Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Glioblastoma D005909 27 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Hypothyroidism D007037 32 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Thrombosis D013927 49 associated lipids
Leukemia D007938 74 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Glioma D005910 112 associated lipids
Hypertension D006973 115 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 25

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Davis RA et al. Bile acid synthesis by cultured hepatocytes. Inhibition by mevinolin, but not by bile acids. 1983 J. Biol. Chem. pmid:6550600
Newman CM et al. Post-translational processing of Schizosaccharomyces pombe YPT proteins. 1992 J. Biol. Chem. pmid:1597466
Graber SG et al. Expression of functional G protein beta gamma dimers of defined subunit composition using a baculovirus expression system. 1992 J. Biol. Chem. pmid:1618813
Schafer BL et al. Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria. 1992 J. Biol. Chem. pmid:1377680
Correll CC and Edwards PA Mevalonic acid-dependent degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo and in vitro. 1994 J. Biol. Chem. pmid:8276863
Bradfute DL et al. Squalene synthase-deficient mutant of Chinese hamster ovary cells. 1992 J. Biol. Chem. pmid:1526971
Richard SB et al. Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway. 2002 J. Biol. Chem. pmid:11786530
Roitelman J et al. Involvement of calcium in the mevalonate-accelerated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase. 1991 J. Biol. Chem. pmid:1908464
Theesfeld CL and Hampton RY Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast. 2013 J. Biol. Chem. pmid:23306196
Murthy S et al. Regulation of fatty acid synthesis by farnesyl pyrophosphate. 2005 J. Biol. Chem. pmid:16221687
Fujiyama A et al. S-farnesylation and methyl esterification of C-terminal domain of yeast RAS2 protein prior to fatty acid acylation. 1991 J. Biol. Chem. pmid:1917931
Maltese WA and Sheridan KM Isoprenoid modification of G25K (Gp), a low molecular mass GTP-binding protein distinct from p21ras. 1990 J. Biol. Chem. pmid:2120220
Rieder C et al. Biosynthesis of the diterpene verrucosan-2beta-ol in the phototrophic eubacterium Chloroflexus aurantiacus. A retrobiosynthetic NMR study. 1998 J. Biol. Chem. pmid:9660767
Plemenitas A et al. Sterol-mediated regulation of mevalonic acid synthesis. Accumulation of 4-carboxysterols as the predominant sterols synthesized in a Chinese hamster ovary cell cholesterol auxotroph (mutant 215). 1990 J. Biol. Chem. pmid:2211607
Sundseth SS and Waxman DJ Hepatic P-450 cholesterol 7 alpha-hydroxylase. Regulation in vivo at the protein and mRNA level in response to mevalonate, diurnal rhythm, and bile acid feedback. 1990 J. Biol. Chem. pmid:2394714
Ginger ML et al. The biosynthetic incorporation of the intact leucine skeleton into sterol by the trypanosomatid Leishmania mexicana. 2001 J. Biol. Chem. pmid:11148203
Repko EM and Maltese WA Post-translational isoprenylation of cellular proteins is altered in response to mevalonate availability. 1989 J. Biol. Chem. pmid:2722887
Panini SR et al. Sterol-independent regulation of 3-hydroxy-3-methylglutaryl-CoA reductase by mevalonate in Chinese hamster ovary cells. Magnitude and specificity. 1989 J. Biol. Chem. pmid:2567731
Righetti M et al. The in vitro metabolism of mevalonate by sterol and non-sterol pathways. 1976 J. Biol. Chem. pmid:1262340
Brown D and Simoni RD Mevalonate deprivation leads to aneuploidy in Chinese hamster ovary cells. 1988 J. Biol. Chem. pmid:3417669
Gan X et al. Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate. 2001 J. Biol. Chem. pmid:11641412
Bi X et al. Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia. 2004 J. Biol. Chem. pmid:15364922
Stoll J et al. A Chinese hamster ovary cell mutant F2A8 utilizes polyprenol rather than dolichol for its lipid-dependent asparagine-linked glycosylation reactions. 1988 J. Biol. Chem. pmid:3392042
