| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ozaki N et al. | Mechanosensitive properties of gastric vagal afferent fibers in the rat. | 1999 | J. Neurophysiol. | pmid:10561400 |
| Torras J et al. | Long-term protective effect of UR-12670 after warm renal ischemia in uninephrectomized rats. | 1999 | Kidney Int. | pmid:10571788 |
| Bratt T et al. | Interactions between neutrophil gelatinase-associated lipocalin and natural lipophilic ligands. | 1999 | Biochim. Biophys. Acta | pmid:10572948 |
| Grutters JC et al. | Asthma therapy modulates priming-associated blood eosinophil responsiveness in allergic asthmatics. | 1999 | Eur. Respir. J. | pmid:10573242 |
| Tekgül H et al. | Lymphocyte subsets and inflammatory mediators in patients with subacute sclerosing panencephalitis. | 1999 | J. Child Neurol. | pmid:10573462 |
| Olszanecki R and Chłopicki S | Endotoxaemia in rats: role of NO, PAF and TXA2 in pulmonary neutrophil sequestration and hyperlactataemia. | 1999 | J. Physiol. Pharmacol. | pmid:10574473 |
| Kuśnierz B and Naskalski JW | [Mediators of the inflammatory response in the course of acute pancreatitis]. | 1999 | Prz. Lek. | pmid:10575924 |
| Grassi S et al. | Platelet-activating factor and group I metabotropic glutamate receptors interact for full development and maintenance of long-term potentiation in the rat medial vestibular nuclei. | 1999 | Neuroscience | pmid:10579215 |
| Quinn JV and Slotman GJ | Platelet-activating factor and arachidonic acid metabolites mediate tumor necrosis factor and eicosanoid kinetics and cardiopulmonary dysfunction during bacteremic shock. | 1999 | Crit. Care Med. | pmid:10579269 |
| Goldfarb R | Investigations into the polydeterminant nature of sepsis. | 1999 | Crit. Care Med. | pmid:10579296 |
| Mizuki M et al. | Inhibition of eosinophil activation in bronchoalveolar lavage fluid from atopic asthmatics by Y-24180, an antagonist to platelet-activating factor. | 1999 | Life Sci. | pmid:10579457 |
| Shin BA et al. | Lyso-PAF analogues and lysophosphatidylcholines from the marine sponge Spirastrella abata as inhibitors of cholesterol biosynthesis. | 1999 | J. Nat. Prod. | pmid:10579872 |
| Rodrigues CO et al. | Platelet-activating factor induction of secreted phosphatase activity in Trypanosoma cruzi. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10581161 |
| Wu R et al. | Antibodies to platelet-activating factor are associated with borderline hypertension, early atherosclerosis and the metabolic syndrome. | 1999 | J. Intern. Med. | pmid:10583710 |
| Hendrickson HS et al. | Intramolecularly quenched BODIPY-labeled phospholipid analogs in phospholipase A(2) and platelet-activating factor acetylhydrolase assays and in vivo fluorescence imaging. | 1999 | Anal. Biochem. | pmid:10585741 |
| Byrum RS et al. | Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice. | 1999 | J. Immunol. | pmid:10586081 |
| Kafoury RM et al. | Induction of inflammatory mediators in human airway epithelial cells by lipid ozonation products. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10588609 |
| Kitsiouli EI et al. | Differential determination of phospholipase A(2) and PAF-acetylhydrolase in biological fluids using fluorescent substrates. | 1999 | J. Lipid Res. | pmid:10588961 |
| Burns AR et al. | Analysis of tight junctions during neutrophil transendothelial migration. | 2000 | J. Cell. Sci. | pmid:10591624 |
| Arbabi S et al. | Priming interleukin 8 production: role of platelet-activating factor and p38. | 1999 | Arch Surg | pmid:10593333 |
