| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shibamoto T et al. | PAF, rather than histamine, participates in mouse anaphylactic hypotension. | 2008 | Pharmacology | pmid:18583921 |
| Zhang XP et al. | The pathogenic mechanism of severe acute pancreatitis complicated with renal injury: a review of current knowledge. | 2008 | Dig. Dis. Sci. | pmid:17597411 |
| Smith JC et al. | Identification of lysophosphatidylcholine (LPC) and platelet activating factor (PAF) from PC12 cells and mouse cortex using liquid chromatography/multi-stage mass spectrometry (LC/MS3). | 2008 | Rapid Commun. Mass Spectrom. | pmid:18937225 |
| Kihara Y et al. | Platelet-activating factor production in the spinal cord of experimental allergic encephalomyelitis mice via the group IVA cytosolic phospholipase A2-lyso-PAFAT axis. | 2008 | J. Immunol. | pmid:18802104 |
| Wislet-Gendebien S et al. | Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors. | 2008 | BMC Neurosci | pmid:18808659 |
| Zheng M et al. | (3S)-N-(L-Aminoacyl)-1,2,3,4-tetrahydroisoquinolines, a class of novel antithrombotic agents: synthesis, bioassay, 3D QSAR, and ADME analysis. | 2008 | Bioorg. Med. Chem. | pmid:18835178 |
| Vadas P et al. | Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis. | 2008 | N. Engl. J. Med. | pmid:18172172 |
| Burks AW | Factoring PAF in anaphylaxis. | 2008 | N. Engl. J. Med. | pmid:18172180 |
| Menzies-Gow NJ et al. | Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses. | 2008 | Am. J. Vet. Res. | pmid:18241016 |
| Li J et al. | PMS777, a bis-interacting ligand for PAF receptor antagonism and AChE inhibition, attenuates PAF-induced neurocytotoxicity in SH-SY5Y cells. | 2008 | Cell. Mol. Neurobiol. | pmid:17712622 |
| Hemetsberger R et al. | Association between the efficacy of dual antiplatelet therapy and the development of in-stent neointimal hyperplasia in porcine coronary arteries. | 2008 | Coron. Artery Dis. | pmid:19005299 |
| Kasperska-Zajac A et al. | Platelet-activating factor (PAF): a review of its role in asthma and clinical efficacy of PAF antagonists in the disease therapy. | 2008 | Recent Pat Inflamm Allergy Drug Discov | pmid:19075994 |
| XUE M et al. | Relationship between platelet activation related factors and polymorphism of related genes in patients with coronary heart disease of blood-stasis syndrome. | 2008 | Chin J Integr Med | pmid:19082798 |
| Shiva D et al. | High dose of lipopolysaccharide pre-treatment prevents OVA-induced anaphylactic decreases in rectal temperature in the immunized mice. | 2008 | Immunol. Lett. | pmid:18433880 |
| Leary PJ et al. | A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18441203 |
| Cooper D et al. | Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. | 2008 | J. Leukoc. Biol. | pmid:18372340 |
| Bansal AS et al. | Platelet-activating factor, PAF acetylhydrolase, and anaphylaxis. | 2008 | N. Engl. J. Med. | pmid:18389523 |
| Okamoto H and Kamatani N | Platelet-activating factor, PAF acetylhydrolase, and anaphylaxis. | 2008 | N. Engl. J. Med. | pmid:18389524 |
| Torres MI and Rios A | Current view of the immunopathogenesis in inflammatory bowel disease and its implications for therapy. | 2008 | World J. Gastroenterol. | pmid:18395894 |
| Kim HA et al. | Nitric oxide plays a key role in the platelet-activating factor-induced enhancement of resistance against systemic candidiasis. | 2008 | Immunology | pmid:18397269 |
| Galli SJ and Franco CB | Basophils are back! | 2008 | Immunity | pmid:18400194 |
| Levy JH | Platelet-activating factor, PAF acetylhydrolase, and anaphylaxis. | 2008 | N. Engl. J. Med. | pmid:18385504 |
| Sreevidya CS et al. | Inhibition of photocarcinogenesis by platelet-activating factor or serotonin receptor antagonists. | 2008 | Cancer Res. | pmid:18483284 |
| Burks AW | Peanut allergy. | 2008 | Lancet | pmid:18456104 |
| Huang GD et al. | Effect of volatile oil of amomum on expressions of platelet activating factor and mastocarcinoma-related peptide in the gastric membrane of chronic gastritis patients with helicobacter-pylori infection. | 2008 | Chin J Integr Med | pmid:18568325 |
| Landgraf RG et al. | Prostaglandins, leukotrienes and PAF selectively modulate lymphocyte subset and eosinophil infiltration into the airways in a murine model of asthma. | 2007 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17923399 |
