Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Alonso-Gutierrez J et al. Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production. 2013 Metab. Eng. pmid:23727191
Theesfeld CL and Hampton RY Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast. 2013 J. Biol. Chem. pmid:23306196
van der Burgh R et al. Mevalonate kinase deficiency, a metabolic autoinflammatory disease. 2013 Clin. Immunol. pmid:23110805
Hosaka A et al. Statins reduce amyloid β-peptide production by modulating amyloid precursor protein maturation and phosphorylation through a cholesterol-independent mechanism in cultured neurons. 2013 Neurochem. Res. pmid:23269484
Qi XF et al. HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway. 2013 Cell Death Dis pmid:23449454
Tricarico PM et al. Temperature and drug treatments in mevalonate kinase deficiency: an ex vivo study. 2013 Biomed Res Int pmid:24073415
Tyurin M Gene replacement and elimination using λRed- and FLP-based tool to re-direct carbon flux in acetogen biocatalyst during continuous CO₂/H₂ blend fermentation. 2013 J. Ind. Microbiol. Biotechnol. pmid:23649912
Martín-Navarro CM et al. Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and application of statins as a novel effective therapeutic approach against Acanthamoeba infections. 2013 Antimicrob. Agents Chemother. pmid:23114753
Zhang J et al. Statins directly suppress cytokine production in murine intraepithelial lymphocytes. 2013 Cytokine pmid:23290865
Rauthan M et al. The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23530189
Citron CA and Dickschat JS The stereochemical course of tricho-acorenol biosynthesis. 2013 Org. Biomol. Chem. pmid:24084795
Blanc M et al. The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. 2013 Immunity pmid:23273843
Wang C et al. Engineered heterologous FPP synthases-mediated Z,E-FPP synthesis in E. coli. 2013 Metab. Eng. pmid:23608473
Yu W et al. The mevalonate auxotrophic mutant of Staphylococcus aureus can adapt to mevalonate depletion. 2013 Antimicrob. Agents Chemother. pmid:23959312
Szűcs G et al. Cardioprotection by farnesol: role of the mevalonate pathway. 2013 Cardiovasc Drugs Ther pmid:23673412
Ramak P et al. Inhibition of the mevalonate pathway enhances carvacrol biosynthesis and DXR gene expression in shoot cultures of Satureja khuzistanica Jamzad. 2013 J. Plant Physiol. pmid:23611428
Chen X et al. Statistical experimental design guided optimization of a one-pot biphasic multienzyme total synthesis of amorpha-4,11-diene. 2013 PLoS ONE pmid:24278153
Chang WC et al. Current development in isoprenoid precursor biosynthesis and regulation. 2013 Curr Opin Chem Biol pmid:23891475
Tuerdi G et al. Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells. 2013 Cancer Lett. pmid:23879968
Gopalan A et al. Simvastatin inhibition of mevalonate pathway induces apoptosis in human breast cancer cells via activation of JNK/CHOP/DR5 signaling pathway. 2013 Cancer Lett. pmid:22960596
Onono F et al. Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway. 2013 J. Biol. Chem. pmid:23908355
Gopalan A et al. Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol. 2013 Cancer Lett. pmid:23063651
Liu J et al. Overproduction of geraniol by enhanced precursor supply in Saccharomyces cerevisiae. 2013 J. Biotechnol. pmid:24161921
Lee SK and Kim YS Phosphorylation of eIF2α attenuates statin-induced apoptosis by inhibiting the stabilization and translocation of p53 to the mitochondria. 2013 Int. J. Oncol. pmid:23354132
Villanueva JA et al. Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. 2013 J. Clin. Endocrinol. Metab. pmid:23386644
May B et al. Biosynthesis of sesquiterpenes in grape berry exocarp of Vitis vinifera L.: evidence for a transport of farnesyl diphosphate precursors from plastids to the cytosol. 2013 Phytochemistry pmid:23954075
Zeng H et al. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. 2013 Nature pmid:23812589
Chen B et al. Alteration of mevalonate pathway related enzyme expressions in pressure overload-induced cardiac hypertrophy and associated heart failure with preserved ejection fraction. 2013 Cell. Physiol. Biochem. pmid:24356578
Dellas N et al. Discovery of a metabolic alternative to the classical mevalonate pathway. 2013 Elife pmid:24327557
Bruzzese F et al. Panobinostat synergizes with zoledronic acid in prostate cancer and multiple myeloma models by increasing ROS and modulating mevalonate and p38-MAPK pathways. 2013 Cell Death Dis pmid:24157872
Dick M et al. Statin therapy influences endothelial cell morphology and F-actin cytoskeleton structure when exposed to static and laminar shear stress conditions. 2013 Life Sci. pmid:23517776
Fang SY et al. Pleiotropic vascular protective effects of statins in perioperative medicine. 2013 Acta Anaesthesiol Taiwan pmid:24148741
Maciejak A et al. The effects of statins on the mevalonic acid pathway in recombinant yeast strains expressing human HMG-CoA reductase. 2013 BMC Biotechnol. pmid:24128347
Polidoro S et al. Effects of bisphosphonate treatment on DNA methylation in osteonecrosis of the jaw. 2013 Mutat. Res. pmid:23892139
Santolaria T et al. Repeated systemic administrations of both aminobisphosphonates and human Vγ9Vδ2 T cells efficiently control tumor development in vivo. 2013 J. Immunol. pmid:23836057
Poggi A et al. Selective role of mevalonate pathway in regulating perforin but not FasL and TNFalpha release in human Natural Killer cells. 2013 PLoS ONE pmid:23667543
Ohukainen P If the wheel ain't broke, don't reinvent it. 2013 Lipids Health Dis pmid:23577775
Lee NY and Kang YS The effects of bisphosphonates on taurine transport in retinal capillary endothelial cells under high glucose conditions. 2013 Adv. Exp. Med. Biol. pmid:23392871
Corcos L and Le Jossic-Corcos C Statins: perspectives in cancer therapeutics. 2013 Dig Liver Dis pmid:23490341
Lesma E et al. Chromatin remodeling by rosuvastatin normalizes TSC2-/meth cell phenotype through the expression of tuberin. 2013 J. Pharmacol. Exp. Ther. pmid:23426956
Doblas VG et al. The SUD1 gene encodes a putative E3 ubiquitin ligase and is a positive regulator of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in Arabidopsis. 2013 Plant Cell pmid:23404890
Riganti C et al. Zoledronic acid restores doxorubicin chemosensitivity and immunogenic cell death in multidrug-resistant human cancer cells. 2013 PLoS ONE pmid:23593363
Mazein A et al. A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. 2013 Biochem. Pharmacol. pmid:23583456
Ginestier C et al. Mevalonate metabolism regulates Basal breast cancer stem cells and is a potential therapeutic target. 2012 Stem Cells pmid:22605458
Liu D et al. The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation [corrected]. 2012 PLoS ONE pmid:22567134
Shi Z and Ruvkun G The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22396595
Malenda A et al. Statins impair glucose uptake in tumor cells. 2012 Neoplasia pmid:22577346
Ohsawa M et al. Effect of spinally administered simvastatin on the formalin-induced nociceptive response in mice. 2012 J. Pharmacol. Sci. pmid:22510521
Chow KS et al. Metabolic routes affecting rubber biosynthesis in Hevea brasiliensis latex. 2012 J. Exp. Bot. pmid:22162870
Fatima T et al. Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. 2012 PLoS ONE pmid:22558083