Mevalonic acid

Mevalonic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 10134 references associated with Mevalonic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Mevalonic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Mevalonic acid

MeSH term MeSH ID Detail
Peutz-Jeghers Syndrome D010580 2 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Hypergammaglobulinemia D006942 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Glioblastoma D005909 27 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Hypothyroidism D007037 32 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Thrombosis D013927 49 associated lipids
Leukemia D007938 74 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Glioma D005910 112 associated lipids
Hypertension D006973 115 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 25

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All references with Mevalonic acid

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Authors Title Published Journal PubMed Link
Chevallier F et al. [Renewal, by synthesis and transfer, of free and esterified cholesterol. Magnitude of these compartments in adult rats and their distribution in tissues]. 1968 Biochim. Biophys. Acta pmid:5721031
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Sérougne-Gautheron C and Chevallier F Time course of biosynthetic cholesterol in the adult rat brain. 1973 Biochim. Biophys. Acta pmid:4741912
Duncan JL and Buckingham L Resistance to streptolysin O in mammalian cells treated with oxygenated derivatives of cholesterol. Cholesterol content of resistant cells and recovery of streptolysin O sensitivity. 1980 Biochim. Biophys. Acta pmid:7459354
Stokke KT and Norum KR Subcellular distribution of acyl-CoA: cholesterol acyltransferase in rat liver cells. 1970 Biochim. Biophys. Acta pmid:5456044
Kandutsch AA and Saucier SE Sterol and fatty acid synthesis in developing brains of three myelin-deficient mouse mutants. 1972 Biochim. Biophys. Acta pmid:5012453
Rose HG Origin of cholesteryl esters in the blood of cholesterolfed rabbits: relative contributions of serum lecithin-cholesterol acyltransferase and hepatic ester synthesis. 1972 Biochim. Biophys. Acta pmid:5012982
Chiew YE et al. Studies on pig liver mevalonate-5-diphosphate decarboxylase. 1987 Biochim. Biophys. Acta pmid:2825791
Rea TJ et al. Lack of correlation between ACAT mRNA expression and cholesterol esterification in primary liver cells. 1996 Biochim. Biophys. Acta pmid:8555254
Rao KS and Olson RE The effect of excessive vitamin A upon the metabolism of isoprenoid compounds in rat liver. 1967 Biochim. Biophys. Acta pmid:6049507
Stange EF et al. Regulation of 3-hydroxy-3-methylglutaryl-CoA reductase by endogenous sterol synthesis in cultured intestinal mucosa. 1981 Biochim. Biophys. Acta pmid:7225401
Krishnaiah KV and Ramasarma T Regulation of hepatic cholesterolgenesis by ubiquinone. 1970 Biochim. Biophys. Acta pmid:5442761
Filipovic I and Buddecke E Calmodulin antagonists stimulate LDL receptor synthesis in human skin fibroblasts. 1986 Biochim. Biophys. Acta pmid:2418882
Umetani N et al. Lovastatin inhibits gene expression of type-I scavenger receptor in THP-1 human macrophages. 1996 Biochim. Biophys. Acta pmid:8908154
Bifulco M et al. Inhibition of farnesylation blocks growth but not differentiation in FRTL-5 thyroid cells. 1999 Biochimie pmid:10401660
Collignon-Thiennot F et al. [Demonstration of 2 pathways for cholesterol synthesis in the mollusk: patella Patella vulgata L., (Gasteropoda, Prosobranches, Archeogasteropoda)]. 1973 Biochimie pmid:4754188
Sinensky M and Lutz RJ The prenylation of proteins. 1992 Bioessays pmid:1546978
Pallottini V et al. Age-related changes of isoprenoid biosynthesis in rat liver and brain. 2003 Biogerontology pmid:14739708
Kiran U et al. Structural and functional characterization of HMG-COA reductase from Artemisia annua. 2010 Bioinformation pmid:21364776
Elsayed M et al. Synergistic Antiproliferative Effects of Zoledronic Acid and Fluvastatin on Human Pancreatic Cancer Cell Lines: An in Vitro Study. 2016 Biol. Pharm. Bull. pmid:27181081
Aoyama T et al. Pharmacokinetic/pharmacodynamic modeling and simulation of rosuvastatin using an extension of the indirect response model by incorporating a circadian rhythm. 2010 Biol. Pharm. Bull. pmid:20522984
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Piotrowski PC et al. Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability. 2006 Biol. Reprod. pmid:16571871
Tricarico PM et al. Temperature and drug treatments in mevalonate kinase deficiency: an ex vivo study. 2013 Biomed Res Int pmid:24073415
Leitmeyer K et al. Simvastatin Results in a Dose-Dependent Toxic Effect on Spiral Ganglion Neurons in an In Vitro Organotypic Culture Assay. 2016 Biomed Res Int pmid:27051663
