Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
DiNicolantonio JJ CoQ10 and L-carnitine for statin myalgia? 2012 Expert Rev Cardiovasc Ther pmid:23190071
Aliferis KA and Jabaji S FT-ICR/MS and GC-EI/MS metabolomics networking unravels global potato sprout's responses to Rhizoctonia solani infection. 2012 PLoS ONE pmid:22880040
Zaidi N et al. ATP-citrate lyase: a key player in cancer metabolism. 2012 Cancer Res. pmid:22787121
Matsuoka T et al. An ultrasensitive enzymatic method for measuring mevalonic acid in serum. 2012 J. Lipid Res. pmid:22715156
Van Laar TA et al. Effect of levels of acetate on the mevalonate pathway of Borrelia burgdorferi. 2012 PLoS ONE pmid:22675445
Ginestier C et al. Mevalonate metabolism regulates Basal breast cancer stem cells and is a potential therapeutic target. 2012 Stem Cells pmid:22605458
Liu D et al. The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation [corrected]. 2012 PLoS ONE pmid:22567134
Yang J et al. Enhancing production of bio-isoprene using hybrid MVA pathway and isoprene synthase in E. coli. 2012 PLoS ONE pmid:22558074
Thurnher M et al. Novel aspects of mevalonate pathway inhibitors as antitumor agents. 2012 Clin. Cancer Res. pmid:22529099
Hong SY et al. Isoprene hydrocarbons production upon heterologous transformation of Saccharomyces cerevisiae. 2012 J. Appl. Microbiol. pmid:22519412
Iwata A et al. Inhibitory effect of statins on inflammatory cytokine production from human bronchial epithelial cells. 2012 Clin. Exp. Immunol. pmid:22471285
Luvai A et al. Rosuvastatin: a review of the pharmacology and clinical effectiveness in cardiovascular disease. 2012 Clin Med Insights Cardiol pmid:22442638
Lachenmeier DW et al. NMR evaluation of total statin content and HMG-CoA reductase inhibition in red yeast rice (Monascus spp.) food supplements. 2012 Chin Med pmid:22439629
Keizer HG The "Mevalonate hypothesis": a cholesterol-independent alternative for the etiology of atherosclerosis. 2012 Lipids Health Dis pmid:23122424
Yano K Lipid metabolic pathways as lung cancer therapeutic targets: a computational study. 2012 Int. J. Mol. Med. pmid:22211244
Shimane M et al. Mevalonate-dependent enzymatic synthesis of amorphadiene driven by an ATP-regeneration system using polyphosphate kinase. 2012 Biosci. Biotechnol. Biochem. pmid:22878192
Mans RA et al. Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. 2012 Neuroscience pmid:22192838
Fu X et al. Plastid structure and carotenogenic gene expression in red- and white-fleshed loquat (Eriobotrya japonica) fruits. 2012 J. Exp. Bot. pmid:21994170
Murphy LA et al. Propiconazole-enhanced hepatic cell proliferation is associated with dysregulation of the cholesterol biosynthesis pathway leading to activation of Erk1/2 through Ras farnesylation. 2012 Toxicol. Appl. Pharmacol. pmid:22361350
Zhou K et al. Metabolite profiling identified methylerythritol cyclodiphosphate efflux as a limiting step in microbial isoprenoid production. 2012 PLoS ONE pmid:23133596
Fuhrmeister J et al. Prooxidative toxicity and selenoprotein suppression by cerivastatin in muscle cells. 2012 Toxicol. Lett. pmid:23092657
Scalcinati G et al. Combined metabolic engineering of precursor and co-factor supply to increase α-santalene production by Saccharomyces cerevisiae. 2012 Microb. Cell Fact. pmid:22938570
Baadhe RR et al. Development of petri net-based dynamic model for improved production of farnesyl pyrophosphate by integrating mevalonate and methylerythritol phosphate pathways in yeast. 2012 Appl. Biochem. Biotechnol. pmid:22350871
Panicker SP et al. Sterol intermediates of cholesterol biosynthesis inhibit hair growth and trigger an innate immune response in cicatricial alopecia. 2012 PLoS ONE pmid:22685570
