Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Ruiz-Velasco N et al. Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression. 2004 Biochem. Pharmacol. pmid:14698043
Schulz JG et al. HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. 2004 J. Neurochem. pmid:15030386
Danesh FR and Kanwar YS Modulatory effects of HMG-CoA reductase inhibitors in diabetic microangiopathy. 2004 FASEB J. pmid:15117885
Kizu A et al. Statins inhibit in vitro calcification of human vascular smooth muscle cells induced by inflammatory mediators. 2004 J. Cell. Biochem. pmid:15389884
Suzuki M et al. Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels. 2004 Plant J. pmid:14871314
Rasouli M et al. Calmodulin antagonist W-7 inhibits de novo synthesis of cholesterol and suppresses secretion of de novo synthesized and preformed lipids from cultured hepatocytes. 2004 Biochim. Biophys. Acta pmid:15158760
Gerber R et al. Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS. 2004 Anal. Biochem. pmid:15136164
Bi X et al. Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia. 2004 J. Biol. Chem. pmid:15364922
del Real G et al. Statins inhibit HIV-1 infection by down-regulating Rho activity. 2004 J. Exp. Med. pmid:15314078
Peña-Diaz J et al. Mitochondrial localization of the mevalonate pathway enzyme 3-Hydroxy-3-methyl-glutaryl-CoA reductase in the Trypanosomatidae. 2004 Mol. Biol. Cell pmid:14699057
Rodríguez JM et al. Fungal metabolic model for 3-methylcrotonyl-CoA carboxylase deficiency. 2004 J. Biol. Chem. pmid:14612443
Sauane M et al. Leukaemia inhibitory factor or oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication. 2004 Biochem. Biophys. Res. Commun. pmid:14706631
Panda T and Devi VA Regulation and degradation of HMGCo-A reductase. 2004 Appl. Microbiol. Biotechnol. pmid:15558272
Fuse M et al. Regulation of geranylgeranyl pyrophosphate synthase in the proliferation of rat FRTL-5 cells: involvement of both cAMP-PKA and PI3-AKT pathways. 2004 Biochem. Biophys. Res. Commun. pmid:14985133
Tabata K and Hashimoto S Production of mevalonate by a metabolically-engineered Escherichia coli. 2004 Biotechnol. Lett. pmid:15604784
Zanotti I et al. Pitavastatin increases ABCA1-mediated lipid efflux from Fu5AH rat hepatoma cells. 2004 Biochem. Biophys. Res. Commun. pmid:15358158
Schwartz CC et al. Lipoprotein cholesteryl ester production, transfer, and output in vivo in humans. 2004 J. Lipid Res. pmid:15145983
Umlauf D et al. Biosynthesis of the irregular monoterpene artemisia ketone, the sesquiterpene germacrene D and other isoprenoids in Tanacetum vulgare L. (Asteraceae). 2004 Phytochemistry pmid:15381410
Tringali G et al. Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase. 2004 Neurosci. Lett. pmid:14698450
Bellosta S et al. Statins effect on smooth muscle cell proliferation. 2004 Semin Vasc Med pmid:15861311
Hedl M et al. Class II 3-hydroxy-3-methylglutaryl coenzyme A reductases. 2004 J. Bacteriol. pmid:15028676
Barkley SJ et al. Identification of an Archaeal type II isopentenyl diphosphate isomerase in methanothermobacter thermautotrophicus. 2004 J. Bacteriol. pmid:14996812
Patel NV and Forman BM Linking lipids, Alzheimer's and LXRs? 2004 Nucl Recept Signal pmid:16604185
Raschke M et al. A high-performance liquid chromatography method for the analysis of intermediates of the deoxyxylulose phosphate pathway. 2004 Anal. Biochem. pmid:15556562
Tokoro T et al. The novel HMG-CoA reductase inhibitor, Pitavastatin, induces a protective action in vascular endothelial cells through the production of nitric oxide (NO). 2004 Yakugaku Zasshi pmid:15049129
Kawasaki T et al. Presence of copalyl diphosphate synthase gene in an actinomycete possessing the mevalonate pathway. 2004 J. Antibiot. pmid:15712669
