Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Gerber R et al. Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS. 2004 Anal. Biochem. pmid:15136164
Schwartz CC et al. Lipoprotein cholesteryl ester production, transfer, and output in vivo in humans. 2004 J. Lipid Res. pmid:15145983
Hedl M and Rodwell VW Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii. 2004 Protein Sci. pmid:15152097
Duncan RE et al. Mevalonate promotes the growth of tumors derived from human cancer cells in vivo and stimulates proliferation in vitro with enhanced cyclin-dependent kinase-2 activity. 2004 J. Biol. Chem. pmid:15155733
Rasouli M et al. Calmodulin antagonist W-7 inhibits de novo synthesis of cholesterol and suppresses secretion of de novo synthesized and preformed lipids from cultured hepatocytes. 2004 Biochim. Biophys. Acta pmid:15158760
pmid:15169608
pmid:15171940
Dickschat JS et al. Biosynthesis of volatiles by the myxobacterium Myxococcus xanthus. 2004 Chembiochem pmid:15174160
Dubuc G et al. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15178557
Stojanov S et al. Molecular analysis of the MVK and TNFRSF1A genes in patients with a clinical presentation typical of the hyperimmunoglobulinemia D with periodic fever syndrome: a low-penetrance TNFRSF1A variant in a heterozygous MVK carrier possibly influences the phenotype of hyperimmunoglobulinemia D with periodic fever syndrome or vice versa. 2004 Arthritis Rheum. pmid:15188372
pmid:15197467
Ando H et al. Effects of pravastatin on the expression of ATP-binding cassette transporter A1. 2004 J. Pharmacol. Exp. Ther. pmid:15210833
Le Jossic-Corcos C et al. Effects of peroxisome proliferator-activated receptor alpha activation on pathways contributing to cholesterol homeostasis in rat hepatocytes. 2004 Biochim. Biophys. Acta pmid:15238219
pmid:1524429
Siddals KW et al. Abrogation of insulin-like growth factor-I (IGF-I) and insulin action by mevalonic acid depletion: synergy between protein prenylation and receptor glycosylation pathways. 2004 J. Biol. Chem. pmid:15247258
Harada-Shiba M et al. Siblings with normal LDL receptor activity and severe hypercholesterolemia. 1992 Arterioscler. Thromb. pmid:1525122
Bradfute DL et al. Squalene synthase-deficient mutant of Chinese hamster ovary cells. 1992 J. Biol. Chem. pmid:1526971
pmid:15279616
Fortin DL et al. Lipid rafts mediate the synaptic localization of alpha-synuclein. 2004 J. Neurosci. pmid:15282274
Sutherlin A and Rodwell VW Multienzyme mevalonate pathway bioreactor. 2004 Biotechnol. Bioeng. pmid:15286992
Werner M et al. Mutual amplification of apoptosis by statin-induced mitochondrial stress and doxorubicin toxicity in human rhabdomyosarcoma cells. 2004 Br. J. Pharmacol. pmid:15289292
Schulz S et al. Mechanisms of cell growth inhibition and cell cycle arrest in human colonic adenocarcinoma cells by dehydroepiandrosterone: role of isoprenoid biosynthesis. 1992 Cancer Res. pmid:1531325
Vaughan CJ and Gotto AM Update on statins: 2003. 2004 Circulation pmid:15313959
del Real G et al. Statins inhibit HIV-1 infection by down-regulating Rho activity. 2004 J. Exp. Med. pmid:15314078
Ikeuchi H et al. Fluvastatin reduces renal fibroblast proliferation and production of type III collagen: therapeutic implications for tubulointerstitial fibrosis. 2004 Nephron Exp. Nephrol. pmid:15331935
pmid:15332174
Ferrara DE et al. Fluvastatin inhibits up-regulation of tissue factor expression by antiphospholipid antibodies on endothelial cells. 2004 J. Thromb. Haemost. pmid:15333031
pmid:15352124
pmid:15355237
Zanotti I et al. Pitavastatin increases ABCA1-mediated lipid efflux from Fu5AH rat hepatoma cells. 2004 Biochem. Biophys. Res. Commun. pmid:15358158
Bi X et al. Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia. 2004 J. Biol. Chem. pmid:15364922
pmid:15370280
Sauter GH et al. Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects. 2004 Digestion pmid:15375335
Dahl NK et al. Isolation and characterization of Chinese hamster ovary cells defective in the intracellular metabolism of low density lipoprotein-derived cholesterol. 1992 J. Biol. Chem. pmid:1537866
Umlauf D et al. Biosynthesis of the irregular monoterpene artemisia ketone, the sesquiterpene germacrene D and other isoprenoids in Tanacetum vulgare L. (Asteraceae). 2004 Phytochemistry pmid:15381410
Duncan RE et al. Delivery of mevalonate to murine extrahepatic tissues via mini-osmotic pumps. 2004 Sep-Oct J Pharmacol Toxicol Methods pmid:15385088
Kizu A et al. Statins inhibit in vitro calcification of human vascular smooth muscle cells induced by inflammatory mediators. 2004 J. Cell. Biochem. pmid:15389884
Seker T et al. Analysis of acyl CoA ester intermediates of the mevalonate pathway in Saccharomyces cerevisiae. 2005 Appl. Microbiol. Biotechnol. pmid:15448940
Neville-Webbe HL et al. Sequence- and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubicin in breast and prostate cancer cells. 2005 Int. J. Cancer pmid:15455384
Sinensky M and Lutz RJ The prenylation of proteins. 1992 Bioessays pmid:1546978
Bhavnani BR and Woolever CA Formation of steroids by the pregnant mare. VI. Metabolism of [14C]farnesyl pyrophosphate and [3H]dehydroepiandrosterone injected into the fetus. 1978 Endocrinology pmid:155006
Fan P et al. Pitavastatin, a potent hydroxymethylglutaryl coenzyme a reductase inhibitor, increases cholesterol 7 alpha-hydroxylase gene expression in HepG2 cells. 2004 Circ. J. pmid:15502389
pmid:15503662
Anant JS and Fung BK In vivo farnesylation of rat rhodopsin kinase. 1992 Biochem. Biophys. Res. Commun. pmid:1550556
Giannakouros T et al. Protein prenylation in Schizosaccharomyces pombe. 1992 FEBS Lett. pmid:1551414
Kasim SE et al. Mechanisms of triglyceride-lowering effect of an HMG-CoA reductase inhibitor in a hypertriglyceridemic animal model, the Zucker obese rat. 1992 J. Lipid Res. pmid:1552226
Bell FP et al. L-carnitine administration and withdrawal affect plasma and hepatic carnitine concentrations, plasma lipid and lipoprotein composition, and in vitro hepatic lipogenesis from labeled mevalonate and oleate in normal rabbits. 1992 J. Nutr. pmid:1552371
Friesen JA and Rodwell VW The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases. 2004 Genome Biol. pmid:15535874
pmid:15542379
pmid:15544330