WITTING LA and PORTER JW Intermediates in the conversion of mevalonic acid to squalene by a rat liver enzyme system. 1959 J. Biol. Chem. pmid:13845505
Middleton B et al. The control of sterol synthesis during development of rabbit mammary gland. 1981 J. Biol. Chem. pmid:7014559
Rodríguez JM et al. Fungal metabolic model for 3-methylcrotonyl-CoA carboxylase deficiency. 2004 J. Biol. Chem. pmid:14612443
POPJAK G et al. Studies on the biosynthesis of cholesterol. XV. Mechanism of squalene biosynthesis from farnesyl pyrophosphate and from mevalonate. 1961 J. Biol. Chem. pmid:13737104
Siddals KW et al. Apposite insulin-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization. 2011 J. Biol. Chem. pmid:21454560
Bate C et al. Squalestatin cures prion-infected neurons and protects against prion neurotoxicity. 2004 J. Biol. Chem. pmid:14754889
Derksen A and Cohen P Extensive incorporation of (2-14C) mevalonic acid into cholesterol precursors by human platelets in vitro. 1973 J. Biol. Chem. pmid:4355579
Sprott GD et al. Isolation and chemical composition of the cytoplasmic membrane of the archaebacterium Methanospirillum hungatei. 1983 J. Biol. Chem. pmid:6833242
Swift IE and Milborrow BV Stereochemistry of beta-, gamma-, and epsilon-ring formation in bacterial C50. 1981 J. Biol. Chem. pmid:7028738
Wiley MH et al. Sex differences in the sterol and nonsterol metabolism of mevalonate. 1979 J. Biol. Chem. pmid:762097
Ryan J et al. Isolation and characterization of cells resistant to ML236B (compactin) with increased levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1981 J. Biol. Chem. pmid:7240242
Bergstrom JD et al. The regulation of acetoacetyl-CoA synthetase activity by modulators of cholesterol synthesis in vivo and the utilization of acetoacetate for cholesterogenesis. 1984 J. Biol. Chem. pmid:6501306
Heller RA and Gould RG Reversible cold inactivation of microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase from rat liver. 1974 J. Biol. Chem. pmid:4854147
Goldstein JL and Brown MS Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. 1974 J. Biol. Chem. pmid:4368448
Ekström TJ et al. The alpha-saturation and terminal events in dolichol biosynthesis. 1987 J. Biol. Chem. pmid:3031061
Rosenwald AG et al. Regulation of glycosylation. Three enzymes compete for a common pool of dolichyl phosphate in vivo. 1990 J. Biol. Chem. pmid:2167320
Ramsey RB et al. Formation of methyl sterols in brain cholesterol biosynthesis. Sterol formation in vitro in actively myelinating rat brain. 1972 J. Biol. Chem. pmid:5030627
Hidaka Y et al. Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells. 1991 J. Biol. Chem. pmid:1649182
Meigs TE and Simoni RD Regulated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in permeabilized cells. 1992 J. Biol. Chem. pmid:1618856
Ness GC et al. Feedback regulation of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase activity by dietary cholesterol is not due to altered mRNA levels. 1991 J. Biol. Chem. pmid:1869523
Feyereisen R and Farnsworth DE Precursor supply for insect juvenile hormone III biosynthesis in a cockroach. 1987 J. Biol. Chem. pmid:3818617
Goodwin CD and Margolis S Specific activation of in vitro cholesterol biosynthesis by preincubation of rat liver homogenates. 1973 J. Biol. Chem. pmid:4745786
Parker RA et al. Phosphorylation of native 97-kDa 3-hydroxy-3-methylglutaryl-coenzyme A reductase from rat liver. Impact on activity and degradation of the enzyme. 1989 J. Biol. Chem. pmid:2538466
Sato R et al. Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription. 1999 J. Biol. Chem. pmid:10455139
Dugan RE and Porter JW Stereospecificity of the transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate in each of the two reductive steps catalyzed by beta-hydroxy-beta-methylglutaryl coenzyme A reductase. 1971 J. Biol. Chem. pmid:4398469
Schaber MD et al. Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase. 1990 J. Biol. Chem. pmid:2203759
