| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Moore TL and Weiss TD | Mediators of inflammation. | 1985 | Semin. Arthritis Rheum. | pmid:3936177 |
| Juhan-Vague I et al. | Possible participation of adenosine 5'-diphosphate, arachidonic acid and paf-acether in the platelet pro-aggregating effect of uncontrolled insulin-dependent diabetic erythrocytes in vitro. | 1985 | Thromb. Res. | pmid:3923649 |
| Vanderwel M and Haslam RJ | Inhibition and subsequent enhancement of platelet responsiveness by prostacyclin in the rabbit. Relationship to platelet adenosine 3',5'-cyclic monophosphate. | 1985 | J. Clin. Invest. | pmid:2991338 |
| Naccache PH et al. | Unique inhibitory profile of platelet activating factor induced calcium mobilization, polyphosphoinositide turnover and granule enzyme secretion in rabbit neutrophils towards pertussis toxin and phorbol ester. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2992480 |
| MacIntyre DE et al. | Regulation of platelet cytosolic free calcium by cyclic nucleotides and protein kinase C. | 1985 | FEBS Lett. | pmid:2993027 |
| Hayashi H et al. | Activation of guinea pig peritoneal macrophages by platelet activating factor (PAF) and its agonists. | 1985 | J. Biochem. | pmid:2993272 |
| Avdonin PV et al. | Stimulation of high-affinity hormone-sensitive GTPase of human platelets by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphocholine (platelet activating factor). | 1985 | Biochem. Biophys. Res. Commun. | pmid:2994653 |
| Maridonneau-Parini I et al. | Desensitization to PAF-induced bronchoconstriction and to activation of alveolar macrophages by repeated inhalations of PAF in the guinea pig. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2994661 |
| Zukowska-Grojec Z et al. | The adrenergic system and the cardiovascular effects of platelet activating factor (1-0-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine) in SHR and WKY rats. | 1985 | Clin Exp Hypertens A | pmid:2994912 |
| Murer EH | The role of platelet calcium. | 1985 | Semin. Hematol. | pmid:3901271 |
| Davis JW et al. | Effects of tobacco and non-tobacco cigarette smoking on endothelium and platelets. | 1985 | Clin. Pharmacol. Ther. | pmid:3987176 |
| O'Neill C | Examination of the causes of early pregnancy-associated thrombocytopenia in mice. | 1985 | J. Reprod. Fertil. | pmid:3989801 |
| Kertscher HP and Ostermann G | [Synthesis and biological activity of isomeric structural analogs of platelet activating factor]. | 1985 | Pharmazie | pmid:3991788 |
| Wal F et al. | PAF-acether may not mediate the third pathway of platelet aggregation since self-desensitization reduces the effects of low thrombin but enhances those of convulxin. | 1985 | Thromb. Haemost. | pmid:3992525 |
| Khan SN et al. | Response to platelet-activating factor of platelets from patients with multiple sclerosis. | 1985 | Acta Neurol. Scand. | pmid:3993327 |
| Tokumura A et al. | Structural analogs of alkylacetylglycerophosphocholine inhibitory behavior on platelet activation. | 1985 | J. Biol. Chem. | pmid:3840169 |
| Sánchez-Crespo M et al. | Inhibition of the vascular actions of IgG aggregates by BN 52021, a highly specific antagonist of paf-acether. | 1985 | Immunopharmacology | pmid:3840779 |
| Billah MM et al. | Lipoxygenase products of arachidonic acid modulate biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by human neutrophils via phospholipase A2. | 1985 | J. Biol. Chem. | pmid:3922982 |
| Foa R et al. | Release of platelet-activating factor in human leukemia. | 1985 | Cancer Res. | pmid:3861246 |
| Otsuka A et al. | Hypotensive mechanism of acetyl glyceryl ether phosphorylcholine (AGEPC) in dogs. Effects on hemodynamics and humoral factors. | 1985 | Prostaglandins Leukot Med | pmid:3862138 |
| Haslam RJ et al. | Receptor-effector coupling in platelets: roles of guanine nucleotides. | 1985 | Adv. Exp. Med. Biol. | pmid:3010668 |
| Weintraub ST et al. | Fast atom bombardment-mass spectrometric identification of molecular species of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4015656 |
| Archer CB et al. | Inflammatory cell accumulation in response to intracutaneous Paf-acether: a mediator of acute and persistent inflammation? | 1985 | Br. J. Dermatol. | pmid:4015978 |
