgain RH et al. | Effect of ginkgolide PAF-acether antagonists on arterial thrombosis. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960196 |
| Braquet P et al. | Platelet-activating factor: a potential mediator of shock. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960197 |
| Myers A et al. | Pharmacological manipulation of platelet-activating factor toxicity in rodents. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960198 |
| Benveniste J | Biosynthesis and function of PAF-acether (platelet-activating factor). | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936197 |
| Waku K et al. | Metabolism of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a precursor of platelet-activating factor in macrophages. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936199 |
| Saito K et al. | Determination of AGEPC generated from human neutrophils and rat skin and muscle tissues by a selected ion monitoring technique of GC/MS. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936200 |
| Hanahan DJ et al. | Platelet-activating factor: a unique lipid chemical mediator. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936201 |
| Inoue K et al. | Activation of guinea pig peritoneal macrophages by platelet-activating factor in free form or incorporated into liposomes. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936203 |
| Benveniste J | Paf-acether (platelet-activating factor). | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3159192 |
| Matsumoto M and Miwa M | Platelet-activating factor-binding protein in human serum. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3004155 |
| Terashita Z et al. | Beneficial effects of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate, a specific PAF antagonist, in endotoxin and anaphylactic shock. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3004156 |
| Livio M et al. | A platelet-activating factor receptor antagonist protects against renal function deterioration in nephrotoxic nephritis. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2823570 |
| Vargaftig BB et al. | Synergized activation of human platelets by epinephrine and platelet-activating factor-acether is adenosine diphosphate and thromboxane A2-independent. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221558 |
| Voelkel NF et al. | Platelet-activating factor causes pulmonary vasoconstriction and edema via platelet-independent leukotriene formation. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221590 |
| Izumi T et al. | Regulation and signal transduction of PAF receptor. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732892 |
| Bennett SA and Birnboim HC | Platelet activating factor induces transformation of human fibroblasts. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732893 |
| Summers JB et al. | ABT-299, a potent antagonist of platelet activating factor. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732895 |
| Murphy G | Report of the 14th meeting of the British Inflammation Research Association. Topic: cellular and molecular aspects of inflammatory bowel disease. | 1993 | Agents Actions | pmid:8480529 |