Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Per page 10 20 50 100 | Total 288

PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Platelet activating factor

Download all related citations
Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Straube W [Early embryonal signals]. 1989 Zentralbl Gynakol pmid:2665388
Straube W [Which signals of early pregnancy are known currently, what cer- tainty have they and exactly how far are they applicable in practice?]. 1989 Zentralbl Gynakol pmid:2655355
Marzi I et al. [Involvement of platelet activating factors in pathologic leukocyte-endothelium interactions in the liver after hemorrhagic shock]. 1994 Zentralbl Chir pmid:7846961
Uhlmann D et al. Importance of microcirculatory disturbances in the pathogenesis of pancreatitis. 2001 Zentralbl Chir pmid:11753796
Becker BF et al. [Interaction of adenosine with leukocytes and thrombocytes]. 1996 Z Kardiol pmid:9064961
Krämer K et al. Studies on the metabolism of metallothionein and alkaline phosphatase of adult rat primary hepatocyte cultures: role of fetal calf serum and agonists of the phosphoinositide cascade. 1993 Z Ernahrungswiss pmid:8237077
Nie ZG et al. [Effects of ginkgolide B on lipopolysaccharide-induced TNFalpha production in mouse peritoneal macrophages and NF-kappaB activation in rat pleural polymorphonuclear leukocytes]. 2004 Yao Xue Xue Bao pmid:15491096
Li SH et al. Effects of platelet-activating factor antagonist SRI 63-441 on endotoxin-induced changes in rat mesenteric microcirculation. 1991 Yao Xue Xue Bao pmid:1887797
Zhang LL et al. [Protective effect of rupatadine against oleic acid-induced acute lung injury in rabbits]. 2007 Yao Xue Xue Bao pmid:17520822
Ju DW et al. [Leflunomide inhibits PAF induced DNA synthesis in rabbit synovial cells and PAF production from rat peritoneal macrophages]. 1994 Yao Xue Xue Bao pmid:8042517
Ou-Yang XY et al. [Inhibitory effect of ginkgolide B on angiogenesis in chronic inflammation]. 2005 Yao Xue Xue Bao pmid:16011257
Hu JH et al. [Effects of calcimycin on platelet adhesion to cultured bovine cerebral microvascular endothelial cells and its antagonism by drugs]. 1994 Yao Xue Xue Bao pmid:7976350
Ju DW et al. Effect of platelet activating factor antagonist WEB 2086 on the production of TNF from murine peritoneal macrophages. 1993 Yao Xue Xue Bao pmid:8009983
Cheng NN et al. [The composition of phospholipid and biosynthesis of platelet-activating factor in earthworm (Eisenia foetida)]. 1992 Yao Xue Xue Bao pmid:1299136
Han GQ et al. [The isolation and identification of PAF inhibitors from Piper wallichii (Miq.) Hand-Mazz and P. hancei Maxim]. 1989 Yao Xue Xue Bao pmid:2609983
Fang J and Zheng QY [Inhibitory effect of esculentoside A on platelet activating factor released from calcimycin induced rat peritoneal macrophages]. 1991 Yao Xue Xue Bao pmid:1823713
Zeng GQ et al. Effects of dauricine and tetrandrine on [3H] WEB 2086 specific binding to bovine anterior cerebral arterial smooth muscle cells in vitro. 1993 Yao Xue Xue Bao pmid:8285049
Ma Y et al. [PAF antagonistic benzofuran neolignans from Piper kadsura]. 1993 Yao Xue Xue Bao pmid:8237383
Peng SY et al. Effect of ginkgolide B on the platelet-activating factor induced changes of chemotaxis and cytoskeleton of macrophages. 2006 Yao Xue Xue Bao pmid:16671547
Mao YJ et al. [Effect of ginkgolide B on the function of rat aorta smooth cells and U937 cells stimulated by oxLDL]. 2006 Yao Xue Xue Bao pmid:16683525
Nie ZG and Wang WJ [Effect of ginkgolide B on platelet-activating factor induced activation of rat polymorphonuclear leukocytes]. 2003 Yao Xue Xue Bao pmid:12778742
Zang BX et al. [Antagonistic effect of myricetin on platelet activing factor]. 2003 Yao Xue Xue Bao pmid:14991995
Ma Y et al. [Studies on PAF antagonistic bicyclo(3,2,1) octanoid neolignans from Piper kadsura]. 1993 Yao Xue Xue Bao pmid:8368081
Han GQ et al. [Neolignans from Piper hancei Maxim]. 1986 Yao Xue Xue Bao pmid:3776545
Peng SY et al. [Effect of ginkgolide B on the production of NO, IL-6 and RANTES from astrocytes]. 2010 Yao Xue Xue Bao pmid:21351565
