| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Page CP et al. | Platelets and asthma. | 1985 | Lancet | pmid:2857401 |
| Gresele P et al. | Platelets and asthma. | 1985 | Lancet | pmid:2857402 |
| Lenihan DJ et al. | Involvement of platelet activating factor in physiological stress in the lizard, Anolis carolinensis. | 1985 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:2861063 |
| Matsumoto M and Miwa M | Platelet-activating factor-binding protein in human serum. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3004155 |
| Terashita Z et al. | Beneficial effects of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate, a specific PAF antagonist, in endotoxin and anaphylactic shock. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3004156 |
| Barnes JL and Venkatachalam MA | The role of platelets and polycationic mediators in glomerular vascular injury. | 1985 | Semin. Nephrol. | pmid:2957770 |
| Leid RW and Potter KA | Inflammation and mediators of lung injury. | 1985 | Vet. Clin. North Am. Food Anim. Pract. | pmid:3907779 |
| Shukla SD | Platelet activating factor-stimulated formation of inositol triphosphate in platelets and its regulation by various agents including Ca2+, indomethacin, CV-3988, and forskolin. | 1985 | Arch. Biochem. Biophys. | pmid:3875314 |
| Roubin R and Benveniste J | Formation of prostaglandins, leukotrienes and paf-acether by macrophages. | 1985 | Comp. Immunol. Microbiol. Infect. Dis. | pmid:3910339 |
| Billah MM et al. | Platelet-activating factor metabolism in human amnion and the responses of this tissue to extracellular platelet-activating factor. | 1985 | Prostaglandins | pmid:3936121 |
| Wasserman SI | Mast cell mediators in the blood of patients with asthma. | 1985 | Chest | pmid:3880526 |
| Halonen M et al. | Participation of platelets in the physiologic alterations of the AGEPC response and of IgE anaphylaxis in the rabbit. Effects of PGI2 inhibition of platelet function. | 1985 | Am. Rev. Respir. Dis. | pmid:3881060 |
| Sybertz EJ et al. | Cardiac, coronary and peripheral vascular effects of acetyl glyceryl ether phosphoryl choline in the anesthetized dog. | 1985 | J. Pharmacol. Exp. Ther. | pmid:3917504 |
| Harlan JM | Leukocyte-endothelial interactions. | 1985 | Blood | pmid:3918593 |
| McKean ML and Silver MJ | Phospholipid biosynthesis in human platelets. The acylation of lyso-platelet-activating factor. | 1985 | Biochem. J. | pmid:3919710 |
| Bruynzeel PL et al. | Exclusive leukotriene C4 synthesis by purified human eosinophils induced by opsonized zymosan. | 1985 | FEBS Lett. | pmid:2995125 |
| Archer CB et al. | Actions of disodium cromoglycate (DSCG) on human skin responses to histamine, codeine and Paf-acether. | 1985 | Agents Actions | pmid:3923788 |
| Sturk A et al. | Synergistic effects of platelet-activating factor and other platelet agonists in human platelet aggregation and release: the role of ADP and products of the cyclooxygenase pathway. | 1985 | Thromb. Res. | pmid:2934863 |
| Morley J et al. | Pharmacology of the late response to allergen and its relevance to asthma prophylaxis. | 1985 | Int. Arch. Allergy Appl. Immunol. | pmid:3924841 |
| Hwang SB et al. | Characterization of cutaneous vascular permeability induced by platelet-activating factor in guinea pigs and rats and its inhibition by a platelet-activating factor receptor antagonist. | 1985 | Lab. Invest. | pmid:3925239 |
| Malone B et al. | Inactivation of platelet activating factor by rabbit platelets. Lyso-platelet activating factor as a key intermediate with phosphatidylcholine as the source of arachidonic acid in its conversion to a tetraenoic acylated product. | 1985 | J. Biol. Chem. | pmid:3918041 |
| Valone FH and Johnson B | Modulation of cytoplasmic calcium in human platelets by the phospholipid platelet-activating factor 1-O-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine. | 1985 | J. Immunol. | pmid:2578151 |
| Zukowska-Grojec Z et al. | The adrenergic system and the cardiovascular effects of platelet activating factor (1-0-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine) in SHR and WKY rats. | 1985 | Clin Exp Hypertens A | pmid:2994912 |
| Shen TY et al. | The isolation and characterization of kadsurenone from haifenteng (Piper futokadsura) as an orally active specific receptor antagonist of platelet-activating factor. | 1985 | Int J Tissue React | pmid:2997065 |
