| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shmueli O et al. | Platelet-activating factor (PAF) acetylhydrolase activity, LIS1 expression, and seizures. | 1999 | J. Neurosci. Res. | pmid:10398295 |
| Liu Q et al. | The effect of lexipafant on bacterial translocation in acute necrotizing pancreatitis in rats. | 1999 | Am Surg | pmid:10399968 |
| Li L et al. | Estrogen effects on platelet-activating factor and platelet-activating factor acetylhydrolase activity in rat uterus during the late stages of pregnancy. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10402216 |
| Kudolo GB and DeFronzo RA | Urinary platelet-activating factor excretion is elevated in non-insulin dependent diabetes mellitus. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10410380 |
| Salas A et al. | Reperfusion-induced oxidative stress in diabetes: cellular and enzymatic sources. | 1999 | J. Leukoc. Biol. | pmid:10410990 |
| Calcerrada MC et al. | Platelet-activating factor stimulation of p125(FAK) and p130(Cas) tyrosine phosphorylation in brain. | 1999 | Brain Res. | pmid:10415383 |
| M'Rabet L et al. | Differential fMet-Leu-Phe- and platelet-activating factor-induced signaling toward Ral activation in primary human neutrophils. | 1999 | J. Biol. Chem. | pmid:10419502 |
| Geijsen N et al. | Regulation of p21rac activation in human neutrophils. | 1999 | Blood | pmid:10419906 |
| Panés J et al. | Impaired mesenteric leukocyte recruitment in experimental portal hypertension in the rat. | 1999 | Hepatology | pmid:10421653 |
| Shan L et al. | Platelet-activating factor increases the expression of metalloproteinase-9 in human bronchial epithelial cells. | 1999 | Eur. J. Pharmacol. | pmid:10422651 |
| Yamada M et al. | Possible participation of intracellular platelet-activating factor in tumor necrosis factor-alpha production by rat peritoneal macrophages. | 1999 | Eur. J. Pharmacol. | pmid:10422778 |
| Bocheński J et al. | Role of thromboxane A2 and platelet activating factor in early haemodynamic response to lipopolysaccharide in rats. | 1999 | J. Physiol. Pharmacol. | pmid:10424723 |
| Asano K et al. | Cellular source(s) of platelet-activating-factor acetylhydrolase activity in plasma. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10425216 |
| Rodrigues CR et al. | Proposal of a new PAF pharmacophoric map by the AM1 method. | 1999 | Eur J Pharm Sci | pmid:10425381 |
| Ambrosio G and Tritto I | Reperfusion injury: experimental evidence and clinical implications. | 1999 | Am. Heart J. | pmid:10426862 |
| Maggirwar SB et al. | HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity. | 1999 | J. Neurochem. | pmid:10428053 |
| Fiotti N et al. | Atherosclerosis and inflammation. Patterns of cytokine regulation in patients with peripheral arterial disease. | 1999 | Atherosclerosis | pmid:10428295 |
| Schifitto G et al. | Randomized trial of the platelet-activating factor antagonist lexipafant in HIV-associated cognitive impairment. Neurological AIDS Research Consortium. | 1999 | Neurology | pmid:10430432 |
| Tanaka R et al. | Role of platelet-activating factor acetylhydrolase gene mutation in Japanese childhood IgA nephropathy. | 1999 | Am. J. Kidney Dis. | pmid:10430976 |
| Zouki C et al. | Endothelin-1 enhances neutrophil adhesion to human coronary artery endothelial cells: role of ET(A) receptors and platelet-activating factor. | 1999 | Br. J. Pharmacol. | pmid:10433505 |
| Alloatti G et al. | Role of nitric oxide and platelet-activating factor in cardiac alterations induced by tumor necrosis factor-alpha in the guinea-pig papillary muscle. | 1999 | Cardiovasc. Res. | pmid:10435033 |
