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Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells. |
2008 |
Am. J. Gastroenterol. |
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Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. |
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J. Immunol. |
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Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. |
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J. Am. Chem. Soc. |
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Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway. |
2008 |
Kidney Int. |
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Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. |
2008 |
BMC Syst Biol |
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Udagawa H et al. |
Increase of serum cholesterol levels by heat-moisture-treated high-amylose cornstarch in rats fed a high-cholesterol diet. |
2008 |
Lipids |
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Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells. |
2008 |
J. Biochem. Biophys. Methods |
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Modulation of osteoclastogenesis by fatty acids. |
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Endocrinology |
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Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis. |
2008 |
Plant Cell Physiol. |
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Hexadecylphosphocholine interferes with the intracellular transport of cholesterol in HepG2 cells. |
2008 |
FEBS J. |
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Statins impair antitumor effects of rituximab by inducing conformational changes of CD20. |
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PLoS Med. |
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Statins but not thiazolidinediones attenuate albumin-mediated chemokine production by proximal tubular cells independently of endocytosis. |
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Am. J. Nephrol. |
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Plant sterols/stanols as cholesterol lowering agents: A meta-analysis of randomized controlled trials. |
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Food Nutr Res |
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Peroxisomal localization of Arabidopsis isopentenyl diphosphate isomerases suggests that part of the plant isoprenoid mevalonic acid pathway is compartmentalized to peroxisomes. |
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Plant Physiol. |
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[The anticancer properties of statins]. |
2008 |
Postepy Hig Med Dosw (Online) |
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Acharjee S and Welty FK |
Atorvastatin and cardiovascular risk in the elderly--patient considerations. |
2008 |
Clin Interv Aging |
pmid:18686752
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Journe F et al. |
Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. |
2008 |
Breast Cancer Res. Treat. |
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Cloning and characterization of mevalonate pathway genes in a natural rubber producing plant, Hevea brasiliensis. |
2008 |
Biosci. Biotechnol. Biochem. |
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The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway. |
2008 |
Endocr. Relat. Cancer |
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Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells. |
2008 |
BMC Biol. |
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Effects of HMG-CoA reductase inhibitors (statins) on progression of kidney disease. |
2008 |
Kidney Int. |
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Skorupinska-Tudek K et al. |
Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants. |
2008 |
J. Biol. Chem. |
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Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. |
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J. Immunol. |
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Atorvastatin induces apoptosis by a caspase-9-dependent pathway: an in vitro study on activated rat hepatic stellate cells. |
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Liver Int. |
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[Effect of pitavastatin on macrophage cholesterol metabolism]. |
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Yakugaku Zasshi |
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Statins induce lethal effects in acute myeloblastic leukemia [corrected] cells within 72 hours. |
2008 |
Leuk. Lymphoma |
pmid:18231920
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Glynn SA et al. |
The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells. |
2008 |
BMC Cancer |
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Farnesylation directs AtIPT3 subcellular localization and modulates cytokinin biosynthesis in Arabidopsis. |
2008 |
Plant Physiol. |
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Kodaman PH and Duleba AJ |
Statins in the treatment of polycystic ovary syndrome. |
2008 |
Semin. Reprod. Med. |
pmid:18181091
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Wilson GJ et al. |
Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review. |
2008 |
Nutr Metab (Lond) |
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Mathew B and Biju R |
Neuroprotective effects of garlic a review. |
2008 |
Libyan J Med |
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Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry. |
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Anal Chem Insights |
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Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. |
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Melanoma Res. |
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Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. |
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J. Muscle Res. Cell. Motil. |
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Simvastatin activates Keap1/Nrf2 signaling in rat liver. |
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J. Mol. Med. |
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Atorvastatin accelerates extracellular nucleotide degradation in human endothelial cells. |
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Mol. Cell. Biochem. |
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Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis. |
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Mol. Pharmacol. |
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LDL induces parathyroid hormone-related protein expression in vascular smooth muscle cells: Modulation by simvastatin. |
2008 |
Atherosclerosis |
pmid:18378243
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Baldi A and Dixit VK |
Yield enhancement strategies for artemisinin production by suspension cultures of Artemisia annua. |
2008 |
Bioresour. Technol. |
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Inhibitory effect of simvastatin on the TNF-alpha- and angiotensin II-induced monocyte adhesion to endothelial cells is mediated through the suppression of geranylgeranyl isoprenoid-dependent ROS generation. |
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Arch. Pharm. Res. |
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High-content assay to study protein prenylation. |
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J Biomol Screen |
pmid:18509097
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Effect of rosuvastatin on capillary filtration of albumin and blood pressure in rats with streptozotocin-induced diabetes. |
2008 |
Diabetes Res. Clin. Pract. |
pmid:18406000
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Bioconversion of lovastatin to a novel statin by Amycolatopsis sp. |
2008 |
Appl. Microbiol. Biotechnol. |
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Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae. |
2008 |
Biochim. Biophys. Acta |
pmid:18771750
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Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. |
2008 |
Arch. Biochem. Biophys. |
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Yeast cell factories for fine chemical and API production. |
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Microb. Cell Fact. |
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Cholesterol-induced stimulation of postinflammatory liver fibrosis. |
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Bull. Exp. Biol. Med. |
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Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products. |
2008 |
Cardiology |
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Yu F et al. |
Isolation and functional characterization of a beta-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet Smith. |
2008 |
FEBS Lett. |
pmid:18242187
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Structure-based drug design targeting biosynthesis of isoprenoids: a crystallographic state of the art of the involved enzymes. |
2008 |
Curr. Protein Pept. Sci. |
pmid:18393884
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