Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Brunengraber H et al. Urinary clearance and metabolism of mevalonate by the isolataed perfused rat kidney. 1981 J. Lipid Res. pmid:7276751
Humphries GM Difference in the ability of compactin and oxidized cholesterol, both known inhibitors of cholesterol biosynthesis, to suppress in vitro immune responses. 1981 Cancer Res. pmid:7260948
Ryan J et al. Isolation and characterization of cells resistant to ML236B (compactin) with increased levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1981 J. Biol. Chem. pmid:7240242
pmid:7236655
Hagler WM et al. Biosynthesis of radiolabeled T-2 toxin by Fusarium tricinctum. 1981 Appl. Environ. Microbiol. pmid:7235702
Stange EF et al. Regulation of 3-hydroxy-3-methylglutaryl-CoA reductase by endogenous sterol synthesis in cultured intestinal mucosa. 1981 Biochim. Biophys. Acta pmid:7225401
Stange EF et al. Influence of dietary cholesterol, saturated and unsaturated lipid on 3-hydroxy-3-methylglutaryl CoA reductase activity in rabbit intestine and liver. 1981 J. Lipid Res. pmid:7217785
pmid:7212258
Sable-Amplis R et al. Abnormal liver cholesteryl ester storage in a strain of golden hamsters. Possible model for studies on cholesterol metabolism. 1978 Biochim. Biophys. Acta pmid:718971
Allen KG and Klevay LM Copper deficiency and cholesterol metabolism in the rat. 1978 Atherosclerosis pmid:718736
Nes WD et al. Metabolism of mevalonic acid to long chain fatty alcohols in an insect. 1982 Biochem. Biophys. Res. Commun. pmid:7181890
Sablé-Amplis R and Sicart R Evidence for negative feedback control of cholesterogenesis from mevalonate in liver: absence in the intestine of guinea pigs fed a 0.5% cholesterol diet. 1982 Biochem. Biophys. Res. Commun. pmid:7181883
Greenwood DR and Rees HH Mechanism of hydroxylation at C-22 during the biosynthesis of ecdysteroids in the locust Schistocerca gregaria. 1982 Biochem. J. pmid:7165737
Masuda A et al. Chinese hamster cell mutant resistant to ML236B (Compactin) is defective in endocytosis of low-density lipo-protein. 1982 Mol. Cell. Biol. pmid:7162516
Ekström T et al. Biosynthesis of dolichol and dolichylphosphate in rat hepatocytes in vivo. 1982 FEBS Lett. pmid:7160467
pmid:7159436
pmid:7151179
Ranganathan S et al. Effect of pantethine on the biosynthesis of cholesterol in human skin fibroblasts. 1982 Atherosclerosis pmid:7150392
Schmidt RA et al. A study of the Influence of mevalonic acid and its metabolites on the morphology of swiss 3T3 cells. 1982 J. Cell Biol. pmid:7142283
Lovati MR et al. Cholesterol and bile-acid metabolism in normal and cholesterol-fed rabbits after partial ileal bypass. 1982 Exp. Mol. Pathol. pmid:7140933
Nestel PJ et al. The effect of dietary fat supplements on cholesterol metabolism in ruminants. 1978 J. Lipid Res. pmid:712248
Linder JR and Beitz DC Sterol synthesis and CO2 production from mevalonate in calves. 1978 J. Lipid Res. pmid:712243
Angelin B et al. Hepatic cholesterol metabolism in obesity: activity of microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1982 J. Lipid Res. pmid:7119574
Schwartz CC et al. Multicompartmental analysis of cholesterol metabolism in man. Quantitative kinetic evaluation of precursor sources and turnover of high density lipoprotein cholesterol esters. 1982 J. Clin. Invest. pmid:7119117
Kleist H et al. Metabolism in the hypothermically perfused kidney: utilization of mevalonate in the human and in the dog kidney. 1982 Eur Surg Res pmid:7117329
Cohen DC et al. Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vascular endothelial cells. Separate sterol and non-sterol components. 1982 J. Biol. Chem. pmid:7107647
