Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Glioblastoma D005909 27 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Hypothyroidism D007037 32 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Thrombosis D013927 49 associated lipids
Leukemia D007938 74 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Glioma D005910 112 associated lipids
Hypertension D006973 115 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 25

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Authors Title Published Journal PubMed Link
Kandutsch AA and Hancock RL Regulation of the rate of sterol synthesis and the level of beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity in mouse liver and hepatomas. 1971 Cancer Res. pmid:4328734
Hornby GM and Boyd GS The origin of lanosta-7,24-dienol in rat skin. 1971 Biochem. J. pmid:5131739
Richards JB et al. Dolichol phosphates as acceptors of mannose from guanosine diphosphate mannose in liver systems. 1971 Biochem. J. pmid:5131017
Yamasaki K et al. Isolation of 3 7 -dihydroxychol-5-en-24-oic acid, an intermediate of chenodeoxycholic acid biogenesis, from fistula bile of the rat and hen. 1971 J. Biochem. pmid:5134665
McNamara DJ et al. Regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase. Developmental pattern. 1972 J. Biol. Chem. pmid:5057084
Williams CD and Avigan J In vitro effects of serum proteins and lipids on lipid synthesis in human skin fibroblasts and leukocytes grown in culture. 1972 Biochim. Biophys. Acta pmid:4338876
Edgren B and Hellström K Lipid biosynthesis from DL (2- 14 C) mevalonic acid in intact mice and rabbits. 1972 Acta Physiol. Scand. pmid:4640173
Cuzzopoli M et al. Effect of nephrectomy and cholesterol feeding on the metabolism of intravenously administered DL-mevalonate in the rat. 1972 Metab. Clin. Exp. pmid:4641957
Mak KM and Trier JS Radioautographic and chemical evidence for (5- 3 H)mevalonate incorporation into cholesterol by rat villous absorptive cells. 1972 Biochim. Biophys. Acta pmid:4642214
Richards JB and Hemming FW Dolichols, ubiquinones, geranylgeraniol and farnesol as the major metabolites of mevalonate in Phytophthora cactorum. 1972 Biochem. J. pmid:4643705
Hickman PE et al. Effect of adrenalectomy on the diurnal variation of hepatic cholesterogenesis in the rat. 1972 J. Lipid Res. pmid:5059193
Lefevre AF et al. Effect of ethanol on cholesterol and bile acid metabolism. 1972 J. Lipid Res. pmid:5059198
Salen G and Polito A Biosynthesis of 5 -cholestan-3 -ol in cerebrotendinous xanthomatosis. 1972 J. Clin. Invest. pmid:4550120
Aiyar AS and Olson RE Enhancement of ubiquinone-9 biosynthesis in rat-liver slices by exogenous mevalonate. 1972 Eur. J. Biochem. pmid:4340277
Sharma RK et al. Steroidogenesis in isolated adrenal cells of rat. 3. Morphological and biochemical correlation of cholesterol and cholesterol ester content in ACTH and N6-2'-O-dibutyryl-adenosine-3',5'-monophosphate activated adrenal cells. 1972 Endocrinology pmid:4340613
Gaskin F and Clayton RB An interstrain difference in cholesterol synthesis in vitro in mice, dependent upon a difference in endogenous NADPH-generating capacity. 1972 J. Lipid Res. pmid:4400581
White LW Feedback regulation of cholesterol biosynthesis: studies with cholestyramine. 1972 Circ. Res. pmid:4641786
Walton MJ and Pennock JF Some studies on the biosynthesis of ubiguinone, isoprenoid alcohols, squalene and sterols by marine invertebrates. 1972 Biochem. J. pmid:4403925
Green TR and Baisted DJ Development of the activities of enzymes of the isoprenoid pathway during early stages of pea-seed germination. 1972 Biochem. J. pmid:4348263
Beg ZH and Lupien PJ In vitro and in vivo inhibition of hepatic cholesterol synthesis by 3-hydroxy-3-methylglutaric acid. 1972 Biochim. Biophys. Acta pmid:5061662
Gaskin F and Clayton RB Decreased availability of hepatic NADPH in stressed mice. 1972 Biochem. Biophys. Res. Commun. pmid:4400445
Craig MC et al. Comparative effects of dietary regimens on the levels of enzymes regulating the synthesis of fatty acids and cholesterol in rat liver. 1972 Arch. Biochem. Biophys. pmid:5044513
