Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Mokashi V et al. Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro. 2005 Arch. Biochem. Biophys. pmid:15581604
Yazawa H et al. Simvastatin promotes cell metabolism, proliferation, and osteoblastic differentiation in human periodontal ligament cells. 2005 J. Periodontol. pmid:15974856
Han KH et al. HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo. 2005 Circulation pmid:15781755
Hampel D et al. Induction of de novo volatile terpene biosynthesis via cytosolic and plastidial pathways by methyl jasmonate in foliage of Vitis vinifera L. 2005 J. Agric. Food Chem. pmid:15796607
Argmann CA et al. Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux. 2005 J. Biol. Chem. pmid:15817453
Murthy S et al. Regulation of fatty acid synthesis by farnesyl pyrophosphate. 2005 J. Biol. Chem. pmid:16221687
Ota K et al. Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene. 2005 Metab. Clin. Exp. pmid:15690306
Bevilacqua M et al. Bisphosphonates and atherosclerosis: why? 2005 Lupus pmid:16218486
Sakamoto K et al. Fluvastatin prevents vascular hyperplasia by inhibiting phenotype modulation and proliferation through extracellular signal-regulated kinase 1 and 2 and p38 mitogen-activated protein kinase inactivation in organ-cultured artery. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:15591221
Kim J et al. 4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway. 2005 J. Chem. Ecol. pmid:16222778
Baker SK Molecular clues into the pathogenesis of statin-mediated muscle toxicity. 2005 Muscle Nerve pmid:15712281
Neville-Webbe HL et al. Sequence- and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubicin in breast and prostate cancer cells. 2005 Int. J. Cancer pmid:15455384
Enfissi EM et al. Metabolic engineering of the mevalonate and non-mevalonate isopentenyl diphosphate-forming pathways for the production of health-promoting isoprenoids in tomato. 2005 Plant Biotechnol. J. pmid:17168896
Dudareva N et al. The nonmevalonate pathway supports both monoterpene and sesquiterpene formation in snapdragon flowers. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:15630092
Duncan RE et al. Dietary factors and the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for breast cancer and development. 2005 Mol Nutr Food Res pmid:15617098
Nair AK and Menon KM Regulation of luteinizing hormone receptor expression: evidence of translational suppression in vitro by a hormonally regulated mRNA-binding protein and its endogenous association with luteinizing hormone receptor mRNA in the ovary. 2005 J. Biol. Chem. pmid:16263716
Duncan RE et al. Statins and cancer development. 2005 Cancer Epidemiol. Biomarkers Prev. pmid:16103434
Girlanda S et al. MICA expressed by multiple myeloma and monoclonal gammopathy of undetermined significance plasma cells Costimulates pamidronate-activated gammadelta lymphocytes. 2005 Cancer Res. pmid:16103105
Tucker DE et al. Group IVC cytosolic phospholipase A2gamma is farnesylated and palmitoylated in mammalian cells. 2005 J. Lipid Res. pmid:16061942
Bocci G et al. Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells. 2005 Br. J. Cancer pmid:16052215
Luckman SP et al. JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998). 2005 J. Bone Miner. Res. pmid:16050006
Saiki A et al. Pitavastatin enhanced lipoprotein lipase expression in 3T3-L1 preadipocytes. 2005 J. Atheroscler. Thromb. pmid:16020917
Wei H et al. Statin-inhibited endothelial permeability could be associated with its effect on PECAM-1 in endothelial cells. 2005 FEBS Lett. pmid:15710425
Paradisi M et al. Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress. 2005 BMC Cell Biol. pmid:15982412
Viereck V et al. Atorvastatin stimulates the production of osteoprotegerin by human osteoblasts. 2005 J. Cell. Biochem. pmid:16152630
Sacher J et al. Delineation of myotoxicity induced by 3-hydroxy-3-methylglutaryl CoA reductase inhibitors in human skeletal muscle cells. 2005 J. Pharmacol. Exp. Ther. pmid:15914674
Wang C et al. Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. 2005 Mol. Cell pmid:15893726
Mahmud T et al. A biosynthetic pathway to isovaleryl-CoA in myxobacteria: the involvement of the mevalonate pathway. 2005 Chembiochem pmid:15619721
Okada K and Hase T Cyanobacterial non-mevalonate pathway: (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase interacts with ferredoxin in Thermosynechococcus elongatus BP-1. 2005 J. Biol. Chem. pmid:15792953
Mantha AJ et al. Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor. 2005 Clin. Cancer Res. pmid:15788691
McCarey DW et al. Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases? 2005 Arthritis Res. Ther. pmid:15743490
Zeng L et al. HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation. 2005 FASEB J. pmid:16160062
Luebker DJ et al. Neonatal mortality from in utero exposure to perfluorooctanesulfonate (PFOS) in Sprague-Dawley rats: dose-response, and biochemical and pharamacokinetic parameters. 2005 Toxicology pmid:16129535
Duncan RE et al. Delivery of mevalonate to murine extrahepatic tissues via mini-osmotic pumps. 2004 Sep-Oct J Pharmacol Toxicol Methods pmid:15385088
Ruiz-Velasco N et al. Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression. 2004 Biochem. Pharmacol. pmid:14698043
Kizu A et al. Statins inhibit in vitro calcification of human vascular smooth muscle cells induced by inflammatory mediators. 2004 J. Cell. Biochem. pmid:15389884
Suzuki M et al. Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels. 2004 Plant J. pmid:14871314
Bate C et al. Squalestatin cures prion-infected neurons and protects against prion neurotoxicity. 2004 J. Biol. Chem. pmid:14754889
Sauane M et al. Leukaemia inhibitory factor or oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication. 2004 Biochem. Biophys. Res. Commun. pmid:14706631
Fuse M et al. Regulation of geranylgeranyl pyrophosphate synthase in the proliferation of rat FRTL-5 cells: involvement of both cAMP-PKA and PI3-AKT pathways. 2004 Biochem. Biophys. Res. Commun. pmid:14985133
Umlauf D et al. Biosynthesis of the irregular monoterpene artemisia ketone, the sesquiterpene germacrene D and other isoprenoids in Tanacetum vulgare L. (Asteraceae). 2004 Phytochemistry pmid:15381410
Tringali G et al. Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase. 2004 Neurosci. Lett. pmid:14698450
Patel NV and Forman BM Linking lipids, Alzheimer's and LXRs? 2004 Nucl Recept Signal pmid:16604185
Raschke M et al. A high-performance liquid chromatography method for the analysis of intermediates of the deoxyxylulose phosphate pathway. 2004 Anal. Biochem. pmid:15556562
Inomata M et al. Biosynthesis of abscisic acid by the direct pathway via ionylideneethane in a fungus, Cercospora cruenta. 2004 Biosci. Biotechnol. Biochem. pmid:15618629
Thompson K and Rogers MJ Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro. 2004 J. Bone Miner. Res. pmid:14969398
Hedl M and Rodwell VW Enterococcus faecalis mevalonate kinase. 2004 Protein Sci. pmid:14767074
Turunen M et al. Metabolism and function of coenzyme Q. 2004 Biochim. Biophys. Acta pmid:14757233
Kasahara H et al. Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis. 2004 J. Biol. Chem. pmid:14726522
Thorpe JL et al. Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. 2004 Dev. Cell pmid:14960282