Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Cox AD Mutation and analysis of prenylation signal sequences. 1995 Meth. Enzymol. pmid:7651143
Burton PM et al. Azalanstat (RS-21607), a lanosterol 14 alpha-demethylase inhibitor with cholesterol-lowering activity. 1995 Biochem. Pharmacol. pmid:7646560
Crick DC et al. Selective inhibition of cholesterol biosynthesis in brain cells by squalestatin 1. 1995 J. Neurochem. pmid:7643114
Meigs TE et al. Farnesyl acetate, a derivative of an isoprenoid of the mevalonate pathway, inhibits DNA replication in hamster and human cells. 1995 Exp. Cell Res. pmid:7641798
Watts GF et al. Direct correlation between cholesterol synthesis and hepatic secretion of apolipoprotein B-100 in normolipidemic subjects. 1995 Metab. Clin. Exp. pmid:7637647
Schroeder WA and Johnson EA Singlet oxygen and peroxyl radicals regulate carotenoid biosynthesis in Phaffia rhodozyma. 1995 J. Biol. Chem. pmid:7629161
Kwiterovich PO and Motevalli M Inhibition of protein tyrosine kinase alters the effect of serum basic protein I on triacylglycerols and cholesterol differently in normal and hyperapoB fibroblasts. 1995 Arterioscler. Thromb. Vasc. Biol. pmid:7627714
Wiley MH et al. Sex differences in the sterol and nonsterol metabolism of mevalonate. 1979 J. Biol. Chem. pmid:762097
Schedin S et al. Changes in the levels of dolichol and dolichyl phosphate in a murine model of Niemann-Pick's type C disease. 1995 J. Neurochem. pmid:7616223
Roullet JB et al. Mevalonate availability affects human and rat resistance vessel function. 1995 J. Clin. Invest. pmid:7615793
Dalton MB et al. The farnesyl protein transferase inhibitor BZA-5B blocks farnesylation of nuclear lamins and p21ras but does not affect their function or localization. 1995 Cancer Res. pmid:7614464
Corsini A et al. Pathogenesis of atherosclerosis and the role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. 1995 Am. J. Cardiol. pmid:7604791
Rogler G et al. Effects of fluvastatin on growth of porcine and human vascular smooth muscle cells in vitro. 1995 Am. J. Cardiol. pmid:7604784
Ranganathan G and Mukkada AJ Ubiquinone biosynthesis in Leishmania major promastigotes. 1995 Int. J. Parasitol. pmid:7601585
pmid:7589240
Gayen AK and Peffley DM The length of 5'-untranslated leader sequences influences distribution of 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA in polysomes: effects of lovastatin, oxysterols, and mevalonate. 1995 Arch. Biochem. Biophys. pmid:7574724
Lin Y et al. Differences in propionate-induced inhibition of cholesterol and triacylglycerol synthesis between human and rat hepatocytes in primary culture. 1995 Br. J. Nutr. pmid:7547837
Hokland BM et al. Cyclic AMP stimulates efflux of intracellular sterol from cholesterol-loaded cells. 1993 J. Biol. Chem. pmid:7503979
Latruffe N et al. Stimulation of protein kinase C activity by compactin in vascular smooth muscle cells. 1995 Biochem. Biophys. Res. Commun. pmid:7503722
Yu SG et al. Geraniol, an inhibitor of mevalonate biosynthesis, suppresses the growth of hepatomas and melanomas transplanted to rats and mice. 1995 J. Nutr. pmid:7472655
Drevon CA et al. Secretion of very low density lipoproteins enriched in cholesteryl esters by cultured rat hepatocytes during simulation of intracellular cholesterol esterification. 1980 J. Lipid Res. pmid:7462802
Duncan JL and Buckingham L Resistance to streptolysin O in mammalian cells treated with oxygenated derivatives of cholesterol. Cholesterol content of resistant cells and recovery of streptolysin O sensitivity. 1980 Biochim. Biophys. Acta pmid:7459354
Hoffman PC et al. Effect of oxygenated sterol compounds on human bone marrow granulocytic progenitor cells. 1981 Blood pmid:7448408
Subbiah MT Incorporation of 14C-mevalonate into biliary cholesterol and bile acids by perfused rat liver: effect of plasma and individual lipoproteins. 1980 Steroids pmid:7444999