| Sánchez Crespo M et al. | Synthesis of platelet-activating factor from human polymorphonuclear leukocytes: regulation and pharmacological approaches. | 1985 | Int J Tissue React | pmid:2997066 |
| Proll MA et al. | Phosphatidate and monooleylphosphatidate inhibition of fibroblast adenylate cyclase is mediated by the inhibitory coupling protein, Ni. | 1985 | Mol. Pharmacol. | pmid:2997592 |
| MacIntyre DE et al. | Endogenous and pharmacological mechanisms for the regulation of human platelet cytosolic free Ca2+. | 1985 | Nouv Rev Fr Hematol | pmid:2997706 |
| Lachachi H et al. | Inhibition of transmembrane movement and metabolism of platelet activating factor (PAF-acether) by a specific antagonist, BN 52021. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2998370 |
| Hwang SB et al. | trans-2,5-Bis-(3,4,5-trimethoxyphenyl)tetrahydrofuran. An orally active specific and competitive receptor antagonist of platelet activating factor. | 1985 | J. Biol. Chem. | pmid:2999126 |
| Camussi G et al. | The role of platelet-activating factor in experimental immune complex pathology. | 1985 | Int J Tissue React | pmid:2932406 |
| Benveniste J | Biosynthesis and function of PAF-acether (platelet-activating factor). | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936197 |
| Waku K et al. | Metabolism of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a precursor of platelet-activating factor in macrophages. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936199 |
| Saito K et al. | Determination of AGEPC generated from human neutrophils and rat skin and muscle tissues by a selected ion monitoring technique of GC/MS. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936200 |
| Tamargo J et al. | Electrophysiological effects of platelet-activating factor (PAF-acether) in guinea-pig papillary muscles. | 1985 | Eur. J. Pharmacol. | pmid:3996472 |
| Terashita Z et al. | Is platelet activating factor (PAF) a mediator of endotoxin shock? | 1985 | Eur. J. Pharmacol. | pmid:3996473 |
| Zimmerman GA et al. | Production of platelet-activating factor by human vascular endothelial cells: evidence for a requirement for specific agonists and modulation by prostacyclin. | 1985 | Circulation | pmid:3928193 |
| Heymans F et al. | Structure-activity relationship in PAF-acether. 2. rac-1-O-Octadecyl-2-O-acetyl-3-O-[gamma-(dimethylamino)propyl]glycerol . | 1985 | J. Med. Chem. | pmid:4020830 |
| Brain SD and Williams TJ | Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability. | 1985 | Br. J. Pharmacol. | pmid:2416378 |
| Touqui L et al. | 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylcholine is the precursor of platelet-activating factor in stimulated rabbit platelets. Evidence for an alkylacetyl-glycerophosphorylcholine cycle. | 1985 | Biochim. Biophys. Acta | pmid:3967037 |
| Weber N and Benning H | Ether glycerolipids: novel substrates for studying specificity of enzymes involved in glycerolipid biosynthesis in higher plants. | 1985 | Eur. J. Biochem. | pmid:3967662 |
| O'Neill C | Partial characterization of the embryo-derived platelet-activating factor in mice. | 1985 | J. Reprod. Fertil. | pmid:4067921 |
| Mallet AI and Cunningham FM | Structural identification of platelet activating factor in psoriatic scale. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3970690 |
| Valone FH | Inhibition of binding of the platelet-activating factor AGEPC to platelets by the AGEPC analog rac-3-(N-n-octadecylcarbamoyloxy)-2-methoxypropyl 2-thiazolioethyl phosphate (CV-3988). | 1985 | Biochem. Biophys. Res. Commun. | pmid:3970703 |
| Camussi G and Brentjens JR | Inhalation of horseradish peroxidase by rabbits with specific IgE antibodies results in release into the circulation of platelet-activating factor and in lung lesions. | 1985 | Clin. Immunol. Immunopathol. | pmid:3971603 |
| Darius H et al. | Beneficial effects of a new potent and specific thromboxane receptor antagonist (SQ-29,548) in vitro and in vivo. | 1985 | J. Pharmacol. Exp. Ther. | pmid:2997428 |
| Chesney CM et al. | Desensitization of human platelets by platelet activating factor. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3977920 |
| Nakayama R et al. | Generation of acetyl glyceryl ether phosphorylcholine from the rat skin and muscle tissues stimulated by moxibustion. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3977939 |
| Archer CB et al. | Accumulation of inflammatory cells in response to intracutaneous platelet activating factor (Paf-acether) in man. | 1985 | Br. J. Dermatol. | pmid:3978036 |
