Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Xanthomatosis D014973 17 associated lipids
Thrombosis D013927 49 associated lipids
Refsum Disease D012035 19 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Peutz-Jeghers Syndrome D010580 2 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Leukemia D007938 74 associated lipids
Hypothyroidism D007037 32 associated lipids
Hypertension D006973 115 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Glioma D005910 112 associated lipids
Glioblastoma D005909 27 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Rydgren T and Sandler S The protective effect of simvastatin against low dose streptozotocin induced type 1 diabetes in mice is independent of inhibition of HMG-CoA reductase. 2009 Biochem. Biophys. Res. Commun. pmid:19150339
Yoon HE and Yang CW Established and newly proposed mechanisms of chronic cyclosporine nephropathy. 2009 Korean J. Intern. Med. pmid:19543484
Jauhiainen M et al. Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19665949
Anthony JR et al. Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene. 2009 Metab. Eng. pmid:18775787
Lorenzen W et al. Isoprenoids are essential for fruiting body formation in Myxococcus xanthus. 2009 J. Bacteriol. pmid:19617362
Zhao S et al. Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones. 2009 Bioorg. Med. Chem. pmid:19879766
Domoki F et al. Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons. 2009 Am. J. Physiol., Cell Physiol. pmid:18971391
Xu Q et al. Comparative transcripts profiling reveals new insight into molecular processes regulating lycopene accumulation in a sweet orange (Citrus sinensis) red-flesh mutant. 2009 BMC Genomics pmid:19922663
Rothwell C et al. Cholesterol biosynthesis modulation regulates dengue viral replication. 2009 Virology pmid:19419745
Iriti M and Faoro F Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution. 2009 Int J Mol Sci pmid:20111684
Jawaid S et al. Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). 2009 PLoS ONE pmid:20011597
Raemer PC et al. Statins inhibit NK-cell cytotoxicity by interfering with LFA-1-mediated conjugate formation. 2009 Eur. J. Immunol. pmid:19424968
Chang PK et al. Cyclopiazonic acid biosynthesis of Aspergillus flavus and Aspergillus oryzae. 2009 Toxins (Basel) pmid:22069533
Kirmizis D and Chatzidimitriou D Pleiotropic vasoprotective effects of statins: the chicken or the egg? 2009 Drug Des Devel Ther pmid:19920934
de Souza W and Rodrigues JC Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs. 2009 Interdiscip Perspect Infect Dis pmid:19680554
Zeki AA et al. Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond. 2009 Am. J. Respir. Crit. Care Med. pmid:19608720
Minichsdorfer C and Hohenegger M Autocrine amplification loop in statin-induced apoptosis of human melanoma cells. 2009 Br. J. Pharmacol. pmid:19563533
Perttilä J et al. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. 2009 J. Mol. Med. pmid:19554302
Montoya CJ et al. Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial. 2009 Trials pmid:19538732
Li J et al. Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. 2009 J. Immunol. pmid:19494338
Suzuki M et al. Complete blockage of the mevalonate pathway results in male gametophyte lethality. 2009 J. Exp. Bot. pmid:19363204
Balibar CJ et al. The mevalonate pathway of Staphylococcus aureus. 2009 J. Bacteriol. pmid:19028897
Khan MA et al. Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation. 2009 J. Immunol. pmid:19342651
Alvarez Y et al. Cyclooxygenase-2 induced by zymosan in human monocyte-derived dendritic cells shows high stability, and its expression is enhanced by atorvastatin. 2009 J. Pharmacol. Exp. Ther. pmid:19318593
Niessen J et al. Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. 2009 Drug Metab. Dispos. pmid:19237515
Lachmann HJ and Hawkins PN Developments in the scientific and clinical understanding of autoinflammatory disorders. 2009 Arthritis Res. Ther. pmid:19232070
Kim WY et al. Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation. 2009 J. Neurochem. pmid:19209406
Zeiser R et al. Regulation of different inflammatory diseases by impacting the mevalonate pathway. 2009 Immunology pmid:19191903
Yeger-Lotem E et al. Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. 2009 Nat. Genet. pmid:19234470
Mansouri H et al. Effects of gibberellic acid on primary terpenoids and delta-tetrahydrocannabinol in Cannabis sativa at flowering stage. 2009 J Integr Plant Biol pmid:19522814
Xiang Z and Reeves SA Simvastatin induces cell death in a mouse cerebellar slice culture (CSC) model of developmental myelination. 2009 Exp. Neurol. pmid:18929563
Olson AL et al. Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism. 2009 Proteins pmid:18798562
Dueber JE et al. Synthetic protein scaffolds provide modular control over metabolic flux. 2009 Nat. Biotechnol. pmid:19648908
Leszczynska A et al. Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. 2009 PLoS ONE pmid:20041128
Tsuruta H et al. High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli. 2009 PLoS ONE pmid:19221601
Fujimoto M et al. Fluvastatin inhibits mast cell degranulation without changing the cytoplasmic Ca2+ level. 2009 Eur. J. Pharmacol. pmid:19059394
Sidorkiewicz M et al. Mevalonate pathway modulation is associated with hepatitis C virus RNA presence in peripheral blood mononuclear cells. 2009 Virus Res. pmid:19540284
Bełtowski J et al. Adverse effects of statins - mechanisms and consequences. 2009 Curr Drug Saf pmid:19534648
García I et al. QSAR and complex network study of the chiral HMGR inhibitor structural diversity. 2009 Bioorg. Med. Chem. pmid:19026553
Ohyama K et al. Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19139393
Kroll J et al. Establishment of a novel anabolism-based addiction system with an artificially introduced mevalonate pathway: complete stabilization of plasmids as universal application in white biotechnology. 2009 Metab. Eng. pmid:19558962
Alagna F et al. Comparative 454 pyrosequencing of transcripts from two olive genotypes during fruit development. 2009 BMC Genomics pmid:19709400
Wali VB et al. Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. 2009 Lipids pmid:19777282
Udagawa H et al. Increase of serum cholesterol levels by heat-moisture-treated high-amylose cornstarch in rats fed a high-cholesterol diet. 2008 Lipids pmid:18509689
Abumweis SS et al. Plant sterols/stanols as cholesterol lowering agents: A meta-analysis of randomized controlled trials. 2008 Food Nutr Res pmid:19109655
Akisato Y et al. [Effect of pitavastatin on macrophage cholesterol metabolism]. 2008 Yakugaku Zasshi pmid:18311054
Burke LP and Kukoly CA Statins induce lethal effects in acute myeloblastic leukemia [corrected] cells within 72 hours. 2008 Leuk. Lymphoma pmid:18231920
Paintlia AS et al. Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis. 2008 Mol. Pharmacol. pmid:18239032
Simonen M et al. High-content assay to study protein prenylation. 2008 J Biomol Screen pmid:18509097
Yu F et al. Isolation and functional characterization of a beta-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet Smith. 2008 FEBS Lett. pmid:18242187