Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Zia-ul-Haq M et al. Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpea and Kabuli chickpea. 2012 Jul-Aug Acta Pol Pharm pmid:22876614
Rubio de Krömer MT et al. Differences in eosinophil and neutrophil chemotactic responses in sowda and generalized form of onchocerciasis. 1995 Acta Trop. pmid:8546035
Konstantinov SM et al. Efficacy of anticancer alkylphosphocholines in Trypanosoma brucei subspecies. 1997 Acta Trop. pmid:9107362
Dutra PM et al. Stimulation of Leishmania tropica protein kinase CK2 activities by platelet-activating factor (PAF). 2009 Acta Trop. pmid:19433049
Bazan NG and Allan G Platelet-activating factor is both a modulator of synaptic function and a mediator of cerebral injury and inflammation. 1996 Adv Neurol pmid:8790822
Söling HD et al. Regulation of protein kinases in exocrine secretory cells during agonist-induced exocytosis. 1985 Adv. Enzyme Regul. pmid:4072796
Hanahan DJ The continuing biochemical challenge of PAF and closely related lipid mediators. 1996 Adv. Exp. Med. Biol. pmid:9131117
Snyder F et al. Biosynthesis of platelet-activating factor and enzyme inhibitors. 1996 Adv. Exp. Med. Biol. pmid:9131118
Satoh K et al. Production of platelet-activating factor by brain microvascular endothelial cells. 1996 Adv. Exp. Med. Biol. pmid:9131120
Francescangeli E et al. PAF-synthesizing enzymes in neural cells during differentiation and in gerbil brain during ischemia. 1996 Adv. Exp. Med. Biol. pmid:9131121
Korth RM Non-specific PAF binding to embryonal F9 cells and prostacyclin synthesis in human umbilical vein endothelial cells. 1996 Adv. Exp. Med. Biol. pmid:9131162
Zimmerman GA et al. Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions. 1996 Adv. Exp. Med. Biol. pmid:9131163
Yang HC et al. Characterization of plasmalogen-selective phospholipase A2 from bovine brain. 1996 Adv. Exp. Med. Biol. pmid:9131165
Ferby I et al. PAF-induced MAPK activation is inhibited by wortmannin in neutrophils and macrophages. 1996 Adv. Exp. Med. Biol. pmid:9131167
Thierse HJ et al. Evidence for activation of cyclooxygenase-1/-2 by endogenous nitric oxide in adjuvant arthritic Lewis rats. 1996 Adv. Exp. Med. Biol. pmid:9131171
Rabinovici R et al. PAF and TNF alpha interactions in the pathophysiology of septic shock. 1991 Adv. Exp. Med. Biol. pmid:1818486
Kochanek PM et al. Platelet activating factor antagonists do not alter normal cerebral blood flow or cerebral oxygen consumption. 1990 Adv. Exp. Med. Biol. pmid:2096640
Camussi G et al. Antiflammins inhibit synthesis of platelet-activating factor and intradermal inflammatory reactions. 1990 Adv. Exp. Med. Biol. pmid:2096695
Elizarova EP Effects of taurine on calcium in platelets and their aggregation. 1996 Adv. Exp. Med. Biol. pmid:8915398
Kurachi M et al. Suppression of bronchial response to platelet activating factor following taurine administration. 1987 Adv. Exp. Med. Biol. pmid:3434419