| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Denizot Y et al. | Deregulated platelet-activating factor levels and acetylhydrolase activity in patients with idiopathic IgA nephropathy. | 2000 | Nephrol. Dial. Transplant. | pmid:10978389 |
| Clark WF et al. | A novel treatment for lupus nephritis: lignan precursor derived from flax. | 2000 | Lupus | pmid:10981647 |
| Suzuki T et al. | Thromboxane A(2)-mediated Cl(-) secretion induced by platelet-activating factor in isolated rat colon. | 2000 | Eur. J. Pharmacol. | pmid:10988347 |
| Kallan NC and Halcomb RL | Synthesis of the ring system of phomactin D using a Suzuki macrocyclization. | 2000 | Org. Lett. | pmid:10990428 |
| Turner PJ et al. | Induction by inhibitors of nitric oxide synthase of hyperresponsiveness in the human nasal airway. | 2000 | Br. J. Pharmacol. | pmid:10991932 |
| Klabunde RE and Anderson DE | Obligatory role of nitric oxide in platelet-activating factor-induced microvascular leakage. | 2000 | Eur. J. Pharmacol. | pmid:10996604 |
| Zăgrean L et al. | Preliminary EEG study of protective effects of Tebonin in transient global cerebral ischemia in rats. | 1998 Jan-Jun | Rom J Physiol | pmid:11000876 |
| Nieswandt B et al. | Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice. | 2000 | Blood | pmid:11001906 |
| Gastaldello K et al. | Role of complement and platelet-activating factor in the stimulation of phagocytosis and reactive oxygen species production during haemodialysis. | 2000 | Nephrol. Dial. Transplant. | pmid:11007834 |
| Wratten ML et al. | Hemolipodialysis attenuates oxidative stress and removes hydrophobic toxins. | 2000 | Artif Organs | pmid:11012537 |
| Wagner F et al. | Ether lipids in the cell membrane of Mycoplasma fermentans. | 2000 | Eur. J. Biochem. | pmid:11012682 |
| Montrucchio G et al. | Role of platelet-activating factor in cardiovascular pathophysiology. | 2000 | Physiol. Rev. | pmid:11015622 |
| Walther A et al. | Role of platelet-activating factor in leukocyte-independent plasma extravasation and mast cell activation during endotoxemia. | 2000 | J. Surg. Res. | pmid:11027469 |
| Ciesla DJ et al. | Hypertonic saline inhibits neutrophil (PMN) priming via attenuation of p38 MAPK signaling. | 2000 | Shock | pmid:11028541 |
| Brady M et al. | Cytokines and acute pancreatitis. | 1999 | Baillieres Best Pract Res Clin Gastroenterol | pmid:11030606 |
| Imrie CW and McKay CJ | The possible role of platelet-activating factor antagonist therapy in the management of severe acute pancreatitis. | 1999 | Baillieres Best Pract Res Clin Gastroenterol | pmid:11030612 |
| De Geest B et al. | Effect of overexpression of human apo A-I in C57BL/6 and C57BL/6 apo E-deficient mice on 2 lipoprotein-associated enzymes, platelet-activating factor acetylhydrolase and paraoxonase. Comparison of adenovirus-mediated human apo A-I gene transfer and human apo A-I transgenesis. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:11031226 |
| McLarnon JG et al. | Anion channels modulate store-operated calcium influx in human microglia. | 2000 | Cell Calcium | pmid:11032781 |
| Fraga AG et al. | Synthesis and pharmacological evaluation of novel heterotricyclic acylhydrazone derivatives, designed as PAF antagonists. | 2000 | Eur J Pharm Sci | pmid:11033071 |
| Choi SY et al. | Capsaicin inhibits platelet-activating factor-induced cytosolic Ca2+ rise and superoxide production. | 2000 | J. Immunol. | pmid:11034409 |
| Simon HU et al. | Eosinophils maintain their capacity to signal and release eosinophil cationic protein upon repetitive stimulation with the same agonist. | 2000 | J. Immunol. | pmid:11034418 |
| Rowland BL et al. | Elevated circulating concentrations of platelet activating factor in preeclampsia. | 2000 | Am. J. Obstet. Gynecol. | pmid:11035340 |
| Lonardoni MV et al. | Essential role of platelet-activating factor in control of Leishmania (Leishmania) amazonensis infection. | 2000 | Infect. Immun. | pmid:11035745 |
| Mul FP et al. | Sequential migration of neutrophils across monolayers of endothelial and epithelial cells. | 2000 | J. Leukoc. Biol. | pmid:11037975 |
| Gu M et al. | Pharmacologic graft protection without donor pretreatment in liver transplantation from non-heart-beating donors. | 2000 | Transplantation | pmid:11045637 |