Kindt E et al. The validation of a simple LC/MS/MS method for determining the level of mevalonic acid in human plasma. 2011 Biomed. Chromatogr. pmid:21110384
O'Neill HJ et al. Identification of isoprenoid-type components in human expired air: a possible shunt pathway in sterol metabolism. 1987 Biomed. Chromatogr. pmid:3147729
Spencer TA et al. Feasibility of an immunoassay for mevalonolactone. 1997 Bioorg. Med. Chem. pmid:9208099
Zhao S et al. Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones. 2009 Bioorg. Med. Chem. pmid:19879766
García I et al. QSAR and complex network study of the chiral HMGR inhibitor structural diversity. 2009 Bioorg. Med. Chem. pmid:19026553
Kudoh T et al. Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae. 2010 Bioorg. Med. Chem. pmid:20056424
Sun X et al. Identified biosynthetic pathway of aspergiolide A and a novel strategy to increase its production in a marine-derived fungus Aspergillus glaucus by feeding of biosynthetic precursors and inhibitors simultaneously. 2009 Bioresour. Technol. pmid:19386490
Baldi A and Dixit VK Yield enhancement strategies for artemisinin production by suspension cultures of Artemisia annua. 2008 Bioresour. Technol. pmid:17804216
Kuzuyama T Mevalonate and nonmevalonate pathways for the biosynthesis of isoprene units. 2002 Biosci. Biotechnol. Biochem. pmid:12353619
Hamano Y et al. Growth-phase dependent expression of the mevalonate pathway in a terpenoid antibiotic-producing Streptomyces strain. 2002 Biosci. Biotechnol. Biochem. pmid:12036054
Shimane M et al. Mevalonate-dependent enzymatic synthesis of amorphadiene driven by an ATP-regeneration system using polyphosphate kinase. 2012 Biosci. Biotechnol. Biochem. pmid:22878192
Karunagoda RP et al. Labeling patterns of chloroplastidic isoprenoids in cultured cells of liverwort Ptychanthus striatus. 2001 Biosci. Biotechnol. Biochem. pmid:11440120
Sivy TL et al. Evidence of isoprenoid precursor toxicity in Bacillus subtilis. 2011 Biosci. Biotechnol. Biochem. pmid:22146731
Hirai N et al. Biosynthesis of abscisic acid by the non-mevalonate pathway in plants, and by the mevalonate pathway in fungi. 2000 Biosci. Biotechnol. Biochem. pmid:10945263
Yamauchi N The pathway of leucine to mevalonate in halophilic archaea: efficient incorporation of leucine into isoprenoidal lipid with the involvement of isovaleryl-CoA dehydrogenase in Halobacterium salinarum. 2010 Biosci. Biotechnol. Biochem. pmid:20139592
Sando T et al. Cloning and characterization of mevalonate pathway genes in a natural rubber producing plant, Hevea brasiliensis. 2008 Biosci. Biotechnol. Biochem. pmid:18685207
Hamano Y et al. Cloning of a gene cluster encoding enzymes responsible for the mevalonate pathway from a terpenoid-antibiotic-producing Streptomyces strain. 2001 Biosci. Biotechnol. Biochem. pmid:11515548
Okada K The biosynthesis of isoprenoids and the mechanisms regulating it in plants. 2011 Biosci. Biotechnol. Biochem. pmid:21737944
Inomata M et al. Biosynthesis of abscisic acid by the direct pathway via ionylideneethane in a fungus, Cercospora cruenta. 2004 Biosci. Biotechnol. Biochem. pmid:15618629
Herawati E and Ishizaki A Optimization of the culture medium for growth and the kinetics of lactate fermentation by Pediococcus sp. ISK-1. 1997 Biosci. Biotechnol. Biochem. pmid:9145518
Kuzuyama T et al. Heterologous mevalonate production in Streptomyces lividans TK23. 2004 Biosci. Biotechnol. Biochem. pmid:15118326
Boo KH et al. Distribution and biosynthesis of 20-hydroxyecdysone in plants of Achyranthes japonica Nakai. 2010 Biosci. Biotechnol. Biochem. pmid:21071854
Manzi P et al. Seasonal commitment of HMGCoA reductase activity to vitellogenin production. 1992 Biosci. Rep. pmid:1391685
Bruscalupi G et al. Regulation of acyl CoA: cholesterol acyl transferase (ACAT) activity by mevalonate and cholesterol in isolated rat hepatocytes during perinatal development. 1986 Biosci. Rep. pmid:3814768
Appelkvist EL In vitro labeling of peroxisomal cholesterol with radioactive precursors. 1987 Biosci. Rep. pmid:3449127
Edlund C et al. The half-lives of dolichol and dolichyl phosphate in rat liver. 1988 Biosci. Rep. pmid:3136813
Marino M et al. Enhanced production of dolichol, but not dolichyl phosphate, in the earliest stages of rat liver regeneration. 1986 Biosci. Rep. pmid:3742013
Aguilera JA et al. Regulation of hepatic cholesterogenesis by polar steroids accumulated after cholesterol feeding. 1988 Biosci. Rep. pmid:3408811
Wang C et al. Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. 2010 Biotechnol. Bioeng. pmid:20552672
Yuan J and Ching CB Combinatorial engineering of mevalonate pathway for improved amorpha-4,11-diene production in budding yeast. 2014 Biotechnol. Bioeng. pmid:24122315
