Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Biliary Fistula D001658 13 associated lipids
Body Weight D001835 333 associated lipids
Celiac Disease D002446 16 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Hypertension D006973 115 associated lipids
Hypothyroidism D007037 32 associated lipids
Leukemia D007938 74 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Peutz-Jeghers Syndrome D010580 2 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Liu JC et al. The in vitro inhibitory effects of crude extracts of traditional Chinese herbs on 3-hydroxy-3-methylglutaryl-coenzyme A reductase on Vero cells. 2002 Am. J. Chin. Med. pmid:12568290
pmid:12605351
Masamura K et al. Pitavastatin-induced thrombomodulin expression by endothelial cells acts via inhibition of small G proteins of the Rho family. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12615662
De-Eknamkul W and Potduang B Biosynthesis of beta-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units. 2003 Phytochemistry pmid:12620352
Righetti M et al. The in vitro metabolism of mevalonate by sterol and non-sterol pathways. 1976 J. Biol. Chem. pmid:1262340
Aktas O et al. Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin. 2003 J. Exp. Med. pmid:12629065
Laufs U Beyond lipid-lowering: effects of statins on endothelial nitric oxide. 2003 Eur. J. Clin. Pharmacol. pmid:12634978
pmid:12636409
Poirier J Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease. 2003 Trends Mol Med pmid:12657430
Abernethy D et al. In vitro inhibition of rat liver cholest-5en-3 beta-ol (cholesterol) biosynthesis by non-mercurial sulfhydryl reagents. 1976 Steroids pmid:1265795
Itoh D et al. Biosynthesis of chloroplastidic and extrachloroplastidic terpenoids in liverwort cultured cells: 13C serine as a probe of terpene biosynthesis via mevalonate and non-mevalonate pathways. 2003 J. Nat. Prod. pmid:12662088
Luan Z et al. Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12663370
Awad AB et al. Effect of phytosterols on cholesterol metabolism and MAP kinase in MDA-MB-231 human breast cancer cells. 2003 J. Nutr. Biochem. pmid:12667603
Holstein SA and Hohl RJ Monoterpene regulation of Ras and Ras-related protein expression. 2003 J. Lipid Res. pmid:12671036
pmid:12677167
pmid:12677170
Suzuki K Effects of S-8527 (1,1-bis(4'-(1'-carboxy-1'-methylpropoxy)phenyl) cyclohexane), a new hypolipidemic compound, on cholesterol and lipoprotein metabolism in rats. 1976 Biochem. Pharmacol. pmid:1267828
pmid:12693933
Grabińska K and Palamarczyk G Dolichol biosynthesis in the yeast Saccharomyces cerevisiae: an insight into the regulatory role of farnesyl diphosphate synthase. 2002 FEMS Yeast Res. pmid:12702274
Hemmerlin A et al. Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells. 2003 J. Biol. Chem. pmid:12736259
Iguchi T et al. Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway. 2003 Cell. Signal. pmid:12742232
Haslinger B et al. Simvastatin suppresses tissue factor expression and increases fibrinolytic activity in tumor necrosis factor-alpha-activated human peritoneal mesothelial cells. 2003 Kidney Int. pmid:12753293
pmid:12773152
pmid:12778056
Hong SB et al. Role of the non-mevalonate pathway in indole alkaloid production by Catharanthus roseus hairy roots. 2003 May-Jun Biotechnol. Prog. pmid:12790690
pmid:12792788
pmid:12796698
pmid:12798327
Silber JR et al. The effect of mevalonic acid deprivation on enzymes of DNA replication in cells emerging from quiescence. 1992 Biochem. J. pmid:1281982
Hall FC Put your heart into the joint benefits of statins! 2003 Arthritis Res. Ther. pmid:12823851
Zheng YH et al. Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12824470
Houten SM et al. Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. 2003 Cell. Mol. Life Sci. pmid:12861380
Vamvakopoulos JE and Green C HMG-CoA reductase inhibition aborts functional differentiation and triggers apoptosis in cultured primary human monocytes: a potential mechanism of statin-mediated vasculoprotection. 2003 BMC Cardiovasc Disord pmid:12871602
pmid:12872277
Töyräs A et al. Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro. 2003 Eur J Pharm Sci pmid:12885386
Laufs U and Liao JK Isoprenoid metabolism and the pleiotropic effects of statins. 2003 Curr Atheroscler Rep pmid:12911847
Bank I et al. Lovastatin and phospholipase Cgamma regulate constitutive and protein kinase C dependent integrin mediated interactions of human T-cells with collagen. 2003 Cell. Immunol. pmid:12914756
pmid:12914758
Ohashi K et al. Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene. 2003 J. Biol. Chem. pmid:12920113
Meyers CD et al. Statin-exposed vascular smooth muscle cells secrete proteoglycans with decreased binding affinity for LDL. 2003 J. Lipid Res. pmid:12923222
Monick MM et al. Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposure. 2003 J. Immunol. pmid:12928415
pmid:12941308
Blanco-Colio LM et al. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors decrease Fas ligand expression and cytotoxicity in activated human T lymphocytes. 2003 Circulation pmid:12952848
pmid:12953163
Giricz Z et al. Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis. 2003 Basic Res. Cardiol. pmid:12955403
pmid:12957384
Shi J et al. Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation. 2003 Blood Coagul. Fibrinolysis pmid:12960612
pmid:12963986
Shiota Y et al. Effects of peroxisome proliferators gemfibrozil and clofibrate on syntheses of dolichol and cholesterol in rat liver. 2003 J. Biochem. pmid:12966067
pmid:12969437