Jayaram M and Raman TS Metabolism of ergosterol in the larva of the rice moth (Corcyra cephalonica St.). 1972 Biochem. J. pmid:5085614
Shefer S et al. Diurnal variation of HMG CoA reductase activity in rat intestine. 1972 J. Lipid Res. pmid:5075502
Ramsey RB et al. The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection into developing brain of (2- 14 C)mevalonic. 1972 J. Neurochem. pmid:5009889
Gibbons GF and Mitropoulos KA Inhibition of cholesterol biosynthesis by carbon monoxide: accumulation of lanosterol and 24,25-dihydrolanosterol. 1972 Biochem. J. pmid:5073750
Ramsey RB et al. Formation of methyl sterols in brain cholesterol biosynthesis. Sterol formation in vitro in actively myelinating rat brain. 1972 J. Biol. Chem. pmid:5030627
Rao GS and Ramasarma T ATP in the regulation of cholesterol biosynthesis- a supra-energetic role. 1972 Biochem. Biophys. Res. Commun. pmid:5077855
Gregory KW et al. Diurnal variations in rat liver 3-hydroxy-3-methylglutaryl-Coenzyme A reductase activity in relation to feeding. 1972 Biochem. J. pmid:4656802
Robbers JE et al. Physiological studies on ergot: further studies on the induction of alkaloid synthesis by tryptophan and its inhibition by phosphate. 1972 J. Bacteriol. pmid:5086659
Avigan J et al. In vitro biosynthesis of lipids, proteins and deoxyribonucleic acid in aortic tissue and in culture aortic cells. 1972 Biochim. Biophys. Acta pmid:5041430
Goldfarb S and Pitot HC Stimulatory effect of dietary lipid and cholestyramine on hepatic HMG CoA reductase. 1972 J. Lipid Res. pmid:4641420
Ray PH et al. Consequences of glycerol deprivation on the synthesis of membrane components in a glycerol auxotroph of Staphylococcus aureus. 1972 J. Bacteriol. pmid:5079070
Goodwin TW Recent developments in the study of the biosynthesis of carotenoids. 1972 Biochem. J. pmid:5085548
Nomura S et al. Inhibition of sterol and fatty acid biosyntheses by cerulenin in cell-free systems of yeast. 1972 J. Antibiot. pmid:4568013
Trumpower BL et al. Studies on ubiquinone. The isolation and identification of 5-demethoxyubiquinone-9 as an intermediate in biosynthesis of ubiquinone-9 in the rat. 1972 J. Biol. Chem. pmid:4553441
Durr IF and Habbal MZ The biosynthesis of C 55 polyprenols by a cell-free preparation of Lactobacillus plantarum. 1972 Biochem. J. pmid:5076663
Thorne KJ and Barker DC The occurrence of bactoprenol in the mesosome and plasma membranes of Lactobacillus casei and Lactobacillus plantarum. 1972 J. Gen. Microbiol. pmid:4625239
Hardman R and Fazli FR Labelled steroidal sapogenins and hydrocarbons from Trigonella foenumgraecum by acetate, mevalonate and cholesterol feeds to seeds. 1972 Planta Med. pmid:5018497
Momose K and Rudney H 3-Polyprenyl-4-hydroxybenzoate synthesis in the inner membrane of mitochondria from p-hydroxybenzoate and isopentenylpyrophosphate. A demonstration of isoprenoid synthesis in rat liver mitochondria. 1972 J. Biol. Chem. pmid:4338233
Slakey LL et al. The effects of fasting, refeeding, and time of day on the levels of enzymes effecting the conversion of -hydroxy- -methylglutaryl-coenzyme A to squalene. 1972 J. Biol. Chem. pmid:4337504
Stone KJ and Strominger JL Inhibition of sterol biosynthesis by bacitracin. 1972 Proc. Natl. Acad. Sci. U.S.A. pmid:4338587
Malhotra HC and Nes WR The conversion of mevalonate to 24-methylenecycloartanol by a cell-free enzyme preparation from nonphotosynthetic tissue. 1972 J. Biol. Chem. pmid:4651646
Heintz R et al. Plant sterol metabolism. Demonstration and identification of a biosynthetic intermediate between farnesyl PP and squalene in a higher plant. 1972 Biochem. Biophys. Res. Commun. pmid:4344813
Atkin SD et al. The isolation of 2,3-oxidosqualene from the liver of rats treated with 1-dodecylimidazole, a novel hypocholesterolaemic agent. 1972 Biochem. J. pmid:4655417
Barr RM and Hemming FW Polyprenol phosphate as an acceptor of mannose from guanosine diphosphate mannose in Aspergillus niger. 1972 Biochem. J. pmid:5073732
