Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypothyroidism D007037 32 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Refsum Disease D012035 19 associated lipids
Leukemia D007938 74 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hypertension D006973 115 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Glioblastoma D005909 27 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Bergstrom JD et al. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. 2000 Arch. Biochem. Biophys. pmid:10620343
Szkopińska A et al. The regulation of activity of main mevalonic acid pathway enzymes: farnesyl diphosphate synthase, 3-hydroxy-3-methylglutaryl-CoA reductase, and squalene synthase in yeast Saccharomyces cerevisiae. 2000 Biochem. Biophys. Res. Commun. pmid:10623644
Aboushadi N et al. Characterization of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme A reductase in UT2 cells: sterol biosynthesis, phosphorylation, degradation, and statin inhibition. 2000 Biochemistry pmid:10625499
Wagner AH et al. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. 2000 Arterioscler. Thromb. Vasc. Biol. pmid:10634801
Lindenthal B and von Bergmann K Urinary excretion and serum concentration of mevalonic acid during acute intake of alcohol. 2000 Metab. Clin. Exp. pmid:10647065
Kuzuyama T et al. Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. Strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis. 2000 J. Bacteriol. pmid:10648511
Haratake A et al. Topical mevalonic acid stimulates de novo cholesterol synthesis and epidermal permeability barrier homeostasis in aged mice. 2000 J. Invest. Dermatol. pmid:10651982
Cvejić JH and Rohmer M CO2 as main carbon source for isoprenoid biosynthesis via the mevalonate-independent methylerythritol 4-phosphate route in the marine diatoms Phaeodactylum tricornutum and Nitzschia ovalis. 2000 Phytochemistry pmid:10656403
pmid:10665838
Hanley K et al. Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. 2000 J. Invest. Dermatol. pmid:10692116
Lambert M and Bui ND Dexamethasone-induced decrease in HMG-CoA reductase and protein-farnesyl transferase activities does not impair ras processing in AR 4-2J cells. 1999 Mol. Cell. Biochem. pmid:10706000
pmid:10728920
Turunen M et al. Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis. 2000 J. Mol. Biol. pmid:10731415
Flach J et al. The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol. 2000 Biochem. Biophys. Res. Commun. pmid:10733934
Hashimoto F et al. Changes in isoprenoid lipid synthesis by gemfibrozil and clofibric acid in rat hepatocytes. 2000 Biochem. Pharmacol. pmid:10736420
Coppens I et al. Toxoplasma gondii exploits host low-density lipoprotein receptor-mediated endocytosis for cholesterol acquisition. 2000 J. Cell Biol. pmid:10747095
Tanaka T et al. Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. 2000 J. Neurosci. pmid:10751437
pmid:10774794
Woo JT et al. Compactin suppresses bone resorption by inhibiting the fusion of prefusion osteoclasts and disrupting the actin ring in osteoclasts. 2000 J. Bone Miner. Res. pmid:10780857
Leonardsen L et al. Effect of inhibition of sterol delta 14-reductase on accumulation of meiosis-activating sterol and meiotic resumption in cumulus-enclosed mouse oocytes in vitro. 2000 J. Reprod. Fertil. pmid:10793639
Tasevski V et al. Mitogenic effect of lithium in FRTL-5 cells can be reversed by blocking de novo cholesterol synthesis and subsequent signal transduction. 2000 Thyroid pmid:10807058
pmid:10814523
Rodríguez-Concepción M et al. Genetic evidence of branching in the isoprenoid pathway for the production of isopentenyl diphosphate and dimethylallyl diphosphate in Escherichia coli. 2000 FEBS Lett. pmid:10818234
Vishnuvardhan D and Beinfeld MC Lovastatin is a potent inhibitor of cholecystokinin secretion in endocrine tumor cells in culture. 2000 Peptides pmid:10822111
Ashar HR et al. Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. 2000 J. Biol. Chem. pmid:10852915
pmid:10856525
Raal FJ et al. Inhibition of cholesterol synthesis by atorvastatin in homozygous familial hypercholesterolaemia. 2000 Atherosclerosis pmid:10856535
Schulte AE et al. Purification and characterization of mevalonate kinase from suspension-cultured cells of Catharanthus roseus (L.) G. Don. 2000 Arch. Biochem. Biophys. pmid:10860546
Montalvetti A et al. Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase. 2000 Biochem. J. pmid:10861207
pmid:10872206
Stickney JT and Buss JE Murine guanylate-binding protein: incomplete geranylgeranyl isoprenoid modification of an interferon-gamma-inducible guanosine triphosphate-binding protein. 2000 Mol. Biol. Cell pmid:10888661
Takagi M et al. A gene cluster for the mevalonate pathway from Streptomyces sp. Strain CL190. 2000 J. Bacteriol. pmid:10894721
Wilding EI et al. Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci. 2000 J. Bacteriol. pmid:10894743
pmid:10896295
pmid:10896296
pmid:10899
pmid:10908155
pmid:10917872
Hirai N et al. Biosynthesis of abscisic acid by the non-mevalonate pathway in plants, and by the mevalonate pathway in fungi. 2000 Biosci. Biotechnol. Biochem. pmid:10945263
Nilsson A Increased cholesterol-ester formation during forced cholesterol synthesis in rat hepatocytes. 1975 Eur. J. Biochem. pmid:1097241
Itoh D et al. Nonequivalent labeling of the phytyl side chain of chlorophyll a in callus of the hornwort Anthoceros punctatus. 2000 J. Nat. Prod. pmid:10978203
Ikeda U et al. Fluvastatin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells. 2000 Hypertension pmid:10988259
Shimizu I and Katsuki H Effect of temperature on ergosterol biosynthesis in yeast. 1975 J. Biochem. pmid:1099086
Moreau JP et al. Biosynthesis of sterols by a yeast homogenate. Incorporation of mevalonic acid into cholesta-5,7,24-trien-3beta-ol and 5alpha-cholesta-7,24-dien-3beta-ol. 1975 Eur. J. Biochem. pmid:1100393
Hernández-Perera O et al. Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells. 2000 Circ. Res. pmid:11009568
Hausding M et al. Inhibition of small G proteins of the rho family by statins or clostridium difficile toxin B enhances cytokine-mediated induction of NO synthase II. 2000 Br. J. Pharmacol. pmid:11015307
pmid:11035257
Smit A and Mushegian A Biosynthesis of isoprenoids via mevalonate in Archaea: the lost pathway. 2000 Genome Res. pmid:11042147
pmid:11053993
pmid:11058703