| Morley J et al. | The role of circulating cells in skin reactions. | 1985 | Br. J. Dermatol. | pmid:4015983 |
| Pirotzky E et al. | A role for Paf-acether (platelet-activating factor) in acute skin inflammation? | 1985 | Br. J. Dermatol. | pmid:4015984 |
| Ohno M et al. | An enantioselective synthesis of platelet-activating factors, their enantiomers, and their analogues from D- and L-tartaric acids. | 1985 | Chem. Pharm. Bull. | pmid:4017109 |
| O'Neill C et al. | Maternal blood platelet physiology and luteal-phase endocrinology as a means of monitoring pre- and postimplantation embryo viability following in vitro fertilization. | 1985 | J In Vitro Fert Embryo Transf | pmid:4020241 |
| Heymans F et al. | Structure-activity relationship in PAF-acether. 2. rac-1-O-Octadecyl-2-O-acetyl-3-O-[gamma-(dimethylamino)propyl]glycerol . | 1985 | J. Med. Chem. | pmid:4020830 |
| Suemune H et al. | Synthetic studies on platelet-activating factor (PAF). | 1985 | Chem. Pharm. Bull. | pmid:4028291 |
| Parente L et al. | The release of lyso-PAF from guinea-pig lungs. | 1985 | Eur. J. Pharmacol. | pmid:4029263 |
| Young JM et al. | Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse. | 1985 | Prostaglandins | pmid:4081060 |
| Is there a case for PAF-acether antagonists? Institut Pasteur, Paris, 21 June 1985. Abstracts. | 1985 | Prostaglandins | pmid:4081064 | |
| Valone FH and Johnson B | Decay of the activating signal after platelet stimulation with 1-0-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine: changes in calcium permeability. | 1985 | Thromb. Res. | pmid:4082115 |
| Scherer GF | 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) stimulates plant H+ transport in vitro and growth. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4084306 |
| Handley DA et al. | Evidence for a direct effect on vascular permeability of platelet-activating factor induced hemoconcentration in the guinea pig. | 1985 | Thromb. Haemost. | pmid:4089809 |
| Hemker HC and Béguin S | The generation of thrombin in whole plasma. Biochemical possibilities and physiological realities. | 1985 | Verh. K. Acad. Geneeskd. Belg. | pmid:4090648 |
| Hallam TJ et al. | Relationship between cytoplasmic free calcium and myosin light chain phosphorylation in intact platelets. | 1985 | Biochem. J. | pmid:4091795 |
| Fouque F and Vargaftig BB | Adrenaline/PAF acether synergism on human platelets: involvement of Hydergine. | 1985 | J Pharmacol | pmid:4094442 |
| Armstrong RA et al. | Mechanism of the inhibition of platelet aggregation produced by prostaglandin F2 alpha. | 1985 | Prostaglandins | pmid:2988022 |
| Dewald B and Baggiolini M | Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2985075 |
| Peach MJ et al. | Mechanisms of endothelium-dependent vascular smooth muscle relaxation. | 1985 | Biochem. Pharmacol. | pmid:2988558 |
| Orlov SM et al. | [Histamine release from human leukocytes after treatment with 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) and its structural analogs]. | 1985 | Biokhimiia | pmid:2408682 |
| Braquet M et al. | Leukocytic functions in burn-injured patients. | 1985 | Prostaglandins | pmid:2989978 |
| Hallam TJ and Rink TJ | Agonists stimulate divalent cation channels in the plasma membrane of human platelets. | 1985 | FEBS Lett. | pmid:2408921 |
| Snyder F | Chemical and biochemical aspects of platelet activating factor: a novel class of acetylated ether-linked choline-phospholipids. | 1985 Jan-Mar | Med Res Rev | pmid:2984489 |
| Kozubski W and Stańczyk L | [Platelet aggregation in patients with migraine during the pain attack and in the pain-free period]. | 1985 Jul-Aug | Neurol. Neurochir. Pol. | pmid:4094642 |
| Bette-Bobillo P et al. | Synthesis and characterization of a radioiodinated, photoreactive and physiologically active analogue of platelet activating factor. | 1985 Jun-Jul | Chem. Phys. Lipids | pmid:4042252 |
| Leprán I and Lefer AM | Ischemia aggravating effects of platelet-activating factor in acute myocardial ischemia. | 1985 Mar-Apr | Basic Res. Cardiol. | pmid:4039929 |
| Feuerstein G et al. | Thyrotropin-releasing hormone blocks the hypotensive effects of platelet-activating factor in the unanesthetized guinea pig. | 1985 Mar-Apr | J. Cardiovasc. Pharmacol. | pmid:2581089 |
