Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Biliary Fistula D001658 13 associated lipids
Body Weight D001835 333 associated lipids
Celiac Disease D002446 16 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Hypertension D006973 115 associated lipids
Hypothyroidism D007037 32 associated lipids
Leukemia D007938 74 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Peutz-Jeghers Syndrome D010580 2 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Voynova NE et al. Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. 2008 Arch. Biochem. Biophys. pmid:18823933
Schwartz YSh et al. Cholesterol-induced stimulation of postinflammatory liver fibrosis. 2008 Bull. Exp. Biol. Med. pmid:19110552
Lazzerini PE et al. Simvastatin inhibits cytokine production and nuclear factor-kB activation in interleukin 1beta-stimulated synoviocytes from rheumatoid arthritis patients. 2007 Sep-Oct Clin. Exp. Rheumatol. pmid:18078616
Yoon SH et al. Increased beta-carotene production in recombinant Escherichia coli harboring an engineered isoprenoid precursor pathway with mevalonate addition. 2007 May-Jun Biotechnol. Prog. pmid:17500531
Matsunaga S et al. Incadronate induces cell detachment and apoptosis in prostatic PC-3 cells. 2007 Mar-Apr Anticancer Res. pmid:17465222
Bock O et al. Common musculoskeletal adverse effects of oral treatment with once weekly alendronate and risedronate in patients with osteoporosis and ways for their prevention. 2007 Apr-Jun J Musculoskelet Neuronal Interact pmid:17627083
Yoon SH et al. Engineering the lycopene synthetic pathway in E. coli by comparison of the carotenoid genes of Pantoea agglomerans and Pantoea ananatis. 2007 Appl. Microbiol. Biotechnol. pmid:17115209
Ye J Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus. 2007 PLoS Pathog. pmid:17784784
Saijonmaa O et al. Atorvastatin inhibits angiotensin-converting enzyme induction in differentiating human macrophages. 2007 Am. J. Physiol. Heart Circ. Physiol. pmid:17158648
Honda A et al. Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS. 2007 J. Lipid Res. pmid:17272831
Hao M et al. Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction. 2007 Diabetes pmid:17575085
Bretón Martínez JR et al. Mevalonic aciduria: report of two cases. 2007 J. Inherit. Metab. Dis. pmid:17578678
Ben-Tal Cohen E et al. Statins decrease TNF-alpha-induced osteoprotegerin production by endothelial cells and smooth muscle cells in vitro. 2007 Biochem. Pharmacol. pmid:17070781
Igarashi J et al. Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins. 2007 Br. J. Pharmacol. pmid:17220911
Araki S et al. Simvastatin enhances induction of inducible nitric oxide synthase in 3T3-L1 adipocytes. 2007 Free Radic. Res. pmid:17729120
Hargreaves IP Coenzyme Q10 in phenylketonuria and mevalonic aciduria. 2007 Mitochondrion pmid:17442628
Kettawan A et al. Protective effects of coenzyme q(10) on decreased oxidative stress resistance induced by simvastatin. 2007 J Clin Biochem Nutr pmid:18398496
Ferri N et al. Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17303772
Li M et al. Inhibition of serotonin-induced mitogenesis, migration, and ERK MAPK nuclear translocation in vascular smooth muscle cells by atorvastatin. 2007 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:17545489
Ohyama K et al. Chemical phenotypes of the hmg1 and hmg2 mutants of Arabidopsis demonstrate the in-planta role of HMG-CoA reductase in triterpene biosynthesis. 2007 Chem. Pharm. Bull. pmid:17917299
Muñoz-Bertomeu J et al. Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia. 2007 Plant Biotechnol. J. pmid:17714440
Corsini A et al. Are pleiotropic effects of statins real? 2007 Vasc Health Risk Manag pmid:18078012
Nakao T et al. Pravastatin induces rat aortic endothelial cell proliferation and migration via activation of PI3K/Akt/mTOR/p70 S6 kinase signaling. 2007 J. Pharmacol. Sci. pmid:18057776
Ali F et al. Statin-mediated cytoprotection of human vascular endothelial cells: a role for Kruppel-like factor 2-dependent induction of heme oxygenase-1. 2007 J. Thromb. Haemost. pmid:17927807
Arkwright PD et al. Mevalonic aciduria cured by bone marrow transplantation. 2007 N. Engl. J. Med. pmid:17898110
Zeiser R et al. Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity. 2007 Blood pmid:17827390
Niknejad N et al. Activation of the integrated stress response regulates lovastatin-induced apoptosis. 2007 J. Biol. Chem. pmid:17699156
Kotamraju S et al. Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. 2007 Cancer Res. pmid:17671209
Ostrowski SM et al. Statins reduce amyloid-beta production through inhibition of protein isoprenylation. 2007 J. Biol. Chem. pmid:17646164
Hu WL et al. Decreased C-reactive protein-induced resistin production in human monocytes by simvastatin. 2007 Cytokine pmid:18023360
Neven B et al. Allogeneic bone marrow transplantation in mevalonic aciduria. 2007 N. Engl. J. Med. pmid:17596604
Wong WW et al. Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma. 2007 Mol. Cancer Ther. pmid:17575117
Kutrzeba L et al. Biosynthesis of salvinorin A proceeds via the deoxyxylulose phosphate pathway. 2007 Phytochemistry pmid:17574635
Lopes AA et al. Biosynthetic origins of the isoprene units of gaudichaudianic acid in Piper gaudichaudianum (Piperaceae). 2007 Phytochemistry pmid:17574633
D'Amico L et al. A mutation in zebrafish hmgcr1b reveals a role for isoprenoids in vertebrate heart-tube formation. 2007 Curr. Biol. pmid:17276918
Nodari S et al. The combination of Ezetimibe and Statin: a new treatment for hypercholesterolemia. 2007 Heart Int pmid:21977270
Henriksson LM et al. Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis. 2007 J. Biol. Chem. pmid:17491006
Dietzen DJ et al. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase blunts factor VIIa/tissue factor and prothrombinase activities via effects on membrane phosphatidylserine. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17185615
Nakata S et al. Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17082483
Loiseau L et al. ErpA, an iron sulfur (Fe S) protein of the A-type essential for respiratory metabolism in Escherichia coli. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17698959
Mönkkönen H et al. Zoledronic acid-induced IPP/ApppI production in vivo. 2007 Life Sci. pmid:17850825
Withers ST et al. Identification of isopentenol biosynthetic genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity. 2007 Appl. Environ. Microbiol. pmid:17693564
Buhaescu I and Izzedine H Mevalonate pathway: a review of clinical and therapeutical implications. 2007 Clin. Biochem. pmid:17467679
März P et al. Statins induce differentiation and cell death in neurons and astroglia. 2007 Glia pmid:16998865
Riganti C et al. Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition. 2007 Am. J. Respir. Cell Mol. Biol. pmid:17322126
Habib A et al. Modulation of COX-2 expression by statins in human monocytic cells. 2007 FASEB J. pmid:17317725
Pertusa M et al. Transcriptional control of cholesterol biosynthesis in Schwann cells by axonal neuregulin 1. 2007 J. Biol. Chem. pmid:17652086
Jantzen F et al. Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells. 2007 J. Physiol. Pharmacol. pmid:17928646
Nakajima H et al. Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate. 2007 Cancer Lett. pmid:17316980
Takahashi HK et al. Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction. 2007 Clin. Immunol. pmid:17482516