Kase N et al. [Pharmacological profile of F-0401, a novel dihydropyridine derivative. III. The anti-aggregatory action of F-0401 on rabbit platelets]. 1995 Yakugaku Zasshi pmid:7699581
Matsubara C et al. [Densitometric quantitation of platelet activating factor and other phospholipids in human saliva using enzyme reaction on a silica plate]. 1994 Yakugaku Zasshi pmid:7965653
Ohishi S [Evaluation of time course and inter-relationship of inflammatory mediators in experimental inflammatory reaction]. 2000 Yakugaku Zasshi pmid:10825809
Tanaka E et al. Dual effects of a novel thienodiazepine platelet-activating factor antagonist, on drug-oxidizing enzymes in beagle dog. 1994 Xenobiotica pmid:8059533
Nunoya K et al. S-oxidation of (+)-cis-3,5-dimethyl-2-(3-pyridyl)-thiazolidin-4-one hydrochloride by rat hepatic flavin-containing monooxygenase 1 expressed in yeast. 1995 Xenobiotica pmid:8719904
Thomson KL et al. Metabolism of the platelet-activating factor antagonist (+/-)-trans-2-(3'-methoxy-5'-methylsulphonyl-4'-propoxyphenyl)-5-(3",4" ,5"- trimethoxyphenyl)tetrahydrofuran (L-659,989) in rhesus monkeys. 1991 Xenobiotica pmid:1949894
Kobayashi T et al. Metabolism and disposition of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate (MOTP) in rats and dogs. 1988 Xenobiotica pmid:3354232
Kusano K et al. Pharmacokinetics of a new thienodiazepine platelet activating factor receptor antagonist (E6123) in laboratory animals. Is there a metabolic polymorphism in the rhesus monkey? 1993 Xenobiotica pmid:8212733
Kusano K et al. Metabolic polymorphism of E6123 in rhesus monkey. 1993 Xenobiotica pmid:8212734
Sperling RI Effects of dietary fish oil on leukocyte leukotriene and PAF generation and on neutrophil chemotaxis. 1991 World Rev Nutr Diet pmid:2053354
Bang UC et al. Pharmacological approach to acute pancreatitis. 2008 World J. Gastroenterol. pmid:18494044
Xia SH et al. Significance of platelet activating factor receptor expression in pancreatic tissues of rats with severe acute pancreatitis and effects of BN52021. 2007 World J. Gastroenterol. pmid:17589953
Xia SH et al. Roles of BN52021 in platelet-activating factor pathway in inflammatory MS1 cells. 2013 World J. Gastroenterol. pmid:23840141
Chen Y et al. Hepatic stellate cells may be potential effectors of platelet activating factor induced portal hypertension. 2008 World J. Gastroenterol. pmid:18186558
Lu YY et al. Synthesis of platelet-activating factor and its receptor expression in Kupffer cells in rat carbon tetrachloride-induced cirrhosis. 2008 World J. Gastroenterol. pmid:18205269
Cao HC et al. Determination of platelet-activating factor by reverse phase high-performance liquid chromatography and its application in viral hepatitis. 2005 World J. Gastroenterol. pmid:16437644
Bock J et al. Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function. 2007 World J. Gastroenterol. pmid:17876892
Liu LR and Xia SH Role of platelet-activating factor in the pathogenesis of acute pancreatitis. 2006 World J. Gastroenterol. pmid:16489665
Zhou ZG and Chen YD Influencing factors of pancreatic microcirculatory impairment in acute panceatitis. 2002 World J. Gastroenterol. pmid:12046059
Torres MI and Rios A Current view of the immunopathogenesis in inflammatory bowel disease and its implications for therapy. 2008 World J. Gastroenterol. pmid:18395894
Yang YP et al. Effect of increased hepatic platelet activating factor and its receptor portal hypertension in CCl4-induced liver cirrhosis. 2006 World J. Gastroenterol. pmid:16521183
Mathonnet M et al. Platelet-activating factor in cirrhotic liver and hepatocellular carcinoma. 2006 World J. Gastroenterol. pmid:16718768
Karidis NP et al. Platelet-activating factor in liver injury: a relational scope. 2006 World J. Gastroenterol. pmid:16773686
Zhao H et al. Influence of platelet activating factor on expression of adhesion molecules in experimental pancreatitis. 2003 World J. Gastroenterol. pmid:12532462
Connolly AB and Vernon DR Manipulations of the metabolic response for management of patients with severe surgical illness: review. 2000 World J Surg pmid:10773122
