Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Yoon SH et al. Engineering the lycopene synthetic pathway in E. coli by comparison of the carotenoid genes of Pantoea agglomerans and Pantoea ananatis. 2007 Appl. Microbiol. Biotechnol. pmid:17115209
Ye J Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus. 2007 PLoS Pathog. pmid:17784784
Saijonmaa O et al. Atorvastatin inhibits angiotensin-converting enzyme induction in differentiating human macrophages. 2007 Am. J. Physiol. Heart Circ. Physiol. pmid:17158648
Honda A et al. Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS. 2007 J. Lipid Res. pmid:17272831
Sarrabayrouse G et al. Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells. 2007 Neoplasia pmid:18084615
Bretón Martínez JR et al. Mevalonic aciduria: report of two cases. 2007 J. Inherit. Metab. Dis. pmid:17578678
Ben-Tal Cohen E et al. Statins decrease TNF-alpha-induced osteoprotegerin production by endothelial cells and smooth muscle cells in vitro. 2007 Biochem. Pharmacol. pmid:17070781
Igarashi J et al. Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins. 2007 Br. J. Pharmacol. pmid:17220911
Ferri N et al. Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17303772
Ohyama K et al. Chemical phenotypes of the hmg1 and hmg2 mutants of Arabidopsis demonstrate the in-planta role of HMG-CoA reductase in triterpene biosynthesis. 2007 Chem. Pharm. Bull. pmid:17917299
Corsini A et al. Are pleiotropic effects of statins real? 2007 Vasc Health Risk Manag pmid:18078012
Nakao T et al. Pravastatin induces rat aortic endothelial cell proliferation and migration via activation of PI3K/Akt/mTOR/p70 S6 kinase signaling. 2007 J. Pharmacol. Sci. pmid:18057776
Ali F et al. Statin-mediated cytoprotection of human vascular endothelial cells: a role for Kruppel-like factor 2-dependent induction of heme oxygenase-1. 2007 J. Thromb. Haemost. pmid:17927807
Arkwright PD et al. Mevalonic aciduria cured by bone marrow transplantation. 2007 N. Engl. J. Med. pmid:17898110
Zeiser R et al. Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity. 2007 Blood pmid:17827390
Lopes AA et al. Biosynthetic origins of the isoprene units of gaudichaudianic acid in Piper gaudichaudianum (Piperaceae). 2007 Phytochemistry pmid:17574633
Desai B et al. Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells. 2007 Mol. Cancer pmid:17343740
D'Amico L et al. A mutation in zebrafish hmgcr1b reveals a role for isoprenoids in vertebrate heart-tube formation. 2007 Curr. Biol. pmid:17276918
Nodari S et al. The combination of Ezetimibe and Statin: a new treatment for hypercholesterolemia. 2007 Heart Int pmid:21977270
Dietzen DJ et al. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase blunts factor VIIa/tissue factor and prothrombinase activities via effects on membrane phosphatidylserine. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17185615
Jantzen F et al. Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells. 2007 J. Physiol. Pharmacol. pmid:17928646
Byres E et al. Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity. 2007 J. Mol. Biol. pmid:17583736
Saha RN and Pahan K Regulation of inducible nitric oxide synthase gene in glial cells. 2006 May-Jun Antioxid. Redox Signal. pmid:16771683
Dincer M et al. Statins may decrease skeletal-related events in breast cancer patients with bone metastases. 2006 Med. Hypotheses pmid:16844315
Kwintkiewicz J et al. Mevastatin inhibits proliferation of rat ovarian theca-interstitial cells by blocking the mitogen-activated protein kinase pathway. 2006 Fertil. Steril. pmid:16963032
Pozo M et al. Simvastatin inhibits the migration and adhesion of monocytic cells and disorganizes the cytoskeleton of activated endothelial cells. 2006 Eur. J. Pharmacol. pmid:16973154
Polo MP and de Bravo MG Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. 2006 Biochem. Cell Biol. pmid:16462894
Hampel D et al. Biosynthesis of mono- and sesquiterpenes in strawberry fruits and foliage: 2H labeling studies. 2006 J. Agric. Food Chem. pmid:16478276
Ohm TG and Meske V Cholesterol, statins and tau. 2006 Acta Neurol. Scand., Suppl.c pmid:16866917
Crisby M The role of pleiotropic effects of statins in dementia. 2006 Acta Neurol. Scand., Suppl.c pmid:16866920
Macreadie IG et al. Growth inhibition of Candida species and Aspergillus fumigatus by statins. 2006 FEMS Microbiol. Lett. pmid:16907733
Ridsdale A et al. Cholesterol is required for efficient endoplasmic reticulum-to-Golgi transport of secretory membrane proteins. 2006 Mol. Biol. Cell pmid:16452637
Gómez-Hernández A et al. Atorvastatin reduces the expression of prostaglandin E2 receptors in human carotid atherosclerotic plaques and monocytic cells: potential implications for plaque stabilization. 2006 J. Cardiovasc. Pharmacol. pmid:16424787
Kinderlerer AR et al. Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis. 2006 Arthritis Res. Ther. pmid:16859540
Kotti TJ et al. Brain cholesterol turnover required for geranylgeraniol production and learning in mice. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16505352
Sato M et al. Effects of exogenous mevalonic acid on sterol lipid classes in Larix kaempferi callus. 2006 J Oleo Sci pmid:17693695
Kuzina V et al. Relationships among the biosyntheses of ubiquinone, carotene, sterols, and triacylglycerols in Zygomycetes. 2006 Arch. Microbiol. pmid:17009023
Li JQ et al. Atorvastatin reduces plasminogen activator inhibitor-1 expression in adipose tissue of atherosclerotic rabbits. 2006 Clin. Chim. Acta pmid:16507303
Brinkkoetter PT et al. Atorvastatin interferes with activation of human CD4(+) T cells via inhibition of small guanosine triphosphatase (GTPase) activity and caspase-independent apoptosis. 2006 Clin. Exp. Immunol. pmid:17100774
Mandey SH et al. A role for geranylgeranylation in interleukin-1beta secretion. 2006 Arthritis Rheum. pmid:17075828
Ural AU et al. In vitro synergistic cytoreductive effects of zoledronic acid and radiation on breast cancer cells. 2006 Breast Cancer Res. pmid:16925824
van Hellemond JJ and Tielens AG Adaptations in the lipid metabolism of the protozoan parasite Trypanosoma brucei. 2006 FEBS Lett. pmid:16920110
Saini GS et al. Validation of the LC-MS/MS method for the quantification of mevalonic acid in human plasma and determination of the matrix effect. 2006 J. Lipid Res. pmid:16861623
Yi P et al. The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. 2006 Science pmid:16857902
Dimitroulakos J et al. Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathway. 2006 Clin. Cancer Res. pmid:16857822
Kawasaki T et al. Biosynthesis of a natural polyketide-isoprenoid hybrid compound, furaquinocin A: identification and heterologous expression of the gene cluster. 2006 J. Bacteriol. pmid:16452404
Pappu AS et al. Increased nonsterol isoprenoids, dolichol and ubiquinone, in the Smith-Lemli-Opitz syndrome: effects of dietary cholesterol. 2006 J. Lipid Res. pmid:16983147
Grochowski LL et al. Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. 2006 J. Bacteriol. pmid:16621811
Thompson K et al. Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway. 2006 Blood pmid:16179378
Hamadmad SN et al. Erythropoietin receptor signal transduction requires protein geranylgeranylation. 2006 J. Pharmacol. Exp. Ther. pmid:16203826