| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li SQ et al. | Improving effect of Ginkgolide B on mitochondrial respiration of ischemic neuron after cerebral thrombosis in tree shrewa. | 2007 | Chin. Med. J. | pmid:17908463 |
| Doublier S et al. | The proangiogenic phenotype of tumor-derived endothelial cells is reverted by the overexpression of platelet-activating factor acetylhydrolase. | 2007 | Clin. Cancer Res. | pmid:17908960 |
| Shimada T et al. | Cross-regulation of cortisol secretion by adrenocorticotropin and platelet-activating factor in perfused guinea pig adrenals. | 2007 | J. Endocrinol. | pmid:17911394 |
| Whitehead SN et al. | Identification and quantitation of changes in the platelet activating factor family of glycerophospholipids over the course of neuronal differentiation by high-performance liquid chromatography electrospray ionization tandem mass spectrometry. | 2007 | Anal. Chem. | pmid:17949058 |
| Bixby CE et al. | Role of platelet-activating factor in pulmonary vascular remodeling associated with chronic high altitude hypoxia in ovine fetal lambs. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17951313 |
| Liu WC et al. | Lipopolysaccharide-induced cerebral inflammatory damage and the therapeutic effect of platelet activating factor receptor antagonist. | 2007 | Neurosci Bull | pmid:17952135 |
| Ferreira MA et al. | Tumor growth, angiogenesis and inflammation in mice lacking receptors for platelet activating factor (PAF). | 2007 | Life Sci. | pmid:17588613 |
| Xia SH et al. | Significance of platelet activating factor receptor expression in pancreatic tissues of rats with severe acute pancreatitis and effects of BN52021. | 2007 | World J. Gastroenterol. | pmid:17589953 |
| Tosaki T et al. | Enhancement of acetyl-CoA: 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity by hydrogen peroxide. | 2007 | Biol. Pharm. Bull. | pmid:17268064 |
| Zhang X et al. | Down-regulation of platelet-activating factor receptor gene expression during focal reversible cerebral ischemia in rats. | 2007 | Neurochem. Res. | pmid:17268849 |
| Sandford RM et al. | The genetic basis of abdominal aortic aneurysms: a review. | 2007 | Eur J Vasc Endovasc Surg | pmid:17276705 |
| Slomiany BL and Slomiany A | Interference by leptin with Helicobacter pylori lipopolysaccharide-induced cytosolic phospholipase A2 activation in gastric mucosal cells. | 2007 | J. Physiol. Pharmacol. | pmid:17440231 |
| Ullrich SE | Sunlight and skin cancer: lessons from the immune system. | 2007 | Mol. Carcinog. | pmid:17443748 |
| Zhao W et al. | [Effect of PAF on the expression of PACAP mRNA in the granulosa cells of rat ovary]. | 2007 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21180114 |
| Xavier RG et al. | Enhanced platelet aggregation and activation under conditions of hypothermia. | 2007 | Thromb. Haemost. | pmid:18064324 |
| Dunkel B et al. | Platelet activation in ponies with airway inflammation. | 2007 | Equine Vet. J. | pmid:18065316 |
| Lu SM et al. | The phospholipid mediator platelet-activating factor mediates striatal synaptic facilitation. | 2007 | J Neuroimmune Pharmacol | pmid:18040844 |
| Rockel N et al. | The osmolyte taurine protects against ultraviolet B radiation-induced immunosuppression. | 2007 | J. Immunol. | pmid:17785795 |
| Li J et al. | Pharmacological profile of PMS777, a new AChE inhibitor with PAF antagonistic activity. | 2007 | Int. J. Neuropsychopharmacol. | pmid:16426477 |
| Chen J et al. | Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis. | 2007 | J. Lipid Res. | pmid:17693621 |
| Shi W et al. | [Study on composing mechanism by effect of disassembled compositions of Yiqi Huoxue decoction on platelet aggregation of health adults]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18309677 |
| Ibe BO et al. | Platelet-activating factor modulates activity of cyclic nucleotides in fetal ovine pulmonary vascular smooth muscle. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17085546 |
| Saluk-Juszczak J et al. | The effect of lipopolysaccharide from Proteus mirabilis on the level of the stable end metabolic products of nitric oxide in blood platelets. | 2007 | Curr. Microbiol. | pmid:17160361 |
| Huang YH et al. | Suppression effect of seminal vesicle autoantigen on platelet-activating factor-induced mouse sperm capacitation. | 2007 | J. Cell. Biochem. | pmid:17131380 |