| Vadnais ML et al. | Current concepts of molecular events during bovine and porcine spermatozoa capacitation. | 2007 May-Jun | Arch. Androl. | pmid:17612869 |
| Rosenwasser L | New insights into the pathophysiology of allergic rhinitis. | 2007 Jan-Feb | Allergy Asthma Proc | pmid:17390750 |
| Hattermann K et al. | The Toll-like receptor 7/8-ligand resiquimod (R-848) primes human neutrophils for leukotriene B4, prostaglandin E2 and platelet-activating factor biosynthesis. | 2007 | FASEB J. | pmid:17264163 |
| De Vriese C et al. | Ghrelin interacts with human plasma lipoproteins. | 2007 | Endocrinology | pmid:17289852 |
| Li SQ et al. | Improving effect of Ginkgolide B on mitochondrial respiration of ischemic neuron after cerebral thrombosis in tree shrewa. | 2007 | Chin. Med. J. | pmid:17908463 |
| Doublier S et al. | The proangiogenic phenotype of tumor-derived endothelial cells is reverted by the overexpression of platelet-activating factor acetylhydrolase. | 2007 | Clin. Cancer Res. | pmid:17908960 |
| Shimada T et al. | Cross-regulation of cortisol secretion by adrenocorticotropin and platelet-activating factor in perfused guinea pig adrenals. | 2007 | J. Endocrinol. | pmid:17911394 |
| Whitehead SN et al. | Identification and quantitation of changes in the platelet activating factor family of glycerophospholipids over the course of neuronal differentiation by high-performance liquid chromatography electrospray ionization tandem mass spectrometry. | 2007 | Anal. Chem. | pmid:17949058 |
| Bixby CE et al. | Role of platelet-activating factor in pulmonary vascular remodeling associated with chronic high altitude hypoxia in ovine fetal lambs. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17951313 |
| Liu WC et al. | Lipopolysaccharide-induced cerebral inflammatory damage and the therapeutic effect of platelet activating factor receptor antagonist. | 2007 | Neurosci Bull | pmid:17952135 |
| Wu B et al. | [Effects of bificobacterium longum on neonatal rat model of necrotizing enterocolitis and roles of platelet-activating factor and tumor necrosis factor-alpha]. | 2007 | Zhonghua Er Ke Za Zhi | pmid:17953818 |
| Owen JS et al. | Platelet-activating factor. | 2007 | Meth. Enzymol. | pmid:17954244 |
| Ying-fang S et al. | Effect of platelet-activating factor on cell proliferation & NF-kappaB activation in airway smooth muscle cells in rats. | 2007 | Indian J. Med. Res. | pmid:17932440 |
| Guerra CT et al. | Effect of chronic hepatitis C virus infection on inflammatory lipid mediators. | 2007 | Dig Liver Dis | pmid:17936229 |
| Kawano Y et al. | The effects of platelet-activating factor on the secretion of interleukin-8 and growth-regulated oncogene alpha in human immortalized granulosa cell line (GC1a). | 2007 | Am. J. Reprod. Immunol. | pmid:17922696 |
| Keam SJ and Plosker GL | Rupatadine: a review of its use in the management of allergic disorders. | 2007 | Drugs | pmid:17335300 |
| Van Overloop H et al. | On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase. | 2007 | Biol. Chem. | pmid:17338639 |
| Ebihara S et al. | A simple preparation method for mouse eosinophils and their responses to anti-allergic drugs. | 2007 | Inflamm. Res. | pmid:17406808 |
| Simonenko VB et al. | [Comparative evaluation of the influence of sulfhydryl and phosphate ACE inhibitors on thrombocyte aggregation in patients suffering from atrerial hypertension with metabolic syndrome]. | 2007 | Klin Med (Mosk) | pmid:17564032 |
| Li Y et al. | Autocrine activation of ion currents in the two-cell mouse embryo. | 2007 | Exp. Cell Res. | pmid:17583695 |
| Martin J et al. | The dialogue between endothelial cells and monocytes/macrophages in vascular syndromes. | 2007 | Curr. Pharm. Des. | pmid:17584105 |
| Ferreira MA et al. | Tumor growth, angiogenesis and inflammation in mice lacking receptors for platelet activating factor (PAF). | 2007 | Life Sci. | pmid:17588613 |
| Xia SH et al. | Significance of platelet activating factor receptor expression in pancreatic tissues of rats with severe acute pancreatitis and effects of BN52021. | 2007 | World J. Gastroenterol. | pmid:17589953 |
