| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shao P et al. | [Research on relationship of syndrome type and parameters of hemorheology and platelet activation in patients with acute gout arthritis of dampness-heat blockage type and stasis-heat accumulate type]. | 2006 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:17186728 |
| Chen WM et al. | [Experimental study on inhibitory effect of rutin against platelet activation induced by platelet activating factor in rabbits]. | 2002 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12584792 |
| Zhao W et al. | [Expression and regulation of pituitary adenylate cyclase-activating polypeptide mRNA in pregnant rat corpus luteum]. | 2010 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21038678 |
| Di Y et al. | [Effect of ginkgolide B on plasma levels of interleukin-12 and PAF in severe acute pancreatitis in rats]. | 2008 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21141514 |
| Zhao W et al. | [Effect of PAF on the expression of PACAP mRNA in the granulosa cells of rat ovary]. | 2007 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21180114 |
| Dong J et al. | [Effect of platelet-activating factor on long-term potentiation in rat hippocampal slices]. | 2005 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21171322 |
| Liu SH et al. | [Effects of p38 mitogen-activated protein kinase in protection of carbon monoxide against lipopolysaccharide induced rat small intestine injury]. | 2009 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21189571 |
| Song SQ and Hu YM | Effects of tetrandrine, Fura 2-AM, and Bay k 8644 on platelet-activating factor release from rat peritoneal macrophages stimulated by lipopolysaccharides. | 1996 | Zhongguo Yao Li Xue Bao | pmid:9812743 |
| Chen SF et al. | Three drugs inhibit phospholipase A2-induced high permeability of endothelial monolayers. | 1994 | Zhongguo Yao Li Xue Bao | pmid:7801767 |
| Shen ZQ et al. | Effect of protopine on cytosolic Ca2+ in rabbit platelets. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10452120 |
| Zeng S et al. | Platelet activating factor-induced P-selectin expression in platelets and its related signal transduction. | 1999 | Zhongguo Yao Li Xue Bao | pmid:11270998 |
| Li SH et al. | Effects of platelet-activating factor on rat mesenteric microcirculation. | 1990 | Zhongguo Yao Li Xue Bao | pmid:2104488 |
| Zeng GQ and Rui YC | [Inhibitory effect of dauricine on platelet activating factor released from calcimycin-induced mouse peritoneal macrophages]. | 1990 | Zhongguo Yao Li Xue Bao | pmid:2104489 |
| Fu Y and Hu YM | Prophylactic effects of tetramethyl pyrazine on mice with endotoxemia and its relationship with platelet-activating factor. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10678147 |
| Wang XD and Bian RL | [Effects of ketotifen on rabbit platelet aggregation and platelet activating factor formation from rat neutrophils]. | 1990 | Zhongguo Yao Li Xue Bao | pmid:2130617 |
| Yi FX and Guo ZG | Platelet-released ADP stabilizes PAF-induced rabbit platelet aggregation by stabilizing intracellular calcium. | 1998 | Zhongguo Yao Li Xue Bao | pmid:10375790 |
| Sun DX et al. | Specific binding sites of platelet activating factor on the intact bovine cerebral microvascular endothelial cells and antagonism of drugs. | 1992 | Zhongguo Yao Li Xue Bao | pmid:1333718 |
| Li SH et al. | Pentoxifylline attenuates platelet activating factor-induced permeable edema in isolated perfused guinea pig lungs. | 1994 | Zhongguo Yao Li Xue Bao | pmid:7976374 |
| Hu JH et al. | Platelet adhesion to cultured bovine cerebral microvascular endothelial cells by stimulation of platelet activating factor and antagonism of drugs. | 1995 | Zhongguo Yao Li Xue Bao | pmid:7668100 |
| Zhang M et al. | Effects of tetrandrine on rabbit platelet aggregation and platelet activating factor generation. | 1995 | Zhongguo Yao Li Xue Bao | pmid:7660812 |
| Ju DW et al. | Inhibitory effects of triazolodiazepine on mouse splenocytes and peritoneal macrophages in vitro. | 1994 | Zhongguo Yao Li Xue Bao | pmid:8010089 |
| Qian R et al. | Platelet activation by platelet aggregation factor from Eisenia foelide. | 1994 | Zhongguo Yao Li Xue Bao | pmid:7717070 |
| Hong JL et al. | [Effects of tetrandrine on cytoplasmic free calcium in rat neutrophils]. | 1989 | Zhongguo Yao Li Xue Bao | pmid:2561935 |
| Zeng S and Guo ZG | Mepyramine inhibits platelet activating factor-induced rabbit platelet aggregation: role of intracellular histamine. | 1997 | Zhongguo Yao Li Xue Bao | pmid:10072970 |
| Zeng GQ et al. | Dauricine and anisodamine inhibited leukotrienes- and platelet activating factor-induced DNA synthesis and proliferation of bovine cerebral microvascular smooth muscle cells in culture. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8249627 |