Momose K and Rudney H 3-Polyprenyl-4-hydroxybenzoate synthesis in the inner membrane of mitochondria from p-hydroxybenzoate and isopentenylpyrophosphate. A demonstration of isoprenoid synthesis in rat liver mitochondria. 1972 J. Biol. Chem. pmid:4338233
Bensch WR and Rodwell VW Purification and properties of 3-hydroxy-3-methylglutaryl coenzyme A reductase from Pseudomonas. 1970 J. Biol. Chem. pmid:4321764
Li J et al. De novo synthesis of steroids and oxysterols in adipocytes. 2014 J. Biol. Chem. pmid:24280213
Brown MS et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase. Solubilization and purification of a cold-sensitive microsomal enzyme. 1973 J. Biol. Chem. pmid:4146267
Chakrabarti R and Engleman EG Interrelationships between mevalonate metabolism and the mitogenic signaling pathway in T lymphocyte proliferation. 1991 J. Biol. Chem. pmid:1712015
Trzaskos JM et al. In situ accumulation of 3 beta-hydroxylanost-8-en-32-aldehyde in hepatocyte cultures. A putative regulator of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity. 1987 J. Biol. Chem. pmid:3624256
Quesney-Huneeus V et al. The dual role of mevalonate in the cell cycle. 1983 J. Biol. Chem. pmid:6848509
Niknejad N et al. Activation of the integrated stress response regulates lovastatin-induced apoptosis. 2007 J. Biol. Chem. pmid:17699156
Horodysky AG et al. Biosynthesis of methylcyclopentane monoterpenoids. IV. Verbenalin. 1969 J. Biol. Chem. pmid:5792652
Rahman R et al. Removal of the 4,4-dimethyl carbons in the enzymic conversion of lanosterol to cholesterol. Initial loss of the 4-alpha-methyl group. 1970 J. Biol. Chem. pmid:5445804
Shechter I and West CA Biosynthesis of gibberellins. IV. Biosynthesis of cyclic diterpenes from trans-geranylgeranyl pyrophosphate. 1969 J. Biol. Chem. pmid:4183095
Castle M et al. The mechanism of introduction of alkyl groups at C-24 of sterols. I. The precursor of the C2 group. 1967 J. Biol. Chem. pmid:6073661
Kandutsch AA and Chen HW Inhibition of sterol synthesis in cultured mouse cells by 7alpha-hydroxycholesterol, 7beta-hydroxycholesterol, and 7-ketocholesterol. 1973 J. Biol. Chem. pmid:4797016
Kirsten ES and Watson JA Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in hepatoma tissue culture cells by serum lipoproteins. 1974 J. Biol. Chem. pmid:4371188
Faust J and Krieger M Expression of specific high capacity mevalonate transport in a Chinese hamster cell variant. 1987 J. Biol. Chem. pmid:3643925
Auda H et al. Biosynthesis of methylcyclopentane monoterpenoids. 3. Actinidine. 1967 J. Biol. Chem. pmid:6061704
Dennis DT and West CA Biosynthesis of gibberellins. 3. The conversion of (-)-kaurene to (-)-kauren-19-oic acid in endosperm of Echinocystis macrocarpa Greene. 1967 J. Biol. Chem. pmid:4382094
Muscio F et al. Prequalene pyrophosphate. A normal intermediate in squalene biosynthesis. 1974 J. Biol. Chem. pmid:4152099
Luskey KL et al. Stimulation of the synthesis of very low density lipoproteins in rooster liver by estradiol. 1974 J. Biol. Chem. pmid:4370392
James MJ and Kandutsch AA Elevated dolichol synthesis in mouse testes during spermatogenesis. 1980 J. Biol. Chem. pmid:7350150
Hsu RY et al. The purification and properties of the fatty acid synthetase of pigeon liver. 1965 J. Biol. Chem. pmid:4378857
Stamatakis K et al. Isoprenylation of RhoB is necessary for its degradation. A novel determinant in the complex regulation of RhoB expression by the mevalonate pathway. 2002 J. Biol. Chem. pmid:12384510
Nair AK and Menon KM Regulation of luteinizing hormone receptor expression: evidence of translational suppression in vitro by a hormonally regulated mRNA-binding protein and its endogenous association with luteinizing hormone receptor mRNA in the ovary. 2005 J. Biol. Chem. pmid:16263716
Holstein SA et al. Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB. 2002 J. Biol. Chem. pmid:11788600
Laufs U et al. 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1). 1999 J. Biol. Chem. pmid:10419514