| Wechsung E and Houvenaghel A | Influence of platelet activating factor on gastrointestinal electrical activity and some haematological and clinical parameters in the conscious miniature pig. | 1999 | J. Vet. Pharmacol. Ther. | pmid:10597537 |
| Bosch RJ et al. | Effects of parathyroid hormone-related protein on human mesangial cells in culture. | 1999 | Am. J. Physiol. | pmid:10600786 |
| Hashimoto S et al. | p38 MAP kinase regulates TNF alpha-, IL-1 alpha- and PAF-induced RANTES and GM-CSF production by human bronchial epithelial cells. | 2000 | Clin. Exp. Allergy | pmid:10606930 |
| Sawai H et al. | Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C. | 1999 | J. Biol. Chem. | pmid:10608884 |
| Thurston G et al. | Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. | 1999 | Science | pmid:10617467 |
| Sibelius U et al. | Staphylococcal alpha-toxin provokes coronary vasoconstriction and loss in myocardial contractility in perfused rat hearts: role of thromboxane generation. | 2000 Jan 4-11 | Circulation | pmid:10618308 |
| Fukuda S et al. | Mechanisms for regulation of fluid shear stress response in circulating leukocytes. | 2000 | Circ. Res. | pmid:10625314 |
| Kim DD et al. | Platelet-activating factor modulates microvascular dynamics through phospholipase C in the hamster cheek pouch. | 2000 | Microvasc. Res. | pmid:10625566 |
| Kaul DK et al. | Monoclonal antibodies to alphaVbeta3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor. | 2000 | Blood | pmid:10627437 |
| Franke B et al. | Sequential regulation of the small GTPase Rap1 in human platelets. | 2000 | Mol. Cell. Biol. | pmid:10629034 |
| Haines DD et al. | Cardioprotective effects of the calcineurin inhibitor FK506 and the PAF receptor antagonist and free radical scavenger, EGb 761, in isolated ischemic/reperfused rat hearts. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10630731 |
| Montrucchio G et al. | Platelet-activating factor enhances vascular endothelial growth factor-induced endothelial cell motility and neoangiogenesis in a murine matrigel model. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10634803 |
| Atuma C et al. | Helicobacter pylori extracts reduce gastric mucosal blood flow by a nitric oxide-independent but mast cell- and platelet-activating factor receptor-dependent pathway in rats. | 1999 | Scand. J. Gastroenterol. | pmid:10636064 |
| Keularts IM et al. | alpha(2A)-adrenergic receptor stimulation potentiates calcium release in platelets by modulating cAMP levels. | 2000 | J. Biol. Chem. | pmid:10636873 |
| Chlopicki S et al. | Biphasic response to lipopolysaccharide from E. coli in the isolated ventilated blood-perfused rat lung. | 1999 | J. Physiol. Pharmacol. | pmid:10639006 |
| Tong N et al. | Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system. | 2000 | J. Immunol. | pmid:10640747 |
| Clavijo LC et al. | Platelet-activating factor and bacteremia-induced pulmonary hypertension. | 2000 | J. Surg. Res. | pmid:10644485 |
| Owaki T et al. | Endothelial cells potentiate phagocytic killing by macrophages via platelet-activating factor release. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10644608 |
| Munir I et al. | Mitogen-activated protein kinase activation and regulation of cyclooxygenase 2 expression by platelet-activating factor and hCG in human endometrial adenocarcinoma cell line HEC-1B. | 1999 | J. Reprod. Fertil. | pmid:10645245 |
| Michibayashi T | Interaction between platelet-aggregating response and vasoconstrictive response to platelet activating factor. | 1999 | J Smooth Muscle Res | pmid:10647808 |
| Miike S et al. | Platelet-activating factor activates mitogen-activated protein kinases through the activation of phosphatidylinositol 3-kinase and tyrosine kinase in human eosinophils. | 2000 | J. Leukoc. Biol. | pmid:10648006 |
