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Established and newly proposed mechanisms of chronic cyclosporine nephropathy. |
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Korean J. Intern. Med. |
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Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry. |
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J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
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Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene. |
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Comparative transcripts profiling reveals new insight into molecular processes regulating lycopene accumulation in a sweet orange (Citrus sinensis) red-flesh mutant. |
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BMC Genomics |
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Cholesterol biosynthesis modulation regulates dengue viral replication. |
2009 |
Virology |
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Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells. |
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Melanoma Res. |
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Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation. |
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J. Biochem. |
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Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. |
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Arterioscler. Thromb. Vasc. Biol. |
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Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution. |
2009 |
Int J Mol Sci |
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Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). |
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PLoS ONE |
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Statins inhibit NK-cell cytotoxicity by interfering with LFA-1-mediated conjugate formation. |
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Toxins (Basel) |
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Pleiotropic vasoprotective effects of statins: the chicken or the egg? |
2009 |
Drug Des Devel Ther |
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American Diabetes Association indications for statins in diabetes: is there evidence? |
2009 |
Diabetes Care |
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Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond. |
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Am. J. Respir. Crit. Care Med. |
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Br. J. Pharmacol. |
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OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. |
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Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial. |
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Trials |
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Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. |
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Complete blockage of the mevalonate pathway results in male gametophyte lethality. |
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Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. |
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Drug Metab. Dispos. |
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Developments in the scientific and clinical understanding of autoinflammatory disorders. |
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Arthritis Res. Ther. |
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Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation. |
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Regulation of different inflammatory diseases by impacting the mevalonate pathway. |
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Immunology |
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Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay. |
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BMC Cancer |
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Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. |
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Effects of gibberellic acid on primary terpenoids and delta-tetrahydrocannabinol in Cannabis sativa at flowering stage. |
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J Integr Plant Biol |
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Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. |
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Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. |
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PLoS ONE |
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High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli. |
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PLoS ONE |
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Identified biosynthetic pathway of aspergiolide A and a novel strategy to increase its production in a marine-derived fungus Aspergillus glaucus by feeding of biosynthetic precursors and inhibitors simultaneously. |
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Mevalonate pathway modulation is associated with hepatitis C virus RNA presence in peripheral blood mononuclear cells. |
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Curr Drug Saf |
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Proc. Natl. Acad. Sci. U.S.A. |
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Establishment of a novel anabolism-based addiction system with an artificially introduced mevalonate pathway: complete stabilization of plasmids as universal application in white biotechnology. |
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Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. |
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Lipids |
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Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. |
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Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review. |
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Nutr Metab (Lond) |
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Neuroprotective effects of garlic a review. |
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Libyan J Med |
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Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry. |
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Anal Chem Insights |
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Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. |
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Melanoma Res. |
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Inhibitory effect of simvastatin on the TNF-alpha- and angiotensin II-induced monocyte adhesion to endothelial cells is mediated through the suppression of geranylgeranyl isoprenoid-dependent ROS generation. |
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Bioconversion of lovastatin to a novel statin by Amycolatopsis sp. |
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