| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hypergammaglobulinemia | D006942 | 9 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Peutz-Jeghers Syndrome | D010580 | 2 associated lipids |
Mevalonic acid
Mevalonic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Mevalonic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Mevalonic acid
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with Mevalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Redding-Johanson AM et al. | Targeted proteomics for metabolic pathway optimization: application to terpene production. | 2011 | Metab. Eng. | pmid:21215324 |
| Huang SH et al. | Imaging of zebrafish in vivo with second-harmonic generation reveals shortened sarcomeres associated with myopathy induced by statin. | 2011 | PLoS ONE | pmid:21966365 |
| Singh NK et al. | 12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation. | 2011 | Blood | pmid:21841162 |
| Ma SM et al. | Optimization of a heterologous mevalonate pathway through the use of variant HMG-CoA reductases. | 2011 | Metab. Eng. | pmid:21810477 |
| Yu F et al. | Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis. | 2011 | Cell. Mol. Life Sci. | pmid:20730551 |
| Luo H et al. | Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. | 2011 | BMC Genomics | pmid:22369100 |
| Youn YN et al. | Impact of High-Dose Statin Pretreatment in Patients with Stable Angina during Off-Pump Coronary Artery Bypass. | 2011 | Korean J Thorac Cardiovasc Surg | pmid:22263153 |
| Odom AR | Five questions about non-mevalonate isoprenoid biosynthesis. | 2011 | PLoS Pathog. | pmid:22216001 |
| Rauthan M and Pilon M | The mevalonate pathway in C. elegans. | 2011 | Lipids Health Dis | pmid:22204706 |
| Barrero RA et al. | De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes. | 2011 | BMC Genomics | pmid:22151917 |
| Nes WD | Biosynthesis of cholesterol and other sterols. | 2011 | Chem. Rev. | pmid:21902244 |
| Bergman P et al. | Studies on the antibacterial effects of statins--in vitro and in vivo. | 2011 | PLoS ONE | pmid:21912631 |
| Emma F et al. | Renal mitochondrial cytopathies. | 2011 | Int J Nephrol | pmid:21811680 |
| Ageenko NV et al. | Expression of Pigment Cell-Specific Genes in the Ontogenesis of the Sea Urchin Strongylocentrotus intermedius. | 2011 | Evid Based Complement Alternat Med | pmid:21804858 |
| Cheng G et al. | Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells. | 2011 | Cancer Biol. Ther. | pmid:21799303 |
| Katuru R et al. | Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells. | 2011 | Exp. Biol. Med. (Maywood) | pmid:21540247 |
| Peng LF et al. | Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase. | 2011 | J. Infect. Dis. | pmid:21791663 |
| Bajgain P et al. | Transcriptome characterization and polymorphism detection between subspecies of big sagebrush (Artemisia tridentata). | 2011 | BMC Genomics | pmid:21767398 |
| Scheller EL et al. | Zoledronic acid inhibits macrophage SOCS3 expression and enhances cytokine production. | 2011 | J. Cell. Biochem. | pmid:21751240 |
| Sun S and McKenna CE | Farnesyl pyrophosphate synthase modulators: a patent review (2006 - 2010). | 2011 | Expert Opin Ther Pat | pmid:21702715 |
| Rizzo WB | The role of fatty aldehyde dehydrogenase in epidermal structure and function. | 2011 | Dermatoendocrinol | pmid:21695018 |
| Sakamoto K et al. | Simvastatin suppresses dexamethasone-induced secretion of plasminogen activator inhibitor-1 in human bone marrow adipocytes. | 2011 | BMC Musculoskelet Disord | pmid:21524281 |
| Han J et al. | Alteration of enzyme expressions in mevalonate pathway: possible role for cardiovascular remodeling in spontaneously hypertensive rats. | 2011 | Circ. J. | pmid:21467659 |
| Song JX et al. | Simvastatin reduces lipoprotein-associated phospholipase A2 in lipopolysaccharide-stimulated human monocyte-derived macrophages through inhibition of the mevalonate-geranylgeranyl pyrophosphate-RhoA-p38 mitogen-activated protein kinase pathway. | 2011 | J. Cardiovasc. Pharmacol. | pmid:21052011 |