Inomata M et al. Biosynthesis of abscisic acid by the direct pathway via ionylideneethane in a fungus, Cercospora cruenta. 2004 Biosci. Biotechnol. Biochem. pmid:15618629
Friesen JA and Rodwell VW The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases. 2004 Genome Biol. pmid:15535874
Sauter GH et al. Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects. 2004 Digestion pmid:15375335
Fan P et al. Pitavastatin, a potent hydroxymethylglutaryl coenzyme a reductase inhibitor, increases cholesterol 7 alpha-hydroxylase gene expression in HepG2 cells. 2004 Circ. J. pmid:15502389
Ferrara DE et al. Fluvastatin inhibits up-regulation of tissue factor expression by antiphospholipid antibodies on endothelial cells. 2004 J. Thromb. Haemost. pmid:15333031
Duncan RE et al. Mevalonate promotes the growth of tumors derived from human cancer cells in vivo and stimulates proliferation in vitro with enhanced cyclin-dependent kinase-2 activity. 2004 J. Biol. Chem. pmid:15155733
Hedl M and Rodwell VW Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii. 2004 Protein Sci. pmid:15152097
Kuzuyama T et al. Heterologous mevalonate production in Streptomyces lividans TK23. 2004 Biosci. Biotechnol. Biochem. pmid:15118326
Andreassi JL et al. Streptococcus pneumoniae isoprenoid biosynthesis is downregulated by diphosphomevalonate: an antimicrobial target. 2004 Biochemistry pmid:15610040
Andela VB Correspondence Re S. S. Virtanen et al., Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. Cancer Res 2002;62:2708-14. Re K. Sawada et al., Alendronate inhibits lysophosphatidic acid-induced migration of human ovarian cancer cells by attenuating the activation of Rho. Cancer Res 2002;62:6015-20. 2004 Cancer Res. pmid:15087415
Boucher Y et al. Origins and evolution of isoprenoid lipid biosynthesis in archaea. 2004 Mol. Microbiol. pmid:15066037
Blanco-Colio LM et al. Decreased circulating Fas ligand in patients with familial combined hyperlipidemia or carotid atherosclerosis: normalization by atorvastatin. 2004 J. Am. Coll. Cardiol. pmid:15063428
Reichart B et al. Expression and localization of nuclear proteins in autosomal-dominant Emery-Dreifuss muscular dystrophy with LMNA R377H mutation. 2004 BMC Cell Biol. pmid:15053843
Begley M et al. The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes. 2004 FEBS Lett. pmid:15013758
Thompson K and Rogers MJ Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro. 2004 J. Bone Miner. Res. pmid:14969398
Hedl M and Rodwell VW Enterococcus faecalis mevalonate kinase. 2004 Protein Sci. pmid:14767074
Turunen M et al. Metabolism and function of coenzyme Q. 2004 Biochim. Biophys. Acta pmid:14757233
Thorpe JL et al. Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. 2004 Dev. Cell pmid:14960282
Hong SB et al. Role of the non-mevalonate pathway in indole alkaloid production by Catharanthus roseus hairy roots. 2003 May-Jun Biotechnol. Prog. pmid:12790690
Laufs U Beyond lipid-lowering: effects of statins on endothelial nitric oxide. 2003 Eur. J. Clin. Pharmacol. pmid:12634978
García-Pelayo MC et al. Modification of phospholipids fatty acid composition in reuber H35 hepatoma cells: effect on HMG-CoA reductase activity. 2003 J. Cell. Biochem. pmid:14523992
Ohm TG et al. Cholesterol and tau protein--findings in Alzheimer's and Niemann Pick C's disease. 2003 Pharmacopsychiatry pmid:14574625
Poirier J Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease. 2003 Trends Mol Med pmid:12657430
De-Eknamkul W and Potduang B Biosynthesis of beta-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units. 2003 Phytochemistry pmid:12620352