| Poeze M et al. | Decreased organ failure in patients with severe SIRS and septic shock treated with the platelet-activating factor antagonist TCV-309: a prospective, multicenter, double-blind, randomized phase II trial. TCV-309 Septic Shock Study Group. | 2000 | Shock | pmid:11049104 |
| Karlstad MD et al. | Platelet-activating factor (PAF)-induced decreases in whole-body and skeletal muscle protein synthesis. | 2000 | Shock | pmid:11049115 |
| James JH and Fischer JE | Are the effects of platelet-activating factor on muscle metabolism of carbohydrates, amino acids and proteins attributable mainly to epinephrine? | 2000 | Shock | pmid:11049116 |
| Chłopicki S et al. | Residual pulmonary neutrophils are involved in vaso- and bronchoconstrictor responses to platelet activating factor in the isolated buffer-perfused rat lung. | 2000 May-Jun | Pol J Pharmacol | pmid:11055579 |
| Dichmann S et al. | Downregulation of platelet-activating factor responsiveness during maturation of human dendritic cells. | 2000 | J. Cell. Physiol. | pmid:11056009 |
| Peri A et al. | Uteroglobin reverts the transformed phenotype in the endometrial adenocarcinoma cell line HEC-1A by disrupting the metabolic pathways generating platelet-activating factor. | 2000 | Int. J. Cancer | pmid:11058867 |
| Tiano L et al. | Oxidative response and membrane modification of diabetic platelets challenged with PAF. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:11060899 |
| Shibata K et al. | Mediation by platelet-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in neutrophils. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:11060901 |
| Bracco E et al. | Cell-cell signaling and adhesion in phagocytosis and early development of Dictyostelium. | 2000 | Int. J. Dev. Biol. | pmid:11061438 |
| Biancone L et al. | Role of platelet-activating factor in functional alterations induced by xenoreactive antibodies in porcine endothelial cells. | 2000 | Transplantation | pmid:11063341 |
| Okunuki H et al. | Induction of active systemic anaphylaxis by oral sensitization with ovalbumin in mast-cell-deficient mice. | 2000 | Immunol. Lett. | pmid:11064108 |
| Grassi S and Pettorossi VE | Role of nitric oxide in long-term potentiation of the rat medial vestibular nuclei. | 2000 | Neuroscience | pmid:11068144 |
| Bussolati B et al. | PAF produced by human breast cancer cells promotes migration and proliferation of tumor cells and neo-angiogenesis. | 2000 | Am. J. Pathol. | pmid:11073830 |
| Yoshimatsu Y et al. | Platelet-activating factor-induced intracellular calcium waves in human uterine myometrial cells. | 2000 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:11074135 |
| Alloatti G et al. | Role of NO and PAF in the impairment of skeletal muscle contractility induced by TNF-alpha. | 2000 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11080081 |
| Tjoelker LW and Stafforini DM | Platelet-activating factor acetylhydrolases in health and disease. | 2000 | Biochim. Biophys. Acta | pmid:11080681 |
| Tanaka Y et al. | Possible involvement of endothelium-derived hyperpolarizing factor (EDHF) in the depressor responses to platelet activating factor (PAF) in rats. | 2000 | Br. J. Pharmacol. | pmid:11082118 |
| Le Blanc K et al. | Defective platelet aggregation in polycythaemia vera is not caused by impaired calcium signaling, phospholipase D activation or decreased amounts of focal adhesion proteins. | 2000 | Eur. J. Haematol. | pmid:11092463 |
| Chroni A and Mavri-Vavayanni M | Characterization of a platelet activating factor acetylhydrolase from rat adipocyte. | 2000 | Life Sci. | pmid:11105997 |
| Murakami M et al. | Distinct arachidonate-releasing functions of mammalian secreted phospholipase A2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms. | 2001 | J. Biol. Chem. | pmid:11106649 |
| Wechsung E and Houvenaghel A | Involvement of platelet activating factor in the endotoxin-induced effects on gastrointestinal electrical activity and some haematological parameters in the conscious miniature pig. | 2000 | J. Vet. Pharmacol. Ther. | pmid:11107007 |
| Johnson CD et al. | Double blind, randomised, placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitis. | 2001 | Gut | pmid:11115824 |
| Li N et al. | Platelet-leukocyte cross talk in whole blood. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:11116075 |
| Iwamoto H et al. | Beneficial effect of machine perfusion preservation on liver transplantation from non-heart-beating donors. | 2000 | Transplant. Proc. | pmid:11119873 |