| Zhang B and Long K | Effects of glaucocalyxin A on aggregation and cAMP levels of rabbit platelets in vitro. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8249632 |
| Sun DX et al. | Platelet activating factor production in bovine cerebral microvascular endothelial cells and its drug inhibition. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8503282 |
| Zeng S et al. | Regulatory role of protein tyrosine phosphorylation in platelet activating factor-induced signal transduction in platelets. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10437164 |
| Jia XQ et al. | [Changes in coagulation and fibrinolysis in the patients with coronary heart disease in acute period and effect of drug intervention]. | 2012 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:22464576 |
| Shi B et al. | [Influence of intensive insulin therapy on the intestinal microcirculatory dysfunction in rats with sepsis]. | 2009 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:19695175 |
| Chen S et al. | [Induction effect of platelet-activating factor on Src-suppressed C kinase substrate gene expression in rat pulmonary microvascular endothelial cells]. | 2010 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:20367900 |
| Hao J et al. | [Dynamic changes of platelet number in early multiple injury and it is effect on prognosis]. | 2003 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:14552687 |
| Ding DD et al. | [Changes of platelet α-particle membrane protein, platelet activating factor and platelet parameters in patients with hyperuricemia]. | 2012 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:22541106 |
| Guo NJ et al. | [Activation of platelet-neutrophil mediated by platelet-activating factor]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15972139 |
| Bao GQ and Ju AZ | [Signal pathways of eryptosis-review]. | 2009 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:19698269 |
| Wang LJ et al. | [Role of platelet activating factor in the injury of intestinal immuno-barrier function in young rats]. | 2006 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:16522243 |
| Li X and Luo H | [Advances in pharmacological study of Piper kadsura (Choisy) Ohwi]. | 2002 | Zhong Yao Cai | pmid:14748373 |
| Xu CL et al. | [Inhibitory effect of TBN on platelet aggregation in rabbit]. | 2010 | Zhong Yao Cai | pmid:21243778 |
| Zhang XT et al. | [Study on the pharmacokinetics of ginkgolide B for injection in rats]. | 2012 | Zhong Yao Cai | pmid:22876684 |
| Zhang XT et al. | [Study on pharmacokinetics of ginkgolide B injection in Beagle dogs]. | 2012 | Zhong Yao Cai | pmid:23213741 |
| Huang GD et al. | [Observation on the expression of PS2 and platelet activating factor affected by Jianwei Yuyang granules and study its potential mechanisim against peptic ulcer]. | 2007 | Zhong Yao Cai | pmid:18422199 |
| Xiao HS | [Relation of blood platelets and the cause of bronchial asthma]. | 1989 | Zhong Xi Yi Jie He Za Zhi | pmid:2532572 |
| Zong RK and Liu J | [Effects of Chinese herbal medicine Xinfeng Capsule on expressions of platelet-activating factor and interleukins 6 and 17 in peripheral blood of rats with adjuvant arthritis]. | 2011 | Zhong Xi Yi Jie He Xue Bao | pmid:22152774 |
| Xie DS and Xie YT | [Role of platelet activating factor in hepatorenal syndrome]. | 2005 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:16045031 |
| Zhao XY et al. | [Effects of BIO-1211 on eosinophil chemotaxis, recruitment and mediator release]. | 2003 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:12970925 |
| Poveshchenko AF and Kozlov VA | [The effect of platelet-activating factor and its antagonist--BN 52021--on immune reactions in vivo in mice and in vitro]. | 1999 Jul-Aug | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:10852052 |
| Shebzukhov IuV et al. | [The effect of platelet-activating factor and its synthetic analogs on Ia-antigen expression by mouse peritoneal macrophages]. | 1996 May-Jun | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:8771751 |
| Van de Weerdt ML et al. | Role of the cholinergic pathway in mediating platelet-activating factor-induced pulmonary dysfunctions in unsedated calves. | 1999 | Zentralbl Veterinarmed A | pmid:10216447 |
| Bastos da Silva M et al. | Combined effect of Web 2086 (Paf antagonist) and ketoprofen (Nsaid) on Paf-induced ex vivo platelet aggregation in bovine. | 1997 | Zentralbl Veterinarmed A | pmid:9284631 |
| da Silva MB et al. | Inhibition of PAF-induced platelet aggregation by WEB 2086 'in-vitro', an antagonist to the receptor for platelet-activating factor, in bovine. | 1996 | Zentralbl Veterinarmed A | pmid:8921726 |