Prottey C et al. Lipid synthesis in rat skin. 1972 Br. J. Dermatol. pmid:4648803
Atkin SD et al. The role of cytochrome P-450 in cholesterol biogenesis and catabolism. 1972 Biochem. J. pmid:5084788
Lehner ND et al. Effects of insulin deficiency, hypothyroidism, and hypertension on cholesterol metabolism in the squirrel monkey. 1972 Exp. Mol. Pathol. pmid:4622478
Rodwell VW Cholesterol regulation of hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 1972 Biochem. J. pmid:5085556
Kandutsch AA and Saucier SE Sterol and fatty acid synthesis in developing brains of three myelin-deficient mouse mutants. 1972 Biochim. Biophys. Acta pmid:5012453
Rose HG Origin of cholesteryl esters in the blood of cholesterolfed rabbits: relative contributions of serum lecithin-cholesterol acyltransferase and hepatic ester synthesis. 1972 Biochim. Biophys. Acta pmid:5012982
Jedlicki E et al. Stereospecificity of isopentenylpyrophosphate isomerase and prenyl transferase from pinus and citrus. 1972 Arch. Biochem. Biophys. pmid:4635785
Milborrow BV Stereochemical aspects of the formation of double bonds in abscisic acid. 1972 Biochem. J. pmid:4643698
Madyastha KM et al. Carboxyl group methylation of loganic acid by a cell-free enzyme preparation from Vinca rosea. 1972 Biochem. J. pmid:4404427
Logan DM Thermal and pH stability of 2 -isopentenyl pyrophosphate. 1972 J. Lipid Res. pmid:4333821
Beedle AS et al. The stereochemistry of hydrogen transfer from NADPH catalysed by 3-hydroxy-3-methylglutaryl-coenzyme A reductase from rat liver. 1972 Eur. J. Biochem. pmid:4403574
Banthorpe DV et al. Biosynthesis of geraniol and nerol and beta-D-glucosides in Pelargonium graveolens and Rosa dilecta. 1972 Biochem. J. pmid:4348258
Beedle AS et al. The stereochemistry of the reduction of mevaldic acid-coenzyme A hemithioacetal by rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1972 FEBS Lett. pmid:4405222
Ayaki Y and Yamasaki Identification of 3 , 7 -dihydroxychol-5-enoic acid in fistula bile of the rat given cholesterol-4- 14 C and DL-mevalonate-2- 14 C. 1972 J. Biochem. pmid:5015370
Barr RM and Hemming FW Polyprenols of Aspergillus niger. Their characterization, biosynthesis and subcellular distribution. 1972 Biochem. J. pmid:5073731
Ramsey RB et al. The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection of (2- 14 C)mevalonic acid into 30-day-old rat brain: a period of transition. 1972 J. Neurochem. pmid:5019590
Miettinen TA Mode of action of a new hypocholesteraemic drug (DH-581) in familial hypercholesteraemia. 1972 Mar-Apr Atherosclerosis pmid:4666121
Thorne KJ Identification of prenol intermediates of wall biosynthesis in growing cells of Lactobacillus plantarum. 1973 J. Bacteriol. pmid:4745415
Grigor MR et al. Cholesterol metabolism in rats bearing Morris hepatoma 7777. 1973 Cancer Res. pmid:4352741
Bortz WM On the control of cholesterol synthesis. 1973 Metab. Clin. Exp. pmid:4206254
Bojesen E et al. Sterol biosynthesis in vitro of rat renal inner medulla. 1973 Biochim. Biophys. Acta pmid:4713153
Bhavnani BR and Short RV Formation of steroids by the pregnant mare. IV. Metabolism of 14 C-mevalonic acid and 3 H-dehydroisoandrosterone injected into the fetal circulation. 1973 Endocrinology pmid:4266621
Hellstrom KH et al. Studies of the in vivo metabolism of mevalonic acid in the normal rat. 1973 J. Clin. Invest. pmid:4703220
Slakey LL et al. Occurrence of the enzymes effecting the conversion of acetyl CoA to squalene in homogenates of hog aorta. 1973 J. Lipid Res. pmid:4351784
Derksen A and Cohen P Extensive incorporation of (2-14C) mevalonic acid into cholesterol precursors by human platelets in vitro. 1973 J. Biol. Chem. pmid:4355579
Bojesen I and Roepstorff P Identification of C sterols produced by rat renal inner medulla in vitro. 1973 Biochim. Biophys. Acta pmid:4722467
Goldstein JL and Brown MS Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol. 1973 Proc. Natl. Acad. Sci. U.S.A. pmid:4355366
Shimizu I et al. Mevalonate synthesis in the mitochondria of yeast. 1973 Biochim. Biophys. Acta pmid:4569545