NICHOLAS HJ Biosynthesis of sclareol, beta-sitosterol, and oleanolic acid from mevalonic acid-2-C-14. 1962 J. Biol. Chem. pmid:14479433
Cuthbert JA and Lipsky PE Inhibition by 6-fluoromevalonate demonstrates that mevalonate or one of the mevalonate phosphates is necessary for lymphocyte proliferation. 1990 J. Biol. Chem. pmid:2211719
Kikuchi A et al. Evidence for covalent attachment of diphytanylglyceryl phosphate to the cell-surface glycoprotein of Halobacterium halobium. 1999 J. Biol. Chem. pmid:10364251
SCHLESINGER MJ and COON MJ Reduction of mevaldic acid to mevalonic acid by a partially purified enzyme from liver. 1961 J. Biol. Chem. pmid:13747804
DURR IF and RUDNEY H The reduction of beta-hydroxy-beta-methyl-glutaryl coenzyme A to mevalonic acid. 1960 J. Biol. Chem. pmid:13818862
Yan D et al. Biochemical characterization and subcellular localization of the mouse retinitis pigmentosa GTPase regulator (mRpgr). 1998 J. Biol. Chem. pmid:9677393
ELWOOD JC et al. Lipid metabolism in the diabetic rat. IV. Metabolism of acetate, acetoacetate, butyrate, and mevalonate in vitro. 1960 J. Biol. Chem. pmid:13820133
Jakoi L and Quarfordt SH The induction of hepatic cholesterol synthesis in the rat by lecithin mesophase infusions. 1974 J. Biol. Chem. pmid:4416309
KNAUSS HJ et al. The biosynthesis of mevalonic acid from 1-C14-acetate by a rat liver enzyme system. 1959 J. Biol. Chem. pmid:14410081
Malhotra HC and Nes WR The mechanism of introduction of alkyl groups at C-24 of sterols. IV. Inhibition by triparanol. 1971 J. Biol. Chem. pmid:5570429
Mitchell ED and Avigan J Control of phosphorylation and decarboxylation of mevalonic acid and its metabolites in cultured human fibroblasts and in rat liver in vivo. 1981 J. Biol. Chem. pmid:6263908
Siperstein MD et al. A gas-liquid chromatographic procedure for the measurement of mevalonic acid synthesis. 1966 J. Biol. Chem. pmid:5908124
Siperstein MD and Fagan VM Feedback control of mevalonate synthesis by dietary cholesterol. 1966 J. Biol. Chem. pmid:5908125
Deneris ES et al. Acid-catalyzed formation of isoprene from a mevalonate-derived product using a rat liver cytosolic fraction. 1985 J. Biol. Chem. pmid:3968076
Edwards PA et al. Mevalonolactone inhibits the rate of synthesis and enhances the rate of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat hepatocytes. 1983 J. Biol. Chem. pmid:6863245
Hanson RF et al. Stereochemistry of the side chain oxidation of 5 beta-cholestane-3 alpha,7 alpha,12 alpha-triol in man. 1980 J. Biol. Chem. pmid:7354041
Barta ML et al. Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis. 2011 J. Biol. Chem. pmid:21561869
Siddals KW et al. Abrogation of insulin-like growth factor-I (IGF-I) and insulin action by mevalonic acid depletion: synergy between protein prenylation and receptor glycosylation pathways. 2004 J. Biol. Chem. pmid:15247258
Sagami H et al. A novel type of protein modification by isoprenoid-derived materials. Diphytanylglycerylated proteins in Halobacteria. 1995 J. Biol. Chem. pmid:7797461
Pérez-Sala D et al. Intracellular alkalinization suppresses lovastatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease. 1995 J. Biol. Chem. pmid:7890761
Hokland BM et al. Cyclic AMP stimulates efflux of intracellular sterol from cholesterol-loaded cells. 1993 J. Biol. Chem. pmid:7503979
Sever N et al. Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. 2003 J. Biol. Chem. pmid:14563840
Kasahara H et al. Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis. 2004 J. Biol. Chem. pmid:14726522
Paton VG et al. Cloning and subcellular localization of hamster and rat isopentenyl diphosphate dimethylallyl diphosphate isomerase. A PTS1 motif targets the enzyme to peroxisomes. 1997 J. Biol. Chem. pmid:9228075
Schroeder WA and Johnson EA Singlet oxygen and peroxyl radicals regulate carotenoid biosynthesis in Phaffia rhodozyma. 1995 J. Biol. Chem. pmid:7629161
Camp LA and Hofmann SL Purification and properties of a palmitoyl-protein thioesterase that cleaves palmitate from H-Ras. 1993 J. Biol. Chem. pmid:7901201