| Siddals KW et al. | Apposite insulin-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization. | 2011 | J. Biol. Chem. | pmid:21454560 |
| Mongélard G et al. | Measurement of carbon flux through the MEP pathway for isoprenoid synthesis by (31)P-NMR spectroscopy after specific inhibition of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate reductase. Effect of light and temperature. | 2011 | Plant Cell Environ. | pmid:21443577 |
| Zhang B et al. | A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling. | 2011 | Biochemistry | pmid:21438569 |
| Kim RH et al. | Bisphosphonates induce senescence in normal human oral keratinocytes. | 2011 | J. Dent. Res. | pmid:21427353 |
| Kyathanahalli CN and Kowluru A | A farnesylated G-protein suppresses Akt phosphorylation in INS 832/13 cells and normal rat islets: regulation by pertussis toxin and PGEâ‚‚. | 2011 | Biochem. Pharmacol. | pmid:21406184 |
| Zhao Y et al. | Statins downregulate K6a promoter activity: a possible therapeutic avenue for pachyonychia congenita. | 2011 | J. Invest. Dermatol. | pmid:21390048 |
| Blankier S et al. | The role of atorvastatin in regulating the immune response leading to vascular damage in a model of Kawasaki disease. | 2011 | Clin. Exp. Immunol. | pmid:21361911 |
| Ghavami S et al. | Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. | 2011 | PLoS ONE | pmid:21304979 |
| Ignea C et al. | Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids. | 2011 | Microb. Cell Fact. | pmid:21276210 |
| Tuckow AP et al. | Simvastatin represses protein synthesis in the muscle-derived Câ‚‚Câ‚â‚‚ cell line with a concomitant reduction in eukaryotic initiation factor 2B expression. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21224482 |
| Sawai S and Saito K | Triterpenoid biosynthesis and engineering in plants. | 2011 | Front Plant Sci | pmid:22639586 |
| Hong C et al. | Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. | 2011 | J. Lipid Res. | pmid:21187453 |
| Nishikawa Y et al. | Host cholesterol synthesis contributes to growth of intracellular Toxoplasma gondii in macrophages. | 2011 | J. Vet. Med. Sci. | pmid:21187676 |
| Relja B et al. | Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK. | 2011 | Int. J. Oncol. | pmid:21206971 |
| Li YY et al. | Zoledronic acid induces cell-cycle prolongation in murine lung cancer cells by perturbing cyclin and Ras expression. | 2011 | Anticancer Drugs | pmid:20926944 |
| Liu Q et al. | Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana. | 2011 | PLoS ONE | pmid:21858047 |
| Jouneau S et al. | Anti-inflammatory effect of fluvastatin on IL-8 production induced by Pseudomonas aeruginosa and Aspergillus fumigatus antigens in cystic fibrosis. | 2011 | PLoS ONE | pmid:21826199 |
| Lin Y et al. | Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters. | 2011 | Evid Based Complement Alternat Med | pmid:19228775 |
| Zhong WB et al. | Lovastatin inhibits proliferation of anaplastic thyroid cancer cells through up-regulation of p27 by interfering with the Rho/ROCK-mediated pathway. | 2011 | Biochem. Pharmacol. | pmid:21907187 |
| Issat T et al. | Antitumor effects of the combination of cholesterol reducing drugs. | 2011 | Oncol. Rep. | pmid:21491092 |
| Zeki AA et al. | Statin drugs, metabolic pathways, and asthma: a therapeutic opportunity needing further research. | 2011 | Drug Metab Lett | pmid:21198438 |
| Llacuna L et al. | Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia-reperfusion injury. | 2011 | J. Hepatol. | pmid:21145825 |
| Hamada M et al. | Antithrombotic properties of pravastatin reducing intra-thrombus fibrin deposition under high shear blood flow conditions. | 2011 | Thromb. Haemost. | pmid:21136018 |
| Hao Q et al. | Synthesis and anti-hypercholesterolemic evaluations of calcium salts of 4-substituted quinoline-based mevalonic acid. | 2011 | Chem Biol Drug Des | pmid:21791012 |
