Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Leukemia D007938 74 associated lipids
Thrombosis D013927 49 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Hypothyroidism D007037 32 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Glioblastoma D005909 27 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Refsum Disease D012035 19 associated lipids
Xanthomatosis D014973 17 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Shack S et al. Activation of the cholesterol pathway and Ras maturation in response to stress. 1999 Oncogene pmid:10557091
Kaul D and Kaur M Receptor-Ck regulates the expression of cyclin-dependent kinase inhibitors (p16; p27). 1999 Mol. Cell. Biochem. pmid:10569199
Lange BM and Croteau R Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10570138
Reszka AA et al. Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase. 1999 J. Biol. Chem. pmid:10574973
pmid:10591153
Kim DY et al. Expression and characterization of the HMG-CoA reductase of the thermophilic archaeon Sulfolobus solfataricus. 1999 Protein Expr. Purif. pmid:10600463
Keller RK and Fliesler SJ Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway. 1999 Biochem. Biophys. Res. Commun. pmid:10600541
Liu GC et al. Measurement of cholesterol synthesis in man by isotope kinetics of squalene. 1975 Proc. Natl. Acad. Sci. U.S.A. pmid:1060141
Elkin RG and Yan Z Relationship between inhibition of mevalonate biosynthesis and reduced fertility in laying hens. 1999 J. Reprod. Fertil. pmid:10615252
Kim SI et al. Lovastatin inhibits transforming growth factor-beta1 expression in diabetic rat glomeruli and cultured rat mesangial cells. 2000 J. Am. Soc. Nephrol. pmid:10616843
Bergstrom JD et al. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. 2000 Arch. Biochem. Biophys. pmid:10620343
Szkopińska A et al. The regulation of activity of main mevalonic acid pathway enzymes: farnesyl diphosphate synthase, 3-hydroxy-3-methylglutaryl-CoA reductase, and squalene synthase in yeast Saccharomyces cerevisiae. 2000 Biochem. Biophys. Res. Commun. pmid:10623644
Aboushadi N et al. Characterization of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme A reductase in UT2 cells: sterol biosynthesis, phosphorylation, degradation, and statin inhibition. 2000 Biochemistry pmid:10625499
Wagner AH et al. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. 2000 Arterioscler. Thromb. Vasc. Biol. pmid:10634801
Lindenthal B and von Bergmann K Urinary excretion and serum concentration of mevalonic acid during acute intake of alcohol. 2000 Metab. Clin. Exp. pmid:10647065
Kuzuyama T et al. Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. Strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis. 2000 J. Bacteriol. pmid:10648511
Haratake A et al. Topical mevalonic acid stimulates de novo cholesterol synthesis and epidermal permeability barrier homeostasis in aged mice. 2000 J. Invest. Dermatol. pmid:10651982
Cvejić JH and Rohmer M CO2 as main carbon source for isoprenoid biosynthesis via the mevalonate-independent methylerythritol 4-phosphate route in the marine diatoms Phaeodactylum tricornutum and Nitzschia ovalis. 2000 Phytochemistry pmid:10656403
pmid:10665838
Hanley K et al. Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. 2000 J. Invest. Dermatol. pmid:10692116