| Mencia-Huerta JM | Possible role of the T-cell-factor-dependent mast cell subclass in the generation of leukotrienes from lung. | 1985 Sep-Oct | Ann. Inst. Pasteur Immunol. | pmid:3878684 |
| Masugi F et al. | Role of acetyl glyceryl ether phosphorylcholine in blood pressure regulation in rats. | 1985 Sep-Oct | Hypertension | pmid:4030044 |
| Yamazaki H | [Recent medical topics on platelets in hemorrhagic and thrombotic diseases]. | 1986 | Nippon Naika Gakkai Zasshi | pmid:3027214 |
| Rink TJ | Stimulus-response coupling mechanisms in human platelets. | 1986 | Agents Actions Suppl. | pmid:3028101 |
| Vanhoutte PM et al. | Modulation of vascular smooth muscle contraction by the endothelium. | 1986 | Annu. Rev. Physiol. | pmid:2871807 |
| Handley DA et al. | Inhibition and reversal of endotoxin-, aggregated IgG- and paf-induced hypotension in the rat by SRI 63-072, a paf receptor antagonist. | 1986 | Immunopharmacology | pmid:3019921 |
| Hwang SB et al. | Specific binding of [3H]dihydrokadsurenone to rabbit platelet membranes and its inhibition by the receptor agonists and antagonists of platelet-activating factor. | 1986 | J. Biol. Chem. | pmid:3020044 |
| Biftu T et al. | Conformation and activity of tetrahydrofuran lignans and analogues as specific platelet activating factor antagonists. | 1986 | J. Med. Chem. | pmid:3020247 |
| Zanetti A et al. | The effect of AD6 (8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxy- carbonylmethoxycoumarin) on washed human platelet aggregation induced by platelet activating factor (PAF) and epinephrine. | 1986 | Eur. J. Pharmacol. | pmid:2944757 |
| Bush LR and Smith SG | Antagonism of U46619-induced aggregation of human and canine platelets by four TXA2 receptor antagonists. | 1986 | Thromb. Res. | pmid:2948294 |
| Valone FH and Ruis NM | Platelet-activating factor binding to human platelet membranes. | 1986 | Biotechnol. Appl. Biochem. | pmid:3021183 |
| Braquet P | Proofs of involvement of PAF-acether in various immune disorders using BN 52021 (ginkgolide B): a powerful PAF-acether antagonist isolated from Ginkgo biloba L. | 1986 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2949548 |
| Bourgain RH et al. | Vivo effects of PAF-acether and arterial thrombosis. | 1986 | Adv. Exp. Med. Biol. | pmid:3799334 |
| Kloprogge E et al. | PAF-acether (1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphocholine)-induced fibrinogen binding to platelets depends on metabolic energy. | 1986 | Biochem. J. | pmid:3800968 |
| Panchenko EP et al. | [Free cytoplasmic calcium and thrombocyte aggregation in patients with ischemic heart disease. The effect of ADP, thrombocyte activation factor and serotonin]. | 1986 | Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR | pmid:3801147 |
| Chamone DF et al. | Increased levels of eosinophil-derived PAF-acether activity in a patient with idiopathic hypereosinophilic syndrome. | 1986 | Braz. J. Med. Biol. Res. | pmid:3801724 |
| Toth PD and Mikulaschek AW | Effects of a platelet-activating factor antagonist, CV-3988, on different shock models in the rat. | 1986 | Circ. Shock | pmid:3802423 |
| Desquand S et al. | Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig. | 1986 | Eur. J. Pharmacol. | pmid:3019727 |
| Daniel LW et al. | A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine. | 1986 | J. Biol. Chem. | pmid:3087989 |
| Malavasi F et al. | Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3085094 |
| Wissner A et al. | Analogues of platelet activating factor. 5. Multiple oxygen substitution of the alkoxy chain. | 1986 | J. Med. Chem. | pmid:3806583 |
| Simpson AW et al. | Low concentrations of the stable prostaglandin endoperoxide U44069 stimulate shape change in quin2-loaded platelets without a measurable increase in [Ca2+]i. | 1986 | FEBS Lett. | pmid:3086128 |
| Nakaya H and Tohse N | Electrophysiological effects of acetyl glyceryl ether phosphorylcholine on cardiac tissues: comparison with lysophosphatidylcholine and long chain acyl carnitine. | 1986 | Br. J. Pharmacol. | pmid:3814909 |
| Schlondorff D et al. | Production of platelet-activating factor in glomeruli and cultured glomerular mesangial cells. | 1986 | Am. J. Physiol. | pmid:3087218 |
| Coëffier E et al. | Effects of PAF-acether and structural analogues on platelet activation and bronchoconstriction in guinea-pigs. | 1986 | Eur. J. Pharmacol. | pmid:3816952 |