| Osborn TM et al. | Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17135294 |
| Bathgate R et al. | Effects of platelet-activating factor and platelet-activating factor: acetylhydrolase on in vitro post-thaw boar sperm parameters. | 2007 | Theriogenology | pmid:17157372 |
| Hammond A et al. | Platelets in equine recurrent airway obstruction. | 2007 | Res. Vet. Sci. | pmid:17107696 |
| Park EJ et al. | Dietary ganglioside inhibits acute inflammatory signals in intestinal mucosa and blood induced by systemic inflammation of Escherichia coli lipopolysaccharide. | 2007 | Shock | pmid:17510604 |
| Steel HC et al. | Itraconazole-mediated inhibition of calcium entry into platelet-activating factor-stimulated human neutrophils is due to interference with production of leukotriene B4. | 2007 | Clin. Exp. Immunol. | pmid:17683509 |
| Eckert RE and Jones SL | Regulation of VASP serine 157 phosphorylation in human neutrophils after stimulation by a chemoattractant. | 2007 | J. Leukoc. Biol. | pmid:17684042 |
| Subbotina LA | [Procedure of blood agregation system analysis]. | 2006 Sep-Oct | Aviakosm Ekolog Med | pmid:17357632 |
| Givehchi A et al. | Analysis of activity space by fragment fingerprints, 2D descriptors, and multitarget dependent transformation of 2D descriptors. | 2006 May-Jun | J Chem Inf Model | pmid:16711727 |
| Lang F et al. | Osmotic shock-induced suicidal death of erythrocytes. | 2006 May-Jun | Acta Physiol (Oxf) | pmid:16734755 |
| Zhu T et al. | Intracrine signaling through lipid mediators and their cognate nuclear G-protein-coupled receptors: a paradigm based on PGE2, PAF, and LPA1 receptors. | 2006 Mar-Apr | Can. J. Physiol. Pharmacol. | pmid:16902584 |
| Gu Y et al. | PAF levels and PAF-AH activities in placentas from normal and preeclamptic pregnancies. | 2006 Jun-Jul | Placenta | pmid:16122793 |
| Lang F et al. | Mechanisms and significance of eryptosis. | 2006 Jul-Aug | Antioxid. Redox Signal. | pmid:16910766 |
| Vasques E et al. | Impairment of endothelium-dependent aorta relaxation by phospholipid components of oxidized low-density lipoprotein. | 2006 Jan-Feb | Endothelium | pmid:16885061 |
| Davoine F et al. | Interleukin-12 inhibits eosinophil degranulation and migration but does not promote eosinophil apoptosis. | 2006 | Int. Arch. Allergy Immunol. | pmid:16735797 |
| Zheng P et al. | Periodontal parameters and platelet-activating factor levels in serum and gingival crevicular fluid in a Chinese population. | 2006 | J. Clin. Periodontol. | pmid:16970624 |
| Tsoupras AB et al. | Isolation and identification of hydroxyl-platelet-activating factor from natural sources. | 2006 | Life Sci. | pmid:16860827 |
| Woo HY et al. | Mechanism for acute oral desensitization to antibiotics. | 2006 | Allergy | pmid:16867049 |
| Sallem W et al. | Structure-activity relationships in platelet-activating factor. Part 14: synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 activity. | 2006 | Bioorg. Med. Chem. | pmid:16908170 |
| Lima RG et al. | Interaction of macrophages with apoptotic cells enhances HIV Type 1 replication through PGE2, PAF, and vitronectin receptor. | 2006 | AIDS Res. Hum. Retroviruses | pmid:16910832 |
| Gora S et al. | The proinflammatory mediator Platelet Activating Factor is an effective substrate for human group X secreted phospholipase A2. | 2006 | Biochim. Biophys. Acta | pmid:16962371 |
| Kassuya CA et al. | Antiinflammatory and antiallodynic actions of the lignan niranthin isolated from Phyllanthus amarus. Evidence for interaction with platelet activating factor receptor. | 2006 | Eur. J. Pharmacol. | pmid:16925995 |
| Cauwels A et al. | Anaphylactic shock depends on PI3K and eNOS-derived NO. | 2006 | J. Clin. Invest. | pmid:16886062 |
| Wolf P et al. | Platelet-activating factor is crucial in psoralen and ultraviolet A-induced immune suppression, inflammation, and apoptosis. | 2006 | Am. J. Pathol. | pmid:16936256 |
| Fischer A et al. | The ether lipid inositol-C2-PAF is a potent inhibitor of cell proliferation in HaCaT cells. | 2006 | Chembiochem | pmid:16453359 |
| Liu LR and Xia SH | Role of platelet-activating factor in the pathogenesis of acute pancreatitis. | 2006 | World J. Gastroenterol. | pmid:16489665 |
| Spitzer AL et al. | Applying Ockham's razor to pancreatitis prognostication: a four-variable predictive model. | 2006 | Ann. Surg. | pmid:16495704 |