| Gerdin B et al. | Permeability-increasing ability of PAF-acether in rat skin. | 1985 | Inflammation | pmid:3980073 |
| Emeis JJ and Kluft C | PAF-acether-induced release of tissue-type plasminogen activator from vessel walls. | 1985 | Blood | pmid:3924144 |
| Ardaillou N et al. | Vasoconstrictor-evoked prostaglandin synthesis in cultured human mesangial cells. | 1985 | Am. J. Physiol. | pmid:3918460 |
| Benveniste J and Chignard M | A role for PAF-acether (platelet-activating factor) in platelet-dependent vascular diseases? | 1985 | Circulation | pmid:3928192 |
| Lee TC | Biosynthesis of platelet activating factor. Substrate specificity of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase in rat spleen microsomes. | 1985 | J. Biol. Chem. | pmid:4030776 |
| Wissner A et al. | Analogues of platelet activating factor (PAF). 2. Some modifications of the glycerine backbone. | 1985 | J. Med. Chem. | pmid:4032422 |
| Pritchard PH et al. | The degradation of platelet-activating factor in the plasma of a patient with familial high density lipoprotein deficiency (Tangier disease). | 1985 | Blood | pmid:4063532 |
| Wissner A et al. | Analogues of platelet activating factor. 3. Replacement of the phosphate moiety with a sulfonylbismethylene group. | 1985 | J. Med. Chem. | pmid:4032438 |
| Wimberly HC et al. | Functional and biochemical characterization of immunologically derived equine platelet-activating factor. | 1985 | Vet. Pathol. | pmid:4035942 |
| MacIntyre DE et al. | Tumour-promoting phorbol esters inhibit agonist-induced phosphatidate formation and Ca2+ flux in human platelets. | 1985 | FEBS Lett. | pmid:2981715 |
| Ludwig JC et al. | Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular albumin. | 1985 | Arch. Biochem. Biophys. | pmid:4037794 |
| Surles JR et al. | Facile synthesis of platelet-activating factor and racemic analogues containing unsaturation in the sn-1-alkyl chain. | 1985 | J. Med. Chem. | pmid:4038418 |
| Aul C et al. | [Thrombotic thrombocytopenic purpura]. | 1985 | Klin. Wochenschr. | pmid:4038757 |
| Hanahan DJ et al. | A novel approach to structure proof of glyceryl ether-containing glycerophospholipids. Base-catalyzed methanolysis of platelet-activating factor (AGEPC) at 60 degrees C. | 1985 | J. Lipid Res. | pmid:4067422 |
| Atkins JN | Platelet-aggregating factor in thrombotic thrombocytopenic purpura. | 1985 | Ann. Intern. Med. | pmid:4038861 |
| Cordón-Cardó C | [The barley cell or mastocyte: cellular and molecular biology]. | 1985 | Med Clin (Barc) | pmid:2580196 |
| Klöcking HP et al. | Release of tissue-type plasminogen activator by platelet-activating factor. | 1985 | Thromb. Res. | pmid:4040278 |
| Pedersen AK and FitzGerald GA | Cyclooxygenase inhibition, platelet function, and metabolite formation during chronic sulfinpyrazone dosing. | 1985 | Clin. Pharmacol. Ther. | pmid:3917387 |
| McManus LM and Pinckard RN | Kinetics of acetyl glyceryl ether phosphorylcholine (AGEPC)-induced acute lung alterations in the rabbit. | 1985 | Am. J. Pathol. | pmid:4050977 |
| Disselnkötter H et al. | [Synthesis of phosphono analogs of 2-O-acetyl-1-O-hexadecyl(octadecyl)-sn-3-glycerylphosphorylcholine (platelet-activating factor)]. | 1985 | Arch. Pharm. (Weinheim) | pmid:4051690 |
| Robinson M and Snyder F | Metabolism of platelet-activating factor by rat alveolar macrophages: lyso-PAF as an obligatory intermediate in the formation of alkylarachidonoyl glycerophosphocholine species. | 1985 | Biochim. Biophys. Acta | pmid:4052436 |
| Vanhoutte PM and Houston DS | Platelets, endothelium, and vasospasm. | 1985 | Circulation | pmid:3861273 |
| Oda M et al. | Molecular species of platelet-activating factor generated by human neutrophils challenged with ionophore A23187. | 1985 | J. Immunol. | pmid:3917470 |
| Bergelson LD et al. | Influence of platelet activation factor and prostaglandins on cholesterol esterification in human plasma. | 1985 | FEBS Lett. | pmid:4043408 |
| Kilpatrick JM and Virella G | Inhibition of platelet-activating factor by rabbit C-reactive protein. | 1985 | Clin. Immunol. Immunopathol. | pmid:4042435 |
| Monnens L et al. | Platelet aggregating factor in the epidemic form of hemolytic-uremic syndrome in childhood. | 1985 | Clin. Nephrol. | pmid:4042442 |
| Pirotzky E et al. | Vascular permeability induced by Paf-acether (platelet-activating factor) in the isolated perfused rat kidney. | 1985 | Agents Actions | pmid:4003192 |