| Zeng S et al. | Regulatory role of protein tyrosine phosphorylation in platelet activating factor-induced signal transduction in platelets. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10437164 |
| Soybir G et al. | The effects of free oxygen radical scavenger and platelet-activating factor antagonist agents in experimental acute pancreatitis. | 1999 | Pancreas | pmid:10438161 |
| Dentelli P et al. | Human IL-3 stimulates endothelial cell motility and promotes in vivo new vessel formation. | 1999 | J. Immunol. | pmid:10438956 |
| Shehnaz D et al. | Effect of the crude extract of Cestrum parqui on carrageenin-induced rat paw oedema and aggregation of human blood platelets. | 1999 | Phytother Res | pmid:10441792 |
| Qu XW et al. | Type I nitric oxide synthase (NOS) is the predominant NOS in rat small intestine. Regulation by platelet-activating factor. | 1999 | Biochim. Biophys. Acta | pmid:10446403 |
| Davies D et al. | VCAM-1 contributes to rapid eosinophil accumulation induced by the chemoattractants PAF and LTB4: evidence for basal expression of functional VCAM-1 in rat skin. | 1999 | Immunology | pmid:10447726 |
| Alvi SA et al. | The production of interleukin-1beta from human fetal membranes is not obligatory for increased prostaglandin output. | 1999 | Immunology | pmid:10447739 |
| Wang H et al. | Platelet-activating factor receptor mRNA is localized in eosinophils and epithelial cells in rat small intestine: regulation by dexamethasone and gut flora. | 1999 | Immunology | pmid:10447766 |
| Birk-Sørensen L et al. | Platelet activating factor antagonism in pure skin flaps exposed to ischaemia-reperfusion injury. | 1999 | Scand J Plast Reconstr Surg Hand Surg | pmid:10450571 |
| Shen ZQ et al. | Effect of protopine on cytosolic Ca2+ in rabbit platelets. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10452120 |
| Partrick DA et al. | Cardiopulmonary bypass renders patients at risk for multiple organ failure via early neutrophil priming and late neutrophil disability. | 1999 | J. Surg. Res. | pmid:10452867 |
| Sakaguchi T et al. | Acute portal hypertension increases ileal vulnerability to platelet-activating factor in rats. | 1999 | J. Surg. Res. | pmid:10452877 |
| Dervenis C et al. | Diagnosis, objective assessment of severity, and management of acute pancreatitis. Santorini consensus conference. | 1999 | Int. J. Pancreatol. | pmid:10453421 |
| Nikbakht-Sangari M et al. | Platelet-activating factor plays a role in the mechanism of major histocompatibility complex in T lymphocytes. | 1999 | Immunol. Invest. | pmid:10454000 |
| Subbanagounder G et al. | Evidence that phospholipid oxidation products and/or platelet-activating factor play an important role in early atherogenesis : in vitro and In vivo inhibition by WEB 2086. | 1999 | Circ. Res. | pmid:10455059 |
| Yaffe MB et al. | Priming of the neutrophil respiratory burst is species-dependent and involves MAP kinase activation. | 1999 | Surgery | pmid:10455891 |
| Downing SJ et al. | Effect of inflammatory mediators on the electrophysiology of the human oviduct. | 1999 | Biol. Reprod. | pmid:10456842 |
| Rengan R and Omann GM | Regulation of oscillations in filamentous actin content in polymorphonuclear leukocytes stimulated with leukotriene B(4) and platelet-activating factor. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10462500 |
| Zardini DM et al. | Release of O2- by human umbilical cord blood-derived eosinophils: role of intra- and extracellular calcium. | 1999 | Cell Calcium | pmid:10463102 |
| Hsueh W et al. | Necrotizing enterocolitis of the newborn: pathogenetic concepts in perspective. | 1998 Jan-Feb | Pediatr. Dev. Pathol. | pmid:10463267 |