| Biancone L et al. | Platelet-activating factor synthesis and response on pancreatic islet endothelial cells: relevance for islet transplantation. | 2006 | Transplantation | pmid:16495796 |
| McMeekin SR et al. | E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils. | 2006 | Blood | pmid:16514053 |
| Ramirez R et al. | Angiotensin II effect on hydraulic permeability: interaction with endothelin-1, nitric oxide, and platelet activating factor. | 2006 | J. Surg. Res. | pmid:16515797 |
| He P et al. | Leukocyte-platelet aggregate adhesion and vascular permeability in intact microvessels: role of activated endothelial cells. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16517944 |
| Okumura N et al. | Pharmacokinetic analysis of platelet-activating factor in the tears of guinea pigs with allergic conjunctivitis. | 2006 | J Ocul Pharmacol Ther | pmid:17076629 |
| Keles GC et al. | Levels of platelet activating factor in gingival crevice fluid following periodontal surgical therapy. | 2006 | J. Periodont. Res. | pmid:17076775 |
| Denizot Y et al. | Platelet-activating factor and human meningiomas. | 2006 | Neuropathol. Appl. Neurobiol. | pmid:17083481 |
| Wang GD et al. | Platelet-activating factor in the enteric nervous system of the guinea pig small intestine. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17030900 |
| Herman AG and Stockwell BR | Enzyme annotation with chemical tools. | 2006 | Chem. Biol. | pmid:17052604 |
| Chiang KP et al. | An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. | 2006 | Chem. Biol. | pmid:17052608 |
| Brown SL et al. | Activation and regulation of platelet-activating factor receptor: role of G(i) and G(q) in receptor-mediated chemotactic, cytotoxic, and cross-regulatory signals. | 2006 | J. Immunol. | pmid:16920964 |
| Serradji N et al. | Structure-activity relationships in platelet-activating factor. Part 13: synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity. | 2006 | Bioorg. Med. Chem. | pmid:16893650 |
| Yang YP et al. | Effect of increased hepatic platelet activating factor and its receptor portal hypertension in CCl4-induced liver cirrhosis. | 2006 | World J. Gastroenterol. | pmid:16521183 |
| Wang LJ et al. | [Role of platelet activating factor in the injury of intestinal immuno-barrier function in young rats]. | 2006 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:16522243 |
| Hong SH et al. | Mitochondrial ligand inhibits store-operated calcium influx and COX-2 production in human microglia. | 2006 | J. Neurosci. Res. | pmid:16547968 |
| Tabarés-Seisdedos R et al. | Variations in genes regulating neuronal migration predict reduced prefrontal cognition in schizophrenia and bipolar subjects from mediterranean Spain: a preliminary study. | 2006 | Neuroscience | pmid:16549273 |
| Heon Seo K et al. | Platelet-activating factor induces up-regulation of antiapoptotic factors in a melanoma cell line through nuclear factor-kappaB activation. | 2006 | Cancer Res. | pmid:16651419 |
| Doi K et al. | Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice. | 2006 | Am. J. Pathol. | pmid:16651609 |
| Coleus forskohlii. Monograph. | 2006 | Altern Med Rev | pmid:16597194 | |
| Fernandes CJ and O'Donovan DJ | Platelet transfusions in infants with necrotizing enterocolitis. | 2006 | Curr. Hematol. Rep. | pmid:16537050 |
| Maliba R et al. | Angiopoietins-1 and -2 are both capable of mediating endothelial PAF synthesis: intracellular signalling pathways. | 2006 | Cell. Signal. | pmid:16617006 |
| Hsu HC et al. | Alpha-bulnesene, a novel PAF receptor antagonist isolated from Pogostemon cablin. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16712790 |
| Mathonnet M et al. | Platelet-activating factor in cirrhotic liver and hepatocellular carcinoma. | 2006 | World J. Gastroenterol. | pmid:16718768 |
| Cellai C et al. | Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086. | 2006 | Br. J. Cancer | pmid:16721373 |
| Goldring WP and Pattenden G | The phomactins. A novel group of terpenoid platelet activating factor antagonists related biogenetically to the taxanes. | 2006 | Acc. Chem. Res. | pmid:16700534 |
| Peng SY et al. | Effect of ginkgolide B on the platelet-activating factor induced changes of chemotaxis and cytoskeleton of macrophages. | 2006 | Yao Xue Xue Bao | pmid:16671547 |