| Dichmann S et al. | Adenosine triphosphate-induced oxygen radical production and CD11b up-regulation: Ca(++) mobilization and actin reorganization in human eosinophils. | 2000 | Blood | pmid:10648411 |
| Ibe BO et al. | Platelet activating factor acetylhydrolase activity in lamb lungs is up-regulated in the immediate newborn period. | 2000 | Mol. Genet. Metab. | pmid:10655157 |
| Modschiedler K et al. | Dapsone and colchicine inhibit adhesion of neutrophilic granulocytes to epidermal sections. | 2000 | Arch. Dermatol. Res. | pmid:10664013 |
| Grimminger F et al. | PAF-induced synthesis of tetraenoic and pentaenoic leukotrienes in the isolated rabbit lung. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10666110 |
| Marshall LA et al. | Respective roles of the 14 kDa and 85 kDa phospholipase A2 enzymes in human monocyte eicosanoid formation. | 1999 | Adv. Exp. Med. Biol. | pmid:10667333 |
| Kato K | Modulation of long-term potentiation in the CA1 area of rat hippocampus by platelet-activating factor. | 1999 | Adv. Exp. Med. Biol. | pmid:10667334 |
| Goldman R et al. | Lipid mediators stimulate reactive oxygen species formation in immortalized human keratinocytes. | 1999 | Adv. Exp. Med. Biol. | pmid:10667361 |
| Yu R et al. | Studies on the callus cultures of Ginkgo biloba and its metabolites-ginkgolides. | 1999 | Chin. J. Biotechnol. | pmid:10668135 |
| Gelbard HA | Neuroprotective strategies for HIV-1-associated neurologic disease. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10668436 |
| Partrick DA et al. | Maximal human neutrophil priming for superoxide production and elastase release requires p38 mitogen-activated protein kinase activation. | 2000 | Arch Surg | pmid:10668885 |
| Cowling RT and Birnboim HC | Expression of serum- and glucocorticoid-regulated kinase (sgk) mRNA is up-regulated by GM-CSF and other proinflammatory mediators in human granulocytes. | 2000 | J. Leukoc. Biol. | pmid:10670586 |
| Burgermeister E et al. | Inhibition of cytosolic phospholipase A(2) attenuates activation of mitogen-activated protein kinases in human monocytic cells. | 2000 | Eur. J. Pharmacol. | pmid:10675727 |
| Fu Y and Hu YM | Prophylactic effects of tetramethyl pyrazine on mice with endotoxemia and its relationship with platelet-activating factor. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10678147 |
| Kimura I et al. | Release of endothelins and platelet-activating factor by a rat pleural mesothelial cell line. | 2000 | Eur. Respir. J. | pmid:10678641 |
| Orozco AS et al. | Mechanisms of the proinflammatory response of endothelial cells to Candida albicans infection. | 2000 | Infect. Immun. | pmid:10678917 |
| Ishihara Y et al. | Regulation of immunoglobulin G2 production by prostaglandin E(2) and platelet-activating factor. | 2000 | Infect. Immun. | pmid:10678975 |
| Fujimura M et al. | No involvement of lipid mediators in a guinea pig model of ultrasonically nebulized distilled water-induced bronchoconstriction. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10680775 |
| Sugano T et al. | Platelet-activating factor induces an imbalance between matrix metalloproteinase-1 and tissue inhibitor of metalloproteinases-1 expression in human uterine cervical fibroblasts. | 2000 | Biol. Reprod. | pmid:10684793 |
| Werr J et al. | Integrin alpha(2)beta(1) (VLA-2) is a principal receptor used by neutrophils for locomotion in extravascular tissue. | 2000 | Blood | pmid:10688841 |
| Bleeker WK et al. | Vasoactive side effects of intravenous immunoglobulin preparations in a rat model and their treatment with recombinant platelet-activating factor acetylhydrolase. | 2000 | Blood | pmid:10688848 |
