Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Raschke M et al. A high-performance liquid chromatography method for the analysis of intermediates of the deoxyxylulose phosphate pathway. 2004 Anal. Biochem. pmid:15556562
Panda T and Devi VA Regulation and degradation of HMGCo-A reductase. 2004 Appl. Microbiol. Biotechnol. pmid:15558272
Sawamura M et al. Liver mevalonate 5-pyrophosphate decarboxylase is responsible for reduced serum cholesterol in stroke-prone spontaneously hypertensive rat. 1992 J. Biol. Chem. pmid:1556116
Mokashi V et al. Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro. 2005 Arch. Biochem. Biophys. pmid:15581604
Sakamoto K et al. Fluvastatin prevents vascular hyperplasia by inhibiting phenotype modulation and proliferation through extracellular signal-regulated kinase 1 and 2 and p38 mitogen-activated protein kinase inactivation in organ-cultured artery. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:15591221
pmid:15591471
Fenton RG et al. Regulation of intracellular actin polymerization by prenylated cellular proteins. 1992 J. Cell Biol. pmid:1560030
Tabata K and Hashimoto S Production of mevalonate by a metabolically-engineered Escherichia coli. 2004 Biotechnol. Lett. pmid:15604784
pmid:15605175
Hewitt RE et al. The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins. 2005 Clin. Exp. Immunol. pmid:15606619
Andreassi JL et al. Streptococcus pneumoniae isoprenoid biosynthesis is downregulated by diphosphomevalonate: an antimicrobial target. 2004 Biochemistry pmid:15610040
Duncan RE et al. Dietary factors and the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for breast cancer and development. 2005 Mol Nutr Food Res pmid:15617098
pmid:15618295
Wu B et al. Paradoxical effects of statins on aortic valve myofibroblasts and osteoblasts: implications for end-stage valvular heart disease. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:15618546
Inomata M et al. Biosynthesis of abscisic acid by the direct pathway via ionylideneethane in a fungus, Cercospora cruenta. 2004 Biosci. Biotechnol. Biochem. pmid:15618629
Mahmud T et al. A biosynthetic pathway to isovaleryl-CoA in myxobacteria: the involvement of the mevalonate pathway. 2005 Chembiochem pmid:15619721
Dudareva N et al. The nonmevalonate pathway supports both monoterpene and sesquiterpene formation in snapdragon flowers. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:15630092
Cordle A and Landreth G 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses. 2005 J. Neurosci. pmid:15647473
Pedrini S et al. Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK. 2005 PLoS Med. pmid:15647781
Havel CM and Watson JA Isopentenoid synthesis in isolated embryonic Drosophila cells: absolute, basal mevalonate synthesis rate determination. 1992 Arch. Biochem. Biophys. pmid:1567218
pmid:15680987
Ota K et al. Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene. 2005 Metab. Clin. Exp. pmid:15690306
Lutz RJ et al. Feedback inhibition of polyisoprenyl pyrophosphate synthesis from mevalonate in vitro. Implications for protein prenylation. 1992 J. Biol. Chem. pmid:1569056
Nawarskas JJ HMG-CoA reductase inhibitors and coenzyme Q10. 2005 Mar-Apr Cardiol Rev pmid:15705257
Madonna R et al. Simvastatin attenuates expression of cytokine-inducible nitric-oxide synthase in embryonic cardiac myoblasts. 2005 J. Biol. Chem. pmid:15705589
Wei H et al. Statin-inhibited endothelial permeability could be associated with its effect on PECAM-1 in endothelial cells. 2005 FEBS Lett. pmid:15710425
Baker SK Molecular clues into the pathogenesis of statin-mediated muscle toxicity. 2005 Muscle Nerve pmid:15712281
Kawasaki T et al. Presence of copalyl diphosphate synthase gene in an actinomycete possessing the mevalonate pathway. 2004 J. Antibiot. pmid:15712669
pmid:15733940
McCarey DW et al. Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases? 2005 Arthritis Res. Ther. pmid:15743490
Han KH et al. HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo. 2005 Circulation pmid:15781755
Mantha AJ et al. Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor. 2005 Clin. Cancer Res. pmid:15788691
Okada K and Hase T Cyanobacterial non-mevalonate pathway: (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase interacts with ferredoxin in Thermosynechococcus elongatus BP-1. 2005 J. Biol. Chem. pmid:15792953
Akiyama K et al. Antitumor effect of geranylamine derivatives on human hepatoma. 2005 Jan-Feb In Vivo pmid:15796170
Hampel D et al. Induction of de novo volatile terpene biosynthesis via cytosolic and plastidial pathways by methyl jasmonate in foliage of Vitis vinifera L. 2005 J. Agric. Food Chem. pmid:15796607
Argmann CA et al. Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux. 2005 J. Biol. Chem. pmid:15817453
pmid:15822054
pmid:15850779
pmid:15857290
pmid:15857307
Bellosta S et al. Statins effect on smooth muscle cell proliferation. 2004 Semin Vasc Med pmid:15861311
pmid:1586169
Wang C et al. Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. 2005 Mol. Cell pmid:15893726
Sacher J et al. Delineation of myotoxicity induced by 3-hydroxy-3-methylglutaryl CoA reductase inhibitors in human skeletal muscle cells. 2005 J. Pharmacol. Exp. Ther. pmid:15914674
pmid:15920353
pmid:15936988
pmid:15960521
Newman CM et al. Post-translational processing of Schizosaccharomyces pombe YPT proteins. 1992 J. Biol. Chem. pmid:1597466
Yazawa H et al. Simvastatin promotes cell metabolism, proliferation, and osteoblastic differentiation in human periodontal ligament cells. 2005 J. Periodontol. pmid:15974856
pmid:15981409