| Tosaki T et al. | Enhancement of acetyl-CoA: 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity by hydrogen peroxide. | 2007 | Biol. Pharm. Bull. | pmid:17268064 |
| Zhang X et al. | Down-regulation of platelet-activating factor receptor gene expression during focal reversible cerebral ischemia in rats. | 2007 | Neurochem. Res. | pmid:17268849 |
| Sandford RM et al. | The genetic basis of abdominal aortic aneurysms: a review. | 2007 | Eur J Vasc Endovasc Surg | pmid:17276705 |
| Slomiany BL and Slomiany A | Interference by leptin with Helicobacter pylori lipopolysaccharide-induced cytosolic phospholipase A2 activation in gastric mucosal cells. | 2007 | J. Physiol. Pharmacol. | pmid:17440231 |
| Ullrich SE | Sunlight and skin cancer: lessons from the immune system. | 2007 | Mol. Carcinog. | pmid:17443748 |
| Richter M et al. | Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17448648 |
| Finnegan EM et al. | Small-molecule cyclic alpha V beta 3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17483236 |
| Cattaneo M et al. | Platelet aggregation studies: autologous platelet-poor plasma inhibits platelet aggregation when added to platelet-rich plasma to normalize platelet count. | 2007 | Haematologica | pmid:17488697 |
| Kälvegren H et al. | Platelet activation triggered by Chlamydia pneumoniae is antagonized by 12-lipoxygenase inhibitors but not cyclooxygenase inhibitors. | 2007 | Eur. J. Pharmacol. | pmid:17459368 |
| Taheri F and Bazan HE | Platelet-activating factor overturns the transcriptional repressor disposition of Sp1 in the expression of MMP-9 in human corneal epithelial cells. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17460244 |
| Dinubile MJ | Plasma gelsolin: in search of its raison d'etre. Focus on "Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin". | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17428843 |
| Souza LJ et al. | Acute pancreatitis affects non-parenchymal liver cells by a mechanism dependent on platelet-activating factor. | 2007 | Pancreatology | pmid:17449968 |
| Shin CR et al. | Differential platelet-activating factor synthesis by monocytes and polymorphonuclear leukocytes from subjects with localized aggressive periodontitis. | 2007 | J. Periodont. Res. | pmid:17451539 |
| Truffinet V et al. | No effect of platelet-activating factor on the proliferation and apoptosis of immature forms of leukemic blasts. | 2007 | Leuk. Res. | pmid:17350684 |
| Zhao W et al. | [Effect of PAF on the expression of PACAP mRNA in the granulosa cells of rat ovary]. | 2007 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21180114 |
| Paterson WG et al. | Role of platelet-activating factor in acid-induced esophageal mucosal injury. | 2007 | Dig. Dis. Sci. | pmid:17415649 |
| Tsimikas S et al. | New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17626905 |
| Viergutz T and Löhrke B | Role of the platelet-activating factor and its receptor in the proliferative regulation of bovine ovarian granulosa cells. | 2007 | Cell Prolif. | pmid:18021181 |
| Chen Q et al. | The yeast acylglycerol acyltransferase LCA1 is a key component of Lands cycle for phosphatidylcholine turnover. | 2007 | FEBS Lett. | pmid:17996202 |
| Ezoulin MJ et al. | A new acetylcholinesterase inhibitor with anti-PAF activity modulates oxidative stress and pro-inflammatory mediators release in stimulated RAW 264.7 macrophage cells. Comparison with tacrine. | 2007 | Int. Immunopharmacol. | pmid:17996678 |
| Xavier RG et al. | Enhanced platelet aggregation and activation under conditions of hypothermia. | 2007 | Thromb. Haemost. | pmid:18064324 |
| Dunkel B et al. | Platelet activation in ponies with airway inflammation. | 2007 | Equine Vet. J. | pmid:18065316 |
| Lu SM et al. | The phospholipid mediator platelet-activating factor mediates striatal synaptic facilitation. | 2007 | J Neuroimmune Pharmacol | pmid:18040844 |
| Rockel N et al. | The osmolyte taurine protects against ultraviolet B radiation-induced immunosuppression. | 2007 | J. Immunol. | pmid:17785795 |
| Tsantila N et al. | Antithrombotic and antiatherosclerotic properties of olive oil and olive pomace polar extracts in rabbits. | 2007 | Mediators Inflamm. | pmid:18253466 |
| Li J et al. | Pharmacological profile of PMS777, a new AChE inhibitor with PAF antagonistic activity. | 2007 | Int. J. Neuropsychopharmacol. | pmid:16426477 |
