Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypothyroidism D007037 32 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Refsum Disease D012035 19 associated lipids
Leukemia D007938 74 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hypertension D006973 115 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Glioblastoma D005909 27 associated lipids
Per page 10 20 50 | Total 25

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Mevalonic acid

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Per page 10 20 50 100 | Total 2899
Authors Title Published Journal PubMed Link
Elsayed M et al. Synergistic Antiproliferative Effects of Zoledronic Acid and Fluvastatin on Human Pancreatic Cancer Cell Lines: An in Vitro Study. 2016 Biol. Pharm. Bull. pmid:27181081
Silva Ramos E et al. Bioenergetic roles of mitochondrial fusion. 2016 Biochim. Biophys. Acta pmid:27060252
Wang T et al. Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway. 2016 Oncotarget pmid:26565813
Yildirim FI et al. Aggravating effect of atorvastatin on indomethacin-induced gastric injury: Focus on PGE2, TNF-α, neutrophils and iNOS. 2015 Prostaglandins Other Lipid Mediat. pmid:26201058
Surup F et al. Deconins A-E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471. 2015 J. Nat. Prod. pmid:25871540
York AG et al. Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling. 2015 Cell pmid:26686653
Miettinen TP and Björklund M Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy. 2015 Cell Rep pmid:26686643
Gallagher KA and Jensen PR Genomic insights into the evolution of hybrid isoprenoid biosynthetic gene clusters in the MAR4 marine streptomycete clade. 2015 BMC Genomics pmid:26578069
Nyati P et al. Negative Feedbacks by Isoprenoids on a Mevalonate Kinase Expressed in the Corpora Allata of Mosquitoes. 2015 PLoS ONE pmid:26566274
Chen Y et al. Mevalonate inhibits acid sphingomyelinase activity, increases sphingomyelin levels and inhibits cell proliferation of HepG2 and Caco-2 cells. 2015 Lipids Health Dis pmid:26493087
Laezza C et al. p53 regulates the mevalonate pathway in human glioblastoma multiforme. 2015 Cell Death Dis pmid:26469958
Rondini EA et al. Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Intermediates of the Cholesterol Biosynthetic Pathway in Primary Cultured Rat Hepatocytes. 2015 J. Pharmacol. Exp. Ther. pmid:26427720
Guan Z et al. Metabolic engineering of Bacillus subtilis for terpenoid production. 2015 Appl. Microbiol. Biotechnol. pmid:26373726
Pandyra AA et al. Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death. 2015 Oncotarget pmid:26353928
Kuo KK et al. Xanthine-based KMUP-1 improves HDL via PPARγ/SR-B1, LDL via LDLRs, and HSL via PKA/PKG for hepatic fat loss. 2015 J. Lipid Res. pmid:26351364
Kain V et al. Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism. 2015 Sci Rep pmid:26345110
Henry LK et al. Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:26216978
Zhang Z et al. Genomic variations of the mevalonate pathway in porokeratosis. 2015 Elife pmid:26202976
Venkateshwaran M et al. A role for the mevalonate pathway in early plant symbiotic signaling. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:26199419
Tricarico PM et al. Mevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible Link. 2015 Int J Mol Sci pmid:26184189
Kobayashi Y et al. Mevalonate Pathway Antagonist Suppresses Formation of Serous Tubal Intraepithelial Carcinoma and Ovarian Carcinoma in Mouse Models. 2015 Clin. Cancer Res. pmid:26109099
Tricarico PM et al. Alendronate, a double-edged sword acting in the mevalonate pathway. 2015 Mol Med Rep pmid:26096667
Hofberger JA et al. Large-Scale Evolutionary Analysis of Genes and Supergene Clusters from Terpenoid Modular Pathways Provides Insights into Metabolic Diversification in Flowering Plants. 2015 PLoS ONE pmid:26046541
Karlic H et al. Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells. 2015 Cancer Genet pmid:25978957
Zhou X et al. Mitogen-activated protein kinase mediates mevalonate-stimulated human mesangial cell proliferation. 2015 Mol Med Rep pmid:25936991