| Esemuede N et al. | Lovastatin inhibits thrombospondin-1-induced smooth muscle cell chemotaxis. | 2011 | J. Surg. Res. | pmid:20338582 |
| Castella B et al. | Immune modulation by zoledronic acid in human myeloma: an advantageous cross-talk between Vγ9Vδ2 T cells, αβ CD8+ T cells, regulatory T cells, and dendritic cells. | 2011 | J. Immunol. | pmid:21753152 |
| Okada K | The biosynthesis of isoprenoids and the mechanisms regulating it in plants. | 2011 | Biosci. Biotechnol. Biochem. | pmid:21737944 |
| Soto G et al. | Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation. | 2011 | J. Exp. Bot. | pmid:21908473 |
| Wong DH et al. | Resveratrol inhibits the mevalonate pathway and potentiates the antiproliferative effects of simvastatin in rat theca-interstitial cells. | 2011 | Fertil. Steril. | pmid:21907337 |
| Kindt E et al. | The validation of a simple LC/MS/MS method for determining the level of mevalonic acid in human plasma. | 2011 | Biomed. Chromatogr. | pmid:21110384 |
| Jang HJ et al. | Retinoid production using metabolically engineered Escherichia coli with a two-phase culture system. | 2011 | Microb. Cell Fact. | pmid:21801353 |
| Schaafsma D et al. | Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts. | 2011 | Respir. Res. | pmid:21864337 |
| Leichner GS et al. | Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein. | 2011 | J. Biol. Chem. | pmid:21778231 |
| Simkin AJ et al. | Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta. | 2011 | Planta | pmid:21655959 |
| Kaneko M et al. | Effect of farnesol on mevalonate pathway of Staphylococcus aureus. | 2011 | J. Antibiot. | pmid:21772307 |
| Yanae M et al. | Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma. | 2011 | J. Exp. Clin. Cancer Res. | pmid:21831290 |
| Maki KC et al. | Effects of soy protein on lipoprotein lipids and fecal bile acid excretion in men and women with moderate hypercholesterolemia. | 2010 Nov-Dec | J Clin Lipidol | pmid:21122701 |
| Camps D | [Controversies regarding the use of statins in the acute coronary syndrome]. | 2010 Aug-Sep | Med Intensiva | pmid:20538377 |
| Omar SH | Oleuropein in olive and its pharmacological effects. | 2010 Apr-Jun | Sci Pharm | pmid:21179340 |
| Björkhem-Bergman L et al. | Lovastatin prevents carcinogenesis in a rat model for liver cancer. Effects of ubiquinone supplementation. | 2010 | Anticancer Res. | pmid:20530415 |
| Wang C et al. | Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. | 2010 | Biotechnol. Bioeng. | pmid:20552672 |
| Bouvier-Navé P et al. | Involvement of the phospholipid sterol acyltransferase1 in plant sterol homeostasis and leaf senescence. | 2010 | Plant Physiol. | pmid:19923239 |
| Deichmann R et al. | Coenzyme q10 and statin-induced mitochondrial dysfunction. | 2010 | Ochsner J | pmid:21603349 |
| Hamdy RC | Zoledronic acid: clinical utility and patient considerations in osteoporosis and low bone mass. | 2010 | Drug Des Devel Ther | pmid:21151620 |
| Stapleton PA et al. | Hypercholesterolemia and microvascular dysfunction: interventional strategies. | 2010 | J Inflamm (Lond) | pmid:21087503 |
| Martin DM et al. | Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, FLcDNA cloning, and enzyme assays. | 2010 | BMC Plant Biol. | pmid:20964856 |
| González-Candelas L et al. | A transcriptomic approach highlights induction of secondary metabolism in citrus fruit in response to Penicillium digitatum infection. | 2010 | BMC Plant Biol. | pmid:20807411 |
| Jarrell KF et al. | S-layer glycoproteins and flagellins: reporters of archaeal posttranslational modifications. | 2010 | Archaea | pmid:20721273 |
| Yang L et al. | [Effects of clinically effective dose of lovastatin on prostate cancer PC3 cells]. | 2010 | Beijing Da Xue Xue Bao | pmid:20721249 |
| Guella G et al. | Structures, biological activities and phylogenetic relationships of terpenoids from marine ciliates of the genus Euplotes. | 2010 | Mar Drugs | pmid:20714425 |