| Kaminski JJ et al. | Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. | 1999 | Bioorg. Med. Chem. | pmid:10465415 |
| Conroy DM and Sirois P | Early bronchial hyperresponsiveness following injection of sephadex beads in the guinea pig: involvement of platelet activating factor and thromboxane A2. | 1999 | Inflammation | pmid:10466580 |
| Ho YS et al. | Probing the substrate specificity of the intracellular brain platelet-activating factor acetylhydrolase. | 1999 | Protein Eng. | pmid:10469831 |
| Denham W and Norman J | The potential role of therapeutic cytokine manipulation in acute pancreatitis. | 1999 | Surg. Clin. North Am. | pmid:10470326 |
| Baker KE and Curtis MJ | Protection against ventricular fibrillation by the PAF antagonist, BN-50739, involves an ischaemia-selective mechanism. | 1999 | J. Cardiovasc. Pharmacol. | pmid:10470998 |
| Oku H and Ishiguro K | Screening method for PAF antagonist substances: on the phenolic compounds from Impatients balsamina L. | 1999 | Phytother Res | pmid:10479766 |
| Casale TB et al. | Eosinophils isolated by magnetic cell sorting respond poorly to lipid chemoattractants. | 1999 | Ann. Allergy Asthma Immunol. | pmid:10480585 |
| Foitzik T et al. | Therapy for microcirculatory disorders in severe acute pancreatitis: effectiveness of platelet-activating factor receptor blockade vs. endothelin receptor blockade. | 1999 May-Jun | J. Gastrointest. Surg. | pmid:10481117 |
| Calcerrada MC et al. | Modulation of protein kinase C isoforms by PAF in cerebral cortex. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10482284 |
| Nakasaki T et al. | Effects of PAF on histamine H1 receptor mRNA expression in rat trigeminal ganglia. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10482285 |
| Kapui Z et al. | Experimental studies on guanosine 3',5'-cyclic monophosphate levels and airway responsiveness of the novel phosphodiesterase type 5 inhibitor SR 265579 in guinea-pigs. | 1999 | Arzneimittelforschung | pmid:10483515 |
| Shah BH et al. | Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling. | 1999 | Biochem. Pharmacol. | pmid:10484074 |
| Kültürsay N et al. | Platelet-activating factor concentrations in healthy and septic neonates. | 1999 | Eur. J. Pediatr. | pmid:10485307 |
| Koyama N and Ogawa Y | Elevated platelet activating factor in the tracheal aspirate at birth and signs of intra-uterine inflammation in infants with neonatal pulmonary emphysema. | 1999 | Eur. J. Pediatr. | pmid:10486094 |
| Piccolo MT et al. | Chemotactic mediator requirements in lung injury following skin burns in rats. | 1999 | Exp. Mol. Pathol. | pmid:10486240 |
| Triggiani M et al. | Inhibition of platelet-activating factor synthesis in human neutrophils and platelets by propionyl-L-carnitine. | 1999 | Biochem. Pharmacol. | pmid:10487538 |
| Blackstone MO | ICAM-1 in cerulein-induced pancreatitis. | 1999 | Gastroenterology | pmid:10490367 |
| Comellas A et al. | Effect of platelet activating factor (PAF) on pulmonary circulation in isolated rabbit lung. | 1999 | J. Physiol. Biochem. | pmid:10494654 |
| GamaleÄ IA et al. | [Post-receptor formation of active forms of oxygen in nonphagocytic cells]. | 1999 | Tsitologiia | pmid:10496012 |
| Dekkers PE et al. | Divergent roles of tumor necrosis factor and platelet-activating factor in endotoxin-induced release of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta in chimpanzees. | 1999 | Infect. Immun. | pmid:10496934 |
| Mitidieri F and de Meis L | Ca(2+) release and heat production by the endoplasmic reticulum Ca(2+)-ATPase of blood platelets. Effect of the platelet activating factor. | 1999 | J. Biol. Chem. | pmid:10497193 |