| Hickey MJ et al. | L-selectin facilitates emigration and extravascular locomotion of leukocytes during acute inflammatory responses in vivo. | 2000 | J. Immunol. | pmid:11120848 |
| Kaplan R et al. | Combined defect in membrane expression and activation of platelet GPIIb--IIIa complex without primary sequence abnormalities in myeloproliferative disease. | 2000 | Br. J. Haematol. | pmid:11122160 |
| Bussolati B et al. | IL-10 stimulates production of platelet-activating factor by monocytes of patients with active systemic lupus erythematosus (SLE). | 2000 | Clin. Exp. Immunol. | pmid:11122257 |
| Kelly RF | Current strategies in lung preservation. | 2000 | J. Lab. Clin. Med. | pmid:11128744 |
| Adams JM et al. | G-protein receptor responses in trauma neutrophils. | 2000 | J Trauma | pmid:11130495 |
| Asimakopoulos G et al. | Inhibition of neutrophil L-selectin shedding: a potential anti-inflammatory effect of aprotinin. | 2000 | Perfusion | pmid:11131212 |
| Tavakoli S et al. | Prostaglandin E(2)-induced interleukin-6 release by a human airway epithelial cell line. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11133502 |
| Clavijo LC et al. | PAF increases vascular permeability without increasing pulmonary arterial pressure in the rat. | 2001 | J. Appl. Physiol. | pmid:11133918 |
| Galimi F et al. | Hepatocyte growth factor is a regulator of monocyte-macrophage function. | 2001 | J. Immunol. | pmid:11145707 |
| Arese M et al. | HIV-1 Tat protein stimulates in vivo vascular permeability and lymphomononuclear cell recruitment. | 2001 | J. Immunol. | pmid:11145723 |
| Rabinowitz SS et al. | Platelet-activating factor in infants at risk for necrotizing enterocolitis. | 2001 | J. Pediatr. | pmid:11148517 |
| Kwan ML et al. | Airway vasculature after mycoplasma infection: chronic leakiness and selective hypersensitivity to substance P. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11159008 |
| Komori M et al. | PAF mediates cigarette smoke-induced goblet cell metaplasia in guinea pig airways. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11159026 |
| Stojanov T and O'Neill C | In vitro fertilization causes epigenetic modifications to the onset of gene expression from the zygotic genome in mice. | 2001 | Biol. Reprod. | pmid:11159375 |
| Roudebush WE et al. | Impact of blood serum insulin-like growth factor I on platelet-activating factor in bull spermatozoa. | 2001 | Domest. Anim. Endocrinol. | pmid:11164329 |
| Giménez R and Aguilar J | Cytidine (5') diphosphocholine-induced decrease in cerebral platelet activating factor is due to inactivation of its synthesizing enzyme cholinephosphotransferase in aged rats. | 2001 | Neurosci. Lett. | pmid:11165772 |
| Goudevenos J et al. | Platelet-associated and secreted PAF-acetylhydrolase activity in patients with stable angina: sequential changes of the enzyme activity after angioplasty. | 2001 | Eur. J. Clin. Invest. | pmid:11168434 |
| Rodrigo L et al. | Hydrolysis of platelet-activating factor by human serum paraoxonase. | 2001 | Biochem. J. | pmid:11171072 |
| Magai RM and Shukla SD | Metabolic fate of [14C]-ethanol into endothelial cell phospholipids including platelet-activating factor, sphingomyelin and phosphatidylethanol. | 2001 Jan-Feb | J. Biomed. Sci. | pmid:11173988 |
| Zaitseva L et al. | Role of eicosanoids in regulation of macrophage phagocytic functions by platelet-activating factor during endotoxic shock. | 2000 | Bull. Exp. Biol. Med. | pmid:11177271 |
| Del Sorbo L et al. | Tat-induced platelet-activating factor synthesis contributes to the angiogenic effect of HIV-1 Tat. | 2001 | Eur. J. Immunol. | pmid:11180101 |
| Herrero-Fresneda I et al. | Cold ischemia in the absence of alloreactivity induces chronic transplant nephropathy through a process mediated by the platelet-activating factor. | 2000 | Transplantation | pmid:11190497 |
| Yildirim G et al. | Effects of platelet-activating factor and hyperbaric oxygenation on antioxidant defense and duodenal contractility. | 2000 | Undersea Hyperb Med | pmid:11191161 |
| Kecskeméti V and Balogh I | The role of platelet-activating factor (PAF) antagonists and nitric oxide in cardiac actions of PAF. Electrophysiological and morphological study. | 2000 | J. Physiol. Pharmacol. | pmid:11192945 |