| Lynch JM and Henson PM | The intracellular retention of newly synthesized platelet-activating factor. | 1986 | J. Immunol. | pmid:3093579 |
| McMurtry IF and Morris KG | Platelet-activating factor causes pulmonary vasodilation in the rat. | 1986 | Am. Rev. Respir. Dis. | pmid:3094417 |
| Gillespie MN and Bowdy BD | Impact of platelet activating factor on vascular responsiveness in isolated rat lungs. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3944767 |
| Viero P et al. | Thrombotic thrombocytopenic purpura and high-dose immunoglobulin treatment. | 1986 | Ann. Intern. Med. | pmid:3946966 |
| Siafaka-Kapadai A et al. | Biological activity of lipids of pine pollen on platelet aggregation in correlation with the platelet activating factor. | 1986 | Biochem. Int. | pmid:3947373 |
| McManus LM | Pathobiology of platelet-activating factors. | 1986 | Pathol Immunopathol Res | pmid:3543915 |
| Davis RB and Johnson MF | Effects of bacterial endotoxin and platelet activating factor (PAF) on human platelet aggregation in native whole blood. | 1986 | Thromb. Res. | pmid:3544327 |
| Darius H et al. | Inhibition of the platelet activating factor mediated component of guinea pig anaphylaxis by receptor antagonists. | 1986 | Int. Arch. Allergy Appl. Immunol. | pmid:3015804 |
| Kloprogge E et al. | Kinetics of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced fibrinogen binding to human platelets. | 1986 | J. Biol. Chem. | pmid:3015954 |
| O'Flaherty JT et al. | Binding and metabolism of platelet-activating factor by human neutrophils. | 1986 | J. Clin. Invest. | pmid:3016027 |
| Hanahan DJ | Platelet activating factor: a biologically active phosphoglyceride. | 1986 | Annu. Rev. Biochem. | pmid:3017194 |
| Bette-Bobillo P et al. | Interaction between blood components and a spin-labeled analogue of PAF-acether. | 1986 | Biochim. Biophys. Acta | pmid:3017416 |
| Coëffier E et al. | Transient activation of the acetyltransferase necessary for paf-acether biosynthesis in thrombin-activated platelets. | 1986 | Br. J. Haematol. | pmid:3964558 |
| Raaijmakers JA et al. | Phospholipase A2 products induce pulmonary beta-adrenoceptor deviations. | 1986 | Eur. J. Pharmacol. | pmid:3019725 |
| Bachelet M et al. | Changes induced by PAF-acether in diacyl and ether phospholipids from guinea-pig alveolar macrophages. | 1986 | Biochim. Biophys. Acta | pmid:3092866 |
| Alonso F et al. | A cytosolic phospholipase in human neutrophils that hydrolyzes arachidonoyl-containing phosphatidylcholine. | 1986 | Biochim. Biophys. Acta | pmid:3092867 |
| Foegh ML et al. | Fatty acids and eicosanoids in organ transplantation. | 1986 | Prog. Lipid Res. | pmid:3321095 |
| McKean ML et al. | Formation of diacyl- and alkylacylphosphatidylcholine by the membranes of human platelets. | 1986 | FEBS Lett. | pmid:3943622 |
| Dewald B and Baggiolini M | Platelet-activating factor as a stimulus of exocytosis in human neutrophils. | 1986 | Biochim. Biophys. Acta | pmid:3017443 |
| Ostermann G et al. | Stimulation and desensitization of human and rabbit platelets by 1-O-hexadecyl-2-O-methyl-rac-glycero-3-phosphocholine and analogues. | 1986 | Thromb. Res. | pmid:3764811 |
| First International Alexis Carrel Conference on Lipid Mediators in Organ Transplantation. April 8-10, 1986, Washington, DC. | 1986 | Transplant. Proc. | pmid:3765055 | |
| Satoh K and Takamatsu S | [Inactivation by plasma of platelet-activating factor]. | 1986 | Nippon Ketsueki Gakkai Zasshi | pmid:3766067 |
| Gordeev KIu et al. | [Synthesis of thioanalogs of platelet activating factor (PAF)]. | 1986 | Bioorg. Khim. | pmid:3768051 |
| Thomas Y et al. | [Synthesis of paf-acether by E. coli K12]. | 1986 | C. R. Acad. Sci. III, Sci. Vie | pmid:3101984 |
| Küster LJ and Frölich JC | Platelet aggregation and thromboxane release induced by arachidonic acid, collagen, ADP and platelet-activating factor following low dose acetylsalicylic acid in man. | 1986 | Prostaglandins | pmid:3097760 |
| Salari H | Solid-phase extraction and reversed-phase high-performance liquid chromatographic technique for isolation and estimation of platelet activating factor in plasma. | 1986 | J. Chromatogr. | pmid:3782417 |