Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Biliary Fistula D001658 13 associated lipids
Body Weight D001835 333 associated lipids
Celiac Disease D002446 16 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

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All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Kuroda M et al. Sesquiterpene farnesol inhibits recycling of the C55 lipid carrier of the murein monomer precursor contributing to increased susceptibility to beta-lactams in methicillin-resistant Staphylococcus aureus. 2007 J. Antimicrob. Chemother. pmid:17242033
Tanaka T et al. Lipophilic statins suppress cytotoxicity by freshly isolated natural killer cells through modulation of granule exocytosis. 2007 Int. Immunol. pmid:17182966
Nishimoto T et al. Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs. 2007 Toxicol. Appl. Pharmacol. pmid:17599378
Sarrabayrouse G et al. Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells. 2007 Neoplasia pmid:18084615
Araki S et al. Simvastatin enhances induction of inducible nitric oxide synthase in 3T3-L1 adipocytes. 2007 Free Radic. Res. pmid:17729120
Haas D and Hoffmann GF Mevalonate kinase deficiency and autoinflammatory disorders. 2007 N. Engl. J. Med. pmid:17596600
Maurer-Stroh S et al. Towards complete sets of farnesylated and geranylgeranylated proteins. 2007 PLoS Comput. Biol. pmid:17411337
Llorente A et al. Cholesterol regulates prostasome release from secretory lysosomes in PC-3 human prostate cancer cells. 2007 Eur. J. Cell Biol. pmid:17601634
Jahangir T and Sultana S Perillyl Alcohol Protects Against Fe-NTA-Induced Nephrotoxicity and Early Tumor Promotional Events in Rat Experimental Model. 2007 Evid Based Complement Alternat Med pmid:18227911
Hamadmad SN and Hohl RJ Lovastatin suppresses erythropoietin receptor surface expression through dual inhibition of glycosylation and geranylgeranylation. 2007 Biochem. Pharmacol. pmid:17586475
Merrell MA et al. Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells. 2007 Eur. J. Pharmacol. pmid:17640631
Wong J et al. Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol. 2007 Lipids Health Dis pmid:17408498
Hunter WN The non-mevalonate pathway of isoprenoid precursor biosynthesis. 2007 J. Biol. Chem. pmid:17442674
Takeda I et al. Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. 2007 Cancer Sci. pmid:17428261
Roelofs AJ et al. Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 2007 J. Pharmacol. Exp. Ther. pmid:17412884
Sgraja T et al. Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase. 2007 BMC Struct. Biol. pmid:17397541
Desai B et al. Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells. 2007 Mol. Cancer pmid:17343740
Towler MJ and Weathers PJ Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways. 2007 Plant Cell Rep. pmid:17710406
Andreassi JL et al. Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate. 2007 Protein Sci. pmid:17400916
Byres E et al. Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity. 2007 J. Mol. Biol. pmid:17583736
Lee MH et al. Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation. 2007 Stem Cells pmid:17464088
Kinjoh T et al. Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata. 2007 Insect Biochem. Mol. Biol. pmid:17628279
Saha RN and Pahan K Regulation of inducible nitric oxide synthase gene in glial cells. 2006 May-Jun Antioxid. Redox Signal. pmid:16771683
Piotrowski PC et al. Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability. 2006 Biol. Reprod. pmid:16571871
Hampel D et al. Biosynthesis of mono- and sesquiterpenes in strawberry fruits and foliage: 2H labeling studies. 2006 J. Agric. Food Chem. pmid:16478276
Sjögren B et al. Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors. 2006 Eur. J. Pharmacol. pmid:17064686
Chana RS and Brunskill NJ Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma. 2006 Am. J. Nephrol. pmid:16508249
Kosztáczky B et al. Neuropeptides induced a pronounced and statin-sensitive dysregulation of mevalonate cycle in human monocytes of patients with hypercholesterolemia. 2006 Neuropeptides pmid:17049599
Sato M et al. Effects of exogenous mevalonic acid on sterol lipid classes in Larix kaempferi callus. 2006 J Oleo Sci pmid:17693695
Kuzina V et al. Relationships among the biosyntheses of ubiquinone, carotene, sterols, and triacylglycerols in Zygomycetes. 2006 Arch. Microbiol. pmid:17009023
Li JQ et al. Atorvastatin reduces plasminogen activator inhibitor-1 expression in adipose tissue of atherosclerotic rabbits. 2006 Clin. Chim. Acta pmid:16507303
Brinkkoetter PT et al. Atorvastatin interferes with activation of human CD4(+) T cells via inhibition of small guanosine triphosphatase (GTPase) activity and caspase-independent apoptosis. 2006 Clin. Exp. Immunol. pmid:17100774
Mandey SH et al. A role for geranylgeranylation in interleukin-1beta secretion. 2006 Arthritis Rheum. pmid:17075828
Neville-Webbe HL et al. Mechanisms of the synergistic interaction between the bisphosphonate zoledronic acid and the chemotherapy agent paclitaxel in breast cancer cells in vitro. 2006 Tumour Biol. pmid:16582586
Xu L et al. [Effects of simvastatin on DNA synthesis in rat cardiac fibroblasts]. 2006 Nan Fang Yi Ke Da Xue Xue Bao pmid:16503530
Riganti C et al. Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma. 2006 Int. J. Cancer pmid:16450390
Ramasubbu K and Mann DL The emerging role of statins in the treatment of heart failure. 2006 J. Am. Coll. Cardiol. pmid:16412858
Christensen M et al. Simvastatin protection against acute immune-mediated glomerulonephritis in mice. 2006 Kidney Int. pmid:16407885
González-Fernández L et al. Cleavage of focal adhesion proteins and PKCdelta during lovastatin-induced apoptosis in spontaneously immortalized rat brain neuroblasts. 2006 FEBS J. pmid:16367743
Pappu AS et al. Increased nonsterol isoprenoids, dolichol and ubiquinone, in the Smith-Lemli-Opitz syndrome: effects of dietary cholesterol. 2006 J. Lipid Res. pmid:16983147
Yoon SH et al. Enhanced lycopene production in Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate. 2006 Biotechnol. Bioeng. pmid:16547999
Nagashima T et al. Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis. 2006 Arthritis Rheum. pmid:16447234
Yokota K et al. Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. 2006 J. Rheumatol. pmid:16511915
Grochowski LL et al. Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. 2006 J. Bacteriol. pmid:16621811
Shang F et al. Simvastatin inhibits lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal rat cardiomyocytes: The role of reactive oxygen species. 2006 Biochem. Biophys. Res. Commun. pmid:17094942
Issat T et al. Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway. 2006 Oncol. Rep. pmid:17089049
Kuwana M Potential benefit of statins for vascular disease in systemic sclerosis. 2006 Curr Opin Rheumatol pmid:17053504
Thompson K et al. Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway. 2006 Blood pmid:16179378
Hamadmad SN et al. Erythropoietin receptor signal transduction requires protein geranylgeranylation. 2006 J. Pharmacol. Exp. Ther. pmid:16203826
Qiu Y and Li D Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. 2006 Org. Lett. pmid:16524256