Du X et al. Nitric Oxide Plays a Central Role in Water Stress-Induced Tanshinone Production in Salvia miltiorrhiza Hairy Roots. 2015 Molecules pmid:25919278
Chen GP et al. Alteration of mevalonate pathway in proliferated vascular smooth muscle from diabetic mice: possible role in high-glucose-induced atherogenic process. 2015 J Diabetes Res pmid:25918730
Sharon C et al. Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo. 2015 Oncotarget pmid:25895029
Hwang HS et al. Transcriptomic analysis of Siberian ginseng (Eleutherococcus senticosus) to discover genes involved in saponin biosynthesis. 2015 BMC Genomics pmid:25888223
Hirota Y et al. Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1. 2015 PLoS ONE pmid:25874989
Autefage H et al. Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:25831522
Wang WQ et al. Proteomic analysis of lettuce seed germination and thermoinhibition by sampling of individual seeds at germination and removal of storage proteins by polyethylene glycol fractionation. 2015 Plant Physiol. pmid:25736209
Sekiya A et al. Fluvastatin Upregulates the Expression of Tissue Factor Pathway Inhibitor in Human Umbilical Vein Endothelial Cells. 2015 J. Atheroscler. Thromb. pmid:25735397
Polotskaia A et al. Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:25733866
de Oliveira LS et al. New Insights on the terpenome of the red seaweed Laurencia dendroidea (Florideophyceae, Rhodophyta). 2015 Mar Drugs pmid:25675000
Rossoni L et al. The Putative mevalonate diphosphate decarboxylase from Picrophilus torridus is in reality a mevalonate-3-kinase with high potential for bioproduction of isobutene. 2015 Appl. Environ. Microbiol. pmid:25636853
Skaff DA et al. Inhibition of bacterial mevalonate diphosphate decarboxylase by eriochrome compounds. 2015 Arch. Biochem. Biophys. pmid:25499551
Kang S et al. Synthesis of mevalonate- and fluorinated mevalonate prodrugs and their in vitro human plasma stability. 2015 Eur J Med Chem pmid:25461893
Matsuo S et al. Single-dose rosuvastatin ameliorates lung ischemia-reperfusion injury via upregulation of endothelial nitric oxide synthase and inhibition of macrophage infiltration in rats with pulmonary hypertension. 2015 J. Thorac. Cardiovasc. Surg. pmid:25454916
Vinokur JM et al. Structural analysis of mevalonate-3-kinase provides insight into the mechanisms of isoprenoid pathway decarboxylases. 2015 Protein Sci. pmid:25422158
Greife A et al. Establishment and characterization of a bladder cancer cell line with enhanced doxorubicin resistance by mevalonate pathway activation. 2015 Tumour Biol. pmid:25566959
Sorrentino G et al. Metabolic control of YAP and TAZ by the mevalonate pathway. 2014 Nat. Cell Biol. pmid:24658687
Al-Haidari AA et al. HMG-CoA reductase regulates CCL17-induced colon cancer cell migration via geranylgeranylation and RhoA activation. 2014 Biochem. Biophys. Res. Commun. pmid:24582560
Huchelmann A et al. S-carvone suppresses cellulase-induced capsidiol production in Nicotiana tabacum by interfering with protein isoprenylation. 2014 Plant Physiol. pmid:24367019
Larson-Casey JL et al. Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosis. 2014 J. Biol. Chem. pmid:25378391
Shimabukuro-Vornhagen A et al. Inhibition of protein geranylgeranylation specifically interferes with CD40-dependent B cell activation, resulting in a reduced capacity to induce T cell immunity. 2014 J. Immunol. pmid:25311809
Chang TI et al. The effect of statin on epithelial-mesenchymal transition in peritoneal mesothelial cells. 2014 PLoS ONE pmid:25275561
Kanugula AK et al. Fluvastatin mediated breast cancer cell death: a proteomic approach to identify differentially regulated proteins in MDA-MB-231 cells. 2014 PLoS ONE pmid:25268751
Vannice JC et al. Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an archaeal alternate mevalonate pathway. 2014 J. Bacteriol. pmid:24375100
Wang Z et al. Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:24367099