| Jana S and Shekhawat GS | Anethum graveolens: An Indian traditional medicinal herb and spice. | 2010 | Pharmacogn Rev | pmid:22228959 |
| Zheng Z et al. | Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha. | 2010 | Diabetes | pmid:20566666 |
| Liu Q et al. | Dynamics of lamin-A processing following precursor accumulation. | 2010 | PLoS ONE | pmid:20526372 |
| Aoyama T et al. | Pharmacokinetic/pharmacodynamic modeling and simulation of rosuvastatin using an extension of the indirect response model by incorporating a circadian rhythm. | 2010 | Biol. Pharm. Bull. | pmid:20522984 |
| Catros V et al. | [Tgammadelta lymphocytes in oncology: unconventional killer lymphocytes]. | 2010 | Med Sci (Paris) | pmid:20188051 |
| Pontillo A et al. | The inhibition of mevalonate pathway induces upregulation of NALP3 expression: new insight in the pathogenesis of mevalonate kinase deficiency. | 2010 | Eur. J. Hum. Genet. | pmid:20179743 |
| Yamauchi N | The pathway of leucine to mevalonate in halophilic archaea: efficient incorporation of leucine into isoprenoidal lipid with the involvement of isovaleryl-CoA dehydrogenase in Halobacterium salinarum. | 2010 | Biosci. Biotechnol. Biochem. | pmid:20139592 |
| Olson AL et al. | NMR dynamics investigation of ligand-induced changes of main and side-chain arginine N-H's in human phosphomevalonate kinase. | 2010 | J. Am. Chem. Soc. | pmid:20112895 |
| Kowluru A et al. | Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. | 2010 | Diabetes | pmid:20071600 |
| Kiran U et al. | Structural and functional characterization of HMG-COA reductase from Artemisia annua. | 2010 | Bioinformation | pmid:21364776 |
| Domoki F et al. | Rosuvastatin induces delayed preconditioning against L-glutamate excitotoxicity in cultured cortical neurons. | 2010 | Neurochem. Int. | pmid:19931334 |
| De Leo L et al. | Targeting farnesyl-transferase as a novel therapeutic strategy for mevalonate kinase deficiency: in vitro and in vivo approaches. | 2010 | Pharmacol. Res. | pmid:20206266 |
| Tisch D and Schmoll M | Light regulation of metabolic pathways in fungi. | 2010 | Appl. Microbiol. Biotechnol. | pmid:19915832 |
| Liu YJ et al. | Simvastatin ameliorates rat cerebrovascular remodeling during hypertension via inhibition of volume-regulated chloride channel. | 2010 | Hypertension | pmid:20644009 |
| Räikkönen J et al. | Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. | 2010 | Biochem. Pharmacol. | pmid:19819230 |
| Mitrofan LM et al. | Lysosomal-mitochondrial axis in zoledronic acid-induced apoptosis in human follicular lymphoma cells. | 2010 | J. Biol. Chem. | pmid:19875454 |
| Singh RS et al. | Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston]. | 2010 | BMC Mol. Biol. | pmid:21092138 |
| Chang TH et al. | Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation. | 2010 | Plant Cell | pmid:20139160 |
| Quist-Paulsen P | Statins and inflammation: an update. | 2010 | Curr. Opin. Cardiol. | pmid:20421792 |
| Kato S et al. | Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase. | 2010 | J. Cell. Mol. Med. | pmid:19432822 |
| Hooff GP et al. | Modulation of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate in neuroblastoma SH-SY5Y-APP695 cells: impact on amyloid beta-protein production. | 2010 | Mol. Neurobiol. | pmid:20405344 |
| Woo IS et al. | Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells. | 2010 | Neurosci. Lett. | pmid:20298756 |
| Asadollahi MA et al. | Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae. | 2010 | Biotechnol. Bioeng. | pmid:20091767 |
| Weerasinghe S and Samantha Dassanayake R | Simulation of structural and functional properties of mevalonate diphosphate decarboxylase (MVD). | 2010 | J Mol Model | pmid:19653015 |
| Kudoh T et al. | Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae. | 2010 | Bioorg. Med. Chem. | pmid:20056424 |
| Boo KH et al. | Distribution and biosynthesis of 20-hydroxyecdysone in plants of Achyranthes japonica Nakai. | 2010 | Biosci. Biotechnol. Biochem. | pmid:21071854 |