Guo H et al. Rosuvastatin may modulate insulin signaling and inhibit atherogenesis beyond its plasma cholesterol-lowering effect in insulin-resistant mice. 2012 Cardiovasc Drugs Ther pmid:22918601
Trapani L et al. 3-hydroxy 3-methylglutaryl coenzyme A reductase inhibition impairs muscle regeneration. 2012 J. Cell. Biochem. pmid:22274883
Hamano T et al. Pitavastatin decreases tau levels via the inactivation of Rho/ROCK. 2012 Neurobiol. Aging pmid:22133277
Nürenberg G and Volmer DA The analytical determination of isoprenoid intermediates from the mevalonate pathway. 2012 Anal Bioanal Chem pmid:21789486
Wu S et al. Engineering triterpene metabolism in tobacco. 2012 Planta pmid:22729821
Henriquez MA et al. Effects of glucans and eicosapentaenoic acid on differential regulation of phenylpropanoid and mevalonic pathways during potato response to Phytophthora infestans. 2012 Plant Physiol. Biochem. pmid:22922112
Song AA et al. Overexpressing 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) in the lactococcal mevalonate pathway for heterologous plant sesquiterpene production. 2012 PLoS ONE pmid:23300671
Partow S et al. Reconstruction and evaluation of the synthetic bacterial MEP pathway in Saccharomyces cerevisiae. 2012 PLoS ONE pmid:23285068
Yang D et al. Different roles of the mevalonate and methylerythritol phosphate pathways in cell growth and tanshinone production of Salvia miltiorrhiza hairy roots. 2012 PLoS ONE pmid:23209548
Iguchi K [Effect of bisphosphonates on anticancer activity in prostate cancer cells]. 2012 Yakugaku Zasshi pmid:23023419
Haines BE et al. Molecular modeling of the reaction pathway and hydride transfer reactions of HMG-CoA reductase. 2012 Biochemistry pmid:22971202
Coscia M et al. Dysfunctional Vγ9Vδ2 T cells are negative prognosticators and markers of dysregulated mevalonate pathway activity in chronic lymphocytic leukemia cells. 2012 Blood pmid:22932792
Malenda A et al. Statins impair glucose uptake in tumor cells. 2012 Neoplasia pmid:22577346
Garjani A et al. Ambivalent effects of atorvastatin on angiogenesis, epidermal cell proliferation and tumorgenesis in animal models. 2012 Iran. Biomed. J. pmid:22801278
Ginestier C et al. p53 and cancer stem cells: the mevalonate connexion. 2012 Cell Cycle pmid:22751434
Roy A et al. Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease. 2012 PLoS ONE pmid:22723850
Khasnavis S and Pahan K Sodium benzoate, a metabolite of cinnamon and a food additive, upregulates neuroprotective Parkinson disease protein DJ-1 in astrocytes and neurons. 2012 J Neuroimmune Pharmacol pmid:21701815
Plée-Gautier E et al. Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: a PXR dependent mechanism. 2012 Biochem. Pharmacol. pmid:22634049
Paintlia AS et al. Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis. 2012 Am. J. Pathol. pmid:22796435
Rad SA et al. Type 2 IDI performs better than type 1 for improving lycopene production in metabolically engineered E. coli strains. 2012 World J. Microbiol. Biotechnol. pmid:22806807
Campia I et al. Digoxin and ouabain induce the efflux of cholesterol via liver X receptor signalling and the synthesis of ATP in cardiomyocytes. 2012 Biochem. J. pmid:22845468
Fatima T et al. Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. 2012 PLoS ONE pmid:22558083
Zhang B et al. Interference in mevalonate pathway ameliorates homocysteine-induced endothelium-dysfunction. 2012 Eur. J. Pharmacol. pmid:22796672
Roullet JB et al. No evidence for mevalonate shunting in moderately affected children with Smith-Lemli-Opitz syndrome. 2012 J. Inherit. Metab. Dis. pmid:22391996
Barta ML et al. Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase. 2012 Biochemistry pmid:22734632
Li J et al. Atorvastatin inhibits myocardin expression in vascular smooth muscle cells. 2012 Hypertension pmid:22615115