| Marathe GK et al. | Inflammatory platelet-activating factor-like phospholipids in oxidized low density lipoproteins are fragmented alkyl phosphatidylcholines. | 1999 | J. Biol. Chem. | pmid:10497200 |
| Sakaguchi T et al. | Participation of platelet-activating factor in the lipopolysaccharide-induced liver injury in partially hepatectomized rats. | 1999 | Hepatology | pmid:10498648 |
| Imrie CW and McKay CJ | The scientific basis of medical therapy of acute pancreatitis. Could it work, and is there a role for lexipafant? | 1999 | Gastroenterol. Clin. North Am. | pmid:10503138 |
| Min JH et al. | Membrane-bound plasma platelet activating factor acetylhydrolase acts on substrate in the aqueous phase. | 1999 | Biochemistry | pmid:10504265 |
| Tiemann U et al. | Influence of inhibitors on increase in intracellular free calcium and proliferation induced by platelet-activating factor in bovine oviductal cells. | 1999 | J. Reprod. Fertil. | pmid:10505057 |
| Peplow PV | Regulation of platelet-activating factor (PAF) activity in human diseases by phospholipase A2 inhibitors, PAF acetylhydrolases, PAF receptor antagonists and free radical scavengers. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10509861 |
| Merendino N et al. | Human intestinal epithelial cells express receptors for platelet-activating factor. | 1999 | Am. J. Physiol. | pmid:10516147 |
| Greenberg SG and Clark KE | Hemodynamic effects of platelet-activating factor in nonpregnant and pregnant sheep. | 1999 | Am. J. Physiol. | pmid:10516237 |
| Bernatchez PN et al. | Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1-dependent. | 1999 | J. Biol. Chem. | pmid:10521504 |
| Sugiura T et al. | Occurrence of lysophosphatidic acid and its alkyl ether-linked analog in rat brain and comparison of their biological activities toward cultured neural cells. | 1999 | Biochim. Biophys. Acta | pmid:10521703 |
| Hocke M et al. | Platelet activating factor in stool from patients with ulcerative colitis and Crohn's disease. | 1999 Jul-Aug | Hepatogastroenterology | pmid:10521992 |
| Monteiro HS et al. | Glomerular effects of cholera toxin in isolated perfused rat kidney: a potential role for platelet activating factor. | 1999 | Pharmacol. Toxicol. | pmid:10522748 |
| Prescott SM et al. | Two of the usual suspects, platelet-activating factor and its receptor, implicated in acute lung injury. | 1999 | J. Clin. Invest. | pmid:10525039 |
| Nagase T et al. | Platelet-activating factor mediates acid-induced lung injury in genetically engineered mice. | 1999 | J. Clin. Invest. | pmid:10525045 |
| Wang X et al. | Platelet-activating factor induced Ca(2+) signaling in human microglia. | 1999 | Brain Res. | pmid:10526106 |
| Kinlough-Rathbone RL et al. | Effects of cathepsin G pretreatment of platelets on their subsequent responses to aggregating agents. | 1999 | Thromb. Res. | pmid:10527409 |
| Sun Z et al. | Roles of platelet-activating factor, interleukin-1beta and interleukin-6 in intestinal barrier dysfunction induced by mesenteric arterial ischemia and reperfusion. | 1999 | J. Surg. Res. | pmid:10527709 |
| Vergnolle N | Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo. | 1999 | J. Immunol. | pmid:10528212 |
| Stammberger U et al. | Combined treatment with endothelin- and PAF-antagonists reduces posttransplant lung ischemia/reperfusion injury. | 1999 | J. Heart Lung Transplant. | pmid:10528748 |
| Marr KA et al. | Agonist-induced adherence of equine neutrophils to fibronectin- and serum-coated plastic is CD18 dependent. | 1999 | Vet. Immunol. Immunopathol. | pmid:10532398 |