| Karasawa K | [Physiological role of novel metabolic pathway of platelet-activating factor(PAF): PAF-dependent transacetylation]. | 2001 | Tanpakushitsu Kakusan Koso | pmid:11193332 |
| Urasaki T et al. | Pivotal role of 5-lipoxygenase in the activation of human eosinophils: platelet-activating factor and interleukin-5 induce CD69 on eosinophils through the 5-lipoxygenase pathway. | 2001 | J. Leukoc. Biol. | pmid:11200053 |
| Hauser CJ et al. | PAF-mediated Ca2+ influx in human neutrophils occurs via store-operated mechanisms. | 2001 | J. Leukoc. Biol. | pmid:11200069 |
| Jeon SY et al. | Nitric oxide mediates platelet activating factor-induced microvascular leakage in rat airways. | 2001 | Ann. Otol. Rhinol. Laryngol. | pmid:11201815 |
| Baker RR and Chang HY | The regulation of CoA-independent transacylation reactions in neuronal nuclei by lysophospholipid, free fatty acid, and lysophospholipase: the control of nuclear lyso platelet-activating factor metabolism. | 2000 | Mol. Cell. Biochem. | pmid:11204449 |
| Mannori G et al. | Interaction of tumor cells with vascular endothelia: role of platelet-activating factor. | 2000 | Clin. Exp. Metastasis | pmid:11206844 |
| Bassi F et al. | Detection of platelet-activating factor in gingival tissue surrounding failed dental implants. | 2001 | J. Periodontol. | pmid:11210074 |
| Ko TC et al. | Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11212091 |
| Taggart DP | Effects of a platelet-activating factor antagonist on lung injury and ventilation after cardiac operation. | 2001 | Ann. Thorac. Surg. | pmid:11216754 |
| Lash GE and Legge M | Localization and distribution of platelet activating factor receptors in the mouse ovary and oviduct during the estrous cycle and early pregnancy. | 2001 | Am. J. Reprod. Immunol. | pmid:11216875 |
| Sun Z et al. | Effects of inhibition of PAF, ICAM-1 and PECAM-1 on gut barrier failure caused by intestinal ischemia and reperfusion. | 2001 | Scand. J. Gastroenterol. | pmid:11218240 |
| Tohda Y et al. | Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. | 2001 | Respiration | pmid:11223734 |
| Kawaguchi A et al. | Preventive effect of platelet-activating factor antagonist, Y-24180, against cyclosporine-induced acute nephrotoxicity. | 2001 | Life Sci. | pmid:11228102 |
| Tokumura A et al. | Platelet-activating factor (PAF)-like oxidized phospholipids: relevance to atherosclerosis. | 2000 | Biofactors | pmid:11237195 |
| Persidsky Y et al. | Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFalpha inhibitor in SCID mice with HIV-1 encephalitis. | 2001 | J. Neuroimmunol. | pmid:11240016 |
| Bachert C | Decongestant efficacy of desloratadine in patients with seasonal allergic rhinitis. | 2001 | Allergy | pmid:11243500 |
| Gandhi CR et al. | A23187 causes release of inositol phosphates from cultured rat Kupffer cells. | 2001 | Eur. J. Pharmacol. | pmid:11245846 |
| Petty HR and Kindzelskii AL | Dissipative metabolic patterns respond during neutrophil transmembrane signaling. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11248046 |
| Denis MA et al. | Increased response of blood eosinophils to various chemotactic agents in quiescent Crohn disease. | 2001 | Scand. J. Gastroenterol. | pmid:11252412 |
| Wittwer T et al. | Impact of PAF antagonist BN 52021 (Ginkolide B) on post-ischemic graft function in clinical lung transplantation. | 2001 | J. Heart Lung Transplant. | pmid:11257563 |
| Chen YG et al. | Lignans from Kadsura angustifolia. | 1998 | J Asian Nat Prod Res | pmid:11261213 |
| Gu M et al. | Role of platelet-activating factor in hepatectomy with Pringle's maneuver. | 2001 | J. Surg. Res. | pmid:11266278 |
| Iwazaki S et al. | FR128998 ameliorates liver injury in extended liver resection with ischemia in dogs. | 2001 Jan-Feb | Hepatogastroenterology | pmid:11268964 |
| Gujrati VR and Sastry BV | Metabolic fate of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine by human spermatozoa: biosynthesis and biodegradation. | 2001 | Life Sci. | pmid:11270625 |
| Zeng S et al. | Platelet activating factor-induced P-selectin expression in platelets and its related signal transduction. | 1999 | Zhongguo Yao Li Xue Bao | pmid:11270998 |
| Ulrich CD | Lexipafant in severe acute pancreatitis: the final word? | 2001 | Curr Gastroenterol Rep | pmid:11276374 |
| Beales IL | Effect of platelet-activating factor on gastrin release from cultured rabbit G-cells. | 2001 | Dig. Dis. Sci. | pmid:11284466 |