Czarnetzki BM [Mediators and the bronchial system. Pathophysiologic and biochemical aspects of mediators of the bronchial system]. 1987 Wien Med Wochenschr Suppl pmid:3078398
Keck M et al. Pathophysiology of burns. 2009 Wien Med Wochenschr pmid:19652939
Chmiel B [The influence of select pathophysiologic factors of acute pancreatitis on erythrocytes' deformability examined in vitro]. 2002 Wiad. Lek. pmid:12715347
Guan Z et al. [Role of interleukin-6 and platelet-activating factor in delaying neutrophil apoptosis]. 2000 Wei Sheng Yan Jiu pmid:12725051
Robeva R et al. [Changes in blood coagulation in glomerulonephritis]. 1982 Vutr Boles pmid:6219496
Denizot Y and Nathan N Platelet-activating factor in operative salvaged blood. 1994 Vox Sang. pmid:7801619
Silliman CC et al. Stored blood components contain agents that prime the neutrophil NADPH oxidase through the platelet-activating-factor receptor. 1992 Vox Sang. pmid:1332255
Sieunarine K et al. Plasma levels of the lipid mediators, leukotriene B4 and lyso platelet-activating factor, in intraoperative salvaged blood. 1992 Vox Sang. pmid:1333134
DaÄ­khin EI et al. [Clinical significance of studies of platelet activating factor (review of the literature)]. 1989 Mar-Apr Vopr. Med. Khim. pmid:2662595
Shebzukhov IuV and Mysiakin EB [Platelet activating factor--role in regulating the functional activity of the mononuclear phagocyte system]. 1996 Oct-Dec Vopr. Med. Khim. pmid:9254510
Muzia GI et al. [Inhibition of formation of superoxide radicals in leukocytes of hypercholesteremic patients under the effect of a lipid platelet activation factor antagonist]. 1995 Jul-Aug Vopr. Med. Khim. pmid:8571587
Bastos da Silva MB et al. The effect of intravenous administration of WEB 2086 on PAF-induced platelet aggregation in healthy Friesian calves. 1997 Vet. Res. Commun. pmid:9345719
da Silva MB et al. Protective effects of WEB 2086 (PAF antagonist) and ketoprofen (NSAID) on PAF-induced changes in the morphological ultrastructure of blood platelets in calves. 1998 Vet. Res. Commun. pmid:9686442
Dawson J et al. Platelet activating factor as a mediator of equine cell locomotion. 1988 Vet. Res. Commun. pmid:3188378
Venugopalan CS et al. Responses of guinea-pig lung parenchymal strips to tracheobronchial lavage fluid from horses affected with summer pasture-associated obstructive pulmonary disease. 1998 Vet. Res. Commun. pmid:9868763
Bastos da Silva M et al. Morphological alterations of blood platelets induced by platelet activating factor (PAF) and partial inhibition by ketoprofen in calves. 1997 Sep-Oct Vet. Res. pmid:9342825
Lallès JP et al. Small intestinal motility disorders in preruminant calves chronically fed a diet based on antigenic soya: characterization and possible mediators. 1998 Jan-Feb Vet. Res. pmid:9559521
Bastos da Silva M et al. In vitro inhibitory effect of SR 27417, a potent platelet-activating factor (PAF) receptor antagonist, on the PAF-induced bovine platelet aggregation. 2000 Mar-Apr Vet. Res. pmid:10779205
Diez-Fraile A et al. Analysis of selective mobilization of L-selectin and Mac-1 reservoirs in bovine neutrophils and eosinophils. 2003 Jan-Feb Vet. Res. pmid:12588684
Van de Weerdt ML et al. Effect of platelet-activating factor on bovine pulmonary function. 1997 Vet. Rec. pmid:9290195
Slauson DO and Sanchez-Vizcaino JM Leukocyte-dependent platelet vasoactive amine release and immune complex deposition in African swine fever. 1981 Vet. Pathol. pmid:6170156
Wimberly HC et al. Functional and biochemical characterization of immunologically derived equine platelet-activating factor. 1985 Vet. Pathol. pmid:4035942
Van de Weerdt ML et al. Ketoprofen and phenylbutazone attenuation of PAF-induced lung inflammation in calves. 1999 Vet. J. pmid:10030127
Michelotto PV et al. Pulmonary inflammation due to exercise-induced pulmonary haemorrhage in Thoroughbred colts during race training. 2011 Vet. J. pmid:22108190
da Silva MB et al. Effect of ketoprofen on PAF-induced bovine platelet aggregation. 1998 Vet. J. pmid:9564275
Alarcón P et al. D-lactic acid interferes with the effects of platelet activating factor on bovine neutrophils. 2011 Vet. Immunol. Immunopathol. pmid:21816488
