| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yu Y et al. | Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells. | 2014 | J. Exp. Clin. Cancer Res. | pmid:25261977 |
| Agrawal V et al. | Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice. | 2014 | Biol. Reprod. | pmid:25253732 |
| Wang M et al. | Mouse anaphylactic shock is caused by reduced cardiac output, but not by systemic vasodilatation or pulmonary vasoconstriction, via PAF and histamine. | 2014 | Life Sci. | pmid:25252221 |
| Liu X et al. | Ginkgolide B inhibits platelet release by blocking Syk and p38 MAPK phosphorylation in thrombin-stimulated platelets. | 2014 | Thromb. Res. | pmid:25223809 |
| Kang LP et al. | Steroidal saponins from Tribulus terrestris. | 2014 | Phytochemistry | pmid:25172515 |
| Wu KZ et al. | Establishment of the method for screening the potential targets and effective components of huatuo reconstruction pill. | 2014 | Interdiscip Sci | pmid:25172450 |
| Nitoda E et al. | Correlation of platelet activating factor and age-related macular degeneration. | 2014 | Expert Opin. Ther. Targets | pmid:25077601 |
| Sirangelo I et al. | Platelet-activating factor mediates the cytotoxicity induced by W7FW14F apomyoglobin amyloid aggregates in neuroblastoma cells. | 2014 | J. Cell. Biochem. | pmid:25053109 |
| Xanthopoulou MN et al. | Effect of Robola and Cabernet Sauvignon extracts on platelet activating factor enzymes activity on U937 cells. | 2014 | Food Chem | pmid:25038648 |
| Concha C et al. | Oxidative response of neutrophils to platelet-activating factor is altered during acute ruminal acidosis induced by oligofructose in heifers. | 2014 | J. Vet. Sci. | pmid:25013355 |
| Chacón-Salinas R et al. | An essential role for platelet-activating factor in activating mast cell migration following ultraviolet irradiation. | 2014 | J. Leukoc. Biol. | pmid:24009177 |
| Mehta A and Sigman M | Identification and preparation of sperm for ART. | 2014 | Urol. Clin. North Am. | pmid:24286775 |
| Reyes-Quiroz ME et al. | Platelet-activating factor downregulates the expression of liver X receptor-α and its target genes in human neutrophils. | 2014 | FEBS J. | pmid:24289152 |
| Semini G et al. | Inositol-C2-PAF down-regulates components of the antigen presentation machinery in a 2D-model of epidermal inflammation. | 2014 | Biochem. Pharmacol. | pmid:24291779 |
| Sugatani J et al. | Antiobese function of platelet-activating factor: increased adiposity in platelet-activating factor receptor-deficient mice with age. | 2014 | FASEB J. | pmid:24100020 |
| Gazos-Lopes F et al. | Structural and functional analysis of a platelet-activating lysophosphatidylcholine of Trypanosoma cruzi. | 2014 | PLoS Negl Trop Dis | pmid:25101628 |
| Semini G et al. | Glycosidated phospholipids - a promising group of anti-tumour lipids. | 2014 | Anticancer Agents Med Chem | pmid:24628240 |
| Morimoto R et al. | Rapid production of platelet-activating factor is induced by protein kinase Cα-mediated phosphorylation of lysophosphatidylcholine acyltransferase 2 protein. | 2014 | J. Biol. Chem. | pmid:24742674 |
| Summers C et al. | Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome. | 2014 | Thorax | pmid:24706039 |
| Yang Y et al. | Basophil activation through ASGM1 stimulation triggers PAF release and anaphylaxis-like shock in mice. | 2014 | Eur. J. Immunol. | pmid:24777913 |