Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Biliary Fistula D001658 13 associated lipids
Body Weight D001835 333 associated lipids
Celiac Disease D002446 16 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Yoon HE and Yang CW Established and newly proposed mechanisms of chronic cyclosporine nephropathy. 2009 Korean J. Intern. Med. pmid:19543484
Jauhiainen M et al. Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19665949
Anthony JR et al. Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene. 2009 Metab. Eng. pmid:18775787
Lorenzen W et al. Isoprenoids are essential for fruiting body formation in Myxococcus xanthus. 2009 J. Bacteriol. pmid:19617362
Xu Q et al. Comparative transcripts profiling reveals new insight into molecular processes regulating lycopene accumulation in a sweet orange (Citrus sinensis) red-flesh mutant. 2009 BMC Genomics pmid:19922663
Rothwell C et al. Cholesterol biosynthesis modulation regulates dengue viral replication. 2009 Virology pmid:19419745
Ledezma E et al. Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells. 2009 Melanoma Res. pmid:19276863
Maeda T and Horiuchi N Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation. 2009 J. Biochem. pmid:19254925
Dje N'Guessan P et al. Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. 2009 Arterioscler. Thromb. Vasc. Biol. pmid:19122173
Iriti M and Faoro F Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution. 2009 Int J Mol Sci pmid:20111684
Jawaid S et al. Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). 2009 PLoS ONE pmid:20011597
Raemer PC et al. Statins inhibit NK-cell cytotoxicity by interfering with LFA-1-mediated conjugate formation. 2009 Eur. J. Immunol. pmid:19424968
Chang PK et al. Cyclopiazonic acid biosynthesis of Aspergillus flavus and Aspergillus oryzae. 2009 Toxins (Basel) pmid:22069533
Kirmizis D and Chatzidimitriou D Pleiotropic vasoprotective effects of statins: the chicken or the egg? 2009 Drug Des Devel Ther pmid:19920934
Eldor R and Raz I American Diabetes Association indications for statins in diabetes: is there evidence? 2009 Diabetes Care pmid:19875586
Zeki AA et al. Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond. 2009 Am. J. Respir. Crit. Care Med. pmid:19608720
Minichsdorfer C and Hohenegger M Autocrine amplification loop in statin-induced apoptosis of human melanoma cells. 2009 Br. J. Pharmacol. pmid:19563533
Perttilä J et al. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. 2009 J. Mol. Med. pmid:19554302
Montoya CJ et al. Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial. 2009 Trials pmid:19538732
Li J et al. Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. 2009 J. Immunol. pmid:19494338
Suzuki M et al. Complete blockage of the mevalonate pathway results in male gametophyte lethality. 2009 J. Exp. Bot. pmid:19363204
Balibar CJ et al. The mevalonate pathway of Staphylococcus aureus. 2009 J. Bacteriol. pmid:19028897
Khan MA et al. Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation. 2009 J. Immunol. pmid:19342651
Alvarez Y et al. Cyclooxygenase-2 induced by zymosan in human monocyte-derived dendritic cells shows high stability, and its expression is enhanced by atorvastatin. 2009 J. Pharmacol. Exp. Ther. pmid:19318593
Niessen J et al. Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. 2009 Drug Metab. Dispos. pmid:19237515
Lachmann HJ and Hawkins PN Developments in the scientific and clinical understanding of autoinflammatory disorders. 2009 Arthritis Res. Ther. pmid:19232070
Kim WY et al. Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation. 2009 J. Neurochem. pmid:19209406
Zeiser R et al. Regulation of different inflammatory diseases by impacting the mevalonate pathway. 2009 Immunology pmid:19191903
Yeger-Lotem E et al. Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. 2009 Nat. Genet. pmid:19234470
Knight LA et al. Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay. 2009 BMC Cancer pmid:19175937
Deshpande G et al. Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. 2009 PLoS Genet. pmid:19132091
Mansouri H et al. Effects of gibberellic acid on primary terpenoids and delta-tetrahydrocannabinol in Cannabis sativa at flowering stage. 2009 J Integr Plant Biol pmid:19522814
Monzack EL et al. Efficacy of simvastatin treatment of valvular interstitial cells varies with the extracellular environment. 2009 Arterioscler. Thromb. Vasc. Biol. pmid:19023089
Sillero MA et al. Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. 2009 Biochem. Pharmacol. pmid:19414000
Dueber JE et al. Synthetic protein scaffolds provide modular control over metabolic flux. 2009 Nat. Biotechnol. pmid:19648908
Leszczynska A et al. Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. 2009 PLoS ONE pmid:20041128
Tsuruta H et al. High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli. 2009 PLoS ONE pmid:19221601
Sun X et al. Identified biosynthetic pathway of aspergiolide A and a novel strategy to increase its production in a marine-derived fungus Aspergillus glaucus by feeding of biosynthetic precursors and inhibitors simultaneously. 2009 Bioresour. Technol. pmid:19386490
Sidorkiewicz M et al. Mevalonate pathway modulation is associated with hepatitis C virus RNA presence in peripheral blood mononuclear cells. 2009 Virus Res. pmid:19540284
Bełtowski J et al. Adverse effects of statins - mechanisms and consequences. 2009 Curr Drug Saf pmid:19534648
Ohyama K et al. Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19139393
Kroll J et al. Establishment of a novel anabolism-based addiction system with an artificially introduced mevalonate pathway: complete stabilization of plasmids as universal application in white biotechnology. 2009 Metab. Eng. pmid:19558962
Wali VB et al. Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. 2009 Lipids pmid:19777282
Kimura T et al. Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. 2008 J. Immunol. pmid:18981156
Wilson GJ et al. Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review. 2008 Nutr Metab (Lond) pmid:18173841
Mathew B and Biju R Neuroprotective effects of garlic a review. 2008 Libyan J Med pmid:21499478
Yoshida T et al. Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry. 2008 Anal Chem Insights pmid:19609389
Saito A et al. Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. 2008 Melanoma Res. pmid:18337644
Park SY et al. Inhibitory effect of simvastatin on the TNF-alpha- and angiotensin II-induced monocyte adhesion to endothelial cells is mediated through the suppression of geranylgeranyl isoprenoid-dependent ROS generation. 2008 Arch. Pharm. Res. pmid:18365690
Zhuge B et al. Bioconversion of lovastatin to a novel statin by Amycolatopsis sp. 2008 Appl. Microbiol. Biotechnol. pmid:18368405