| Bate C et al. | Platelet-activating factor antagonists protect amyloid-beta damaged neurons from microglia-mediated death. | 2006 | Neuropharmacology | pmid:16678220 |
| Sánchez FA et al. | Functional significance of differential eNOS translocation. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16679407 |
| Mao YJ et al. | [Effect of ginkgolide B on the function of rat aorta smooth cells and U937 cells stimulated by oxLDL]. | 2006 | Yao Xue Xue Bao | pmid:16683525 |
| Ko HM et al. | Platelet-activating factor-induced NF-kappaB activation enhances VEGF expression through a decrease in p53 activity. | 2006 | FEBS Lett. | pmid:16684540 |
| Hermle T et al. | Decreased cation channel activity and blunted channel-dependent eryptosis in neonatal erythrocytes. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16723509 |
| Fonseca FV et al. | Characterization of a new platelet aggregating factor from crotoxin Crotalus durissus cascavella venom. | 2006 | Protein J. | pmid:16729248 |
| Wang C et al. | Total synthesis of (+/-)-paeonilide. | 2006 | Org. Lett. | pmid:16737293 |
| Kaul DK et al. | Peptides based on alphaV-binding domains of erythrocyte ICAM-4 inhibit sickle red cell-endothelial interactions and vaso-occlusion in the microcirculation. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16738001 |
| Faghiri Z and Bazan NG | Selective relocalization and proteasomal downregulation of PKCalpha induced by platelet-activating factor in retinal pigment epithelium. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:16384990 |
| Pégorier S et al. | Oxidized phospholipid: POVPC binds to platelet-activating-factor receptor on human macrophages. Implications in atherosclerosis. | 2006 | Atherosclerosis | pmid:16386258 |
| Kikuchi I et al. | Eosinophil trans-basement membrane migration induced by interleukin-8 and neutrophils. | 2006 | Am. J. Respir. Cell Mol. Biol. | pmid:16456187 |
| Mauri P et al. | LC-MS characterization of terpene lactones in plasma of experimental animals treated with Ginkgo biloba extracts Correlation with pharmacological activity. | 2006 | J Pharm Biomed Anal | pmid:16343838 |
| Kishimoto S et al. | Chemotaxis of human peripheral blood eosinophils to 2-arachidonoylglycerol: comparison with other eosinophil chemoattractants. | 2006 | Int. Arch. Allergy Immunol. | pmid:16772720 |
| Cui S et al. | Effects of platelet-activating factor, thromboxane A2 and leukotriene D4 on isolated perfused rat liver. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16846785 |
| Menezes-de-Lima O et al. | Lipoxin A4 inhibits acute edema in mice: implications for the anti-edematogenic mechanism induced by aspirin. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939877 |
| Shao P et al. | [Research on relationship of syndrome type and parameters of hemorheology and platelet activation in patients with acute gout arthritis of dampness-heat blockage type and stasis-heat accumulate type]. | 2006 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:17186728 |
| Crespo A et al. | [Effect of changes in airway pressure and the inspiratory volume on the fluid filtration rate and pulmonary artery pressure in isolated rabbit lungs perfused with blood and acellular solution]. | 2006 | Invest Clin | pmid:17176901 |
| Eckford PD and Sharom FJ | P-glycoprotein (ABCB1) interacts directly with lipid-based anti-cancer drugs and platelet-activating factors. | 2006 | Biochem. Cell Biol. | pmid:17215888 |
| Subbanna PK and Tyagi MG | PAF antagonism modifies neuroprotective action of histone deacetylase and calcineurin phosphatase inhibitors in mice. | 2006 | Indian J. Exp. Biol. | pmid:17205708 |
| Fang H et al. | Anaphylactic reaction induced by Toxoplasma gondii-derived heat shock protein 70. | 2006 | Int. Immunol. | pmid:16943259 |
| Karantonis HC et al. | Effect of fast-food Mediterranean-type diet on type 2 diabetics and healthy human subjects' platelet aggregation. | 2006 | Diabetes Res. Clin. Pract. | pmid:16236380 |
| Wu J et al. | Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity. | 2006 | Biochem. J. | pmid:16255717 |
| Judge A et al. | Hypersensitivity and loss of disease site targeting caused by antibody responses to PEGylated liposomes. | 2006 | Mol. Ther. | pmid:16275098 |
| Desaulniers P et al. | Characterization of an activation factor released from human neutrophils after stimulation by triclinic monosodium urate crystals. | 2006 | J. Rheumatol. | pmid:16652423 |