| Weintraub ST et al. | Mass spectrometric analysis of platelet-activating factor after isolation by solid-phase extraction and direct derivatization with pentafluorobenzoic anhydride. | 2000 | J. Am. Soc. Mass Spectrom. | pmid:10689672 |
| Nilsson G et al. | Demonstration that platelet-activating factor is capable of activating mast cells and inducing a chemotactic response. | 2000 | Immunology | pmid:10692052 |
| De Plaen IG et al. | Lipopolysaccharide activates nuclear factor kappaB in rat intestine: role of endogenous platelet-activating factor and tumour necrosis factor. | 2000 | Br. J. Pharmacol. | pmid:10694237 |
| Emingil G et al. | Levels of leukotriene B4 and platelet activating factor in gingival crevicular fluid in renal transplant patients receiving cyclosporine A. | 2000 | J. Periodontol. | pmid:10695938 |
| Zouki C et al. | The anti-inflammatory peptides, antiflammins, regulate the expression of adhesion molecules on human leukocytes and prevent neutrophil adhesion to endothelial cells. | 2000 | FASEB J. | pmid:10698973 |
| Tremblay G | BN 52021 decreases alveolar macrophage-mediated lung injury in experimental extrinsic allergic alveolitis. | 1999 | Mediators Inflamm. | pmid:10704058 |
| Hidi R et al. | Phosphodiesterase and cyclic adenosine monophosphate-dependent inhibition of T-lymphocyte chemotaxis. | 2000 | Eur. Respir. J. | pmid:10706503 |
| Henderson WR et al. | Recombinant human platelet-activating factor-acetylhydrolase inhibits airway inflammation and hyperreactivity in mouse asthma model. | 2000 | J. Immunol. | pmid:10706731 |
| Fukuda Y et al. | Effect of human plasma-type platelet-activating factor acetylhydrolase in two anaphylactic shock models. | 2000 | Eur. J. Pharmacol. | pmid:10708725 |
| Neuberger Y et al. | A lyso-platelet activating factor phospholipase C, originally suggested to be a neutral-sphingomyelinase, is located in the endoplasmic reticulum. | 2000 | FEBS Lett. | pmid:10708753 |
| Nikbakht-Sangari M et al. | The role of inflammatory mediators in the mechanism of the host immune response induced by ischemia-reperfusion injury. | 2000 | Immunol. Invest. | pmid:10709843 |
| Turner PJ et al. | Involvement of kinins in hyperresponsiveness induced by platelet activating factor in the human nasal airway. | 2000 | Br. J. Pharmacol. | pmid:10711351 |
| Maruoka S et al. | PAF-induced RANTES production by human airway smooth muscle cells requires both p38 MAP kinase and Erk. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10712344 |
| McClenahan DJ et al. | Role of platelet-activating factor in alveolar septal injury associated with experimentally induced pneumonic pasteurellosis in calves. | 2000 | Am. J. Vet. Res. | pmid:10714514 |
| Yamakawa Y et al. | Interaction of platelet activating factor, reactive oxygen species generated by xanthine oxidase, and leukocytes in the generation of hepatic injury after shock/resuscitation. | 2000 | Ann. Surg. | pmid:10714632 |
| Takada Y et al. | Improvement of allograft viability with organs procured from non-heart-beating donors in porcine liver transplantation. | 2000 | Transplant. Proc. | pmid:10715416 |
| Lo EJ et al. | Bradykinin-induced neurogenic migration of neutrophils into the rat knee joint. | 1999 | Neuroreport | pmid:10716216 |
| Chen C and Bazan NG | Platelet-activating factor inhibits ionotropic GABA receptor activity in cultured hippocampal neurons. | 1999 | Neuroreport | pmid:10716218 |
| Chen LW et al. | Differential regulation of Ca2+ influx by fMLP and PAF in human neutrophils: possible involvement of store-operated Ca2+ channel. | 2000 | Shock | pmid:10718373 |