Sutherlin A and Rodwell VW Multienzyme mevalonate pathway bioreactor. 2004 Biotechnol. Bioeng. pmid:15286992
Asadollahi MA et al. Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae. 2010 Biotechnol. Bioeng. pmid:20091767
Yoon SH et al. Enhanced lycopene production in Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate. 2006 Biotechnol. Bioeng. pmid:16547999
Tabata K and Hashimoto S Production of mevalonate by a metabolically-engineered Escherichia coli. 2004 Biotechnol. Lett. pmid:15604784
Hong SB et al. Role of the non-mevalonate pathway in indole alkaloid production by Catharanthus roseus hairy roots. 2003 May-Jun Biotechnol. Prog. pmid:12790690
Yoon SH et al. Increased beta-carotene production in recombinant Escherichia coli harboring an engineered isoprenoid precursor pathway with mevalonate addition. 2007 May-Jun Biotechnol. Prog. pmid:17500531
Hoffman PC et al. Effect of oxygenated sterol compounds on human bone marrow granulocytic progenitor cells. 1981 Blood pmid:7448408
Singh NK et al. 12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation. 2011 Blood pmid:21841162
Gubina E et al. CD43 polarization in unprimed T cells can be dissociated from raft coalescence by inhibition of HMG CoA reductase. 2002 Blood pmid:11895788
Larson RA and Yachnin S Mevalonic acid induces DNA synthesis in chronic lymphocytic leukemia cells. 1984 Blood pmid:6610447
Clendening JW et al. Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma. 2010 Blood pmid:20360469
Zeiser R et al. Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity. 2007 Blood pmid:17827390
Coscia M et al. Dysfunctional Vγ9Vδ2 T cells are negative prognosticators and markers of dysregulated mevalonate pathway activity in chronic lymphocytic leukemia cells. 2012 Blood pmid:22932792
Yachnin S et al. Increased cholesterol biosynthesis in leukemic cells from patients with hairy cell leukemia. 1983 Blood pmid:6600213
Thompson K et al. Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway. 2006 Blood pmid:16179378
Hoffman PC et al. Cholesterol and mevalonic acid are independent requirements for the in vitro proliferation of human bone marrow granulocyte progenitor cells: studies using ML-236B. 1983 Blood pmid:6831033
Shi J et al. Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation. 2003 Blood Coagul. Fibrinolysis pmid:12960612
Benetka W et al. Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo. 2006 BMC Biochem. pmid:16507103
Bate C et al. Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells. 2008 BMC Biol. pmid:18789130
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Maciejak A et al. The effects of statins on the mevalonic acid pathway in recombinant yeast strains expressing human HMG-CoA reductase. 2013 BMC Biotechnol. pmid:24128347
Knight LA et al. Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay. 2009 BMC Cancer pmid:19175937
Glynn SA et al. The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells. 2008 BMC Cancer pmid:18199328
Vamvakopoulos JE and Green C HMG-CoA reductase inhibition aborts functional differentiation and triggers apoptosis in cultured primary human monocytes: a potential mechanism of statin-mediated vasculoprotection. 2003 BMC Cardiovasc Disord pmid:12871602
Paradisi M et al. Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress. 2005 BMC Cell Biol. pmid:15982412
Reichart B et al. Expression and localization of nuclear proteins in autosomal-dominant Emery-Dreifuss muscular dystrophy with LMNA R377H mutation. 2004 BMC Cell Biol. pmid:15053843
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Barrero RA et al. De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes. 2011 BMC Genomics pmid:22151917
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Gallagher KA and Jensen PR Genomic insights into the evolution of hybrid isoprenoid biosynthetic gene clusters in the MAR4 marine streptomycete clade. 2015 BMC Genomics pmid:26578069
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Singh RS et al. Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston]. 2010 BMC Mol. Biol. pmid:21092138
Sakamoto K et al. Simvastatin suppresses dexamethasone-induced secretion of plasminogen activator inhibitor-1 in human bone marrow adipocytes. 2011 BMC Musculoskelet Disord pmid:21524281
Martin DM et al. Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, FLcDNA cloning, and enzyme assays. 2010 BMC Plant Biol. pmid:20964856
González-Candelas L et al. A transcriptomic approach highlights induction of secondary metabolism in citrus fruit in response to Penicillium digitatum infection. 2010 BMC Plant Biol. pmid:20807411
Sgraja T et al. Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase. 2007 BMC Struct. Biol. pmid:17397541
Kervizic G and Corcos L Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. 2008 BMC Syst Biol pmid:19025648