Erickson SK et al. Rat liver acyl-coenzyme A:cholesterol acyltransferase: its regulation in vivo and some of its properties in vitro. 1980 J. Lipid Res. pmid:7441061
George R and Goldfarb S Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in Morris hepatoma 7800 after intravenous injection of mevalonic acid. 1980 Cancer Res. pmid:7438103
Ciavatti M et al. Biosynthesis of cholesterol and cholesterol precursors in platelets of female rats treated with oral contraceptives. 1980 Biochim. Biophys. Acta pmid:7437455
Kritchevsky D et al. Cholesterol synthesis in tissues of young and old Fisher 344 and Sprague-Dawley rats. 1980 Exp. Gerontol. pmid:7428858
Feingold KR et al. Influence of thyroid hormone status on mevalonate metabolism in rats. 1980 J. Clin. Invest. pmid:7419712
Erickson SK et al. Studies on the mechanisms of the rapid modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in intact liver by mevalonolactone and 25-hydroxycholesterol. 1980 Biochim. Biophys. Acta pmid:7417482
Turner JA and Prebble JN Protection of cell viability and respiratory quinone levels by carotenoid in Micrococcus lysodeikticus (M. luteus). 1980 J. Gen. Microbiol. pmid:7411117
Curtiss LK and Edgington TS Differences in the characteristics of inhibition of lymphocyte stimulation by 25-hydroxycholesterol and by the immunoregulatory serum lipoprotein LDL-In. 1980 J. Immunol. pmid:7410845
Drevon CA et al. Regulation of cholesterol esterification and biosynthesis in monolayer cultures of normal adult rat hepatocytes. 1980 J. Biol. Chem. pmid:7410416
Hidaka K et al. Growth of amphotericin B-resistant hamster cell line requires exogenous cholesterol. 1980 Exp. Cell Res. pmid:7408982
Swift IE and Milborrow BV Retention of the 4-pro-R hydrogen atom of mevalonate at C-2,2' of bacterioruberin in Halobacterium halobium. 1980 Biochem. J. pmid:7406867
Feingold KR et al. Sex difference in human mevalonate metabolism. 1980 J. Clin. Invest. pmid:7400320
Hughes PE and Tove SB Synthesis of alpha-tocopherolquinone by the rat and its reduction by mitochondria. 1980 J. Biol. Chem. pmid:7391070
Faust JR et al. Synthesis of delta 2-isopentenyl tRNA from mevalonate in cultured human fibroblasts. 1980 J. Biol. Chem. pmid:7391033
Elliott JG and Lachance PA Effects of vitamin A and ascorbic acid on in vitro cholesterol biosynthesis in the rat. 1980 J. Nutr. pmid:7381607
Shechter I et al. A deficiency of mixed function oxidase activities in the cholesterol biosynthetic pathway of human granulocytes. 1980 J. Lipid Res. pmid:7381322
Nambudiri AM et al. The role of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in the regulation of ubiquinone synthesis in human fibroblasts. 1980 J. Biol. Chem. pmid:7380842
Shao MJ and Lei KY Conversion of [2-14C] mevalonate into cholesterol, lanosterol and squalene in copper-deficient rats. 1980 J. Nutr. pmid:7373433
Raulston DL et al. Cycloheximide inhibits sterol biosynthesis in cell-free preparations of rat liver. 1980 J. Biol. Chem. pmid:7372603
pmid:7371916
Yachnin S and Hsu R Inhibition of human lymphocyte transformation by oxygenated sterol compounds. 1980 Cell. Immunol. pmid:7363333
Hanson RF et al. Stereochemistry of the side chain oxidation of 5 beta-cholestane-3 alpha,7 alpha,12 alpha-triol in man. 1980 J. Biol. Chem. pmid:7354041
James MJ and Kandutsch AA Elevated dolichol synthesis in mouse testes during spermatogenesis. 1980 J. Biol. Chem. pmid:7350150
Swift IE and Milborrow BV Stereochemistry of allene biosynthesis and the formation of the acetylenic carotenoid diadinoxanthin and peridinin (C37) from neoxanthin. 1981 Biochem. J. pmid:7337715
Feingold KR et al. The effect of decreased plasma cholesterol concentration on circulatinga mevalonate metabolism in rats. 1981 J. Lipid Res. pmid:7276756
Douglass TS et al. The biosynthesis, absorption, and origin of cholesterol and plant sterols in the Florida land crab. 1981 J. Lipid Res. pmid:7276755