Carretta MD et al. Butyric acid stimulates bovine neutrophil functions and potentiates the effect of platelet activating factor. 2016 Vet. Immunol. Immunopathol. pmid:27288853
Waller KP Modulation of endotoxin-induced inflammation in the bovine teat using antagonists/inhibitors to leukotrienes, platelet activating factor and interleukin 1 beta. 1997 Vet. Immunol. Immunopathol. pmid:9261962
Conejeros I et al. 2-Aminoethoxydiphenyl borate (2-APB) reduces alkaline phosphatase release, CD63 expression, F-actin polymerization and chemotaxis without affecting the phagocytosis activity in bovine neutrophils. 2012 Vet. Immunol. Immunopathol. pmid:22226550
Cook VL et al. The effect of lidocaine on in vitro adhesion and migration of equine neutrophils. 2009 Vet. Immunol. Immunopathol. pmid:19136156
Aktan I et al. PKC isoenzymes in equine platelets and stimulus induced activation. 2011 Vet. Immunol. Immunopathol. pmid:21513989
Topper EK et al. Induction of tissue eosinophilia by platelet-activating factor in Merino sheep. 1992 Vet. Immunol. Immunopathol. pmid:1604802
Foster AP et al. Platelet activating factor mimics antigen-induced cutaneous inflammatory responses in sweet itch horses. 1995 Vet. Immunol. Immunopathol. pmid:7747395
Brooks AC et al. CXCL8 attenuates chemoattractant-induced equine neutrophil migration. 2011 Vet. Immunol. Immunopathol. pmid:21040981
Corl CM et al. Lipoxygenase metabolites modulate vascular-derived platelet activating factor production following endotoxin challenge. 2010 Vet. Immunol. Immunopathol. pmid:20359754
Strøm H and Thomsen MK Effects of proinflammatory mediators on canine neutrophil chemotaxis and aggregation. 1990 Vet. Immunol. Immunopathol. pmid:2396362
Larrazabal CS et al. Amiloride interferes with platelet- activating factor-induced respiratory burst and MMP-9 release in bovine neutrophils independent of Na/H exchanger 1. 2017 Vet. Immunol. Immunopathol. pmid:28895869
Marr KA et al. Agonist-induced adherence of equine neutrophils to fibronectin- and serum-coated plastic is CD18 dependent. 1999 Vet. Immunol. Immunopathol. pmid:10532398
Leid RW and Potter KA Inflammation and mediators of lung injury. 1985 Vet. Clin. North Am. Food Anim. Pract. pmid:3907779
Moore RM et al. Effect of platelet-activating factor antagonist L-691,880 on low-flow ischemia-reperfusion injury of the large colon in horses. 1998 Jan-Feb Vet Surg pmid:9449176
Kulikov VI and Muzia GI [Phospholipid thrombocyte activating factor, its analogs and antagonists: prospects of their use in medicine]. 1991 Vestn. Akad. Med. Nauk SSSR pmid:1801455
Fedorov NA [Physiological variants of functional and biochemical indicators of thrombocytes]. 1991 Vestn. Akad. Med. Nauk SSSR pmid:1801458
Kaminskaia GO and Aladysheva ZhI [Platelet activating factor and pulmonary tuberculosis]. 1995 Vestn. Akad. Med. Nauk SSSR pmid:7670343
Strukova SM et al. [Regulation of thrombocyte stimulating and other activities of thrombin by modulators of the recognition site]. 1991 Vestn. Akad. Med. Nauk SSSR pmid:1724858
Shabanov VV [Cytokines and other signal molecules in the pathogenesis of acute pancreatitis]. 2003 Vestn. Akad. Med. Nauk SSSR pmid:14598737
Hemker HC and Béguin S The generation of thrombin in whole plasma. Biochemical possibilities and physiological realities. 1985 Verh. K. Acad. Geneeskd. Belg. pmid:4090648
Kim YH et al. SIRT1 attenuates PAF-induced MMP-2 production via down-regulation of PAF receptor expression in vascular smooth muscle cells. 2015 Vascul. Pharmacol. pmid:25967595
Marathe GK et al. Activation of vascular cells by PAF-like lipids in oxidized LDL. 2002 Vascul. Pharmacol. pmid:12449015
Rastogi P et al. Urothelial cell platelet-activating factor production mediated by calcium-independent phospholipase A2γ. 2011 Urology pmid:21094990
Baka S et al. Treatment of sperm with platelet-activating factor does not improve intrauterine insemination outcome in unselected cases of mild male factor infertility: a prospective double-blind randomized crossover study. 2009 Urology pmid:19716589