| Serou MJ et al. | Interleukin-1 beta activates expression of cyclooxygenase-2 and inducible nitric oxide synthase in primary hippocampal neuronal culture: platelet-activating factor as a preferential mediator of cyclooxygenase-2 expression. | 1999 | J. Neurosci. Res. | pmid:10533051 |
| Mustafa SB et al. | Suppression of lipopolysaccharide-induced nitric oxide synthase expression by platelet-activating factor receptor antagonists in the rat liver and cultured rat Kupffer cells. | 1999 | Hepatology | pmid:10534342 |
| Nicholson SC et al. | Echocardiographic and survival studies in mice undergoing endotoxic shock: effects of genetic ablation of inducible nitric oxide synthase and pharmacologic antagonism of platelet-activating factor. | 1999 | J. Surg. Res. | pmid:10534424 |
| McKenna CJ et al. | Familial dilated cardiomyopathy. | 1999 | Circulation | pmid:10534480 |
| Tselepis AD et al. | Platelet aggregatory response to platelet activating factor (PAF), ex vivo, and PAF-acetylhydrolase activity in patients with unstable angina: effect of c7E3 Fab (abciximab) therapy. | 1999 | Cardiovasc. Res. | pmid:10536703 |
| Ernest S and Bello-Reuss E | Secretion of platelet-activating factor is mediated by MDR1 P-glycoprotein in cultured human mesangial cells. | 1999 | J. Am. Soc. Nephrol. | pmid:10541289 |
| Manya H et al. | Biochemical characterization of various catalytic complexes of the brain platelet-activating factor acetylhydrolase. | 1999 | J. Biol. Chem. | pmid:10542206 |
| Koyama S et al. | The potential of various lipopolysaccharides to release monocyte chemotactic activity from lung epithelial cells and fibroblasts. | 1999 | Eur. Respir. J. | pmid:10543273 |
| Echazarreta AL et al. | Effects of inhaled furosemide on platelet-activating factor challenge in mild asthma. | 1999 | Eur. Respir. J. | pmid:10543284 |
| Gómez FP et al. | Gas exchange response to a PAF receptor antagonist, SR 27417A, in acute asthma: a pilot study. | 1999 | Eur. Respir. J. | pmid:10543285 |
| Uluoglu C and Timlioglu O | Endothelium-dependent vasodilation in the isolated rabbit kidney following in vivo and in vitro ischaemia and reperfusion: effects of antagonizing platelet activating factor (PAF). | 1999 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:10543435 |
| Li S et al. | Experimental therapy of a platelet-activating factor antagonist (ginkgolide B) on photochemically induced thrombotic cerebral ischaemia in tree shrews. | 1999 | Clin. Exp. Pharmacol. Physiol. | pmid:10549411 |
| Biancone L et al. | Motility induced by human immunodeficiency virus-1 Tat on Kaposi's sarcoma cells requires platelet-activating factor synthesis. | 1999 | Am. J. Pathol. | pmid:10550329 |
| Wang MM et al. | Stereoselective actions of hepoxilins A3 and B3 and their cyclopropane analogs (HxdeltaA3 and HxdeltaB3) on bradykinin and PAF-evoked potentiation of vascular leakage in rat skin. | 1999 | Gen. Pharmacol. | pmid:10553878 |
| Adunsky A et al. | Infarct volume, neurological severity and PAF binding to platelets of patients with acute cerebral ischemic stroke. | 1999 | Neurol. Res. | pmid:10555184 |
| Falk S et al. | Quinolines attenuate PAF-induced pulmonary pressor responses and edema formation. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10556149 |
| Lauener RW et al. | A role for phosphatidylinositol 3-kinase in platelet aggregation in response to low, but not high, concentrations of PAF or thrombin. | 1999 | Biochim. Biophys. Acta | pmid:10559473 |
| Fuentes E et al. | Lysophospholipids trigger calcium signals but not DNA synthesis in cortical astrocytes. | 1999 | Glia | pmid:10559786 |