Tilvis R et al. Metabolism of squalene in human fat cells. Demonstration of a two-pool system. 1982 J. Biol. Chem. pmid:7107606
Wilson WK et al. Determination of the enantiomeric purity of mevalonolactone via NMR using a chiral lanthanide shift reagent. 1982 J. Lipid Res. pmid:7097129
Kopito RR et al. Metabolism of plasma mevalonate in rats and humans. 1982 J. Lipid Res. pmid:7097123
Sinensky M et al. Analysis of regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in a somatic cell mutant auxotrophic for mevalonate. 1982 J. Biol. Chem. pmid:7085625
Golper TA and Swartz SH Impaired renal mevalonate metabolism in nephrotic syndrome: a stimulus for increased hepatic cholesterogenesis independent of GFR and hypoalbuminemia. 1982 Metab. Clin. Exp. pmid:7078427
pmid:707796
Wong TK and Lennarz WJ The site of biosynthesis and intracellular deposition of dolichol in rat liver. 1982 J. Biol. Chem. pmid:7076684
Volpe JJ and Obert KA Interrelationships of ubiquinone and sterol syntheses in cultured cells of neural origin. 1982 J. Neurochem. pmid:7062041
Poznansky MJ and Czekanski S Cholesterol movement between human skin fibroblasts and phosphatidylcholine vesicles. 1982 Biochim. Biophys. Acta pmid:7059600
Pratt HP Preimplantation mouse embryos synthesize membrane sterols. 1982 Dev. Biol. pmid:7054002
Fears R The contribution of the cholesterol biosynthetic pathway to intermediary metabolism and cell function. 1981 Biochem. J. pmid:7039614
Bard M and Downing JF Genetic and biochemical aspects of yeast sterol regulation involving 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1981 J. Gen. Microbiol. pmid:7033470
Swift IE and Milborrow BV Stereochemistry of beta-, gamma-, and epsilon-ring formation in bacterial C50. 1981 J. Biol. Chem. pmid:7028738
Schroepfer GJ Sterol biosynthesis. 1981 Annu. Rev. Biochem. pmid:7023367
Ramsey RB and Fredericks M Effect of hypocholesterolemic agents on central nervous system cholesterol biosynthesis. II. AY-9944 and AY-9944 plus zuclomiphene. 1977 Biochem. Pharmacol. pmid:70208
Middleton B et al. The control of sterol synthesis during development of rabbit mammary gland. 1981 J. Biol. Chem. pmid:7014559
Brown MS and Goldstein JL Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. 1980 J. Lipid Res. pmid:6995544
Cuthbert JA and Lipsky PE Sterol metabolism and lymphocyte function: inhibition of endogenous sterol biosynthesis does not prevent mitogen-induced human T lymphocyte activation. 1980 J. Immunol. pmid:6965969
Pullinger CR and Gibbons GF Effects of oleate and compactin on the metabolism and secretion of cholesterol and cholesteryl ester by rat hepatocytes. 1982 Biochim. Biophys. Acta pmid:6960928
Parker TS et al. Mevalonic acid in human plasma: relationship of concentration and circadian rhythm to cholesterol synthesis rates in man. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6953446
Larson RA et al. Neutrophils are required for the DNA synthetic response of human lymphocytes to mevalonic acid: evidence suggesting that a nonsterol product of mevalonate is involved. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6953445
Schwartz CC et al. Central role of high density lipoprotein in plasma free cholesterol metabolism. 1982 J. Clin. Invest. pmid:6953075
Arebalo RE et al. In vivo regulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase: immunotitration of the enzyme after short-term mevalonate or cholesterol feeding. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6948302
Sinensky M et al. Somatic cell genetic analysis of regulation of expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 1980 Proc. Natl. Acad. Sci. U.S.A. pmid:6935672