Sérougne-Gautheron C and Chevallier F Time course of biosynthetic cholesterol in the adult rat brain. 1973 Biochim. Biophys. Acta pmid:4741912
Higgins MJ and Kekwick RG An investigation into the role of malonyl-coenzyme A in isoprenoid biosynthesis. 1973 Biochem. J. pmid:4579226
Gibbons GF and Mitropoulos KA The effect of carbon monoxide on the nature of the accumulated 4,4-dimethyl sterol precursors of cholesterol during its biosynthesis from (2-14C)mevalonic acid in vitro. 1973 Biochem. J. pmid:4724584
Kabara JJ A critical review of brain cholesterol metabolism. 1973 Prog. Brain Res. pmid:4608424
Hulcher FH and Oleson WH Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A. 1973 J. Lipid Res. pmid:4147523
Moshier SE and Chapman DJ Biosynthetic studies on aromatic carotenoids. Biosynthesis of chlorobactene. 1973 Biochem. J. pmid:4774401
McDermott JC et al. Carotenoid biosynthesis in a Flavobacterium sp.: stereochemistry of hydrogen elimination in the desaturation of phytoene to lycopene, rubixanthin and zeaxanthin. 1973 Biochem. J. pmid:4762756
Myant NB et al. Turnover of cholesteryl esters in plasma low-density and high-density lipoproteins in familial hyperbetalipoproteinaemia. 1973 Clin Sci Mol Med pmid:4356485
Ranganathan S and Ramasarma T Inhibition of the biosynthesis of sterols by phenyl and phenolic compounds in rat liver. 1973 Biochem. J. pmid:4749274
Ahmad N and Siddiqi M Bacterial metabolism of 3-hydroxy-3-methylglutaric acid. 1973 J. Bacteriol. pmid:4717513
Gray JC and Kekwick RG Mevalonate kinase in green leaves and etiolated cotyledons of the french bean Phaseolus vulgaris. 1973 Biochem. J. pmid:4723778
Bassett RA et al. Biosynthesis of ergotamine by Claviceps purpurea (Fr.) Tul. 1973 Biochem. J. pmid:4723222
Goodwin CD and Margolis S Specific activation of in vitro cholesterol biosynthesis by preincubation of rat liver homogenates. 1973 J. Biol. Chem. pmid:4745786
Brown MS et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase. Solubilization and purification of a cold-sensitive microsomal enzyme. 1973 J. Biol. Chem. pmid:4146267
Ness GC et al. Stimulation of hepatic beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity in hypophysectomized rats by L-triiodothyronine. 1973 Proc. Natl. Acad. Sci. U.S.A. pmid:4521209
Kandutsch AA and Chen HW Inhibition of sterol synthesis in cultured mouse cells by 7alpha-hydroxycholesterol, 7beta-hydroxycholesterol, and 7-ketocholesterol. 1973 J. Biol. Chem. pmid:4797016
Kawaguchi A et al. Subcellular distribution of sesterterpene- and sterol-biosynthesizing activities in Cochliobolus heterostrophus. 1973 Biochim. Biophys. Acta pmid:4120185
Merry AH et al. Oestrogen-stimulated cholesterol and lipid synthesis in Xenopus laevis liver. 1973 Biochem. Soc. Trans. pmid:4802550
McIntyre N and Isselbacher KJ Role of the small intestine in cholesterol metabolism. 1973 Am. J. Clin. Nutr. pmid:4350610
Edwards PA Effect of adrenalectomy and hypophysectomy on the circadian rhythm of -hydroxy- -methylglutaryl coenzyme A reductase activity in rat liver. 1973 J. Biol. Chem. pmid:4697401
Thorne KJ Incorporation of radioactive mevalonate into C50 and C55 phenols by Streptococcus mutans. 1973 Biochem. J. pmid:4772282
Sodhi HS and Kudchodkar BJ Synthesis of cholesterol in hypercholesterolemia and its relationship to plasma trigylcerides. 1973 Metab. Clin. Exp. pmid:4351067
Collignon-Thiennot F et al. [Demonstration of 2 pathways for cholesterol synthesis in the mollusk: patella Patella vulgata L., (Gasteropoda, Prosobranches, Archeogasteropoda)]. 1973 Biochimie pmid:4754188
Sodhi HS et al. Hypocholesterolemic agents and mobilization of tissue cholesterol in man. 1973 Jan-Feb Atherosclerosis pmid:4696743
Sodhi HS et al. Separate pools for endogenous and exogenous cholesterol in rat intestines. 1973 Mar-Apr Atherosclerosis pmid:4709120
Heller RA and Gould RG Reversible cold inactivation of microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase from rat liver. 1974 J. Biol. Chem. pmid:4854147