Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Capra V and Rovati GE Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents. 2014 Pulm Pharmacol Ther pmid:23806820
Bentinger M et al. Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis. 2014 Biochim. Biophys. Acta pmid:24747199
Yuan J and Ching CB Combinatorial engineering of mevalonate pathway for improved amorpha-4,11-diene production in budding yeast. 2014 Biotechnol. Bioeng. pmid:24122315
Sorrentino G et al. Metabolic control of YAP and TAZ by the mevalonate pathway. 2014 Nat. Cell Biol. pmid:24658687
Al-Haidari AA et al. HMG-CoA reductase regulates CCL17-induced colon cancer cell migration via geranylgeranylation and RhoA activation. 2014 Biochem. Biophys. Res. Commun. pmid:24582560
Huchelmann A et al. S-carvone suppresses cellulase-induced capsidiol production in Nicotiana tabacum by interfering with protein isoprenylation. 2014 Plant Physiol. pmid:24367019
Smith R et al. Simvastatin inhibits glucose metabolism and legumain activity in human myotubes. 2014 PLoS ONE pmid:24416446
Liu YP et al. Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators. 2014 J. Clin. Invest. pmid:24691443
Burgazli KM et al. The impact of statins on FGF-2-stimulated human umbilical vein endothelial cells. 2014 Postgrad Med pmid:24393759
Moise AR et al. Mechanistic aspects of carotenoid biosynthesis. 2014 Chem. Rev. pmid:24175570
Khandelwal VK et al. Oxidative stress plays an important role in zoledronic acid-induced autophagy. 2014 Physiol Res pmid:25669691
Warita K et al. Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion. 2014 Sci Rep pmid:25534349
Yang J and Guo L Biosynthesis of β-carotene in engineered E. coli using the MEP and MVA pathways. 2014 Microb. Cell Fact. pmid:25403509
Larson-Casey JL et al. Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosis. 2014 J. Biol. Chem. pmid:25378391
Shimabukuro-Vornhagen A et al. Inhibition of protein geranylgeranylation specifically interferes with CD40-dependent B cell activation, resulting in a reduced capacity to induce T cell immunity. 2014 J. Immunol. pmid:25311809
Chang TI et al. The effect of statin on epithelial-mesenchymal transition in peritoneal mesothelial cells. 2014 PLoS ONE pmid:25275561
Kanugula AK et al. Fluvastatin mediated breast cancer cell death: a proteomic approach to identify differentially regulated proteins in MDA-MB-231 cells. 2014 PLoS ONE pmid:25268751
Sapir A et al. Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25187565
Rodriguez SB and Leyh TS An enzymatic platform for the synthesis of isoprenoid precursors. 2014 PLoS ONE pmid:25153179
Jiang P et al. In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells. 2014 Br. J. Cancer pmid:25093497
Sivanandhan G et al. Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor. 2014 PLoS ONE pmid:25089711
Rastogi S et al. De novo sequencing and comparative analysis of holy and sweet basil transcriptomes. 2014 BMC Genomics pmid:25015319
Fabris M et al. Tracking the sterol biosynthesis pathway of the diatom Phaeodactylum tricornutum. 2014 New Phytol. pmid:24996048
Wang Y et al. 24S,25-Epoxycholesterol in mouse and rat brain. 2014 Biochem. Biophys. Res. Commun. pmid:24832732
Xiong M et al. Scalable production of mechanically tunable block polymers from sugar. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:24912182
Rivera-Perez C et al. Metabolic analysis reveals changes in the mevalonate and juvenile hormone synthesis pathways linked to the mosquito reproductive physiology. 2014 Insect Biochem. Mol. Biol. pmid:24833260
Song AA et al. Engineering the lactococcal mevalonate pathway for increased sesquiterpene production. 2014 FEMS Microbiol. Lett. pmid:24828482
Tricarico PM et al. Block of the mevalonate pathway triggers oxidative and inflammatory molecular mechanisms modulated by exogenous isoprenoid compounds. 2014 Int J Mol Sci pmid:24758928
Azami Y et al. (R)-mevalonate 3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum. 2014 J. Biol. Chem. pmid:24755225
Zheng X et al. Triterpenoid saponin biosynthetic pathway profiling and candidate gene mining of the Ilex asprella root using RNA-Seq. 2014 Int J Mol Sci pmid:24722569
Liu Y et al. Caenorhabditis elegans pathways that surveil and defend mitochondria. 2014 Nature pmid:24695221
Piłsyk S et al. Overexpression of erg20 gene encoding farnesyl pyrophosphate synthase has contrasting effects on activity of enzymes of the dolichyl and sterol branches of mevalonate pathway in Trichoderma reesei. 2014 Gene pmid:24793581
Ghavami S et al. Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins. 2014 Biochim. Biophys. Acta pmid:24637330
Korman TP et al. A synthetic biochemistry system for the in vitro production of isoprene from glycolysis intermediates. 2014 Protein Sci. pmid:24623472
Yeganeh B et al. Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease. 2014 Pharmacol. Ther. pmid:24582968
Rojo-Arreola L et al. Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. 2014 PLoS ONE pmid:24489942
Li J et al. De novo synthesis of steroids and oxysterols in adipocytes. 2014 J. Biol. Chem. pmid:24280213
Vannice JC et al. Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an archaeal alternate mevalonate pathway. 2014 J. Bacteriol. pmid:24375100
Wang Z et al. Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:24367099
Sánchez-Solana B et al. Cytosolic functions of MORC2 in lipogenesis and adipogenesis. 2014 Biochim. Biophys. Acta pmid:24286864
González-Caballero N et al. Expression of the mevalonate pathway enzymes in the Lutzomyia longipalpis (Diptera: Psychodidae) sex pheromone gland demonstrated by an integrated proteomic approach. 2014 J Proteomics pmid:24185139
Fu Z et al. Exometabolome analysis reveals hypoxia at the up-scaling of a Saccharomyces cerevisiae high-cell density fed-batch biopharmaceutical process. 2014 Microb. Cell Fact. pmid:24593159
Zelcer N et al. The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway. 2014 Mol. Cell. Biol. pmid:24449766
Kiser PD et al. Chemistry of the retinoid (visual) cycle. 2014 Chem. Rev. pmid:23905688
Rachner TD et al. Dickkopf-1 is regulated by the mevalonate pathway in breast cancer. 2014 Breast Cancer Res. pmid:24528599
Blanc M et al. The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. 2013 Immunity pmid:23273843
Bruzzese F et al. Panobinostat synergizes with zoledronic acid in prostate cancer and multiple myeloma models by increasing ROS and modulating mevalonate and p38-MAPK pathways. 2013 Cell Death Dis pmid:24157872
Fang SY et al. Pleiotropic vascular protective effects of statins in perioperative medicine. 2013 Acta Anaesthesiol Taiwan pmid:24148741
Maciejak A et al. The effects of statins on the mevalonic acid pathway in recombinant yeast strains expressing human HMG-CoA reductase. 2013 BMC Biotechnol. pmid:24128347
Lee NY and Kang YS The effects of bisphosphonates on taurine transport in retinal capillary endothelial cells under high glucose conditions. 2013 Adv. Exp. Med. Biol. pmid:23392871