| Page CP et al. | Platelet activating factor (Paf-acether) may account for late-onset reactions to allergen inhalation. | 1985 | Agents Actions | pmid:4003195 |
| Page CP et al. | Suppression of Paf-acether responses: an anti-inflammatory effect of anti-asthma drugs. | 1985 | Agents Actions | pmid:4003196 |
| Spicer BA et al. | An investigation of the involvement of platelet activating factor in the non-histamine immediate hypersensitivity reaction in the rat peritoneal cavity. | 1985 | Agents Actions | pmid:4003197 |
| Sandler RM et al. | Heparin-induced thrombocytopenia and thrombosis: detection and specificity of a platelet-aggregating IgG. | 1985 | Am. J. Clin. Pathol. | pmid:4003343 |
| Tencé M et al. | Ether-phospholipid composition in neutrophils and platelets. | 1985 | Thromb. Res. | pmid:4024039 |
| Oda M et al. | Production of platelet-activating factor by washed rabbit platelets. | 1985 | J. Lipid Res. | pmid:3934305 |
| Tan EL and Snyder F | Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by capillary endothelial cells isolated from rat epididymal adipose tissue. | 1985 | Thromb. Res. | pmid:4024051 |
| Weisman SM et al. | Platelet-activating factor is a potent stimulus for renal prostaglandin synthesis: possible significance in unilateral ureteral obstruction. | 1985 | J. Pharmacol. Exp. Ther. | pmid:3862805 |
| O'Flaherty JT | Neutrophil degranulation: evidence pertaining to its mediation by the combined effects of leukotriene B4, platelet-activating factor, and 5-HETE. | 1985 | J. Cell. Physiol. | pmid:2981891 |
| Khan SN et al. | Desaggregation of PAF-acether-aggregated platelets by verapamil and TMB-8 with reversal of phosphorylation of 40K and 20K proteins. | 1985 | Eur. J. Pharmacol. | pmid:3920056 |
| Bushfield M et al. | Inhibition of platelet-activating-factor-induced human platelet activation by prostaglandin D2. Differential sensitivity of platelet transduction processes and functional responses to inhibition by cyclic AMP. | 1985 | Biochem. J. | pmid:3002327 |
| O'Neill C et al. | Maternal recognition of pregnancy prior to implantation: methods for monitoring embryonic viability in vitro and in vivo. | 1985 | Ann. N. Y. Acad. Sci. | pmid:2409860 |
| Sage SO and Rink TJ | Inhibition by forskolin of cytosolic calcium rise, shape change and aggregation in quin2-loaded human platelets. | 1985 | FEBS Lett. | pmid:2410292 |
| Grandel KE et al. | Association of platelet-activating factor with primary acquired cold urticaria. | 1985 | N. Engl. J. Med. | pmid:2410790 |
| Bussolino F et al. | Alkyl-ether phosphoglycerides influence calcium fluxes into human endothelial cells. | 1985 | J. Immunol. | pmid:2411812 |
| Johnson HM and Torres BA | Mechanism of calcium ionophore A23187-induced priming of bone marrow-derived macrophages for tumor cell killing: relationship to priming by interferon. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2412225 |
| Fjellner B and Hägermark O | Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin. | 1985 | Acta Derm. Venereol. | pmid:2416164 |
| Shen TY et al. | Characterization of a platelet-activating factor receptor antagonist isolated from haifenteng (Piper futokadsura): specific inhibition of in vitro and in vivo platelet-activating factor-induced effects. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2983307 |
| Avdonin PV and Altukhova IP | [Blocking with phorbol ester, a protein kinase C activator, of receptor-dependent platelet calcium channels]. | 1985 | Biokhimiia | pmid:2416359 |
| Pannocchia A and Hardisty RM | Cyclic AMP inhibits platelet activation independently of its effect on cytosolic free calcium. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2983714 |
| Avdonin PV et al. | [Mechanism of increase in Ca2+ level in platelet cytoplasm induced by aggregating factors]. | 1985 | Biokhimiia | pmid:3000463 |
| Lee TD et al. | Heterogeneity in mast cell populations. | 1985 | Clin Immunol Rev | pmid:2417770 |
| Leclercq M et al. | [Effects of Hymenoptera stings: physiopathology and immunology according to recent literature findings]. | 1985 | Rev Med Liege | pmid:2418479 |
| Pipili E | Platelet membrane potential: simultaneous measurement of diSC3(5) fluorescence and optical density. | 1985 | Thromb. Haemost. | pmid:2418525 |
| Nishihira J et al. | Purification and characterization of the specific binding protein for platelet activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from human platelets. | 1985 | Tohoku J. Exp. Med. | pmid:3001971 |