| Manabe H et al. | The inhaled administration of KF19514, a phosphodiesterase 4 and 1 inhibitor, prevents antigen-induced lung inflammation in guinea pigs. | 2000 | Pulm Pharmacol Ther | pmid:10718985 |
| Sun Z et al. | Beneficial effects of lexipafant, a PAF antagonist on gut barrier dysfunction caused by intestinal ischemia and reperfusion in rats. | 2000 | Dig Surg | pmid:10720833 |
| Vallee RB et al. | The role of cytoplasmic dynein in the human brain developmental disease lissencephaly. | 2000 | Biochim. Biophys. Acta | pmid:10722879 |
| Wang WZ et al. | Platelet-activating factor contributes to postischemic vasospasm. | 2000 | J. Surg. Res. | pmid:10729242 |
| Ishii S and Shimizu T | Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. | 2000 | Prog. Lipid Res. | pmid:10729607 |
| Iglesias-De La Cruz MC et al. | Phenotypic modifications of human mesangial cells by extracellular matrix: the importance of matrix in the contractile response to reactive oxygen species. | 2000 Mar-Apr | Exp. Nephrol. | pmid:10729749 |
| Schmidt J et al. | Reduced basal and stimulated leukocyte adherence in tumor endothelium of experimental pancreatic cancer. | 1999 | Int. J. Pancreatol. | pmid:10732294 |
| Berthou C et al. | Interferon-gamma-induced membrane PAF-receptor expression confers tumor cell susceptibility to NK perforin-dependent lysis. | 2000 | Blood | pmid:10733503 |
| Desplat V et al. | Metabolism and effect of platelet-activating factor on the growth of human myeloma cell lines. | 2000 | Cancer Lett. | pmid:10737702 |
| Boccellino M et al. | Effect of platelet-activating factor receptor expression on CHO cell motility. | 2000 | J. Cell. Physiol. | pmid:10737901 |
| Hagi A et al. | Activation of G-protein coupled fMLP or PAF receptor directly triggers glucose transporter type 1 (GLUT1) translocation in Chinese hamster ovary (CHO) cells stably expressing fMLP or PAF receptor. | 2000 | J. Med. Invest. | pmid:10740976 |
| Tan XD et al. | Platelet-activating factor increases mucosal permeability in rat intestine via tyrosine phosphorylation of E-cadherin. | 2000 | Br. J. Pharmacol. | pmid:10742310 |
| Wiese A et al. | Structure-dependent effects of glucose-containing analogs of platelet activating factor (PAF) on membrane integrity. | 2000 | Biol. Chem. | pmid:10746745 |
| Howard KM and Olson MS | The expression and localization of plasma platelet-activating factor acetylhydrolase in endotoxemic rats. | 2000 | J. Biol. Chem. | pmid:10748027 |
| Ruchaud-Sparagano MH et al. | Soluble E-selectin acts in synergy with platelet-activating factor to activate neutrophil beta 2-integrins. Role of tyrosine kinases and Ca2+ mobilization. | 2000 | J. Biol. Chem. | pmid:10748085 |
| Ibe BO et al. | Platelet-activating factor receptors in lamb lungs are downregulated immediately after birth. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10749711 |
| Koyama S et al. | The potential of various lipopolysaccharides to release IL-8 and G-CSF. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10749742 |
| Martin-Chouly CA et al. | Modulation of PAF production by incorporation of arachidonic acid and eicosapentaenoic acid in phospholipids of human leukemic monocyte-like cells THP-1. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10751643 |
| Vincent JL et al. | Phase II multicenter clinical study of the platelet-activating factor receptor antagonist BB-882 in the treatment of sepsis. | 2000 | Crit. Care Med. | pmid:10752807 |
| Lendvai N et al. | Mechanism for the isotype dependence of antibody-mediated toxicity in Cryptococcus neoformans-infected mice. | 2000 | J. Immunol. | pmid:10754337 |