| Melnikova V and Bar-Eli M | Inflammation and melanoma growth and metastasis: the role of platelet-activating factor (PAF) and its receptor. | 2007 | Cancer Metastasis Rev. | pmid:17721743 |
| Lo GK et al. | What is the potential for overdiagnosis of heparin-induced thrombocytopenia? | 2007 | Am. J. Hematol. | pmid:17722079 |
| Chen J et al. | Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis. | 2007 | J. Lipid Res. | pmid:17693621 |
| Takahashi T et al. | Neutrophil-activating activity and platelet-activating factor synthesis in cytokine-stimulated endothelial cells: reduced activity in growth-arrested cells. | 2007 | Microvasc. Res. | pmid:17027041 |
| Shi W et al. | [Study on composing mechanism by effect of disassembled compositions of Yiqi Huoxue decoction on platelet aggregation of health adults]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18309677 |
| Kuckleburg CJ et al. | Expression of phosphorylcholine by Histophilus somni induces bovine platelet aggregation. | 2007 | Infect. Immun. | pmid:17118985 |
| Ibe BO et al. | Platelet-activating factor modulates activity of cyclic nucleotides in fetal ovine pulmonary vascular smooth muscle. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17085546 |
| Saluk-Juszczak J et al. | The effect of lipopolysaccharide from Proteus mirabilis on the level of the stable end metabolic products of nitric oxide in blood platelets. | 2007 | Curr. Microbiol. | pmid:17160361 |
| Huang YH et al. | Suppression effect of seminal vesicle autoantigen on platelet-activating factor-induced mouse sperm capacitation. | 2007 | J. Cell. Biochem. | pmid:17131380 |
| Osborn TM et al. | Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17135294 |
| Bathgate R et al. | Effects of platelet-activating factor and platelet-activating factor: acetylhydrolase on in vitro post-thaw boar sperm parameters. | 2007 | Theriogenology | pmid:17157372 |
| Hammond A et al. | Platelets in equine recurrent airway obstruction. | 2007 | Res. Vet. Sci. | pmid:17107696 |
| Vinores SA et al. | TNF-alpha is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage. | 2007 | J. Neuroimmunol. | pmid:17107717 |
| Brkovic A and Sirois MG | Vascular permeability induced by VEGF family members in vivo: role of endogenous PAF and NO synthesis. | 2007 | J. Cell. Biochem. | pmid:17115409 |
| Choi JH et al. | Impairment of p38 MAPK-mediated cytosolic phospholipase A2 activation in the kidneys is associated with pathogenicity of Candida albicans. | 2007 | Immunology | pmid:17054728 |
| El Behi M et al. | Changes in self-reactive IgG antibody repertoire after treatment of experimental autoimmune encephalomyelitis with anti-allergic drugs. | 2007 | J. Neuroimmunol. | pmid:17097744 |
| Blanchet MR et al. | Modulation of eosinophil activation in vitro by a nicotinic receptor agonist. | 2007 | J. Leukoc. Biol. | pmid:17289799 |
| Shindou H et al. | A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase. | 2007 | J. Biol. Chem. | pmid:17182612 |
| Ko HM et al. | Critical role for matrix metalloproteinase-9 in platelet-activating factor-induced experimental tumor metastasis. | 2007 | Int. J. Cancer | pmid:17187368 |
| Bate C et al. | Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage. | 2007 | J Neuroinflammation | pmid:17233902 |
| Caini P et al. | Modifications of plasma platelet-activating factor (PAF)-acetylhydrolase/PAF system activity in patients with chronic hepatitis C virus infection. | 2007 | J. Viral Hepat. | pmid:17212640 |
| Park EJ et al. | Dietary ganglioside inhibits acute inflammatory signals in intestinal mucosa and blood induced by systemic inflammation of Escherichia coli lipopolysaccharide. | 2007 | Shock | pmid:17510604 |
| Young RE et al. | Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice. | 2007 | Br. J. Pharmacol. | pmid:17471175 |
| Steel HC et al. | Itraconazole-mediated inhibition of calcium entry into platelet-activating factor-stimulated human neutrophils is due to interference with production of leukotriene B4. | 2007 | Clin. Exp. Immunol. | pmid:17683509 |
| Eckert RE and Jones SL | Regulation of VASP serine 157 phosphorylation in human neutrophils after stimulation by a chemoattractant. | 2007 | J. Leukoc. Biol. | pmid:17684042 |